SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1mqq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		3 / 3 VAL A  60
VAL A  57
TRP A  68
 None
None
GOL  A 756 (-3.8A)
 0.99A 1bdwA-1mqqA:
undetectable
1bdwB-1mqqA:
undetectable		 1bdwA-1mqqA:
3.46
1bdwB-1mqqA:
3.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_N_ACTN803_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		4 / 6 ARG A 159
GLY A 525
TYR A 535
TRP A 540
 GCU  A 701 (-3.4A)
None
GOL  A 753 (-4.3A)
GOL  A 753 (-3.9A)
 1.44A 1kf6M-1mqqA:
0.0
1kf6N-1mqqA:
0.0		 1kf6M-1mqqA:
21.33
1kf6N-1mqqA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7R_A_NCTA440_1
(CYTOCHROME P450-CAM)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		4 / 7 PHE A 663
VAL A 518
VAL A 604
ILE A 608
 None
 0.69A 1p7rA-1mqqA:
0.0		 1p7rA-1mqqA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		4 / 7 PHE A 663
VAL A 518
VAL A 604
ILE A 608
 None
 0.87A 1t87B-1mqqA:
undetectable		 1t87B-1mqqA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		3 / 3 PHE A 433
ARG A 143
ASN A 382
 None
 0.87A 1xzxX-1mqqA:
undetectable		 1xzxX-1mqqA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_B_DVAB6_0
(GRAMICIDIN D)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		3 / 3 TRP A   9
ALA A 188
VAL A 190
 None
None
GOL  A 751 (-4.1A)
 0.85A 2izqA-1mqqA:
undetectable
2izqB-1mqqA:
undetectable		 2izqA-1mqqA:
3.46
2izqB-1mqqA:
3.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		5 / 11 ILE A 195
SER A 196
ILE A 197
MET A 146
VAL A 218
 None
 0.91A 2kawA-1mqqA:
undetectable		 2kawA-1mqqA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBM_A_CAMA517_0
(CYTOCHROME P450-CAM)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		4 / 8 PHE A 663
VAL A 518
VAL A 604
ILE A 608
 None
 0.97A 2qbmA-1mqqA:
0.0		 2qbmA-1mqqA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		4 / 8 ARG A 318
ILE A 316
LEU A 308
GLY A 313
 GCU  A 701 (-2.8A)
None
None
None
 0.92A 2tsrB-1mqqA:
undetectable		 2tsrB-1mqqA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		4 / 7 ALA A 162
ILE A 446
ILE A 157
HIS A 149
 None
 1.11A 2zm7A-1mqqA:
0.0		 2zm7A-1mqqA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		3 / 3 PRO A 524
GLU A 536
TYR A 535
 None
None
GOL  A 753 (-4.3A)
 0.81A 2zmbA-1mqqA:
undetectable		 2zmbA-1mqqA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		5 / 12 THR A 381
MET A 378
ASN A 302
LEU A 374
ALA A 339
 None
 1.19A 3a50A-1mqqA:
0.0		 3a50A-1mqqA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		4 / 6 GLY A 160
THR A 453
GLU A 158
GLU A 386
 None
None
GCU  A 701 (-3.5A)
None
 0.98A 3fpjA-1mqqA:
undetectable		 3fpjA-1mqqA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 277
SER A 235
ILE A 268
THR A 264
LEU A 308
 None
 1.28A 3iv6A-1mqqA:
undetectable		 3iv6A-1mqqA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		4 / 6 PHE A 663
ASP A 533
TYR A 662
PRO A 515
 None
 1.37A 3jqaA-1mqqA:
2.2		 3jqaA-1mqqA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_B_DX4B270_0
(PTERIDINE REDUCTASE
1)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		4 / 6 PHE A 663
ASP A 533
TYR A 662
PRO A 515
 None
 1.36A 3jqaB-1mqqA:
2.3		 3jqaB-1mqqA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		4 / 6 PHE A 663
ASP A 533
TYR A 662
PRO A 515
 None
 1.39A 3jqaD-1mqqA:
2.4		 3jqaD-1mqqA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		5 / 12 ALA A 132
SER A  95
ILE A 104
LEU A  21
PHE A 102
 None
 1.14A 3k2hA-1mqqA:
0.4		 3k2hA-1mqqA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_A_DVAA6_0
(GRAMICIDIN D)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		3 / 3 ALA A 188
VAL A 190
TRP A   9
 None
GOL  A 751 (-4.1A)
None
 0.82A 3l8lA-1mqqA:
undetectable
3l8lB-1mqqA:
undetectable		 3l8lA-1mqqA:
3.46
3l8lB-1mqqA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		5 / 12 ALA A 132
SER A  95
ILE A 104
LEU A  21
PHE A 102
 None
 1.20A 3nrrB-1mqqA:
0.0		 3nrrB-1mqqA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPS_A_CHDA211_0
(CMER)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		5 / 10 LEU A 411
PHE A 465
ALA A 469
GLY A 439
ILE A 428
 None
 1.47A 3qpsA-1mqqA:
0.4		 3qpsA-1mqqA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		3 / 3 GLY A 560
GLY A 562
THR A 564
 GOL  A 759 ( 4.1A)
None
None
 0.43A 3si7B-1mqqA:
undetectable		 3si7B-1mqqA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		5 / 8 GLY A 464
GLY A 466
ILE A 440
LEU A 411
VAL A 387
 None
 1.37A 3v1nA-1mqqA:
undetectable		 3v1nA-1mqqA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		5 / 12 SER A 444
VAL A 443
PHE A 320
PHE A 365
HIS A 527
 None
None
GCU  A 701 (-3.8A)
None
GOL  A 753 (-4.0A)
 1.45A 4c49C-1mqqA:
undetectable		 4c49C-1mqqA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		5 / 11 PHE A 167
LEU A 187
ILE A 230
SER A 235
ILE A 446
 None
 1.16A 4dm8A-1mqqA:
0.0		 4dm8A-1mqqA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_D_NCTD501_1
(CYTOCHROME P450 2A13)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		4 / 6 PHE A 173
ALA A 222
THR A 232
LEU A 234
 None
 1.05A 4ejgD-1mqqA:
undetectable		 4ejgD-1mqqA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		4 / 8 LEU A 187
ILE A 389
VAL A 387
GLY A 466
 None
 0.92A 4eq4B-1mqqA:
0.0		 4eq4B-1mqqA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		4 / 8 ILE A 230
LEU A 187
ILE A 197
GLY A 442
 None
 0.80A 4hb8A-1mqqA:
undetectable		 4hb8A-1mqqA:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJR_A_0LAA404_1
(DNA POLYMERASE III
SUBUNIT BETA)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		5 / 9 TYR A 293
GLY A 300
LEU A 304
VAL A 280
VAL A 315
 None
 1.47A 4mjrA-1mqqA:
0.0		 4mjrA-1mqqA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		4 / 4 ASN A 360
GLY A 361
ASP A 283
ASP A 364
 None
None
None
GCU  A 701 ( 2.3A)
 1.35A 4n49A-1mqqA:
undetectable		 4n49A-1mqqA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 308
ILE A 236
VAL A 280
PHE A 343
ALA A 301
 None
 1.02A 4o1zB-1mqqA:
0.9		 4o1zB-1mqqA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		3 / 3 ASP A 429
ASN A 471
SER A 422
 None
 0.79A 4obwA-1mqqA:
2.0		 4obwA-1mqqA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		5 / 12 ALA A 469
ALA A 188
ASN A 445
LEU A 462
GLY A 464
 None
 1.22A 4r38D-1mqqA:
undetectable		 4r38D-1mqqA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_J_SPMJ202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		4 / 7 TRP A 483
TYR A   5
GLU A   6
ARG A 179
 None
 1.32A 4r87J-1mqqA:
0.3
4r87L-1mqqA:
0.0		 4r87J-1mqqA:
13.60
4r87L-1mqqA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		5 / 12 THR A 110
ILE A 230
GLY A 229
ALA A  38
PHE A 225
 None
 1.09A 4rvgA-1mqqA:
undetectable		 4rvgA-1mqqA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		4 / 6 VAL A 443
VAL A 200
TRP A 150
PHE A 320
 None
None
GCU  A 701 (-4.7A)
GCU  A 701 (-3.8A)
 1.49A 5adeA-1mqqA:
0.0
5adeB-1mqqA:
0.0		 5adeA-1mqqA:
22.03
5adeB-1mqqA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		4 / 6 LEU A 346
LEU A 374
PHE A 350
HIS A 342
 None
 0.99A 5gs4A-1mqqA:
undetectable		 5gs4A-1mqqA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		4 / 5 LEU A 346
LEU A 374
PHE A 350
HIS A 342
 None
 0.96A 5gtrA-1mqqA:
0.0		 5gtrA-1mqqA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		4 / 7 ILE A 230
GLY A 229
LEU A 308
PHE A 278
 None
 0.88A 5hieB-1mqqA:
undetectable		 5hieB-1mqqA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		3 / 3 ASP A 429
ASN A 471
PHE A 413
 None
None
GOL  A 752 ( 4.6A)
 0.92A 5jglB-1mqqA:
undetectable		 5jglB-1mqqA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		4 / 7 LEU A 314
VAL A 279
ASN A 193
ILE A 230
 None
 0.81A 5jh7C-1mqqA:
undetectable		 5jh7C-1mqqA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		5 / 12 ALA A 338
PHE A 663
ILE A 608
GLY A 550
PHE A 588
 None
 1.09A 5jlcA-1mqqA:
undetectable		 5jlcA-1mqqA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		3 / 3 GLN A 326
THR A 333
ASP A 330
 None
 0.93A 5k9dA-1mqqA:
6.1		 5k9dA-1mqqA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		4 / 8 GLU A 299
PRO A 252
GLY A 294
ASP A 251
 None
 1.14A 5kf8A-1mqqA:
undetectable		 5kf8A-1mqqA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		4 / 7 TYR A 105
ILE A 107
ILE A 106
ILE A 136
 GOL  A 756 ( 3.8A)
None
None
None
 0.91A 5murB-1mqqA:
4.1		 5murB-1mqqA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_E_DVAE7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		3 / 3 TYR A 116
SER A 189
TRP A 470
 GOL  A 751 (-4.8A)
None
GOL  A 751 (-3.6A)
 1.00A 5n8jB-1mqqA:
undetectable		 5n8jB-1mqqA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_O_DVAO7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		3 / 3 TYR A 116
SER A 189
TRP A 470
 GOL  A 751 (-4.8A)
None
GOL  A 751 (-3.6A)
 0.96A 5n8jA-1mqqA:
undetectable		 5n8jA-1mqqA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_P_DVAP5_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		3 / 3 TYR A 116
SER A 189
TRP A 470
 GOL  A 751 (-4.8A)
None
GOL  A 751 (-3.6A)
 0.96A 5n8jD-1mqqA:
undetectable		 5n8jD-1mqqA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		4 / 5 GLY A 447
ASP A 449
ARG A 164
GLN A 396
 None
 1.36A 5zrfB-1mqqA:
undetectable		 5zrfB-1mqqA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		5 / 12 HIS A 120
GLY A 191
ASN A 142
ALA A 469
PRO A  88
 GOL  A 751 (-3.9A)
GOL  A 751 (-3.7A)
None
None
None
 1.19A 6b3aA-1mqqA:
2.2		 6b3aA-1mqqA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		5 / 9 LEU A 134
SER A 135
ILE A 104
ARG A  94
ILE A  93
 None
None
None
GOL  A 762 ( 3.1A)
None
 1.29A 6ef6A-1mqqA:
1.3		 6ef6A-1mqqA:
20.52