SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1mn6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_A_TESA903_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 1mn6 POLYKETIDE SYNTHASE
IV
(Streptomyces
venezuelae) 		4 / 6 TRP A 255
VAL A 232
ILE A 172
LEU A 220
 None
 1.27A 1j96A-1mn6A:
undetectable		 1j96A-1mn6A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGL_L_ESTL911_1
(IG GAMMA-1-CHAIN
IG KAPPA-CHAIN)		 1mn6 POLYKETIDE SYNTHASE
IV
(Streptomyces
venezuelae) 		5 / 10 GLY A 108
ALA A 125
TYR A 216
LEU A 104
PHE A  42
 None
 1.44A 1jglH-1mn6A:
undetectable
1jglL-1mn6A:
undetectable		 1jglH-1mn6A:
18.69
1jglL-1mn6A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		 1mn6 POLYKETIDE SYNTHASE
IV
(Streptomyces
venezuelae) 		5 / 8 LEU A 193
TYR A 178
GLY A 149
TRP A 189
TYR A  25
 None
 1.42A 1jlbA-1mn6A:
undetectable		 1jlbA-1mn6A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 1mn6 POLYKETIDE SYNTHASE
IV
(Streptomyces
venezuelae) 		5 / 7 LEU A 193
TYR A 178
GLY A 149
TRP A 189
TYR A  25
 None
 1.36A 1lweA-1mn6A:
undetectable		 1lweA-1mn6A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1mn6 POLYKETIDE SYNTHASE
IV
(Streptomyces
venezuelae) 		4 / 8 TYR A 216
ALA A 151
ALA A 154
LEU A 126
 None
 0.96A 2wx2B-1mn6A:
undetectable		 2wx2B-1mn6A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 1mn6 POLYKETIDE SYNTHASE
IV
(Streptomyces
venezuelae) 		4 / 6 ARG A 163
ILE A 172
LEU A 174
GLU A 156
 None
 1.07A 2ya7A-1mn6A:
undetectable		 2ya7A-1mn6A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		 1mn6 POLYKETIDE SYNTHASE
IV
(Streptomyces
venezuelae) 		4 / 6 ARG A 163
ILE A 172
LEU A 174
GLU A 156
 None
 1.05A 2ya7B-1mn6A:
undetectable		 2ya7B-1mn6A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 1mn6 POLYKETIDE SYNTHASE
IV
(Streptomyces
venezuelae) 		4 / 6 ARG A 163
ILE A 172
LEU A 174
GLU A 156
 None
 1.06A 2ya7D-1mn6A:
undetectable		 2ya7D-1mn6A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)		 1mn6 POLYKETIDE SYNTHASE
IV
(Streptomyces
venezuelae) 		5 / 10 LEU A 152
HIS A 182
ASP A 256
HIS A 254
TRP A 255
 None
 1.34A 3kcxA-1mn6A:
undetectable		 3kcxA-1mn6A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		 1mn6 POLYKETIDE SYNTHASE
IV
(Streptomyces
venezuelae) 		4 / 5 GLY A  59
ASP A  98
ARG A  97
MET A 272
 None
 1.45A 3qx3B-1mn6A:
2.7		 3qx3B-1mn6A:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)		 1mn6 POLYKETIDE SYNTHASE
IV
(Streptomyces
venezuelae) 		5 / 11 MET A 271
ALA A 282
LEU A 233
GLY A 146
HIS A 147
 None
 1.27A 3uudA-1mn6A:
undetectable		 3uudA-1mn6A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 1mn6 POLYKETIDE SYNTHASE
IV
(Streptomyces
venezuelae) 		5 / 11 GLY A 146
GLY A 150
GLY A 149
ALA A 154
HIS A 155
 None
 1.15A 4l8fB-1mn6A:
2.9		 4l8fB-1mn6A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 1mn6 POLYKETIDE SYNTHASE
IV
(Streptomyces
venezuelae) 		5 / 11 GLY A 150
GLY A 149
ALA A 154
LEU A 153
HIS A 155
 None
 0.98A 4l8fB-1mn6A:
2.9		 4l8fB-1mn6A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 1mn6 POLYKETIDE SYNTHASE
IV
(Streptomyces
venezuelae) 		5 / 11 GLY A 150
GLY A 149
ALA A 154
LEU A 153
HIS A 155
 None
 1.08A 4l8fB-1mn6A:
2.9		 4l8fB-1mn6A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 1mn6 POLYKETIDE SYNTHASE
IV
(Streptomyces
venezuelae) 		5 / 11 PHE A  86
GLY A 149
GLY A 150
GLY A 146
HIS A 155
 None
 1.12A 4l8fB-1mn6A:
2.9		 4l8fB-1mn6A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 1mn6 POLYKETIDE SYNTHASE
IV
(Streptomyces
venezuelae) 		5 / 11 GLY A 146
GLY A 150
GLY A 149
ALA A 154
HIS A 155
 None
 1.18A 4l8fD-1mn6A:
2.9		 4l8fD-1mn6A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 1mn6 POLYKETIDE SYNTHASE
IV
(Streptomyces
venezuelae) 		5 / 11 GLY A 150
GLY A 149
ALA A 154
LEU A 153
HIS A 155
 None
 1.01A 4l8fD-1mn6A:
2.9		 4l8fD-1mn6A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 1mn6 POLYKETIDE SYNTHASE
IV
(Streptomyces
venezuelae) 		5 / 11 PHE A  86
GLY A 149
GLY A 150
GLY A 146
HIS A 155
 None
 1.12A 4l8fD-1mn6A:
2.9		 4l8fD-1mn6A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_A_ACTA401_0
(UNCHARACTERIZED
PROTEIN)		 1mn6 POLYKETIDE SYNTHASE
IV
(Streptomyces
venezuelae) 		5 / 9 GLY A 149
SER A 148
TYR A 107
GLY A  76
THR A  77
 None
 1.44A 4lb0A-1mn6A:
0.0		 4lb0A-1mn6A:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)		 1mn6 POLYKETIDE SYNTHASE
IV
(Streptomyces
venezuelae) 		4 / 5 LEU A 152
GLY A 149
ILE A 186
GLN A 183
 None
 1.17A 4ma8C-1mn6A:
0.0		 4ma8C-1mn6A:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		 1mn6 POLYKETIDE SYNTHASE
IV
(Streptomyces
venezuelae) 		5 / 9 ASP A 207
VAL A  31
ALA A  33
PHE A  28
GLY A 214
 None
 1.21A 4mmbA-1mn6A:
undetectable		 4mmbA-1mn6A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		 1mn6 POLYKETIDE SYNTHASE
IV
(Streptomyces
venezuelae) 		5 / 9 ASP A 207
VAL A  31
ALA A  33
PHE A  28
GLY A 214
 None
 1.18A 4mmfA-1mn6A:
undetectable		 4mmfA-1mn6A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		 1mn6 POLYKETIDE SYNTHASE
IV
(Streptomyces
venezuelae) 		5 / 9 ASP A 207
VAL A  31
ALA A  33
PHE A  28
GLY A 214
 None
 1.17A 4mmfB-1mn6A:
0.0		 4mmfB-1mn6A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_A_ESTA2000_1
(ESTROGEN RECEPTOR)		 1mn6 POLYKETIDE SYNTHASE
IV
(Streptomyces
venezuelae) 		5 / 12 ALA A 282
LEU A 233
LEU A 234
GLY A 146
HIS A 147
 None
 1.08A 4pxmA-1mn6A:
undetectable		 4pxmA-1mn6A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1mn6 POLYKETIDE SYNTHASE
IV
(Streptomyces
venezuelae) 		4 / 7 LEU A  29
ALA A 217
LEU A 197
ALA A  79
 None
 0.58A 4z90F-1mn6A:
undetectable
4z90G-1mn6A:
undetectable
4z90H-1mn6A:
undetectable
4z90J-1mn6A:
undetectable		 4z90F-1mn6A:
19.35
4z90G-1mn6A:
19.35
4z90H-1mn6A:
19.35
4z90J-1mn6A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_A_ESTA601_1
(ESTROGEN RECEPTOR)		 1mn6 POLYKETIDE SYNTHASE
IV
(Streptomyces
venezuelae) 		5 / 10 MET A 271
ALA A 282
LEU A 233
GLY A 146
HIS A 147
 None
 1.25A 5dx3A-1mn6A:
undetectable		 5dx3A-1mn6A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 1mn6 POLYKETIDE SYNTHASE
IV
(Streptomyces
venezuelae) 		5 / 10 MET A 271
ALA A 282
LEU A 233
GLY A 146
HIS A 147
 None
 1.29A 5dxbA-1mn6A:
undetectable		 5dxbA-1mn6A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 1mn6 POLYKETIDE SYNTHASE
IV
(Streptomyces
venezuelae) 		4 / 7 PHE A  99
GLY A 150
ALA A 151
VAL A 232
 None
 0.74A 6dwnB-1mn6A:
undetectable		 6dwnB-1mn6A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1mn6 POLYKETIDE SYNTHASE
IV
(Streptomyces
venezuelae) 		4 / 5 TYR A 107
VAL A 175
PHE A 219
GLY A 214
 None
 1.33A 6hd4A-1mn6A:
undetectable		 6hd4A-1mn6A:
15.89