SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1mqs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_A_CAMA503_0
(CYTOCHROME P450-CAM)		 1mqs SLY1 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 9 PHE A 285
TYR A 616
THR A 166
LEU A 170
GLY A 639
 None
 1.49A 1dz8A-1mqsA:
0.0		 1dz8A-1mqsA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_B_CAMB502_0
(CYTOCHROME P450-CAM)		 1mqs SLY1 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 9 PHE A 285
TYR A 616
THR A 166
LEU A 170
GLY A 639
 None
 1.46A 1dz8B-1mqsA:
0.0		 1dz8B-1mqsA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_B_CAMB502_0
(CYTOCHROME P450-CAM)		 1mqs SLY1 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 9 PHE A 285
TYR A 616
THR A 166
LEU A 170
GLY A 639
 None
 1.48A 1dz9B-1mqsA:
0.0		 1dz9B-1mqsA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E6W_C_ESTC302_1
(SHORT CHAIN
3-HYDROXYACYL-COA
DEHYDROGENASE)		 1mqs INTEGRAL MEMBRANE
PROTEIN SED5
SLY1 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 4 ALA A 141
GLN A 142
TYR B  17
LEU A 136
 None
 1.35A 1e6wC-1mqsA:
0.3		 1e6wC-1mqsA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 1mqs SLY1 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 8 VAL A 295
ASP A 325
TRP A 328
LEU A 407
 None
 1.17A 1pk2A-1mqsA:
undetectable		 1pk2A-1mqsA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 1mqs SLY1 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 238
ILE A 213
LEU A 231
GLY A 232
 None
 0.61A 1rtsA-1mqsA:
undetectable		 1rtsA-1mqsA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 1mqs SLY1 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 261
GLY A 232
PRO A 587
ILE A 213
 None
 0.83A 2q9rA-1mqsA:
undetectable		 2q9rA-1mqsA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)		 1mqs SLY1 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 468
TYR A 458
PHE A 435
LEU A 457
 None
 1.20A 2w98A-1mqsA:
4.2
2w98B-1mqsA:
4.7		 2w98A-1mqsA:
19.06
2w98B-1mqsA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1mqs SLY1 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 216
GLU A 229
ALA A 178
LEU A 173
ILE A 263
 None
 1.16A 2xkwB-1mqsA:
0.0		 2xkwB-1mqsA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 1mqs SLY1 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 210
ASN A 205
GLY A 202
ASP A 201
LEU A 261
 None
 1.23A 2zw9A-1mqsA:
undetectable		 2zw9A-1mqsA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 1mqs SLY1 PROTEIN
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 324
ASN A 293
GLU A 167
 None
 0.84A 3kpdC-1mqsA:
0.0		 3kpdC-1mqsA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 1mqs SLY1 PROTEIN
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 324
ASN A 293
GLU A 167
 None
 0.87A 3kpdB-1mqsA:
undetectable		 3kpdB-1mqsA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		 1mqs SLY1 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 582
PRO A 557
SER A 500
LEU A 264
 None
 0.82A 3lsfH-1mqsA:
undetectable		 3lsfH-1mqsA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 1mqs SLY1 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 489
LEU A 180
ILE A 227
GLY A 222
PRO A 223
 None
 1.06A 3ozwB-1mqsA:
undetectable		 3ozwB-1mqsA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_E_ACTE204_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 1mqs SLY1 PROTEIN
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 120
PRO A  94
LEU A  93
 None
 0.84A 3tpxE-1mqsA:
0.0		 3tpxE-1mqsA:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 1mqs INTEGRAL MEMBRANE
PROTEIN SED5
SLY1 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 153
ILE A 112
SER B  13
LEU A 132
 None
 0.85A 3ua5A-1mqsA:
2.4		 3ua5A-1mqsA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		 1mqs INTEGRAL MEMBRANE
PROTEIN SED5
SLY1 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 153
ILE A 112
SER B  13
LEU A 132
 None
 0.86A 3ua5B-1mqsA:
0.0		 3ua5B-1mqsA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		 1mqs SLY1 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 408
PHE A 404
PRO A 337
ALA A 340
 None
 1.03A 3vm4A-1mqsA:
0.0		 3vm4A-1mqsA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 1mqs INTEGRAL MEMBRANE
PROTEIN SED5
SLY1 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 144
SER A 145
SER B  13
VAL A 156
LEU A 132
 None
 1.41A 3vt7A-1mqsA:
0.0		 3vt7A-1mqsA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 1mqs SLY1 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 336
GLN A 410
ALA A 406
ALA A 405
VAL A 343
 None
 1.12A 4jbtA-1mqsA:
undetectable		 4jbtA-1mqsA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTP_A_ASCA802_0
(RRNA N-GLYCOSIDASE)		 1mqs SLY1 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 109
ASN A 127
TYR A 100
ILE A 112
 None
 1.03A 4jtpA-1mqsA:
undetectable		 4jtpA-1mqsA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1mqs SLY1 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 609
ILE A 199
GLY A 613
THR A 644
 None
 0.95A 4zdzA-1mqsA:
0.0		 4zdzA-1mqsA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)		 1mqs SLY1 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 232
GLN A 601
TYR A 603
ASP A 586
 None
 0.92A 5vlmB-1mqsA:
2.3		 5vlmB-1mqsA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)		 1mqs SLY1 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 232
GLN A 601
TYR A 603
ASP A 586
 None
 0.82A 5vlmE-1mqsA:
2.7		 5vlmE-1mqsA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)		 1mqs SLY1 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 232
GLN A 601
TYR A 603
ASP A 586
 None
 0.86A 5vlmG-1mqsA:
2.4		 5vlmG-1mqsA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 1mqs SLY1 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 238
ILE A 213
LEU A 231
GLY A 232
 None
 0.51A 5x5qC-1mqsA:
undetectable		 5x5qC-1mqsA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1mqs SLY1 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 238
ILE A 213
LEU A 231
GLY A 232
 None
 0.58A 5x5qD-1mqsA:
0.0		 5x5qD-1mqsA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_E_D16E402_1
(THYMIDYLATE SYNTHASE)		 1mqs SLY1 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 238
ILE A 213
LEU A 231
GLY A 232
 None
 0.55A 5x5qE-1mqsA:
undetectable		 5x5qE-1mqsA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_F_D16F402_1
(THYMIDYLATE SYNTHASE)		 1mqs SLY1 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 238
ILE A 213
LEU A 231
GLY A 232
 None
 0.59A 5x5qF-1mqsA:
0.0		 5x5qF-1mqsA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 1mqs SLY1 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 5 PHE A  46
THR A  42
ASP A  36
ASN A  29
 None
 1.32A 5ybbA-1mqsA:
undetectable		 5ybbA-1mqsA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1mqs SLY1 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 649
ILE A 175
LEU A 493
LEU A 656
TYR A 489
 None
 1.45A 5ycpA-1mqsA:
undetectable		 5ycpA-1mqsA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J21_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 1mqs SLY1 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 ASN A 501
PRO A 557
ILE A 558
VAL A 561
VAL A 610
 None
 1.07A 6j21A-1mqsA:
0.0		 6j21A-1mqsA:
20.67