SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1mkp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 1mkp PYST1
(Homo
sapiens) 		3 / 3 ASP A 221
THR A 240
PRO A 241
 None
 0.72A 2qakB-1mkpA:
undetectable		 2qakB-1mkpA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1437_1
(ORF12)		 1mkp PYST1
(Homo
sapiens) 		5 / 11 LYS A 327
SER A 293
SER A 300
GLY A 296
ALA A 219
 None
CL  A 500 (-3.0A)
None
CL  A 500 ( 4.0A)
None
 1.50A 2xh9A-1mkpA:
undetectable		 2xh9A-1mkpA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA305_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 1mkp PYST1
(Homo
sapiens) 		4 / 7 ILE A 330
ILE A 297
SER A 300
THR A 304
 None
 0.85A 3deuA-1mkpA:
undetectable		 3deuA-1mkpA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B304_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 1mkp PYST1
(Homo
sapiens) 		4 / 5 THR A 302
SER A 300
SER A 293
ARG A 299
 MPD  A 501 ( 4.2A)
None
CL  A 500 (-3.0A)
CL  A 500 (-4.6A)
 1.38A 3hlwB-1mkpA:
undetectable		 3hlwB-1mkpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 1mkp PYST1
(Homo
sapiens) 		4 / 6 LEU A 314
MET A 325
LEU A 211
ILE A 276
 None
 0.93A 4okxA-1mkpA:
undetectable		 4okxA-1mkpA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1mkp PYST1
(Homo
sapiens) 		4 / 6 VAL A 323
VAL A 291
SER A 300
ILE A 260
 None
 0.99A 5jw1B-1mkpA:
undetectable		 5jw1B-1mkpA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW3_A_ACTA404_0
(FERREDOXIN--NADP
REDUCTASE)		 1mkp PYST1
(Homo
sapiens) 		4 / 4 GLN A 270
LEU A 268
ASN A 267
GLN A 339
 None
 1.24A 5vw3A-1mkpA:
2.5		 5vw3A-1mkpA:
19.40