SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1mox'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1mox EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		4 / 8 SER A 326
ASN A 328
ILE A 332
GLY A 315
 None
NAG  A 650 (-1.9A)
None
None
 0.81A 1meiA-1moxA:
undetectable		 1meiA-1moxA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1mox EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		3 / 3 ILE A 143
ILE A 119
THR A 187
 None
 0.57A 1rg7A-1moxA:
undetectable		 1rg7A-1moxA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1mox EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		5 / 12 ALA A 448
ILE A 451
ILE A 439
VAL A 437
ILE A 402
 None
 1.11A 1xozA-1moxA:
undetectable		 1xozA-1moxA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG3_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 1mox EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		5 / 11 VAL A 416
ILE A 383
HIS A 346
ILE A 316
PHE A 396
 None
 1.36A 2dg3A-1moxA:
undetectable		 2dg3A-1moxA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 1mox EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		5 / 12 PHE A 335
GLY A 343
GLY A 315
LEU A 399
LEU A 381
 None
 0.91A 2egvA-1moxA:
undetectable		 2egvA-1moxA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 1mox EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		4 / 6 GLN A  81
ASN A 115
ASN A  86
LEU A 120
 None
 1.14A 2nyrA-1moxA:
undetectable		 2nyrA-1moxA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 1mox EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		5 / 12 LEU A  77
ILE A  58
LEU A  80
VAL A  97
PHE A  31
 None
 1.34A 2qo6A-1moxA:
undetectable		 2qo6A-1moxA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_2
(PHOSPHOLIPASE A2)		 1mox EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		4 / 5 VAL A  37
VAL A  36
GLN A  81
PHE A  54
 None
 1.37A 3bjwH-1moxA:
0.0		 3bjwH-1moxA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)		 1mox EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		4 / 5 VAL A  37
VAL A  36
GLN A  81
PHE A  54
 None
 1.36A 3bjwB-1moxA:
undetectable		 3bjwB-1moxA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_1
(FIV PROTEASE)		 1mox EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		5 / 10 LEU A 368
VAL A 374
GLY A 315
ILE A 316
LEU A 371
 None
 0.88A 3ogqA-1moxA:
undetectable		 3ogqA-1moxA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ1_X_DXCX75_0
(CYTOCHROME C7)		 1mox EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		4 / 6 ILE A 347
LEU A 345
LYS A 333
PHE A 335
 None
None
CL  A 737 (-2.8A)
None
 1.00A 3sj1X-1moxA:
0.0		 3sj1X-1moxA:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 1mox EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		4 / 4 ASN A  40
SER A  99
LEU A  98
THR A  10
 None
 1.30A 4an2A-1moxA:
undetectable		 4an2A-1moxA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 1mox EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		3 / 3 TYR A  88
MET A  87
ILE A 318
 None
 0.89A 4c8bB-1moxA:
undetectable		 4c8bB-1moxA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)		 1mox EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		5 / 8 ILE A 347
LEU A 345
LYS A 333
ILE A 370
PHE A 335
 None
None
CL  A 737 (-2.8A)
None
None
 1.45A 4hb8A-1moxA:
undetectable		 4hb8A-1moxA:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HBF_A_DXCA75_0
(PPCA)		 1mox EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		4 / 7 ILE A 347
LEU A 345
LYS A 333
PHE A 335
 None
None
CL  A 737 (-2.8A)
None
 1.07A 4hbfA-1moxA:
undetectable		 4hbfA-1moxA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTR_A_IBPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1mox EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		4 / 8 VAL A 124
TRP A 140
LEU A  80
LEU A 116
 None
 1.09A 4jtrA-1moxA:
undetectable		 4jtrA-1moxA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 1mox EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		3 / 3 ASP A 155
VAL A 124
ASN A 128
 None
 0.80A 4lmnA-1moxA:
undetectable		 4lmnA-1moxA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 1mox EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		4 / 7 ILE A 432
LEU A 426
LEU A 381
ILE A 377
 None
 0.85A 4rmjA-1moxA:
undetectable		 4rmjA-1moxA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_A_ASDA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1mox EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		4 / 7 VAL A 417
ILE A 439
LEU A 399
LEU A 426
 None
 1.02A 4xo7A-1moxA:
undetectable		 4xo7A-1moxA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1mox EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		4 / 7 VAL A 124
TRP A 140
ILE A 143
LEU A  77
 None
 1.07A 4xo7B-1moxA:
undetectable		 4xo7B-1moxA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 1mox EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		3 / 3 ASN A 128
LEU A  14
PHE A 126
 None
 0.81A 5dsgA-1moxA:
undetectable		 5dsgA-1moxA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)		 1mox EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		5 / 12 ILE A 138
TRP A 176
ILE A 143
VAL A  97
LEU A 108
 None
 1.22A 5jkvA-1moxA:
0.0		 5jkvA-1moxA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1mox EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		3 / 3 LYS A  13
LEU A  27
ILE A  67
 MAN  A 653 ( 4.3A)
None
None
 0.66A 5kc0A-1moxA:
undetectable		 5kc0A-1moxA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 1mox EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		4 / 8 THR A 278
SER A 291
ALA A 286
SER A 342
 None
 1.06A 5l5fY-1moxA:
undetectable
5l5fZ-1moxA:
undetectable		 5l5fY-1moxA:
17.66
5l5fZ-1moxA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN8_A_ACRA1015_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 1mox EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		5 / 12 ASP A 369
ILE A 421
ARG A 390
PHE A 352
LEU A 363
 None
 1.32A 5nn8A-1moxA:
undetectable		 5nn8A-1moxA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1mox EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		4 / 4 LEU A 243
GLY A 281
SER A 282
SER A 262
 None
 1.31A 5uunA-1moxA:
0.0		 5uunA-1moxA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB306_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1mox EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		4 / 4 LEU A 243
GLY A 281
SER A 282
SER A 262
 None
 1.33A 5uunB-1moxA:
0.0		 5uunB-1moxA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1mox EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		5 / 8 GLY A 425
LEU A 424
LEU A 382
VAL A 416
ILE A 421
 CD  A 722 ( 4.5A)
None
None
None
None
 1.26A 5vkqB-1moxA:
undetectable
5vkqC-1moxA:
undetectable		 5vkqB-1moxA:
13.28
5vkqC-1moxA:
13.28