SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1mpy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 1mpy CATECHOL
2,3-DIOXYGENASE
(Pseudomonas
putida) 		5 / 12 VAL A   5
LEU A 119
TYR A 120
PRO A   8
PHE A 174
 None
 1.46A 1fdsA-1mpyA:
undetectable		 1fdsA-1mpyA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IA0_B_TXLB502_1
(TUBULIN BETA CHAIN)		 1mpy CATECHOL
2,3-DIOXYGENASE
(Pseudomonas
putida) 		5 / 12 VAL A  72
LEU A 167
PHE A 174
PRO A   8
GLY A  69
 None
 1.23A 1ia0B-1mpyA:
undetectable		 1ia0B-1mpyA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1872_0
(FPRA)		 1mpy CATECHOL
2,3-DIOXYGENASE
(Pseudomonas
putida) 		4 / 5 ASN A 273
ALA A 177
ASP A 271
GLU A 178
 None
 1.25A 1lqtA-1mpyA:
undetectable
1lqtB-1mpyA:
undetectable		 1lqtA-1mpyA:
21.19
1lqtB-1mpyA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1429_0
(FPRA)		 1mpy CATECHOL
2,3-DIOXYGENASE
(Pseudomonas
putida) 		4 / 5 ASN A 273
ALA A 177
ASP A 271
GLU A 178
 None
 1.24A 1lquA-1mpyA:
undetectable
1lquB-1mpyA:
undetectable		 1lquA-1mpyA:
21.19
1lquB-1mpyA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUB_B_TXLB501_1
(TUBULIN)		 1mpy CATECHOL
2,3-DIOXYGENASE
(Pseudomonas
putida) 		5 / 12 VAL A  72
LEU A 167
PHE A 174
PRO A   8
GLY A  69
 None
 1.23A 1tubB-1mpyA:
undetectable		 1tubB-1mpyA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACHA546_0
(ACETYLCHOLINESTERASE)		 1mpy CATECHOL
2,3-DIOXYGENASE
(Pseudomonas
putida) 		4 / 8 GLU A 118
PHE A  53
HIS A  10
GLY A  69
 None
 1.08A 2ha4A-1mpyA:
undetectable		 2ha4A-1mpyA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1470_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 1mpy CATECHOL
2,3-DIOXYGENASE
(Pseudomonas
putida) 		4 / 5 ARG A  14
ALA A  60
ASP A  61
GLU A  62
 None
 1.44A 2xrzA-1mpyA:
undetectable		 2xrzA-1mpyA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 1mpy CATECHOL
2,3-DIOXYGENASE
(Pseudomonas
putida) 		4 / 7 SER A 193
ASP A 200
GLY A 173
THR A 169
 None
 1.04A 4ac9C-1mpyA:
undetectable		 4ac9C-1mpyA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 1mpy CATECHOL
2,3-DIOXYGENASE
(Pseudomonas
putida) 		4 / 7 PHE A 117
PHE A 109
PHE A  70
LEU A 167
 None
 1.06A 4ejgA-1mpyA:
0.1		 4ejgA-1mpyA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IR0_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 1mpy CATECHOL
2,3-DIOXYGENASE
(Pseudomonas
putida) 		5 / 11 HIS A 214
TYR A 255
GLU A 265
HIS A 153
ALA A 202
 FE2  A 308 (-3.7A)
None
FE2  A 308 (-2.6A)
FE2  A 308 (-3.6A)
None
 0.79A 4ir0A-1mpyA:
7.9
4ir0B-1mpyA:
8.4		 4ir0A-1mpyA:
22.26
4ir0B-1mpyA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IR0_B_FCNB202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 1mpy CATECHOL
2,3-DIOXYGENASE
(Pseudomonas
putida) 		5 / 11 HIS A 153
ALA A 202
HIS A 214
TYR A 255
GLU A 265
 FE2  A 308 (-3.6A)
None
FE2  A 308 (-3.7A)
None
FE2  A 308 (-2.6A)
 0.75A 4ir0A-1mpyA:
7.9
4ir0B-1mpyA:
8.4		 4ir0A-1mpyA:
22.26
4ir0B-1mpyA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JD1_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 1mpy CATECHOL
2,3-DIOXYGENASE
(Pseudomonas
putida) 		5 / 12 HIS A 214
TYR A 255
GLU A 265
HIS A 153
ALA A 202
 FE2  A 308 (-3.7A)
None
FE2  A 308 (-2.6A)
FE2  A 308 (-3.6A)
None
 0.75A 4jd1A-1mpyA:
7.7
4jd1B-1mpyA:
8.0		 4jd1A-1mpyA:
22.26
4jd1B-1mpyA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JD1_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 1mpy CATECHOL
2,3-DIOXYGENASE
(Pseudomonas
putida) 		5 / 12 HIS A 153
ALA A 202
HIS A 214
TYR A 255
GLU A 265
 FE2  A 308 (-3.6A)
None
FE2  A 308 (-3.7A)
None
FE2  A 308 (-2.6A)
 0.87A 4jd1A-1mpyA:
7.7
4jd1B-1mpyA:
8.0		 4jd1A-1mpyA:
22.26
4jd1B-1mpyA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH3_A_FCNA204_1
(METALLOTHIOL
TRANSFERASE FOSB)		 1mpy CATECHOL
2,3-DIOXYGENASE
(Pseudomonas
putida) 		5 / 12 HIS A 214
TYR A 255
GLU A 265
HIS A 153
ALA A 202
 FE2  A 308 (-3.7A)
None
FE2  A 308 (-2.6A)
FE2  A 308 (-3.6A)
None
 0.77A 4jh3A-1mpyA:
7.8
4jh3B-1mpyA:
7.9		 4jh3A-1mpyA:
20.00
4jh3B-1mpyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH3_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB)		 1mpy CATECHOL
2,3-DIOXYGENASE
(Pseudomonas
putida) 		5 / 11 HIS A 153
ALA A 202
HIS A 214
TYR A 255
GLU A 265
 FE2  A 308 (-3.6A)
None
FE2  A 308 (-3.7A)
None
FE2  A 308 (-2.6A)
 0.74A 4jh3A-1mpyA:
7.8
4jh3B-1mpyA:
7.9		 4jh3A-1mpyA:
20.00
4jh3B-1mpyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH4_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 1mpy CATECHOL
2,3-DIOXYGENASE
(Pseudomonas
putida) 		5 / 11 HIS A 214
TYR A 255
GLU A 265
HIS A 153
ALA A 202
 FE2  A 308 (-3.7A)
None
FE2  A 308 (-2.6A)
FE2  A 308 (-3.6A)
None
 0.73A 4jh4A-1mpyA:
7.9
4jh4B-1mpyA:
7.8		 4jh4A-1mpyA:
20.00
4jh4B-1mpyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH4_B_FCNB202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 1mpy CATECHOL
2,3-DIOXYGENASE
(Pseudomonas
putida) 		5 / 11 HIS A 153
ALA A 202
HIS A 214
TYR A 255
GLU A 265
 FE2  A 308 (-3.6A)
None
FE2  A 308 (-3.7A)
None
FE2  A 308 (-2.6A)
 0.75A 4jh4A-1mpyA:
7.9
4jh4B-1mpyA:
7.8		 4jh4A-1mpyA:
20.00
4jh4B-1mpyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH5_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 1mpy CATECHOL
2,3-DIOXYGENASE
(Pseudomonas
putida) 		5 / 11 HIS A 214
TYR A 255
GLU A 265
HIS A 153
ALA A 202
 FE2  A 308 (-3.7A)
None
FE2  A 308 (-2.6A)
FE2  A 308 (-3.6A)
None
 0.74A 4jh5A-1mpyA:
7.6
4jh5B-1mpyA:
7.8		 4jh5A-1mpyA:
20.00
4jh5B-1mpyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH5_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB)		 1mpy CATECHOL
2,3-DIOXYGENASE
(Pseudomonas
putida) 		5 / 11 HIS A 153
ALA A 202
HIS A 214
TYR A 255
GLU A 265
 FE2  A 308 (-3.6A)
None
FE2  A 308 (-3.7A)
None
FE2  A 308 (-2.6A)
 0.76A 4jh5A-1mpyA:
7.6
4jh5B-1mpyA:
7.8		 4jh5A-1mpyA:
20.00
4jh5B-1mpyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH6_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 1mpy CATECHOL
2,3-DIOXYGENASE
(Pseudomonas
putida) 		5 / 10 HIS A 214
TYR A 255
GLU A 265
HIS A 153
ALA A 202
 FE2  A 308 (-3.7A)
None
FE2  A 308 (-2.6A)
FE2  A 308 (-3.6A)
None
 0.76A 4jh6A-1mpyA:
8.0
4jh6B-1mpyA:
7.9		 4jh6A-1mpyA:
20.00
4jh6B-1mpyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH6_B_FCNB202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 1mpy CATECHOL
2,3-DIOXYGENASE
(Pseudomonas
putida) 		5 / 10 HIS A 153
ALA A 202
HIS A 214
TYR A 255
GLU A 265
 FE2  A 308 (-3.6A)
None
FE2  A 308 (-3.7A)
None
FE2  A 308 (-2.6A)
 0.77A 4jh6A-1mpyA:
8.0
4jh6B-1mpyA:
7.9		 4jh6A-1mpyA:
20.00
4jh6B-1mpyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH8_A_FCNA204_1
(METALLOTHIOL
TRANSFERASE FOSB)		 1mpy CATECHOL
2,3-DIOXYGENASE
(Pseudomonas
putida) 		5 / 10 HIS A 214
TYR A 255
GLU A 265
HIS A 153
ALA A 202
 FE2  A 308 (-3.7A)
None
FE2  A 308 (-2.6A)
FE2  A 308 (-3.6A)
None
 0.76A 4jh8A-1mpyA:
7.9
4jh8B-1mpyA:
7.8		 4jh8A-1mpyA:
20.00
4jh8B-1mpyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH8_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB)		 1mpy CATECHOL
2,3-DIOXYGENASE
(Pseudomonas
putida) 		5 / 10 HIS A 153
ALA A 202
HIS A 214
TYR A 255
GLU A 265
 FE2  A 308 (-3.6A)
None
FE2  A 308 (-3.7A)
None
FE2  A 308 (-2.6A)
 0.76A 4jh8A-1mpyA:
7.9
4jh8B-1mpyA:
7.8		 4jh8A-1mpyA:
20.00
4jh8B-1mpyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 1mpy CATECHOL
2,3-DIOXYGENASE
(Pseudomonas
putida) 		4 / 6 LEU A 212
HIS A 153
TYR A 255
GLU A 265
 None
FE2  A 308 (-3.6A)
None
FE2  A 308 (-2.6A)
 0.66A 4pahA-1mpyA:
undetectable		 4pahA-1mpyA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_O_ASCO1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 1mpy CATECHOL
2,3-DIOXYGENASE
(Pseudomonas
putida) 		4 / 7 HIS A 214
HIS A 206
ILE A 204
ARG A 263
 FE2  A 308 (-3.7A)
None
None
None
 1.31A 5kkzM-1mpyA:
undetectable
5kkzO-1mpyA:
undetectable		 5kkzM-1mpyA:
21.50
5kkzO-1mpyA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 1mpy CATECHOL
2,3-DIOXYGENASE
(Pseudomonas
putida) 		4 / 6 LEU A 119
PHE A 117
PHE A 109
LEU A  85
 None
 1.18A 5x19P-1mpyA:
undetectable		 5x19P-1mpyA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1mpy CATECHOL
2,3-DIOXYGENASE
(Pseudomonas
putida) 		5 / 12 PHE A  67
GLN A  12
MET A 156
HIS A  10
LEU A 100
 None
 1.16A 5y2tA-1mpyA:
0.0		 5y2tA-1mpyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_1
(BETA-1 ADRENERGIC
RECEPTOR)		 1mpy CATECHOL
2,3-DIOXYGENASE
(Pseudomonas
putida) 		4 / 6 GLY A 210
PHE A 109
PHE A 168
PHE A 174
 None
 1.01A 6h7lA-1mpyA:
undetectable		 6h7lA-1mpyA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_1
(BETA-1 ADRENERGIC
RECEPTOR)		 1mpy CATECHOL
2,3-DIOXYGENASE
(Pseudomonas
putida) 		4 / 6 GLY A 210
PHE A 109
PHE A 168
PHE A 174
 None
 1.02A 6h7lB-1mpyA:
undetectable		 6h7lB-1mpyA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 1mpy CATECHOL
2,3-DIOXYGENASE
(Pseudomonas
putida) 		5 / 11 GLY A 269
GLY A 251
LEU A 225
ASP A 224
ASP A 152
 None
 1.15A 6i5zD-1mpyA:
undetectable		 6i5zD-1mpyA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 1mpy CATECHOL
2,3-DIOXYGENASE
(Pseudomonas
putida) 		4 / 6 LEU A 212
HIS A 153
TYR A 255
GLU A 265
 None
FE2  A 308 (-3.6A)
None
FE2  A 308 (-2.6A)
 0.66A 6pahA-1mpyA:
undetectable		 6pahA-1mpyA:
23.42