SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1mr2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CRB_A_RTLA200_0
(CELLULAR RETINOL
BINDING PROTEIN)		 1mr2 ADPR PYROPHOSPHATASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  94
LEU A 130
ALA A 127
LEU A 126
ILE A 164
 None
 1.13A 1crbA-1mr2A:
undetectable		 1crbA-1mr2A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_O_SAMO302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1mr2 ADPR PYROPHOSPHATASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 172
SER A 167
ILE A  57
LEU A 108
LEU A 126
 None
 0.96A 3cjtO-1mr2A:
undetectable		 3cjtO-1mr2A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1mr2 ADPR PYROPHOSPHATASE
(Mycobacterium
tuberculosis) 		4 / 8 VAL A  98
LEU A 100
LEU A  94
ILE A  57
 None
 0.85A 3u5kA-1mr2A:
1.0		 3u5kA-1mr2A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)		 1mr2 ADPR PYROPHOSPHATASE
(Mycobacterium
tuberculosis) 		4 / 5 VAL A  98
LEU A 100
LEU A  94
ILE A  57
 None
 0.91A 4a9jC-1mr2A:
1.4		 4a9jC-1mr2A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 1mr2 ADPR PYROPHOSPHATASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 164
VAL A 122
ILE A 168
GLU A 120
ARG A  64
 None
None
None
None
A12  A 301 (-2.5A)
 1.37A 4i41A-1mr2A:
undetectable		 4i41A-1mr2A:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LZR_A_LOCA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1mr2 ADPR PYROPHOSPHATASE
(Mycobacterium
tuberculosis) 		4 / 8 VAL A  98
LEU A 100
LEU A  94
ILE A  57
 None
 0.85A 4lzrA-1mr2A:
undetectable		 4lzrA-1mr2A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_B_ACTB403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1mr2 ADPR PYROPHOSPHATASE
(Mycobacterium
tuberculosis) 		3 / 3 ARG A  24
ASP A  25
ARG A  23
 None
 0.67A 4wq4B-1mr2A:
0.0		 4wq4B-1mr2A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 1mr2 ADPR PYROPHOSPHATASE
(Mycobacterium
tuberculosis) 		4 / 4 ILE A  57
LEU A 108
HIS A 177
ALA A 175
 None
 0.90A 6ck2C-1mr2A:
undetectable
6ck2D-1mr2A:
undetectable		 6ck2C-1mr2A:
6.10
6ck2D-1mr2A:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1mr2 ADPR PYROPHOSPHATASE
(Mycobacterium
tuberculosis) 		4 / 7 THR A 113
ARG A 123
HIS A  87
ASP A 110
 None
 1.13A 6mn4E-1mr2A:
0.0		 6mn4E-1mr2A:
24.09