SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1mkm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 1mkm ICLR TRANSCRIPTIONAL
REGULATOR
(Thermotoga
maritima) 		5 / 12 VAL A 197
GLY A 198
LEU A 233
PHE A 221
GLU A 228
 None
 1.50A 1a27A-1mkmA:
undetectable		 1a27A-1mkmA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_B_NCAB1246_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 1mkm ICLR TRANSCRIPTIONAL
REGULATOR
(Thermotoga
maritima) 		4 / 7 GLY A 206
SER A 241
PHE A 202
GLU A 238
 None
 0.99A 2c8aB-1mkmA:
undetectable		 2c8aB-1mkmA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_D_NCAD1247_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 1mkm ICLR TRANSCRIPTIONAL
REGULATOR
(Thermotoga
maritima) 		4 / 7 GLY A 206
SER A 241
PHE A 202
GLU A 238
 None
 1.00A 2c8aD-1mkmA:
undetectable		 2c8aD-1mkmA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 1mkm ICLR TRANSCRIPTIONAL
REGULATOR
(Thermotoga
maritima) 		3 / 3 THR A 133
SER A 135
PHE A 221
 ZN  A 402 (-4.1A)
None
None
 0.72A 3d4sA-1mkmA:
undetectable		 3d4sA-1mkmA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1mkm ICLR TRANSCRIPTIONAL
REGULATOR
(Thermotoga
maritima) 		5 / 10 ILE A 109
ALA A  81
SER A 135
SER A 138
ILE A 139
 None
 1.05A 3qgtB-1mkmA:
undetectable		 3qgtB-1mkmA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 1mkm ICLR TRANSCRIPTIONAL
REGULATOR
(Thermotoga
maritima) 		5 / 12 ASP A 203
PRO A 200
ILE A  77
VAL A 209
ILE A 139
 None
 1.44A 4eb6B-1mkmA:
undetectable
4eb6C-1mkmA:
undetectable		 4eb6B-1mkmA:
19.55
4eb6C-1mkmA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		 1mkm ICLR TRANSCRIPTIONAL
REGULATOR
(Thermotoga
maritima) 		4 / 7 ILE A 201
LEU A 244
ALA A 210
ALA A  81
 None
 0.79A 4g77A-1mkmA:
undetectable		 4g77A-1mkmA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		 1mkm ICLR TRANSCRIPTIONAL
REGULATOR
(Thermotoga
maritima) 		4 / 7 SER A 230
TYR A 183
TYR A 229
GLU A 228
 None
 1.06A 5aclA-1mkmA:
undetectable		 5aclA-1mkmA:
18.14