SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1mld'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 1mld MALATE DEHYDROGENASE
(Sus
scrofa) 		5 / 9 GLY A   7
ASP A  33
ILE A  34
ALA A  76
ILE A  96
 None
 0.49A 1cetA-1mldA:
33.0		 1cetA-1mldA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 1mld MALATE DEHYDROGENASE
(Sus
scrofa) 		6 / 12 LEU A  66
ALA A   4
LEU A   6
ALA A  76
ILE A 113
ILE A  74
 None
 1.14A 1fk6A-1mldA:
undetectable		 1fk6A-1mldA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 1mld MALATE DEHYDROGENASE
(Sus
scrofa) 		4 / 6 ASN A  93
GLY A  10
ILE A  12
ILE A  96
 None
 0.93A 1n49D-1mldA:
undetectable		 1n49D-1mldA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 1mld MALATE DEHYDROGENASE
(Sus
scrofa) 		4 / 6 ASN A 118
ASP A  87
GLY A 178
ILE A 181
 CIT  A 375 (-3.2A)
None
None
None
 0.90A 1n49D-1mldA:
undetectable		 1n49D-1mldA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 1mld MALATE DEHYDROGENASE
(Sus
scrofa) 		4 / 5 PRO A 183
VAL A 170
VAL A 157
ILE A 206
 None
 1.09A 1z2bC-1mldA:
5.7		 1z2bC-1mldA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1mld MALATE DEHYDROGENASE
(Sus
scrofa) 		3 / 3 LEU A  16
PRO A  15
LEU A  19
 None
 0.53A 2po5B-1mldA:
3.3		 2po5B-1mldA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1mld MALATE DEHYDROGENASE
(Sus
scrofa) 		3 / 3 LEU A  16
PRO A  15
LEU A  19
 None
 0.55A 2po7B-1mldA:
3.0		 2po7B-1mldA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 1mld MALATE DEHYDROGENASE
(Sus
scrofa) 		4 / 5 SER A 237
GLY A 231
GLU A 250
CYH A 114
 None
 1.19A 3aiaA-1mldA:
2.1
3aiaB-1mldA:
1.9		 3aiaA-1mldA:
20.89
3aiaB-1mldA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 1mld MALATE DEHYDROGENASE
(Sus
scrofa) 		4 / 5 ASP A  33
ILE A  12
VAL A  73
THR A 101
 None
 1.18A 3eigA-1mldA:
1.1		 3eigA-1mldA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1mld MALATE DEHYDROGENASE
(Sus
scrofa) 		5 / 10 ILE A 113
ILE A  74
GLY A   7
VAL A 235
LEU A  66
 None
 1.38A 3elzB-1mldA:
undetectable		 3elzB-1mldA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 1mld MALATE DEHYDROGENASE
(Sus
scrofa) 		4 / 8 VAL A 172
ILE A 124
VAL A 120
GLY A 175
 None
 0.81A 3hjoB-1mldA:
undetectable		 3hjoB-1mldA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)		 1mld MALATE DEHYDROGENASE
(Sus
scrofa) 		5 / 12 THR A  99
GLY A   7
ILE A  96
LEU A  31
LEU A  16
 None
 1.22A 3q87B-1mldA:
5.0		 3q87B-1mldA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_1
(HIV-1 PROTEASE)		 1mld MALATE DEHYDROGENASE
(Sus
scrofa) 		5 / 8 ASN A 118
ASP A  87
GLY A 178
ILE A 181
THR A 211
 CIT  A 375 (-3.2A)
None
None
None
None
 1.28A 3so9A-1mldA:
undetectable		 3so9A-1mldA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1mld MALATE DEHYDROGENASE
(Sus
scrofa) 		4 / 6 PHE A 156
ILE A 206
ARG A 152
VAL A 213
 None
None
CIT  A 375 (-2.8A)
None
 1.24A 4mk4B-1mldA:
2.3		 4mk4B-1mldA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_1
(PROTEASE)		 1mld MALATE DEHYDROGENASE
(Sus
scrofa) 		5 / 11 GLY A   7
VAL A  97
ILE A 115
THR A  92
ILE A  96
 None
 0.96A 4njvC-1mldA:
undetectable		 4njvC-1mldA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1mld MALATE DEHYDROGENASE
(Sus
scrofa) 		5 / 9 THR A 224
ALA A 228
ALA A 232
GLY A  11
GLY A  13
 None
 1.13A 4qwuK-1mldA:
undetectable
4qwuL-1mldA:
undetectable		 4qwuK-1mldA:
21.67
4qwuL-1mldA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1mld MALATE DEHYDROGENASE
(Sus
scrofa) 		5 / 9 THR A 224
ALA A 228
ALA A 232
GLY A  11
GLY A  13
 None
 1.12A 4qwuY-1mldA:
undetectable
4qwuZ-1mldA:
undetectable		 4qwuY-1mldA:
21.67
4qwuZ-1mldA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1mld MALATE DEHYDROGENASE
(Sus
scrofa) 		5 / 9 THR A 127
ILE A 115
PHE A 131
LEU A  66
LEU A  62
 None
 1.42A 4ze0A-1mldA:
0.0		 4ze0A-1mldA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1mld MALATE DEHYDROGENASE
(Sus
scrofa) 		5 / 11 HIS A 176
THR A 211
GLY A 221
ALA A 223
THR A 224
 CIT  A 375 (-3.8A)
None
None
CIT  A 375 (-3.6A)
None
 1.46A 5bxnV-1mldA:
undetectable
5bxnb-1mldA:
undetectable		 5bxnV-1mldA:
22.22
5bxnb-1mldA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1mld MALATE DEHYDROGENASE
(Sus
scrofa) 		5 / 11 HIS A 176
THR A 211
GLY A 221
ALA A 223
THR A 224
 CIT  A 375 (-3.8A)
None
None
CIT  A 375 (-3.6A)
None
 1.47A 5bxnH-1mldA:
undetectable
5bxnN-1mldA:
undetectable		 5bxnH-1mldA:
22.22
5bxnN-1mldA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 1mld MALATE DEHYDROGENASE
(Sus
scrofa) 		5 / 11 VAL A  73
VAL A   3
VAL A  71
PHE A 236
LEU A  20
 None
 1.08A 5e4dB-1mldA:
0.0		 5e4dB-1mldA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1mld MALATE DEHYDROGENASE
(Sus
scrofa) 		4 / 7 ALA A 102
THR A 101
VAL A 310
HIS A 134
 None
 1.11A 5ecnA-1mldA:
0.1		 5ecnA-1mldA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1mld MALATE DEHYDROGENASE
(Sus
scrofa) 		5 / 11 LEU A   6
ILE A  34
ILE A  74
GLY A  77
LEU A  62
 None
 0.93A 5twjD-1mldA:
2.1		 5twjD-1mldA:
19.22