SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1mlz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 8 ALA A 420
HIS A 372
THR A 370
ILE A 397
 None
 0.81A 1c9sI-1mlzA:
undetectable
1c9sJ-1mlzA:
undetectable		 1c9sI-1mlzA:
12.63
1c9sJ-1mlzA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 8 ALA A 420
HIS A 372
THR A 370
ILE A 397
 None
 0.76A 1c9sU-1mlzA:
undetectable
1c9sV-1mlzA:
undetectable		 1c9sU-1mlzA:
12.63
1c9sV-1mlzA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 8 ASP A 156
PHE A 140
ASN A 142
LEU A 197
 None
 0.90A 1lhvA-1mlzA:
undetectable		 1lhvA-1mlzA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_B_TRPB81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 8 ALA A 420
HIS A 372
THR A 370
ILE A 397
 None
 0.81A 1utdB-1mlzA:
undetectable
1utdC-1mlzA:
undetectable		 1utdB-1mlzA:
12.63
1utdC-1mlzA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_I_TRPI81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 8 ALA A 420
HIS A 372
THR A 370
ILE A 397
 None
 0.80A 1utdI-1mlzA:
undetectable
1utdJ-1mlzA:
undetectable		 1utdI-1mlzA:
12.63
1utdJ-1mlzA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_J_TRPJ81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 8 ALA A 420
HIS A 372
THR A 370
ILE A 397
 None
 0.78A 1utdJ-1mlzA:
undetectable
1utdK-1mlzA:
undetectable		 1utdJ-1mlzA:
12.63
1utdK-1mlzA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 5 LEU A  37
ASP A  47
GLY A 279
ALA A  32
 None
 0.92A 2aohA-1mlzA:
undetectable		 2aohA-1mlzA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE
(Escherichia
coli) 		3 / 3 SER A 111
ASP A 147
CYH A 155
 PLP  A 430 ( 3.9A)
None
None
 1.18A 2br4E-1mlzA:
2.0		 2br4E-1mlzA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA996_1
(GLUCOAMYLASE GLU1)		 1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 7 HIS A  57
ASN A  65
THR A 277
GLY A 278
 None
 0.90A 2f6dA-1mlzA:
undetectable		 2f6dA-1mlzA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)		 1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE
(Escherichia
coli) 		3 / 3 ARG A 221
VAL A 154
THR A 139
 None
 0.67A 2nmzA-1mlzA:
0.0		 2nmzA-1mlzA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE
(Escherichia
coli) 		3 / 3 ARG A 221
VAL A 154
THR A 139
 None
 0.65A 2nnkA-1mlzA:
undetectable		 2nnkA-1mlzA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA802_1
(PROSTAGLANDIN
REDUCTASE 1)		 1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 7 VAL A 367
GLY A 218
VAL A 214
ASP A 156
 None
 0.93A 2y05A-1mlzA:
3.9
2y05B-1mlzA:
undetectable		 2y05A-1mlzA:
20.95
2y05B-1mlzA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 11 GLY A 273
GLY A 112
ALA A 285
THR A 286
ALA A 248
 None
PLP  A 430 (-3.3A)
None
None
PLP  A 430 ( 3.7A)
 1.10A 3g88B-1mlzA:
1.5		 3g88B-1mlzA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 12 GLY A 273
GLY A 112
ALA A 285
THR A 286
ALA A 248
 None
PLP  A 430 (-3.3A)
None
None
PLP  A 430 ( 3.7A)
 1.09A 3g8bB-1mlzA:
undetectable		 3g8bB-1mlzA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 12 ILE A 390
TRP A 389
LEU A 410
GLN A 411
LEU A 347
 None
 1.15A 3ix9A-1mlzA:
undetectable		 3ix9A-1mlzA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 12 PRO A 402
GLY A 366
ARG A 360
VAL A 359
GLU A 369
 None
 1.43A 3jb2A-1mlzA:
0.0		 3jb2A-1mlzA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_2
(HIV-1 PROTEASE)		 1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE
(Escherichia
coli) 		3 / 3 ARG A 221
VAL A 154
THR A 139
 None
 0.67A 3k4vA-1mlzA:
undetectable		 3k4vA-1mlzA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE
(Escherichia
coli) 		3 / 3 ARG A 221
VAL A 154
THR A 139
 None
 0.59A 3k4vD-1mlzA:
0.0		 3k4vD-1mlzA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)		 1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE
(Escherichia
coli) 		3 / 3 ARG A 221
VAL A 154
THR A 139
 None
 0.57A 3nduD-1mlzA:
0.0		 3nduD-1mlzA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_1
(PROTEASE)		 1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 9 ALA A 207
ASP A 268
ILE A 269
VAL A 116
ILE A 243
 None
 1.08A 3nu4A-1mlzA:
undetectable		 3nu4A-1mlzA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE
(Escherichia
coli) 		3 / 3 ARG A 221
VAL A 154
THR A 139
 None
 0.73A 3pwrA-1mlzA:
undetectable		 3pwrA-1mlzA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 6 VAL A 116
SER A 113
TYR A 144
GLY A 146
 None
PLP  A 430 (-2.7A)
TZA  A 431 ( 4.2A)
PLP  A 430 ( 3.7A)
 1.15A 3tj7C-1mlzA:
0.0
3tj7D-1mlzA:
0.0		 3tj7C-1mlzA:
19.85
3tj7D-1mlzA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)		 1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE
(Escherichia
coli) 		3 / 3 ARG A 221
VAL A 154
THR A 139
 None
 0.61A 3tl9A-1mlzA:
undetectable		 3tl9A-1mlzA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE
(Escherichia
coli) 		3 / 3 HIS A  57
HIS A  61
ILE A 404
 None
 0.82A 3u52A-1mlzA:
0.0
3u52C-1mlzA:
undetectable		 3u52A-1mlzA:
21.80
3u52C-1mlzA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 12 ILE A 265
PHE A 251
LEU A  91
LEU A 324
LEU A 103
 None
None
None
None
NA  A 501 (-4.8A)
 1.35A 4j03A-1mlzA:
2.4		 4j03A-1mlzA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_A_H4BA804_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 7 MET A 198
ARG A 136
VAL A 208
GLU A 238
 None
 1.41A 4jseA-1mlzA:
0.0
4jseB-1mlzA:
0.0		 4jseA-1mlzA:
21.06
4jseB-1mlzA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		 1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE
(Escherichia
coli) 		3 / 3 GLY A 394
GLU A 369
THR A 370
 None
 0.55A 4kouA-1mlzA:
0.7		 4kouA-1mlzA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 12 LEU A 173
GLY A 193
PHE A 174
GLU A 188
ALA A 195
 None
 1.20A 4pclA-1mlzA:
3.4		 4pclA-1mlzA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 12 LEU A 276
GLY A 112
ALA A 115
THR A 286
VAL A 106
 None
PLP  A 430 (-3.3A)
None
None
None
 1.02A 4xdrA-1mlzA:
0.0		 4xdrA-1mlzA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 9 ILE A 397
GLY A 366
LEU A 347
LEU A 413
LEU A 410
 None
 1.28A 5fhzB-1mlzA:
0.9		 5fhzB-1mlzA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE
(Escherichia
coli) 		3 / 3 LEU A 399
LEU A 347
ARG A 221
 None
 0.57A 5hnzB-1mlzA:
undetectable		 5hnzB-1mlzA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 7 LEU A 272
ILE A 365
THR A 254
MET A 400
 None
 1.22A 5ljcA-1mlzA:
0.0		 5ljcA-1mlzA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_A_BEZA507_0
(BETA-LACTAMASE VIM-2)		 1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE
(Escherichia
coli) 		3 / 3 THR A 309
HIS A  77
ASN A 313
 None
 0.93A 5n4tA-1mlzA:
0.2		 5n4tA-1mlzA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE
(Escherichia
coli) 		3 / 3 HIS A 224
GLU A 185
TRP A 186
 None
 0.94A 5odiD-1mlzA:
undetectable		 5odiD-1mlzA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE
(Escherichia
coli) 		3 / 3 HIS A 224
GLU A 185
TRP A 186
 None
 1.02A 5odqD-1mlzA:
undetectable		 5odqD-1mlzA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODR_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE
(Escherichia
coli) 		3 / 3 HIS A 224
GLU A 185
TRP A 186
 None
 0.96A 5odrD-1mlzA:
undetectable		 5odrD-1mlzA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)		 1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE
(Escherichia
coli) 		3 / 3 ARG A 253
PRO A 402
TYR A 398
 None
 0.90A 5tzoB-1mlzA:
undetectable		 5tzoB-1mlzA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA612_1
(SERUM ALBUMIN)		 1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 12 GLU A  90
LEU A  64
ILE A 326
ALA A 325
GLU A 328
 None
 1.20A 5v0vA-1mlzA:
undetectable		 5v0vA-1mlzA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)		 1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 12 PHE A  80
ILE A 243
ALA A 123
ILE A 296
ALA A 293
 None
 1.09A 5vc0A-1mlzA:
0.0		 5vc0A-1mlzA:
22.33