SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1moz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 1moz ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
1
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 178
LEU A  64
ILE A  90
ILE A 175
THR A  86
 None
 1.07A 1dyrA-1mozA:
undetectable		 1dyrA-1mozA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 1moz ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
1
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 177
GLU A 181
GLU A 180
 None
 0.72A 2nv4A-1mozA:
undetectable		 2nv4A-1mozA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 1moz ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
1
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  87
ILE A 178
LEU A  62
LEU A 171
ILE A  23
 None
 1.09A 2w3vA-1mozA:
undetectable		 2w3vA-1mozA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 1moz ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
1
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  87
ILE A 178
LEU A  62
LEU A 171
ILE A  90
 None
 1.06A 2w3vA-1mozA:
undetectable		 2w3vA-1mozA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1moz ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
1
(Saccharomyces
cerevisiae) 		5 / 10 MET A   8
ALA A  87
ILE A  21
LEU A  64
PHE A   9
 None
 1.19A 3fl9A-1mozA:
2.1		 3fl9A-1mozA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1moz ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
1
(Saccharomyces
cerevisiae) 		6 / 10 MET A   8
LEU A 123
ALA A  88
ILE A  21
LEU A  64
PHE A   9
 None
 1.28A 3fl9A-1mozA:
2.1		 3fl9A-1mozA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1moz ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
1
(Saccharomyces
cerevisiae) 		5 / 9 MET A   8
LEU A 123
ILE A  21
LEU A  64
PHE A   9
 None
 1.31A 3fl9D-1mozA:
2.0		 3fl9D-1mozA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1moz ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
1
(Saccharomyces
cerevisiae) 		5 / 10 MET A   8
ALA A  87
ILE A  21
LEU A  64
PHE A   9
 None
 1.13A 3fl9F-1mozA:
undetectable		 3fl9F-1mozA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1moz ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
1
(Saccharomyces
cerevisiae) 		6 / 10 MET A   8
LEU A 123
ALA A  88
ILE A  21
LEU A  64
PHE A   9
 None
 1.15A 3fl9F-1mozA:
undetectable		 3fl9F-1mozA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1moz ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
1
(Saccharomyces
cerevisiae) 		4 / 7 SER A   7
LEU A  57
ILE A 175
PHE A   9
 None
 1.01A 3ln1C-1mozA:
0.0		 3ln1C-1mozA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1moz ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
1
(Saccharomyces
cerevisiae) 		3 / 3 GLY A  28
GLY A  30
THR A  32
 GDP  A 184 (-3.7A)
GDP  A 184 (-2.8A)
GDP  A 184 (-3.6A)
 0.41A 3si7B-1mozA:
undetectable		 3si7B-1mozA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJJ_A_SAMA302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 1moz ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
1
(Saccharomyces
cerevisiae) 		5 / 12 ASP A  68
THR A  45
GLU A  55
ASN A  65
ASP A  27
 GDP  A 184 (-3.5A)
None
None
None
None
 1.36A 4njjA-1mozA:
1.6		 4njjA-1mozA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJK_A_SAMA302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 1moz ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
1
(Saccharomyces
cerevisiae) 		5 / 12 ASP A  68
THR A  45
GLU A  55
ASN A  65
ASP A  27
 GDP  A 184 (-3.5A)
None
None
None
None
 1.37A 4njkA-1mozA:
1.5		 4njkA-1mozA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJK_B_SAMB302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 1moz ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
1
(Saccharomyces
cerevisiae) 		5 / 12 ASP A  68
THR A  45
GLU A  55
ASN A  65
ASP A  27
 GDP  A 184 (-3.5A)
None
None
None
None
 1.35A 4njkB-1mozA:
1.4		 4njkB-1mozA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1moz ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
1
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 167
GLY A 170
ILE A  90
LEU A  38
 None
 0.78A 4o8fB-1mozA:
undetectable		 4o8fB-1mozA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 1moz ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
1
(Saccharomyces
cerevisiae) 		5 / 8 ALA A 121
ALA A  88
ILE A 178
ALA A  84
LEU A  19
 None
 1.31A 4v1fA-1mozA:
undetectable
4v1fB-1mozA:
undetectable		 4v1fA-1mozA:
15.96
4v1fB-1mozA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 1moz ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
1
(Saccharomyces
cerevisiae) 		4 / 6 ALA A 126
LEU A 135
SER A 136
VAL A 124
 None
 1.19A 5a6iA-1mozA:
0.0		 5a6iA-1mozA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 1moz ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
1
(Saccharomyces
cerevisiae) 		5 / 12 SER A  95
GLY A  30
SER A 159
THR A  33
VAL A  93
 None
GDP  A 184 (-2.8A)
None
GDP  A 184 (-3.9A)
None
 1.15A 5kocB-1mozA:
undetectable		 5kocB-1mozA:
18.02