SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1mpt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 1mpt M-PROTEASE
(Bacillus
clausii) 		4 / 6 ASP A  60
GLY A  70
ILE A  72
ILE A  44
 None
 0.93A 1n49D-1mptA:
undetectable		 1n49D-1mptA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 1mpt M-PROTEASE
(Bacillus
clausii) 		4 / 8 ARG A 275
GLY A 256
THR A 255
ALA A 254
 None
 0.80A 2a1hA-1mptA:
undetectable
2a1hB-1mptA:
undetectable		 2a1hA-1mptA:
20.92
2a1hB-1mptA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 1mpt M-PROTEASE
(Bacillus
clausii) 		4 / 8 ARG A 275
GLY A 256
THR A 255
ALA A 254
 None
 0.81A 2a1hA-1mptA:
undetectable
2a1hB-1mptA:
undetectable		 2a1hA-1mptA:
20.92
2a1hB-1mptA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 1mpt M-PROTEASE
(Bacillus
clausii) 		5 / 12 ALA A 223
ALA A 270
ALA A 273
ILE A 198
LEU A 148
 None
 1.15A 2nyrA-1mptA:
undetectable		 2nyrA-1mptA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 1mpt M-PROTEASE
(Bacillus
clausii) 		5 / 12 ALA A 151
THR A 220
GLY A 178
LEU A 111
PRO A 168
 None
 0.86A 2y7hB-1mptA:
undetectable		 2y7hB-1mptA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 1mpt M-PROTEASE
(Bacillus
clausii) 		5 / 12 ALA A 151
THR A 220
GLY A 178
LEU A 111
PRO A 168
 None
 0.85A 2y7hC-1mptA:
undetectable		 2y7hC-1mptA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 1mpt M-PROTEASE
(Bacillus
clausii) 		5 / 11 SER A 221
LEU A  96
VAL A  95
ILE A 107
ALA A 114
 None
 1.17A 2zbzA-1mptA:
undetectable		 2zbzA-1mptA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 1mpt M-PROTEASE
(Bacillus
clausii) 		5 / 12 GLY A  70
GLY A  83
ILE A  35
ASP A  41
LEU A  42
 None
None
None
CA  A 276 (-1.9A)
None
 1.01A 3ihtA-1mptA:
2.7		 3ihtA-1mptA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 1mpt M-PROTEASE
(Bacillus
clausii) 		4 / 7 LEU A 135
ALA A 174
GLY A 195
ILE A 165
 None
CA  A 277 (-4.8A)
CA  A 277 (-3.9A)
None
 0.84A 3spkB-1mptA:
undetectable		 3spkB-1mptA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_E_SVRE301_1
(NUCLEOCAPSID PROTEIN)		 1mpt M-PROTEASE
(Bacillus
clausii) 		5 / 10 GLY A 219
ASN A 218
VAL A 203
GLN A 182
PRO A 225
 None
 1.49A 4j4vA-1mptA:
0.0
4j4vE-1mptA:
0.0		 4j4vA-1mptA:
24.21
4j4vE-1mptA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_A_SAMA301_0
(PUTATIVE RNA
METHYLASE)		 1mpt M-PROTEASE
(Bacillus
clausii) 		5 / 12 THR A  71
GLY A  83
HIS A  67
LEU A  82
SER A 216
 None
 1.20A 4pooA-1mptA:
undetectable		 4pooA-1mptA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA602_1
(SERUM ALBUMIN)		 1mpt M-PROTEASE
(Bacillus
clausii) 		4 / 8 LEU A 111
ASN A 123
ALA A 122
VAL A 121
 None
 0.84A 4zbqA-1mptA:
undetectable		 4zbqA-1mptA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 1mpt M-PROTEASE
(Bacillus
clausii) 		5 / 12 LEU A  82
ILE A   8
LEU A 267
GLY A 229
ALA A 223
 None
 1.32A 5j7wC-1mptA:
0.0		 5j7wC-1mptA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1mpt M-PROTEASE
(Bacillus
clausii) 		4 / 4 SER A 141
ALA A 138
GLN A 109
THR A 134
 None
 1.36A 5n0rA-1mptA:
1.5		 5n0rA-1mptA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1mpt M-PROTEASE
(Bacillus
clausii) 		4 / 5 SER A 141
ALA A 138
GLN A 109
THR A 134
 None
 1.39A 5n0tA-1mptA:
0.4		 5n0tA-1mptA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1mpt M-PROTEASE
(Bacillus
clausii) 		4 / 4 SER A 141
ALA A 138
GLN A 109
THR A 134
 None
 1.35A 5n0xA-1mptA:
0.5		 5n0xA-1mptA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1mpt M-PROTEASE
(Bacillus
clausii) 		4 / 5 SER A 141
ALA A 138
GLN A 109
THR A 134
 None
 1.36A 5n4iA-1mptA:
undetectable		 5n4iA-1mptA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 1mpt M-PROTEASE
(Bacillus
clausii) 		5 / 10 VAL A 149
ALA A 174
LEU A 126
TYR A 171
LEU A 111
 None
CA  A 277 (-4.8A)
None
None
None
 0.99A 6f6nA-1mptA:
0.0
6f6nB-1mptA:
0.2		 6f6nA-1mptA:
16.06
6f6nB-1mptA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 1mpt M-PROTEASE
(Bacillus
clausii) 		5 / 12 LEU A  82
ILE A   8
LEU A 267
GLY A 229
ALA A 223
 None
 1.30A 6qyaB-1mptA:
0.0		 6qyaB-1mptA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 1mpt M-PROTEASE
(Bacillus
clausii) 		5 / 12 LEU A  82
ILE A   8
LEU A 267
GLY A 229
ALA A 223
 None
 1.31A 6qyaD-1mptA:
0.0		 6qyaD-1mptA:
19.33