SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1mow'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1mow CHIMERA OF HOMING
ENDONUCLEASE I-DMOI
AND DNA ENDONUCLEASE
I-CREI
(Desulfurococcus
mucosus;
Chlamydomonas
reinhardtii) 		4 / 8 ILE A  18
PHE A  91
ARG A  55
MET A  56
 None
None
SO4  A 271 (-3.1A)
None
 0.92A 1v55N-1mowA:
undetectable
1v55W-1mowA:
undetectable		 1v55N-1mowA:
18.60
1v55W-1mowA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 1mow CHIMERA OF HOMING
ENDONUCLEASE I-DMOI
AND DNA ENDONUCLEASE
I-CREI
(Chlamydomonas
reinhardtii;
Desulfurococcus
mucosus) 		5 / 12 LEU A 110
PHE A 184
GLY A 162
TYR A 173
PHE A 106
 None
 0.96A 1zz1B-1mowA:
undetectable
1zz1C-1mowA:
undetectable		 1zz1B-1mowA:
18.83
1zz1C-1mowA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_2
(MINERALOCORTICOID
RECEPTOR)		 1mow CHIMERA OF HOMING
ENDONUCLEASE I-DMOI
AND DNA ENDONUCLEASE
I-CREI
(Chlamydomonas
reinhardtii;
Desulfurococcus
mucosus) 		4 / 6 LEU A 188
LEU A 185
LEU A 175
LEU A 155
 None
 0.80A 2ab2A-1mowA:
undetectable		 2ab2A-1mowA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1mow CHIMERA OF HOMING
ENDONUCLEASE I-DMOI
AND DNA ENDONUCLEASE
I-CREI
(Desulfurococcus
mucosus;
Chlamydomonas
reinhardtii) 		4 / 8 ILE A  18
PHE A  91
ARG A  55
MET A  56
 None
None
SO4  A 271 (-3.1A)
None
 0.88A 2einA-1mowA:
2.1
2einJ-1mowA:
undetectable		 2einA-1mowA:
18.60
2einJ-1mowA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1mow CHIMERA OF HOMING
ENDONUCLEASE I-DMOI
AND DNA ENDONUCLEASE
I-CREI
(Desulfurococcus
mucosus;
Chlamydomonas
reinhardtii) 		4 / 8 ILE A  18
PHE A  91
ARG A  55
MET A  56
 None
None
SO4  A 271 (-3.1A)
None
 0.91A 3abmN-1mowA:
0.0
3abmW-1mowA:
undetectable		 3abmN-1mowA:
18.60
3abmW-1mowA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1mow CHIMERA OF HOMING
ENDONUCLEASE I-DMOI
AND DNA ENDONUCLEASE
I-CREI
(Desulfurococcus
mucosus;
Chlamydomonas
reinhardtii) 		4 / 7 ILE A  18
PHE A  91
ARG A  55
MET A  56
 None
None
SO4  A 271 (-3.1A)
None
 0.98A 3ag2N-1mowA:
0.2
3ag2W-1mowA:
undetectable		 3ag2N-1mowA:
18.60
3ag2W-1mowA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1mow CHIMERA OF HOMING
ENDONUCLEASE I-DMOI
AND DNA ENDONUCLEASE
I-CREI
(Desulfurococcus
mucosus;
Chlamydomonas
reinhardtii) 		4 / 7 ILE A  18
PHE A  91
ARG A  55
MET A  56
 None
None
SO4  A 271 (-3.1A)
None
 0.92A 3ag4N-1mowA:
0.7
3ag4W-1mowA:
undetectable		 3ag4N-1mowA:
18.60
3ag4W-1mowA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1mow CHIMERA OF HOMING
ENDONUCLEASE I-DMOI
AND DNA ENDONUCLEASE
I-CREI
(Desulfurococcus
mucosus;
Chlamydomonas
reinhardtii) 		5 / 12 PHE A 140
ASP A 115
ILE A  52
GLY A  16
GLN A 144
 None
None
None
None
MG  A 373 ( 4.9A)
 1.43A 4djfB-1mowA:
undetectable		 4djfB-1mowA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QT3_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)		 1mow CHIMERA OF HOMING
ENDONUCLEASE I-DMOI
AND DNA ENDONUCLEASE
I-CREI
(Chlamydomonas
reinhardtii;
Desulfurococcus
mucosus) 		5 / 10 PHE A 184
VAL A 114
ILE A 113
TYR A 109
ILE A  98
 None
 1.42A 4qt3A-1mowA:
undetectable		 4qt3A-1mowA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1mow CHIMERA OF HOMING
ENDONUCLEASE I-DMOI
AND DNA ENDONUCLEASE
I-CREI
(Desulfurococcus
mucosus;
Chlamydomonas
reinhardtii) 		4 / 6 LEU A  59
ILE A  60
LEU A  87
TYR A  90
 None
 0.88A 4w5nA-1mowA:
0.3		 4w5nA-1mowA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_B_5D5B927_1
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 1mow CHIMERA OF HOMING
ENDONUCLEASE I-DMOI
AND DNA ENDONUCLEASE
I-CREI
(Desulfurococcus
mucosus;
Chlamydomonas
reinhardtii) 		4 / 7 SER A 215
LYS A 131
PHE A 132
HIS A 134
 None
 1.14A 5dlvB-1mowA:
0.7		 5dlvB-1mowA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1mow CHIMERA OF HOMING
ENDONUCLEASE I-DMOI
AND DNA ENDONUCLEASE
I-CREI
(Desulfurococcus
mucosus;
Chlamydomonas
reinhardtii) 		4 / 7 ILE A  18
PHE A  91
ARG A  55
MET A  56
 None
None
SO4  A 271 (-3.1A)
None
 0.89A 5iy5N-1mowA:
0.0
5iy5W-1mowA:
0.0		 5iy5N-1mowA:
18.60
5iy5W-1mowA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_2
(PROTEASE E35D-DRV)		 1mow CHIMERA OF HOMING
ENDONUCLEASE I-DMOI
AND DNA ENDONUCLEASE
I-CREI
(Chlamydomonas
reinhardtii;
Desulfurococcus
mucosus) 		4 / 7 GLY A 112
ALA A 111
GLY A   9
ILE A  10
 None
GOL  A 767 ( 4.5A)
GOL  A 767 ( 4.1A)
GOL  A 773 (-4.7A)
 0.65A 5kqyB-1mowA:
undetectable		 5kqyB-1mowA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1mow CHIMERA OF HOMING
ENDONUCLEASE I-DMOI
AND DNA ENDONUCLEASE
I-CREI
(Chlamydomonas
reinhardtii;
Desulfurococcus
mucosus) 		4 / 4 GLN A 189
THR A 186
GLU A 207
LEU A 138
 None
 1.41A 5m66A-1mowA:
undetectable		 5m66A-1mowA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1mow CHIMERA OF HOMING
ENDONUCLEASE I-DMOI
AND DNA ENDONUCLEASE
I-CREI
(Desulfurococcus
mucosus;
Chlamydomonas
reinhardtii) 		5 / 12 GLY A  16
ASP A 115
LEU A 185
GLY A 118
PHE A 151
 None
 1.20A 5vooA-1mowA:
undetectable		 5vooA-1mowA:
22.77