SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1mo0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1mo0 TRIOSEPHOSPHATE
ISOMERASE
(Caenorhabditis
elegans) 		4 / 8 ALA A 216
ASN A 215
LEU A 219
GLY A 208
 None
None
None
ACT  A 906 ( 4.6A)
 0.87A 1rukH-1mo0A:
undetectable
1rukL-1mo0A:
undetectable		 1rukH-1mo0A:
22.50
1rukL-1mo0A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC1383_1
(CES1 PROTEIN)		 1mo0 TRIOSEPHOSPHATE
ISOMERASE
(Caenorhabditis
elegans) 		4 / 5 TRP A  89
LEU A  87
GLY A  86
LYS A  51
 None
 1.46A 1ya4C-1mo0A:
undetectable		 1ya4C-1mo0A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 1mo0 TRIOSEPHOSPHATE
ISOMERASE
(Caenorhabditis
elegans) 		4 / 5 PHE A   6
ILE A 225
ASN A 158
PHE A 228
 None
 1.08A 3octA-1mo0A:
0.0		 3octA-1mo0A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1mo0 TRIOSEPHOSPHATE
ISOMERASE
(Caenorhabditis
elegans) 		5 / 12 ALA A 233
GLY A 231
TRP A  11
SER A 210
ASP A 214
 None
SO4  A 901 ( 3.3A)
None
SO4  A 901 (-3.7A)
None
 1.26A 3ou7D-1mo0A:
undetectable		 3ou7D-1mo0A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 1mo0 TRIOSEPHOSPHATE
ISOMERASE
(Caenorhabditis
elegans) 		4 / 4 ILE A 159
ASN A 158
ILE A 120
VAL A  90
 None
 1.17A 4uy87-1mo0A:
undetectable		 4uy87-1mo0A:
4.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 1mo0 TRIOSEPHOSPHATE
ISOMERASE
(Caenorhabditis
elegans) 		4 / 8 SER A 234
GLY A   9
TYR A  46
ALA A  44
 None
 0.60A 5albL-1mo0A:
undetectable		 5albL-1mo0A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1mo0 TRIOSEPHOSPHATE
ISOMERASE
(Caenorhabditis
elegans) 		4 / 6 ILE A 149
ALA A 115
VAL A 122
HIS A 114
 None
 0.82A 5eclD-1mo0A:
0.6		 5eclD-1mo0A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		 1mo0 TRIOSEPHOSPHATE
ISOMERASE
(Caenorhabditis
elegans) 		5 / 11 VAL A 211
SER A 210
THR A 171
TYR A 207
LEU A 219
 None
SO4  A 901 (-3.7A)
None
None
None
 1.39A 5jh7B-1mo0A:
undetectable		 5jh7B-1mo0A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		 1mo0 TRIOSEPHOSPHATE
ISOMERASE
(Caenorhabditis
elegans) 		5 / 11 VAL A 211
SER A 210
THR A 171
TYR A 207
LEU A 219
 None
SO4  A 901 (-3.7A)
None
None
None
 1.38A 5jh7D-1mo0A:
undetectable		 5jh7D-1mo0A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 1mo0 TRIOSEPHOSPHATE
ISOMERASE
(Caenorhabditis
elegans) 		4 / 7 GLY A   8
ASP A  37
PHE A   6
ASN A  10
 None
None
None
ACT  A 906 (-3.8A)
 0.97A 5mvsA-1mo0A:
undetectable		 5mvsA-1mo0A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 1mo0 TRIOSEPHOSPHATE
ISOMERASE
(Caenorhabditis
elegans) 		4 / 8 GLY A   8
ASP A  37
PHE A   6
ASN A  10
 None
None
None
ACT  A 906 (-3.8A)
 0.97A 5mvsB-1mo0A:
undetectable		 5mvsB-1mo0A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)		 1mo0 TRIOSEPHOSPHATE
ISOMERASE
(Caenorhabditis
elegans) 		3 / 3 GLU A 128
HIS A 137
VAL A 141
 None
 0.93A 5trqB-1mo0A:
undetectable		 5trqB-1mo0A:
24.77