SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1mkx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 1mkx PRETHROMBIN-2
(Bos
taurus) 		4 / 8 HIS K  57
SER K 195
VAL K 213
GLY K 226
 None
 0.49A 1aq7A-1mkxK:
27.3		 1aq7A-1mkxK:
37.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 1mkx PRETHROMBIN-2
(Bos
taurus) 		4 / 6 LEU K  99
ILE K 174
TRP K 215
GLU K 217
 None
 0.66A 1ditH-1mkxK:
36.6
1ditP-1mkxK:
undetectable		 1ditH-1mkxK:
87.26
1ditP-1mkxK:
4.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))		 1mkx PRETHROMBIN-2
(Bos
taurus) 		7 / 9 HIS K  57
TYR K  60
TRP K  60
ILE K 174
SER K 195
TRP K 215
GLY K 226
 None
 0.58A 1dwcH-1mkxK:
36.6		 1dwcH-1mkxK:
87.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 1mkx PRETHROMBIN-2
(Bos
taurus) 		8 / 12 HIS K  57
TYR K  60
TRP K  60
LEU K  99
SER K 195
TRP K 215
GLY K 216
GLY K 226
 None
 0.97A 1etrH-1mkxK:
37.1		 1etrH-1mkxK:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 1mkx PRETHROMBIN-2
(Bos
taurus) 		8 / 12 HIS K  57
TYR K  60
TRP K  60
LEU K  99
SER K 195
VAL K 213
TRP K 215
GLY K 226
 None
 0.62A 1etrH-1mkxK:
37.1		 1etrH-1mkxK:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F9G_A_ASCA950_0
(HYALURONATE LYASE)		 1mkx PRETHROMBIN-2
(Bos
taurus) 		4 / 7 ARG K 233
ASN K  98
ARG K  93
ASN K  95
 None
 0.98A 1f9gA-1mkxK:
undetectable		 1f9gA-1mkxK:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_2
(LIVER
CARBOXYLESTERASE I)		 1mkx PRETHROMBIN-2
(Bos
taurus) 		3 / 3 PHE K 199
LEU K 162
LEU K 130
 None
 0.63A 1mx1E-1mkxK:
undetectable		 1mx1E-1mkxK:
20.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H9T_H_SVRH301_1
(THROMBIN)		 1mkx PRETHROMBIN-2
(Bos
taurus) 		6 / 11 HIS K  91
PRO K  92
ARG K  93
ARG K 101
TRP K 237
VAL K 241
 None
 0.47A 2h9tH-1mkxK:
35.2		 2h9tH-1mkxK:
87.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 1mkx PRETHROMBIN-2
(Bos
taurus) 		5 / 12 SER K 195
VAL K 213
TRP K 215
GLY K 226
TYR K 228
 None
 0.52A 2p16A-1mkxK:
29.2		 2p16A-1mkxK:
40.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 1mkx PRETHROMBIN-2
(Bos
taurus) 		3 / 3 ASP K 100
ASN K  98
THR K 172
 None
 0.78A 2q63B-1mkxK:
undetectable		 2q63B-1mkxK:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1mkx PRETHROMBIN-2
(Bos
taurus) 		4 / 8 LEU K  14
LEU K 162
ALA K 183
PHE K 199
 None
 0.78A 2vcvF-1mkxK:
undetectable		 2vcvF-1mkxK:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1mkx PRETHROMBIN-2
(Bos
taurus) 		4 / 8 LEU K  14
LEU K 162
ALA K 183
PHE K 199
 None
 0.73A 2vcvP-1mkxK:
0.0		 2vcvP-1mkxK:
22.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 1mkx PRETHROMBIN-2
(Bos
taurus) 		5 / 12 SER K 195
VAL K 213
TRP K 215
GLY K 226
TYR K 228
 None
 0.45A 2w26A-1mkxK:
29.1		 2w26A-1mkxK:
40.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BF6_H_SVRH301_1
(THROMBIN, HEAVY
CHAIN)		 1mkx PRETHROMBIN-2
(Bos
taurus) 		6 / 11 HIS K  91
PRO K  92
ARG K  93
ARG K 101
TRP K 237
VAL K 241
 None
 0.77A 3bf6H-1mkxK:
35.7		 3bf6H-1mkxK:
87.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 1mkx PRETHROMBIN-2
(Bos
taurus) 		6 / 11 HIS K  57
LEU K  99
SER K 195
TRP K 215
GLY K 216
GLY K 226
 None
 1.03A 3gy3A-1mkxK:
8.3		 3gy3A-1mkxK:
37.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 1mkx PRETHROMBIN-2
(Bos
taurus) 		5 / 10 VAL K 213
GLY K 196
VAL K 158
ASN K 143
GLY K 193
 None
 1.18A 3km6A-1mkxK:
undetectable		 3km6A-1mkxK:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 1mkx PRETHROMBIN-2
(Bos
taurus) 		5 / 9 VAL K 213
GLY K 196
VAL K 158
ASN K 143
GLY K 193
 None
 1.18A 3kmoA-1mkxK:
undetectable		 3kmoA-1mkxK:
18.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 1mkx PRETHROMBIN-2
(Bos
taurus) 		4 / 6 SER K 195
VAL K 213
TRP K 215
GLY K 226
 None
 0.37A 3rxfA-1mkxK:
27.8		 3rxfA-1mkxK:
37.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 1mkx PRETHROMBIN-2
(Bos
taurus) 		4 / 8 ARG K  77
GLU K  80
LYS K  70
ARG K  67
 None
 1.08A 4bqfB-1mkxK:
undetectable		 4bqfB-1mkxK:
17.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_B_15UB402_1
(PROTHROMBIN)		 1mkx PRETHROMBIN-2
(Bos
taurus) 		6 / 12 HIS K  57
TYR K  60
LEU K  99
GLU K 146
GLY K 216
GLY K 226
 None
 1.24A 4hfpB-1mkxK:
36.0		 4hfpB-1mkxK:
86.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_B_15UB402_1
(PROTHROMBIN)		 1mkx PRETHROMBIN-2
(Bos
taurus) 		6 / 12 HIS K  57
TYR K  60
LEU K  99
ILE K 174
GLU K 146
GLY K 226
 None
 0.86A 4hfpB-1mkxK:
36.0		 4hfpB-1mkxK:
86.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_B_15UB402_1
(PROTHROMBIN)		 1mkx PRETHROMBIN-2
(Bos
taurus) 		6 / 12 HIS K  57
TYR K  60
TRP K  60
LEU K  99
GLY K 216
GLY K 226
 None
 0.87A 4hfpB-1mkxK:
36.0		 4hfpB-1mkxK:
86.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_B_15UB402_1
(PROTHROMBIN)		 1mkx PRETHROMBIN-2
(Bos
taurus) 		6 / 12 HIS K  57
TYR K  60
TRP K  60
LEU K  99
ILE K 174
GLY K 226
 None
 0.57A 4hfpB-1mkxK:
36.0		 4hfpB-1mkxK:
86.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_B_15UB402_1
(PROTHROMBIN)		 1mkx PRETHROMBIN-2
(Bos
taurus) 		6 / 12 TYR K  60
LYS K  60
LEU K  99
GLU K 146
GLY K 216
GLY K 226
 None
 1.34A 4hfpB-1mkxK:
36.0		 4hfpB-1mkxK:
86.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_B_15UB402_1
(PROTHROMBIN)		 1mkx PRETHROMBIN-2
(Bos
taurus) 		6 / 12 TYR K  60
LYS K  60
LEU K  99
ILE K 174
GLU K 146
GLY K 226
 None
 0.98A 4hfpB-1mkxK:
36.0		 4hfpB-1mkxK:
86.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_B_15UB402_1
(PROTHROMBIN)		 1mkx PRETHROMBIN-2
(Bos
taurus) 		6 / 12 TYR K  60
TRP K  60
LYS K  60
LEU K  99
GLY K 216
GLY K 226
 None
 1.06A 4hfpB-1mkxK:
36.0		 4hfpB-1mkxK:
86.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_B_15UB402_1
(PROTHROMBIN)		 1mkx PRETHROMBIN-2
(Bos
taurus) 		6 / 12 TYR K  60
TRP K  60
LYS K  60
LEU K  99
ILE K 174
GLY K 226
 None
 0.80A 4hfpB-1mkxK:
36.0		 4hfpB-1mkxK:
86.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_D_15UD402_1
(PROTHROMBIN)		 1mkx PRETHROMBIN-2
(Bos
taurus) 		8 / 12 HIS K  57
TYR K  60
TRP K  60
LEU K  99
ILE K 174
VAL K 213
TRP K 215
GLY K 226
 None
 0.41A 4hfpD-1mkxK:
36.6		 4hfpD-1mkxK:
86.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_D_15UD402_1
(PROTHROMBIN)		 1mkx PRETHROMBIN-2
(Bos
taurus) 		6 / 12 LEU K  99
ILE K 174
GLU K 146
VAL K 213
TRP K 215
GLY K 226
 None
 0.90A 4hfpD-1mkxK:
36.6		 4hfpD-1mkxK:
86.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		 1mkx PRETHROMBIN-2
(Bos
taurus) 		6 / 10 HIS K  57
TYR K  60
TRP K  60
LEU K  99
ALA K 190
GLY K 216
 None
 1.03A 4rn6A-1mkxK:
42.4		 4rn6A-1mkxK:
85.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		 1mkx PRETHROMBIN-2
(Bos
taurus) 		6 / 10 HIS K  57
TYR K  60
TRP K  60
LEU K  99
TRP K 215
GLY K 216
 None
 0.84A 4rn6A-1mkxK:
42.4		 4rn6A-1mkxK:
85.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 1mkx PRETHROMBIN-2
(Bos
taurus) 		5 / 12 HIS K  57
TYR K  60
TRP K  60
ALA K 190
VAL K 213
 None
 0.75A 4rn6B-1mkxK:
42.9		 4rn6B-1mkxK:
85.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 1mkx PRETHROMBIN-2
(Bos
taurus) 		6 / 12 HIS K  57
TYR K  60
TRP K  60
LEU K  99
TRP K 215
GLY K 216
 None
 0.78A 4rn6B-1mkxK:
42.9		 4rn6B-1mkxK:
85.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 1mkx PRETHROMBIN-2
(Bos
taurus) 		7 / 12 HIS K  57
TYR K  60
TRP K  60
LEU K  99
VAL K 213
TRP K 215
GLY K 226
 None
 0.45A 4rn6B-1mkxK:
42.9		 4rn6B-1mkxK:
85.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1mkx PRETHROMBIN-2
(Bos
taurus) 		4 / 6 VAL K 231
LEU K  46
SER K  45
ILE K  68
 None
 0.80A 5jw1A-1mkxK:
undetectable		 5jw1A-1mkxK:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 1mkx PRETHROMBIN-2
(Bos
taurus) 		5 / 12 GLY K 211
SER K  45
THR K 229
VAL K 200
ALA K 183
 None
 0.93A 5kpcA-1mkxK:
undetectable		 5kpcA-1mkxK:
24.09