SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1mky'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 1mky PROBABLE GTP-BINDING
PROTEIN ENGA
(Thermotoga
maritima) 		5 / 12 VAL A 186
ARG A 188
ARG A 283
ILE A 277
ILE A 269
 None
None
PO4  A 604 (-3.7A)
None
None
 1.10A 1d1gB-1mkyA:
undetectable		 1d1gB-1mkyA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3004_1
(SERUM ALBUMIN)		 1mky PROBABLE GTP-BINDING
PROTEIN ENGA
(Thermotoga
maritima) 		4 / 7 PHE A 414
LEU A 382
VAL A 401
LEU A 369
 None
 0.97A 1hk3A-1mkyA:
undetectable		 1hk3A-1mkyA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)		 1mky PROBABLE GTP-BINDING
PROTEIN ENGA
(Thermotoga
maritima) 		5 / 12 PRO A 395
PHE A 426
GLY A 428
SER A 329
ALA A 354
 None
 1.18A 1nw5A-1mkyA:
undetectable		 1nw5A-1mkyA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VM1_A_TAZA504_1
(BETA-LACTAMASE SHV-1)		 1mky PROBABLE GTP-BINDING
PROTEIN ENGA
(Thermotoga
maritima) 		3 / 3 ASP A 327
TYR A 324
GLU A 289
 None
 0.83A 1vm1A-1mkyA:
undetectable		 1vm1A-1mkyA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1mky PROBABLE GTP-BINDING
PROTEIN ENGA
(Thermotoga
maritima) 		5 / 9 LEU A 238
LEU A 196
ILE A 200
PHE A 232
ILE A 185
 None
 1.25A 2f7aB-1mkyA:
1.4		 2f7aB-1mkyA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)		 1mky PROBABLE GTP-BINDING
PROTEIN ENGA
(Thermotoga
maritima) 		5 / 9 VAL A  12
GLY A   8
LEU A  86
LEU A  53
ASP A  55
 PO4  A 601 (-4.1A)
None
None
None
None
 1.01A 2j2pB-1mkyA:
0.0
2j2pC-1mkyA:
undetectable		 2j2pB-1mkyA:
18.00
2j2pC-1mkyA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1mky PROBABLE GTP-BINDING
PROTEIN ENGA
(Thermotoga
maritima) 		4 / 7 PHE A  51
LEU A 164
LEU A 169
PRO A 361
 None
 1.03A 2jn3A-1mkyA:
undetectable		 2jn3A-1mkyA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)		 1mky PROBABLE GTP-BINDING
PROTEIN ENGA
(Thermotoga
maritima) 		4 / 5 LEU A 378
PRO A 379
LEU A 382
ILE A 384
 None
 0.88A 2qd4A-1mkyA:
3.4		 2qd4A-1mkyA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_A_ADNA1301_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1mky PROBABLE GTP-BINDING
PROTEIN ENGA
(Thermotoga
maritima) 		4 / 7 GLU A 141
ALA A 120
PRO A 142
ALA A 117
 None
 1.10A 2zgwA-1mkyA:
undetectable		 2zgwA-1mkyA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_B_ADNB1302_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1mky PROBABLE GTP-BINDING
PROTEIN ENGA
(Thermotoga
maritima) 		4 / 6 GLU A 141
ALA A 120
PRO A 142
ALA A 117
 None
 1.10A 2zgwB-1mkyA:
undetectable		 2zgwB-1mkyA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 1mky PROBABLE GTP-BINDING
PROTEIN ENGA
(Thermotoga
maritima) 		5 / 11 VAL A 208
ALA A 206
ILE A 346
ILE A 185
LEU A 238
 None
 0.96A 3clbA-1mkyA:
2.8		 3clbA-1mkyA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 1mky PROBABLE GTP-BINDING
PROTEIN ENGA
(Thermotoga
maritima) 		4 / 5 ASP A 347
ARG A 228
ILE A 225
THR A 357
 None
 1.25A 3eigA-1mkyA:
undetectable		 3eigA-1mkyA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1mky PROBABLE GTP-BINDING
PROTEIN ENGA
(Thermotoga
maritima) 		5 / 10 VAL A 208
ALA A 206
ILE A 346
ILE A 185
LEU A 238
 None
 0.96A 3hbbA-1mkyA:
2.9		 3hbbA-1mkyA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM0_B_SALB301_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 1mky PROBABLE GTP-BINDING
PROTEIN ENGA
(Thermotoga
maritima) 		4 / 4 ARG A 293
LYS A 182
ILE A 181
LYS A 393
 None
 1.39A 4em0B-1mkyA:
0.0		 4em0B-1mkyA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1mky PROBABLE GTP-BINDING
PROTEIN ENGA
(Thermotoga
maritima) 		4 / 4 LEU A 378
PRO A 379
LEU A 382
ILE A 384
 None
 0.85A 4f4dB-1mkyA:
2.2		 4f4dB-1mkyA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 1mky PROBABLE GTP-BINDING
PROTEIN ENGA
(Thermotoga
maritima) 		5 / 12 LEU A  53
VAL A   4
ILE A 114
LEU A  84
VAL A  89
 None
 1.06A 4y0qA-1mkyA:
undetectable		 4y0qA-1mkyA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 1mky PROBABLE GTP-BINDING
PROTEIN ENGA
(Thermotoga
maritima) 		3 / 3 ASP A  90
GLU A 125
SER A  15
 None
None
PO4  A 601 (-2.9A)
 0.86A 5bw4B-1mkyA:
undetectable		 5bw4B-1mkyA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_0
(CYTOCHROME P450 1A1)		 1mky PROBABLE GTP-BINDING
PROTEIN ENGA
(Thermotoga
maritima) 		5 / 12 ILE A 365
PHE A 399
ASN A 366
PHE A 386
ILE A 431
 None
 1.33A 6dwnB-1mkyA:
undetectable		 6dwnB-1mkyA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_A_CXQA507_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 1mky PROBABLE GTP-BINDING
PROTEIN ENGA
(Thermotoga
maritima) 		4 / 5 ARG A 293
ALA A 294
TYR A 353
ILE A 392
 None
 1.12A 6f6sA-1mkyA:
0.0
6f6sB-1mkyA:
0.0		 6f6sA-1mkyA:
11.75
6f6sB-1mkyA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_B_IXXB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 1mky PROBABLE GTP-BINDING
PROTEIN ENGA
(Thermotoga
maritima) 		4 / 5 ARG A 293
ALA A 294
TYR A 353
ILE A 392
 None
 1.02A 6g9bA-1mkyA:
0.0
6g9bB-1mkyA:
undetectable		 6g9bA-1mkyA:
11.75
6g9bB-1mkyA:
11.27