SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1mpo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1mpo MALTOPORIN
(Escherichia
coli) 		4 / 8 ARG A 109
GLN A  87
ASN A  63
ASP A  61
 GLC  A 432 (-3.3A)
None
None
None
 1.31A 1rs6A-1mpoA:
0.0		 1rs6A-1mpoA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1mpo MALTOPORIN
(Escherichia
coli) 		4 / 8 ARG A 109
GLN A  87
ASN A  63
ASP A  61
 GLC  A 432 (-3.3A)
None
None
None
 1.20A 1rs6B-1mpoA:
undetectable		 1rs6B-1mpoA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1mpo MALTOPORIN
(Escherichia
coli) 		4 / 8 ARG A 109
GLN A  87
ASN A  63
ASP A  61
 GLC  A 432 (-3.3A)
None
None
None
 1.31A 1zzqA-1mpoA:
0.0		 1zzqA-1mpoA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1mpo MALTOPORIN
(Escherichia
coli) 		4 / 8 ARG A 109
GLN A  87
ASN A  63
ASP A  61
 GLC  A 432 (-3.3A)
None
None
None
 1.18A 1zzqB-1mpoA:
0.0		 1zzqB-1mpoA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1mpo MALTOPORIN
(Escherichia
coli) 		5 / 12 GLY A  18
GLY A  15
THR A  14
GLU A 410
GLN A  21
 None
 1.42A 2akeA-1mpoA:
undetectable		 2akeA-1mpoA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_2
(POL POLYPROTEIN)		 1mpo MALTOPORIN
(Escherichia
coli) 		3 / 3 ASP A  73
VAL A  68
PRO A  79
 None
 0.80A 2avvA-1mpoA:
undetectable		 2avvA-1mpoA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1mpo MALTOPORIN
(Escherichia
coli) 		5 / 11 GLY A  18
GLY A  15
THR A  14
GLU A 410
GLN A  21
 None
 1.39A 2dr2A-1mpoA:
undetectable		 2dr2A-1mpoA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1mpo MALTOPORIN
(Escherichia
coli) 		5 / 7 GLY A 267
THR A 236
TYR A 234
ASP A 298
ASN A 266
 None
 1.45A 2g70A-1mpoA:
undetectable		 2g70A-1mpoA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1mpo MALTOPORIN
(Escherichia
coli) 		5 / 7 GLY A 267
THR A 236
TYR A 234
ASP A 298
ASN A 266
 None
 1.42A 2g70B-1mpoA:
undetectable		 2g70B-1mpoA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1mpo MALTOPORIN
(Escherichia
coli) 		4 / 6 GLY A 267
TYR A 234
ASP A 298
ASN A 266
 None
 1.12A 2g72A-1mpoA:
undetectable		 2g72A-1mpoA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 1mpo MALTOPORIN
(Escherichia
coli) 		4 / 4 ARG A   8
GLY A  35
GLU A  37
SER A 321
 GLC  A 432 (-2.8A)
None
None
None
 1.38A 2xctS-1mpoA:
undetectable
2xctU-1mpoA:
undetectable		 2xctS-1mpoA:
20.51
2xctU-1mpoA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 1mpo MALTOPORIN
(Escherichia
coli) 		4 / 7 ARG A   8
GLU A  43
TYR A 118
ARG A 109
 GLC  A 432 (-2.8A)
GLC  A 432 ( 2.9A)
GLC  A 433 (-4.6A)
GLC  A 432 (-3.3A)
 1.27A 2zt7A-1mpoA:
undetectable		 2zt7A-1mpoA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 1mpo MALTOPORIN
(Escherichia
coli) 		5 / 12 GLU A  83
ARG A 105
VAL A 171
ASP A 121
ILE A 122
 None
 1.41A 3jayA-1mpoA:
0.0		 3jayA-1mpoA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 1mpo MALTOPORIN
(Escherichia
coli) 		5 / 12 GLN A 233
GLY A 243
GLN A 293
SER A 247
ALA A 235
 None
 1.32A 3t7sC-1mpoA:
undetectable		 3t7sC-1mpoA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 1mpo MALTOPORIN
(Escherichia
coli) 		5 / 8 GLY A 151
GLY A 150
SER A 250
GLY A 249
ILE A 263
 None
 1.25A 3v1nA-1mpoA:
undetectable		 3v1nA-1mpoA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1mpo MALTOPORIN
(Escherichia
coli) 		3 / 3 THR A 216
VAL A 231
GLU A 188
 None
 0.70A 3v4tA-1mpoA:
0.0
3v4tD-1mpoA:
0.0		 3v4tA-1mpoA:
23.11
3v4tD-1mpoA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA502_1
(CHITINASE)		 1mpo MALTOPORIN
(Escherichia
coli) 		4 / 5 TRP A 411
GLY A 414
ALA A 367
PHE A  23
 None
 1.37A 3wqwA-1mpoA:
undetectable		 3wqwA-1mpoA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)		 1mpo MALTOPORIN
(Escherichia
coli) 		4 / 8 LEU A  44
THR A  40
ALA A  42
VAL A  68
 None
 0.94A 4iizB-1mpoA:
undetectable		 4iizB-1mpoA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 1mpo MALTOPORIN
(Escherichia
coli) 		4 / 8 LEU A  44
THR A  40
ALA A  42
VAL A  68
 None
 0.96A 4ik6B-1mpoA:
0.0		 4ik6B-1mpoA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 1mpo MALTOPORIN
(Escherichia
coli) 		4 / 7 LEU A  44
THR A  40
ALA A  42
VAL A  68
 None
 0.97A 4ik7A-1mpoA:
undetectable		 4ik7A-1mpoA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 1mpo MALTOPORIN
(Escherichia
coli) 		3 / 3 ASP A 173
TYR A 107
TRP A 120
 None
 1.38A 4p7nA-1mpoA:
undetectable		 4p7nA-1mpoA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_1
(PROTEASE)		 1mpo MALTOPORIN
(Escherichia
coli) 		5 / 12 GLY A 190
ASP A 173
THR A 236
ARG A 175
ILE A 272
 None
 0.98A 4q5mA-1mpoA:
undetectable		 4q5mA-1mpoA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 1mpo MALTOPORIN
(Escherichia
coli) 		3 / 3 ASN A 256
PHE A 254
TYR A 161
 None
 0.76A 4u15A-1mpoA:
undetectable		 4u15A-1mpoA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 1mpo MALTOPORIN
(Escherichia
coli) 		3 / 3 SER A 333
ASP A 237
ASP A 300
 None
 0.80A 4uckA-1mpoA:
undetectable		 4uckA-1mpoA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1mpo MALTOPORIN
(Escherichia
coli) 		3 / 3 SER A  67
ALA A  65
VAL A  64
 None
 0.66A 4x20C-1mpoA:
undetectable		 4x20C-1mpoA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1mpo MALTOPORIN
(Escherichia
coli) 		3 / 3 THR A 236
MET A 269
HIS A 268
 None
 0.95A 5uunA-1mpoA:
0.0		 5uunA-1mpoA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1mpo MALTOPORIN
(Escherichia
coli) 		4 / 8 ARG A 109
GLN A  87
ASN A  63
ASP A  61
 GLC  A 432 (-3.3A)
None
None
None
 1.29A 5vunB-1mpoA:
0.0		 5vunB-1mpoA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1mpo MALTOPORIN
(Escherichia
coli) 		4 / 8 ARG A 109
GLN A  87
ASN A  63
ASP A  61
 GLC  A 432 (-3.3A)
None
None
None
 1.28A 5vuoB-1mpoA:
0.0		 5vuoB-1mpoA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1mpo MALTOPORIN
(Escherichia
coli) 		3 / 3 GLN A  29
TRP A 305
VAL A 331
 None
 0.68A 6auuA-1mpoA:
undetectable		 6auuA-1mpoA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1mpo MALTOPORIN
(Escherichia
coli) 		4 / 8 ARG A 109
GLN A  87
ASN A  63
ASP A  61
 GLC  A 432 (-3.3A)
None
None
None
 1.29A 6auuB-1mpoA:
0.0		 6auuB-1mpoA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA608_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 1mpo MALTOPORIN
(Escherichia
coli) 		3 / 3 GLY A 151
THR A 167
GLU A 148
 None
 0.64A 6b58A-1mpoA:
undetectable		 6b58A-1mpoA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_B_ACTB403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 1mpo MALTOPORIN
(Escherichia
coli) 		3 / 3 PHE A  23
ARG A 405
GLN A  21
 None
 0.79A 6g1pB-1mpoA:
undetectable		 6g1pB-1mpoA:
22.30