SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1mro'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1E7W_A_MTXA301_1 (PTERIDINE REDUCTASE)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	5 / 12	SER A 492 PRO A 473 LEU A 314 TYR A 315 MET A 263	None	1.43A	1e7wA-1mroA: undetectable	1e7wA-1mroA: 20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EQB_A_GLYA1292_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	1mro	METHYL-COENZYME M REDUCTASE METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis; Methanothermobac ter marburgensis)	4 / 8	SER C 118 HIS C 156 HIS C 158 ARG A 401	None	1.34A	1eqbA-1mroC: undetectable 1eqbB-1mroC: undetectable	1eqbA-1mroC: 19.66 1eqbB-1mroC: 19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EQB_A_GLYA1292_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	1mro	METHYL-COENZYME M REDUCTASE METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis; Methanothermobac ter marburgensis)	4 / 8	SER C 118 SER C 159 HIS C 158 ARG A 401	None	1.19A	1eqbA-1mroC: undetectable 1eqbB-1mroC: undetectable	1eqbA-1mroC: 19.66 1eqbB-1mroC: 19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EQB_B_GLYB2292_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	1mro	METHYL-COENZYME M REDUCTASE METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis; Methanothermobac ter marburgensis)	4 / 8	SER C 118 SER C 159 HIS C 158 ARG A 401	None	1.18A	1eqbA-1mroC: undetectable 1eqbB-1mroC: undetectable	1eqbA-1mroC: 19.66 1eqbB-1mroC: 19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EQB_C_GLYC3292_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	1mro	METHYL-COENZYME M REDUCTASE METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis; Methanothermobac ter marburgensis)	4 / 8	SER C 118 SER C 159 HIS C 158 ARG A 401	None	1.18A	1eqbC-1mroC: undetectable 1eqbD-1mroC: undetectable	1eqbC-1mroC: 19.66 1eqbD-1mroC: 19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EQB_D_GLYD4292_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	1mro	METHYL-COENZYME M REDUCTASE METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis; Methanothermobac ter marburgensis)	4 / 8	SER C 118 SER C 159 HIS C 158 ARG A 401	None	1.18A	1eqbC-1mroC: undetectable 1eqbD-1mroC: undetectable	1eqbC-1mroC: 19.66 1eqbD-1mroC: 19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MT1_G_AG2G7003_1 (PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE BETA CHAIN PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE ALPHA CHAIN)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	4 / 6	LEU A 534 ASP A 85 LEU A 86 GLY A 83	None	0.84A	1mt1G-1mroA: undetectable 1mt1J-1mroA: undetectable	1mt1G-1mroA: 9.29 1mt1J-1mroA: 10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MT1_K_AG2K7002_1 (PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE ALPHA CHAIN PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE BETA CHAIN)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	4 / 7	LEU A 534 ASP A 85 LEU A 86 GLY A 83	None	0.84A	1mt1H-1mroA: undetectable 1mt1K-1mroA: undetectable	1mt1H-1mroA: 10.79 1mt1K-1mroA: 9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1N13_D_AG2D7015_1 (PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE ALPHA CHAIN PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE BETA CHAIN)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	4 / 7	LEU A 534 ASP A 85 LEU A 86 GLY A 83	None	0.81A	1n13D-1mroA: 0.7 1n13E-1mroA: undetectable	1n13D-1mroA: 10.79 1n13E-1mroA: 9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1N13_F_AG2F7016_1 (PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE BETA CHAIN PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE ALPHA CHAIN)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	4 / 8	LEU A 534 ASP A 85 LEU A 86 GLY A 83	None	0.80A	1n13A-1mroA: undetectable 1n13F-1mroA: undetectable	1n13A-1mroA: 9.29 1n13F-1mroA: 10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1N13_H_AG2H7012_1 (PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE ALPHA CHAIN PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE BETA CHAIN)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	4 / 6	LEU A 534 ASP A 85 LEU A 86 GLY A 83	None	0.80A	1n13H-1mroA: undetectable 1n13K-1mroA: undetectable	1n13H-1mroA: 10.79 1n13K-1mroA: 9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1N13_J_AG2J7013_1 (PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE BETA CHAIN PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE ALPHA CHAIN)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	4 / 7	LEU A 534 ASP A 85 LEU A 86 GLY A 83	None	0.81A	1n13G-1mroA: undetectable 1n13J-1mroA: undetectable	1n13G-1mroA: 9.29 1n13J-1mroA: 10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NW5_A_SAMA401_0 (MODIFICATION METHYLASE RSRI)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	5 / 12	ASP A 316 THR A 347 SER A 304 ALA A 312 ALA A 309	None	1.09A	1nw5A-1mroA: undetectable	1nw5A-1mroA: 20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1PN0_A_IPHA6012_0 (PHENOL 2-MONOOXYGENASE)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	5 / 10	GLY A 108 VAL A 107 MET A 235 ILE A 231 TYR A 132	None	1.27A	1pn0A-1mroA: undetectable	1pn0A-1mroA: 23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1PN0_B_IPHB6022_0 (PHENOL 2-MONOOXYGENASE)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	5 / 10	GLY A 108 VAL A 107 MET A 235 ILE A 231 TYR A 132	None	1.26A	1pn0B-1mroA: undetectable	1pn0B-1mroA: 23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1PN0_C_IPHC6032_0 (PHENOL 2-MONOOXYGENASE)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	5 / 10	GLY A 108 VAL A 107 MET A 235 ILE A 231 TYR A 132	None	1.24A	1pn0C-1mroA: 1.5	1pn0C-1mroA: 23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1PN0_D_IPHD6042_0 (PHENOL 2-MONOOXYGENASE)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	5 / 10	GLY A 108 VAL A 107 MET A 235 ILE A 231 TYR A 132	None	1.25A	1pn0D-1mroA: 1.5	1pn0D-1mroA: 23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Q23_E_FUAE706_2 (CHLORAMPHENICOL ACETYLTRANSFERASE)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	4 / 4	ALA A 402 VAL A 405 ALA A 406 HIS A 484	None	1.03A	1q23F-1mroA: 1.2	1q23F-1mroA: 16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Q23_J_FUAJ711_2 (CHLORAMPHENICOL ACETYLTRANSFERASE)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	4 / 4	ALA A 402 VAL A 405 ALA A 406 HIS A 484	None	0.94A	1q23K-1mroA: 0.9	1q23K-1mroA: 16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YC2_B_NCAB508_0 (NAD-DEPENDENT DEACETYLASE 2)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	4 / 5	GLN A 421 LEU A 468 TYR A 478 GLN A 449	None	1.50A	1yc2B-1mroA: 0.0 1yc2C-1mroA: 0.0	1yc2B-1mroA: 19.47 1yc2C-1mroA: 19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BFP_C_H4BC1290_1 (PTERIDINE REDUCTASE 1)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	4 / 8	SER C 159 PHE A 396 LEU A 64 LEU A 69	None MGN A 400 (-4.2A) None None	0.91A	2bfpC-1mroC: undetectable	2bfpC-1mroC: 21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BR4_A_SAMA301_1 (CEPHALOSPORIN HYDROXYLASE CMCI)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	3 / 3	LYS A 13 ASP A 344 ASP A 306	None	1.05A	2br4A-1mroA: undetectable	2br4A-1mroA: 17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2EIM_J_CHDJ60_0 (CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	4 / 5	TYR A 338 ARG A 526 MET A 313 THR A 310	None	1.19A	2eimJ-1mroA: 0.0	2eimJ-1mroA: 8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2EIM_W_CHDW1060_0 (CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	4 / 5	TYR A 338 ARG A 526 MET A 313 THR A 310	None	1.19A	2eimW-1mroA: undetectable	2eimW-1mroA: 8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2EJ3_A_GBNA2414_1 (BRANCHED-CHAIN AMINO ACID AMINOTRANSFERASE)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	4 / 8	GLY A 483 THR A 335 ALA A 336 ALA A 337	None None MGN A 400 ( 3.6A) None	0.56A	2ej3A-1mroA: undetectable	2ej3A-1mroA: 19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2EJ3_B_GBNB914_1 (BRANCHED-CHAIN AMINO ACID AMINOTRANSFERASE)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	5 / 10	GLY A 483 GLU A 487 THR A 335 ALA A 336 ALA A 337	None None None MGN A 400 ( 3.6A) None	1.03A	2ej3B-1mroA: undetectable	2ej3B-1mroA: 19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2EJ3_C_GBNC1414_1 (BRANCHED-CHAIN AMINO ACID AMINOTRANSFERASE)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	5 / 8	GLY A 483 GLU A 487 THR A 335 ALA A 336 ALA A 337	None None None MGN A 400 ( 3.6A) None	1.03A	2ej3C-1mroA: undetectable	2ej3C-1mroA: 19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NNH_B_9CRB501_1 (CYTOCHROME P450 2C8)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	5 / 9	GLY C 41 ILE C 85 THR C 140 VAL C 36 ILE C 31	None	1.34A	2nnhB-1mroC: undetectable	2nnhB-1mroC: 18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NYU_A_SAMA201_1 (PUTATIVE RIBOSOMAL RNA METHYLTRANSFERASE 2)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	4 / 4	PRO C 198 ASP C 35 ASP C 33 ASP C 200	None	1.17A	2nyuA-1mroC: undetectable	2nyuA-1mroC: 19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NYU_B_SAMB201_1 (PUTATIVE RIBOSOMAL RNA METHYLTRANSFERASE 2)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	4 / 5	PRO C 198 ASP C 35 ASP C 33 ASP C 200	None	1.15A	2nyuB-1mroC: undetectable	2nyuB-1mroC: 19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QQC_E_AG2E671_1 (PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE (EC 4.1.1.19) (PVLARGDC))	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	4 / 7	LEU A 534 ASP A 85 LEU A 86 GLY A 83	None	0.82A	2qqcD-1mroA: 0.5 2qqcE-1mroA: undetectable	2qqcD-1mroA: 10.89 2qqcE-1mroA: 7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QQC_K_AG2K671_1 (PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE (EC 4.1.1.19) (PVLARGDC))	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	4 / 8	LEU A 534 ASP A 85 LEU A 86 GLY A 83	None	0.82A	2qqcH-1mroA: undetectable 2qqcK-1mroA: undetectable	2qqcH-1mroA: 10.89 2qqcK-1mroA: 7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QQD_B_AG2B671_1 (PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE (EC 4.1.1.19) (PVLARGDC))	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	4 / 8	LEU A 534 ASP A 85 LEU A 86 GLY A 83	None	0.84A	2qqdB-1mroA: undetectable 2qqdC-1mroA: undetectable	2qqdB-1mroA: 10.89 2qqdC-1mroA: 14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XKK_E_MFXE1100_1 (TOPOISOMERASE IV DNA)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	3 / 3	ARG A 216 GLU A 528 SER A 215	None	0.80A	2xkkA-1mroA: 2.7 2xkkC-1mroA: 2.6	2xkkA-1mroA: 21.59 2xkkC-1mroA: 21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZQ9_A_CLSA11_1 (BETA-LACTAMASE TOHO-1)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	4 / 4	GLU A 39 ARG A 36 ASN A 90 ASP A 85	None	1.10A	2zq9A-1mroA: 0.0	2zq9A-1mroA: 19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZW9_A_SAMA801_1 (LEUCINE CARBOXYL METHYLTRANSFERASE 2)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	4 / 8	THR C 140 ARG C 101 ASP C 33 SER C 134	None	0.91A	2zw9A-1mroC: undetectable	2zw9A-1mroC: 15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZZM_A_SAMA401_1 (UNCHARACTERIZED PROTEIN MJ0883)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	3 / 3	ARG A 526 ASP A 78 ASN A 341	None	0.85A	2zzmA-1mroA: undetectable	2zzmA-1mroA: 18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AG2_J_CHDJ60_0 (CYTOCHROME C OXIDASE POLYPEPTIDE 7A1)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	4 / 5	TYR A 338 ARG A 526 MET A 313 THR A 310	None	1.21A	3ag2J-1mroA: undetectable	3ag2J-1mroA: 8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AG4_J_CHDJ60_0 (CYTOCHROME C OXIDASE POLYPEPTIDE 7A1)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	4 / 5	TYR A 338 ARG A 526 MET A 313 THR A 310	None	1.33A	3ag4J-1mroA: undetectable	3ag4J-1mroA: 8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AI9_X_SAMX501_0 (UPF0217 PROTEIN MJ1640)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	5 / 9	ILE C 73 GLY C 75 SER C 134 GLU C 127 LEU C 130	None	1.09A	3ai9X-1mroC: undetectable	3ai9X-1mroC: 22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BWY_A_SAMA301_0 (COMT PROTEIN)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	5 / 12	VAL A 482 GLU A 487 GLY A 486 TYR A 333 SER A 492	TP7 A9000 (-4.1A) None None None None	1.40A	3bwyA-1mroA: undetectable	3bwyA-1mroA: 18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EKQ_A_ROCA100_2 (PROTEASE)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	5 / 9	LEU A 120 VAL A 124 ILE A 129 ILE A 231 ILE A 116	None	1.14A	3ekqB-1mroA: undetectable	3ekqB-1mroA: 10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ELZ_A_CHDA152_0 (ILEAL BILE ACID-BINDING PROTEIN)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	3 / 3	VAL A 354 LYS A 351 HIS A 496	None	0.89A	3elzA-1mroA: undetectable	3elzA-1mroA: 11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ELZ_B_CHDB152_0 (ILEAL BILE ACID-BINDING PROTEIN)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	3 / 3	ASN A 137 HIS A 138 VAL A 145	None None F43 A 700 (-3.5A)	0.88A	3elzB-1mroA: 0.0	3elzB-1mroA: 11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FI0_I_TRPI1001_0 (TRYPTOPHANYL-TRNA SYNTHETASE)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	4 / 8	GLY C 202 ILE C 31 VAL C 199 GLN C 175	None	0.76A	3fi0I-1mroC: undetectable	3fi0I-1mroC: 20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JW2_A_017A401_2 (GAG-POL POLYPROTEIN)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	6 / 12	LEU A 120 VAL A 124 ILE A 129 ILE A 231 VAL A 115 ILE A 116	None	1.23A	3jw2B-1mroA: undetectable	3jw2B-1mroA: 11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3K4V_B_ROCB201_3 (HIV-1 PROTEASE)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	6 / 12	LEU A 120 VAL A 124 ILE A 129 ILE A 231 VAL A 115 ILE A 116	None	1.26A	3k4vB-1mroA: undetectable	3k4vB-1mroA: 11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3R9T_C_BEZC264_0 (ECHA1_1)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	4 / 5	ALA A 114 GLU A 259 ALA A 254 MET A 235	None	1.18A	3r9tC-1mroA: undetectable	3r9tC-1mroA: 19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RF4_C_FUNC203_1 (MACROPHAGE MIGRATION INHIBITORY FACTOR)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	5 / 11	ILE A 210 MET A 140 ILE A 231 VAL A 208 VAL A 107	None	1.34A	3rf4B-1mroA: 2.3 3rf4C-1mroA: undetectable	3rf4B-1mroA: 10.55 3rf4C-1mroA: 10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TKW_B_017B401_2 (PROTEASE)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	6 / 12	LEU A 120 VAL A 124 ILE A 129 ILE A 231 VAL A 115 ILE A 116	None	1.22A	3tkwB-1mroA: undetectable	3tkwB-1mroA: 11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UJ7_B_SAMB302_0 (PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	5 / 12	GLY A 426 GLY A 423 ILE A 491 ALA A 374 LEU A 433	None	1.15A	3uj7B-1mroA: undetectable	3uj7B-1mroA: 17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ZQT_A_30ZA1920_1 (ANDROGEN RECEPTOR)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	4 / 6	PRO A 278 GLY A 279 ASN A 474 LEU A 267	None None AGM A 271 ( 3.7A) AGM A 271 ( 3.8A)	0.79A	3zqtA-1mroA: undetectable	3zqtA-1mroA: 15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4AQL_A_TXCA1452_1 (GUANINE DEAMINASE)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	5 / 12	LEU C 28 LEU C 205 GLU C 26 GLU C 141 ALA C 96	None	1.35A	4aqlA-1mroC: undetectable	4aqlA-1mroC: 18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DQF_B_017B101_1 (ASPARTYL PROTEASE)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	6 / 12	LEU A 120 VAL A 124 ILE A 129 ILE A 231 VAL A 115 ILE A 116	None	1.30A	4dqfA-1mroA: undetectable	4dqfA-1mroA: 10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EMA_A_BRLA601_2 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	3 / 3	PHE C 142 VAL C 36 ILE C 31	None	0.47A	4emaA-1mroC: undetectable	4emaA-1mroC: 23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4GC9_A_SAMA401_1 (DIMETHYLADENOSINE TRANSFERASE 1, MITOCHONDRIAL)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	3 / 3	GLU A 528 ASP A 521 ASP A 100	None	0.75A	4gc9A-1mroA: undetectable	4gc9A-1mroA: 21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4J4V_D_SVRD301_1 (NUCLEOCAPSID PROTEIN)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	5 / 11	GLY A 203 ASN A 110 ALA A 112 GLN A 206 ILE A 172	None	1.21A	4j4vD-1mroA: undetectable 4j4vE-1mroA: 0.0	4j4vD-1mroA: 20.40 4j4vE-1mroA: 20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4J6C_A_STRA501_1 (CYTOCHROME P450 MONOOXYGENASE)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	5 / 11	ALA A 252 ALA A 254 ALA A 255 VAL A 208 GLN A 206	None	1.13A	4j6cA-1mroA: 0.0	4j6cA-1mroA: 20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4J6C_A_STRA501_1 (CYTOCHROME P450 MONOOXYGENASE)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	5 / 11	MET A 235 ALA A 252 ALA A 254 ALA A 255 GLN A 206	None	1.15A	4j6cA-1mroA: 0.0	4j6cA-1mroA: 20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4J6C_B_STRB503_1 (CYTOCHROME P450 MONOOXYGENASE)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	5 / 10	ALA A 252 ALA A 254 ALA A 255 VAL A 208 GLN A 206	None	1.11A	4j6cB-1mroA: 0.0	4j6cB-1mroA: 20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4J6C_B_STRB503_1 (CYTOCHROME P450 MONOOXYGENASE)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	5 / 10	MET A 235 ALA A 252 ALA A 254 ALA A 255 GLN A 206	None	1.14A	4j6cB-1mroA: 0.0	4j6cB-1mroA: 20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4J6D_A_TESA503_1 (CYTOCHROME P450 MONOOXYGENASE)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	5 / 12	ALA A 252 ALA A 254 ALA A 255 VAL A 208 GLN A 206	None	1.11A	4j6dA-1mroA: undetectable	4j6dA-1mroA: 20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4J6D_B_TESB502_1 (CYTOCHROME P450 MONOOXYGENASE)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	5 / 12	ALA A 252 ALA A 254 ALA A 255 VAL A 208 GLN A 206	None	1.10A	4j6dB-1mroA: undetectable	4j6dB-1mroA: 20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4J6D_B_TESB502_1 (CYTOCHROME P450 MONOOXYGENASE)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	5 / 12	MET A 235 ALA A 252 ALA A 254 ALA A 255 GLN A 206	None	1.12A	4j6dB-1mroA: undetectable	4j6dB-1mroA: 20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4JBT_A_ASDA501_1 (CYTOCHROME P450 MONOOXYGENASE)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	5 / 12	ALA A 252 ALA A 254 ALA A 255 VAL A 208 GLN A 206	None	1.11A	4jbtA-1mroA: undetectable	4jbtA-1mroA: 20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4JBT_A_ASDA501_1 (CYTOCHROME P450 MONOOXYGENASE)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	5 / 12	MET A 235 ALA A 252 ALA A 254 ALA A 255 GLN A 206	None	1.11A	4jbtA-1mroA: undetectable	4jbtA-1mroA: 20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4JBT_B_ASDB502_1 (CYTOCHROME P450 MONOOXYGENASE)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	5 / 11	ALA A 252 ALA A 254 ALA A 255 VAL A 208 GLN A 206	None	1.12A	4jbtB-1mroA: 0.0	4jbtB-1mroA: 20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4JBT_B_ASDB502_1 (CYTOCHROME P450 MONOOXYGENASE)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	5 / 11	MET A 235 ALA A 252 ALA A 254 ALA A 255 GLN A 206	None	1.11A	4jbtB-1mroA: 0.0	4jbtB-1mroA: 20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4JEC_B_478B401_1 (HIV-1 PROTEASE)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	6 / 12	LEU A 120 VAL A 124 ILE A 129 ILE A 231 VAL A 115 ILE A 116	None	1.19A	4jecA-1mroA: undetectable	4jecA-1mroA: 11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ODO_B_FK5B203_2 (PEPTIDYL-PROLYL CIS-TRANS ISOMERASE SLYD)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	3 / 3	ALA C 44 GLN C 190 GLY C 152	None	0.64A	4odoC-1mroC: undetectable	4odoC-1mroC: 22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QGI_A_ROCA101_2 (PROTEASE)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	6 / 11	LEU A 120 VAL A 124 ILE A 129 ILE A 231 VAL A 115 ILE A 116	None	1.44A	4qgiB-1mroA: undetectable	4qgiB-1mroA: 10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4R20_A_AERA602_1 (CYTOCHROME P450 FAMILY 17 POLYPEPTIDE 2)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	4 / 8	ALA A 420 GLU A 469 GLY A 284 VAL A 303	None	0.86A	4r20A-1mroA: undetectable	4r20A-1mroA: 20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5A1R_A_STRA600_1 (CYTOCHROME P450 3A4)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	4 / 5	PHE A 529 ASP A 521 PHE A 522 PHE A 520	None	1.08A	5a1rA-1mroA: 0.0	5a1rA-1mroA: 20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5D0Y_A_FOLA201_0 (CONSERVED HYPOTHETICAL MEMBRANE PROTEIN)	1mro	METHYL-COENZYME M REDUCTASE METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis; Methanothermobac ter marburgensis)	5 / 12	GLN A 395 GLY A 397 PHE A 346 THR A 378 HIS C 158	MGN A 400 ( 4.8A) MGN A 400 (-3.6A) None None None	1.46A	5d0yA-1mroA: 1.4	5d0yA-1mroA: 15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5GWZ_D_010D6_0 (N-[(5-METHYLISOXAZOL -3-YL)CARBONYL]ALANY L-L-VALYL-N~1~-((1R, 2Z)-4-(BENZYLOXY)-4- OXO-1-{[(3R)-2-OXOPY RROLIDIN-3-YL]METHYL }BUT-2-ENYL)-L-LEUCI NAMIDE PEDV MAIN PROTEASE)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	3 / 3	MET A 431 HIS A 484 GLY A 442	None	0.81A	5gwzB-1mroA: 0.0	5gwzB-1mroA: 20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5GWZ_D_010D6_0 (N-[(5-METHYLISOXAZOL -3-YL)CARBONYL]ALANY L-L-VALYL-N~1~-((1R, 2Z)-4-(BENZYLOXY)-4- OXO-1-{[(3R)-2-OXOPY RROLIDIN-3-YL]METHYL }BUT-2-ENYL)-L-LEUCI NAMIDE PEDV MAIN PROTEASE)	1mro	METHYL-COENZYME M REDUCTASE METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis; Methanothermobac ter marburgensis)	3 / 3	MET A 367 HIS C 238 GLY A 423	None	0.78A	5gwzB-1mroA: 0.0	5gwzB-1mroA: 20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KQX_A_ROCA101_2 (PROTEASE E35D-SQV)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	5 / 9	LEU A 120 VAL A 124 ILE A 129 ILE A 231 ILE A 116	None	1.13A	5kqxB-1mroA: undetectable	5kqxB-1mroA: 11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KSN_A_NIZA809_1 (CATALASE-PEROXIDASE)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	5 / 9	ARG A 471 GLU A 469 GLN A 421 LEU A 424 THR A 422	None	1.49A	5ksnA-1mroA: 1.2	5ksnA-1mroA: 21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LF7_V_6V8V303_0 (PROTEASOME SUBUNIT BETA TYPE-3 PROTEASOME SUBUNIT BETA TYPE-7)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	5 / 11	ALA A 309 THR A 310 GLY A 490 ASP A 316 LEU A 320	None None None None TP7 A9000 (-4.2A)	1.03A	5lf7V-1mroA: 2.1 5lf7W-1mroA: undetectable	5lf7V-1mroA: 18.23 5lf7W-1mroA: 16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MQT_C_STIC302_1 (DEOXYCYTIDINE KINASE)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	5 / 12	ILE C 123 PRO C 21 GLU C 22 LEU C 25 TYR C 109	None	1.44A	5mqtC-1mroC: undetectable	5mqtC-1mroC: 24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NU7_A_RTLA201_0 (RETINOL-BINDING PROTEIN 4)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	4 / 8	ALA A 374 MET A 431 TYR A 428 GLN A 449	None	0.98A	5nu7A-1mroA: undetectable	5nu7A-1mroA: 14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5SXT_A_NIZA807_1 (CATALASE-PEROXIDASE)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	5 / 8	ARG A 471 GLU A 469 GLN A 421 LEU A 424 THR A 422	None	1.46A	5sxtA-1mroA: 0.9	5sxtA-1mroA: 21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VOO_E_C2FE3001_0 (5-METHYLTETRAHYDROFO LATE HOMOCYSTEINE S-METHYLTRANSFERASE)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	5 / 12	GLY A 418 VAL A 308 LEU A 305 GLY A 410 ILE A 491	None	1.19A	5vooE-1mroA: undetectable	5vooE-1mroA: 20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VOO_F_C2FF3001_0 (5-METHYLTETRAHYDROFO LATE HOMOCYSTEINE S-METHYLTRANSFERASE)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	5 / 12	GLY A 418 VAL A 308 LEU A 305 GLY A 410 ILE A 491	None	1.18A	5vooF-1mroA: undetectable	5vooF-1mroA: 20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5W97_J_CHDJ101_1 (CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	4 / 5	TYR A 338 ARG A 526 MET A 313 THR A 310	None	1.36A	5w97J-1mroA: 0.0	5w97J-1mroA: 8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WAU_J_CHDJ101_1 (CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	4 / 5	TYR A 338 ARG A 526 MET A 313 THR A 310	None	1.34A	5wauJ-1mroA: 0.0	5wauJ-1mroA: 8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Z86_J_CHDJ101_0 (CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	4 / 5	TYR A 338 ARG A 526 MET A 313 THR A 310	None	1.32A	5z86J-1mroA: 0.0	5z86J-1mroA: 8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6A4I_A_TRPA403_0 (TRYPTOPHAN 2,3-DIOXYGENASE)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	4 / 8	ARG A 471 GLU A 469 THR A 422 PRO A 495	None	1.04A	6a4iA-1mroA: 0.0	6a4iA-1mroA: 20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6A4I_B_TRPB403_0 (TRYPTOPHAN 2,3-DIOXYGENASE)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	4 / 7	ARG A 471 GLU A 469 THR A 422 PRO A 495	None	1.04A	6a4iB-1mroA: 0.0	6a4iB-1mroA: 20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CDQ_A_NIZA809_1 (CATALASE-PEROXIDASE)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	5 / 9	ARG A 471 GLU A 469 GLN A 421 LEU A 424 THR A 422	None	1.42A	6cdqA-1mroA: 0.9	6cdqA-1mroA: 8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DEB_B_MTXB303_1 (BIFUNCTIONAL PROTEIN FOLD)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	4 / 5	TYR A 315 GLN A 485 GLY A 220 ILE A 101	None	1.48A	6debB-1mroA: undetectable	6debB-1mroA: 9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MN5_D_LLLD301_0 (AMINOGLYCOSIDE N(3)-ACETYLTRANSFERA SE, AAC(3)-IVA)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	4 / 6	ASP A 344 ARG A 302 ASP A 306 CYH A 290	None	1.48A	6mn5D-1mroA: 0.0	6mn5D-1mroA: 10.00

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1E7W_A_MTXA301_1","PTERIDINE REDUCTASE","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",5,"SER A 492;PRO A 473;LEU A 314;TYR A 315;MET A 263","None","1.43A","1e7wA-1mroA:undetectable","1e7wA-1mroA:20.74"],["1EQB_A_GLYA1292_0","SERINE HYDROXYMETHYLTRANSFERASE","1mro","METHYL-COENZYME M REDUCTASE;METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis;Methanothermobacter marburgensis",4,"SER C 118;HIS C 156;HIS C 158;ARG A 401","None","1.34A","1eqbA-1mroC:undetectable;1eqbB-1mroC:undetectable","1eqbA-1mroC:19.66;1eqbB-1mroC:19.66"],["1EQB_A_GLYA1292_0","SERINE HYDROXYMETHYLTRANSFERASE","1mro","METHYL-COENZYME M REDUCTASE;METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis;Methanothermobacter marburgensis",4,"SER C 118;SER C 159;HIS C 158;ARG A 401","None","1.19A","1eqbA-1mroC:undetectable;1eqbB-1mroC:undetectable","1eqbA-1mroC:19.66;1eqbB-1mroC:19.66"],["1EQB_B_GLYB2292_0","SERINE HYDROXYMETHYLTRANSFERASE","1mro","METHYL-COENZYME M REDUCTASE;METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis;Methanothermobacter marburgensis",4,"SER C 118;SER C 159;HIS C 158;ARG A 401","None","1.18A","1eqbA-1mroC:undetectable;1eqbB-1mroC:undetectable","1eqbA-1mroC:19.66;1eqbB-1mroC:19.66"],["1EQB_C_GLYC3292_0","SERINE HYDROXYMETHYLTRANSFERASE","1mro","METHYL-COENZYME M REDUCTASE;METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis;Methanothermobacter marburgensis",4,"SER C 118;SER C 159;HIS C 158;ARG A 401","None","1.18A","1eqbC-1mroC:undetectable;1eqbD-1mroC:undetectable","1eqbC-1mroC:19.66;1eqbD-1mroC:19.66"],["1EQB_D_GLYD4292_0","SERINE HYDROXYMETHYLTRANSFERASE","1mro","METHYL-COENZYME M REDUCTASE;METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis;Methanothermobacter marburgensis",4,"SER C 118;SER C 159;HIS C 158;ARG A 401","None","1.18A","1eqbC-1mroC:undetectable;1eqbD-1mroC:undetectable","1eqbC-1mroC:19.66;1eqbD-1mroC:19.66"],["1MT1_G_AG2G7003_1","PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE BETA CHAIN;PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE ALPHA CHAIN","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",4,"LEU A 534;ASP A  85;LEU A  86;GLY A  83","None","0.84A","1mt1G-1mroA:undetectable;1mt1J-1mroA:undetectable","1mt1G-1mroA:9.29;1mt1J-1mroA:10.79"],["1MT1_K_AG2K7002_1","PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE ALPHA CHAIN;PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE BETA CHAIN","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",4,"LEU A 534;ASP A  85;LEU A  86;GLY A  83","None","0.84A","1mt1H-1mroA:undetectable;1mt1K-1mroA:undetectable","1mt1H-1mroA:10.79;1mt1K-1mroA:9.29"],["1N13_D_AG2D7015_1","PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE ALPHA CHAIN;PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE BETA CHAIN","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",4,"LEU A 534;ASP A  85;LEU A  86;GLY A  83","None","0.81A","1n13D-1mroA:0.7;1n13E-1mroA:undetectable","1n13D-1mroA:10.79;1n13E-1mroA:9.29"],["1N13_F_AG2F7016_1","PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE BETA CHAIN;PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE ALPHA CHAIN","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",4,"LEU A 534;ASP A  85;LEU A  86;GLY A  83","None","0.80A","1n13A-1mroA:undetectable;1n13F-1mroA:undetectable","1n13A-1mroA:9.29;1n13F-1mroA:10.79"],["1N13_H_AG2H7012_1","PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE ALPHA CHAIN;PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE BETA CHAIN","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",4,"LEU A 534;ASP A  85;LEU A  86;GLY A  83","None","0.80A","1n13H-1mroA:undetectable;1n13K-1mroA:undetectable","1n13H-1mroA:10.79;1n13K-1mroA:9.29"],["1N13_J_AG2J7013_1","PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE BETA CHAIN;PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE ALPHA CHAIN","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",4,"LEU A 534;ASP A  85;LEU A  86;GLY A  83","None","0.81A","1n13G-1mroA:undetectable;1n13J-1mroA:undetectable","1n13G-1mroA:9.29;1n13J-1mroA:10.79"],["1NW5_A_SAMA401_0","MODIFICATION METHYLASE RSRI","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",5,"ASP A 316;THR A 347;SER A 304;ALA A 312;ALA A 309","None","1.09A","1nw5A-1mroA:undetectable","1nw5A-1mroA:20.82"],["1PN0_A_IPHA6012_0","PHENOL 2-MONOOXYGENASE","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",5,"GLY A 108;VAL A 107;MET A 235;ILE A 231;TYR A 132","None","1.27A","1pn0A-1mroA:undetectable","1pn0A-1mroA:23.11"],["1PN0_B_IPHB6022_0","PHENOL 2-MONOOXYGENASE","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",5,"GLY A 108;VAL A 107;MET A 235;ILE A 231;TYR A 132","None","1.26A","1pn0B-1mroA:undetectable","1pn0B-1mroA:23.11"],["1PN0_C_IPHC6032_0","PHENOL 2-MONOOXYGENASE","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",5,"GLY A 108;VAL A 107;MET A 235;ILE A 231;TYR A 132","None","1.24A","1pn0C-1mroA:1.5","1pn0C-1mroA:23.11"],["1PN0_D_IPHD6042_0","PHENOL 2-MONOOXYGENASE","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",5,"GLY A 108;VAL A 107;MET A 235;ILE A 231;TYR A 132","None","1.25A","1pn0D-1mroA:1.5","1pn0D-1mroA:23.11"],["1Q23_E_FUAE706_2","CHLORAMPHENICOL ACETYLTRANSFERASE;CHLORAMPHENICOL ACETYLTRANSFERASE","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",4,"ALA A 402;VAL A 405;ALA A 406;HIS A 484","None","1.03A","1q23F-1mroA:1.2","1q23F-1mroA:16.70"],["1Q23_J_FUAJ711_2","CHLORAMPHENICOL ACETYLTRANSFERASE;CHLORAMPHENICOL ACETYLTRANSFERASE","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",4,"ALA A 402;VAL A 405;ALA A 406;HIS A 484","None","0.94A","1q23K-1mroA:0.9","1q23K-1mroA:16.70"],["1YC2_B_NCAB508_0","NAD-DEPENDENT DEACETYLASE 2","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",4,"GLN A 421;LEU A 468;TYR A 478;GLN A 449","None","1.50A","1yc2B-1mroA:0.0;1yc2C-1mroA:0.0","1yc2B-1mroA:19.47;1yc2C-1mroA:19.47"],["2BFP_C_H4BC1290_1","PTERIDINE REDUCTASE 1","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",4,"SER C 159;PHE A 396;LEU A  64;LEU A  69","None;MGN A 400 (-4.2A);None;None","0.91A","2bfpC-1mroC:undetectable","2bfpC-1mroC:21.93"],["2BR4_A_SAMA301_1","CEPHALOSPORIN HYDROXYLASE CMCI","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",3,"LYS A  13;ASP A 344;ASP A 306","None","1.05A","2br4A-1mroA:undetectable","2br4A-1mroA:17.29"],["2EIM_J_CHDJ60_0","CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",4,"TYR A 338;ARG A 526;MET A 313;THR A 310","None","1.19A","2eimJ-1mroA:0.0","2eimJ-1mroA:8.11"],["2EIM_W_CHDW1060_0","CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",4,"TYR A 338;ARG A 526;MET A 313;THR A 310","None","1.19A","2eimW-1mroA:undetectable","2eimW-1mroA:8.11"],["2EJ3_A_GBNA2414_1","BRANCHED-CHAIN AMINO ACID AMINOTRANSFERASE","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",4,"GLY A 483;THR A 335;ALA A 336;ALA A 337","None;None;MGN A 400 ( 3.6A);None","0.56A","2ej3A-1mroA:undetectable","2ej3A-1mroA:19.78"],["2EJ3_B_GBNB914_1","BRANCHED-CHAIN AMINO ACID AMINOTRANSFERASE","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",5,"GLY A 483;GLU A 487;THR A 335;ALA A 336;ALA A 337","None;None;None;MGN A 400 ( 3.6A);None","1.03A","2ej3B-1mroA:undetectable","2ej3B-1mroA:19.78"],["2EJ3_C_GBNC1414_1","BRANCHED-CHAIN AMINO ACID AMINOTRANSFERASE","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",5,"GLY A 483;GLU A 487;THR A 335;ALA A 336;ALA A 337","None;None;None;MGN A 400 ( 3.6A);None","1.03A","2ej3C-1mroA:undetectable","2ej3C-1mroA:19.78"],["2NNH_B_9CRB501_1","CYTOCHROME P450 2C8","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",5,"GLY C  41;ILE C  85;THR C 140;VAL C  36;ILE C  31","None","1.34A","2nnhB-1mroC:undetectable","2nnhB-1mroC:18.16"],["2NYU_A_SAMA201_1","PUTATIVE RIBOSOMAL RNA METHYLTRANSFERASE 2","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",4,"PRO C 198;ASP C  35;ASP C  33;ASP C 200","None","1.17A","2nyuA-1mroC:undetectable","2nyuA-1mroC:19.37"],["2NYU_B_SAMB201_1","PUTATIVE RIBOSOMAL RNA METHYLTRANSFERASE 2","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",4,"PRO C 198;ASP C  35;ASP C  33;ASP C 200","None","1.15A","2nyuB-1mroC:undetectable","2nyuB-1mroC:19.37"],["2QQC_E_AG2E671_1","PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE (EC 4.1.1.19) (PVLARGDC);PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE (EC 4.1.1.19) (PVLARGDC)","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",4,"LEU A 534;ASP A  85;LEU A  86;GLY A  83","None","0.82A","2qqcD-1mroA:0.5;2qqcE-1mroA:undetectable","2qqcD-1mroA:10.89;2qqcE-1mroA:7.74"],["2QQC_K_AG2K671_1","PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE (EC 4.1.1.19) (PVLARGDC);PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE (EC 4.1.1.19) (PVLARGDC)","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",4,"LEU A 534;ASP A  85;LEU A  86;GLY A  83","None","0.82A","2qqcH-1mroA:undetectable;2qqcK-1mroA:undetectable","2qqcH-1mroA:10.89;2qqcK-1mroA:7.74"],["2QQD_B_AG2B671_1","PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE (EC 4.1.1.19) (PVLARGDC);PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE (EC 4.1.1.19) (PVLARGDC)","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",4,"LEU A 534;ASP A  85;LEU A  86;GLY A  83","None","0.84A","2qqdB-1mroA:undetectable;2qqdC-1mroA:undetectable","2qqdB-1mroA:10.89;2qqdC-1mroA:14.99"],["2XKK_E_MFXE1100_1","TOPOISOMERASE IV;TOPOISOMERASE IV;DNA","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",3,"ARG A 216;GLU A 528;SER A 215","None","0.80A","2xkkA-1mroA:2.7;2xkkC-1mroA:2.6","2xkkA-1mroA:21.59;2xkkC-1mroA:21.59"],["2ZQ9_A_CLSA11_1","BETA-LACTAMASE TOHO-1","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",4,"GLU A  39;ARG A  36;ASN A  90;ASP A  85","None","1.10A","2zq9A-1mroA:0.0","2zq9A-1mroA:19.64"],["2ZW9_A_SAMA801_1","LEUCINE CARBOXYL METHYLTRANSFERASE 2","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",4,"THR C 140;ARG C 101;ASP C  33;SER C 134","None","0.91A","2zw9A-1mroC:undetectable","2zw9A-1mroC:15.84"],["2ZZM_A_SAMA401_1","UNCHARACTERIZED PROTEIN MJ0883","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",3,"ARG A 526;ASP A  78;ASN A 341","None","0.85A","2zzmA-1mroA:undetectable","2zzmA-1mroA:18.69"],["3AG2_J_CHDJ60_0","CYTOCHROME C OXIDASE POLYPEPTIDE 7A1","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",4,"TYR A 338;ARG A 526;MET A 313;THR A 310","None","1.21A","3ag2J-1mroA:undetectable","3ag2J-1mroA:8.11"],["3AG4_J_CHDJ60_0","CYTOCHROME C OXIDASE POLYPEPTIDE 7A1","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",4,"TYR A 338;ARG A 526;MET A 313;THR A 310","None","1.33A","3ag4J-1mroA:undetectable","3ag4J-1mroA:8.11"],["3AI9_X_SAMX501_0","UPF0217 PROTEIN MJ1640","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",5,"ILE C  73;GLY C  75;SER C 134;GLU C 127;LEU C 130","None","1.09A","3ai9X-1mroC:undetectable","3ai9X-1mroC:22.09"],["3BWY_A_SAMA301_0","COMT PROTEIN","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",5,"VAL A 482;GLU A 487;GLY A 486;TYR A 333;SER A 492","TP7 A9000 (-4.1A);None;None;None;None","1.40A","3bwyA-1mroA:undetectable","3bwyA-1mroA:18.11"],["3EKQ_A_ROCA100_2","PROTEASE;PROTEASE","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",5,"LEU A 120;VAL A 124;ILE A 129;ILE A 231;ILE A 116","None","1.14A","3ekqB-1mroA:undetectable","3ekqB-1mroA:10.26"],["3ELZ_A_CHDA152_0","ILEAL BILE ACID-BINDING PROTEIN","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",3,"VAL A 354;LYS A 351;HIS A 496","None","0.89A","3elzA-1mroA:undetectable","3elzA-1mroA:11.86"],["3ELZ_B_CHDB152_0","ILEAL BILE ACID-BINDING PROTEIN","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",3,"ASN A 137;HIS A 138;VAL A 145","None;None;F43 A 700 (-3.5A)","0.88A","3elzB-1mroA:0.0","3elzB-1mroA:11.86"],["3FI0_I_TRPI1001_0","TRYPTOPHANYL-TRNA SYNTHETASE","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",4,"GLY C 202;ILE C  31;VAL C 199;GLN C 175","None","0.76A","3fi0I-1mroC:undetectable","3fi0I-1mroC:20.71"],["3JW2_A_017A401_2","GAG-POL POLYPROTEIN;GAG-POL POLYPROTEIN","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",6,"LEU A 120;VAL A 124;ILE A 129;ILE A 231;VAL A 115;ILE A 116","None","1.23A","3jw2B-1mroA:undetectable","3jw2B-1mroA:11.75"],["3K4V_B_ROCB201_3","HIV-1 PROTEASE","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",6,"LEU A 120;VAL A 124;ILE A 129;ILE A 231;VAL A 115;ILE A 116","None","1.26A","3k4vB-1mroA:undetectable","3k4vB-1mroA:11.19"],["3R9T_C_BEZC264_0","ECHA1_1","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",4,"ALA A 114;GLU A 259;ALA A 254;MET A 235","None","1.18A","3r9tC-1mroA:undetectable","3r9tC-1mroA:19.96"],["3RF4_C_FUNC203_1","MACROPHAGE MIGRATION INHIBITORY FACTOR;MACROPHAGE MIGRATION INHIBITORY FACTOR","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",5,"ILE A 210;MET A 140;ILE A 231;VAL A 208;VAL A 107","None","1.34A","3rf4B-1mroA:2.3;3rf4C-1mroA:undetectable","3rf4B-1mroA:10.55;3rf4C-1mroA:10.55"],["3TKW_B_017B401_2","PROTEASE","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",6,"LEU A 120;VAL A 124;ILE A 129;ILE A 231;VAL A 115;ILE A 116","None","1.22A","3tkwB-1mroA:undetectable","3tkwB-1mroA:11.75"],["3UJ7_B_SAMB302_0","PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",5,"GLY A 426;GLY A 423;ILE A 491;ALA A 374;LEU A 433","None","1.15A","3uj7B-1mroA:undetectable","3uj7B-1mroA:17.82"],["3ZQT_A_30ZA1920_1","ANDROGEN RECEPTOR","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",4,"PRO A 278;GLY A 279;ASN A 474;LEU A 267","None;None;AGM A 271 ( 3.7A);AGM A 271 ( 3.8A)","0.79A","3zqtA-1mroA:undetectable","3zqtA-1mroA:15.72"],["4AQL_A_TXCA1452_1","GUANINE DEAMINASE","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",5,"LEU C  28;LEU C 205;GLU C  26;GLU C 141;ALA C  96","None","1.35A","4aqlA-1mroC:undetectable","4aqlA-1mroC:18.33"],["4DQF_B_017B101_1","ASPARTYL PROTEASE;ASPARTYL PROTEASE","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",6,"LEU A 120;VAL A 124;ILE A 129;ILE A 231;VAL A 115;ILE A 116","None","1.30A","4dqfA-1mroA:undetectable","4dqfA-1mroA:10.63"],["4EMA_A_BRLA601_2","PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",3,"PHE C 142;VAL C  36;ILE C  31","None","0.47A","4emaA-1mroC:undetectable","4emaA-1mroC:23.63"],["4GC9_A_SAMA401_1","DIMETHYLADENOSINE TRANSFERASE 1, MITOCHONDRIAL","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",3,"GLU A 528;ASP A 521;ASP A 100","None","0.75A","4gc9A-1mroA:undetectable","4gc9A-1mroA:21.27"],["4J4V_D_SVRD301_1","NUCLEOCAPSID PROTEIN;NUCLEOCAPSID PROTEIN","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",5,"GLY A 203;ASN A 110;ALA A 112;GLN A 206;ILE A 172","None","1.21A","4j4vD-1mroA:undetectable;4j4vE-1mroA:0.0","4j4vD-1mroA:20.40;4j4vE-1mroA:20.40"],["4J6C_A_STRA501_1","CYTOCHROME P450 MONOOXYGENASE","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",5,"ALA A 252;ALA A 254;ALA A 255;VAL A 208;GLN A 206","None","1.13A","4j6cA-1mroA:0.0","4j6cA-1mroA:20.54"],["4J6C_A_STRA501_1","CYTOCHROME P450 MONOOXYGENASE","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",5,"MET A 235;ALA A 252;ALA A 254;ALA A 255;GLN A 206","None","1.15A","4j6cA-1mroA:0.0","4j6cA-1mroA:20.54"],["4J6C_B_STRB503_1","CYTOCHROME P450 MONOOXYGENASE","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",5,"ALA A 252;ALA A 254;ALA A 255;VAL A 208;GLN A 206","None","1.11A","4j6cB-1mroA:0.0","4j6cB-1mroA:20.54"],["4J6C_B_STRB503_1","CYTOCHROME P450 MONOOXYGENASE","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",5,"MET A 235;ALA A 252;ALA A 254;ALA A 255;GLN A 206","None","1.14A","4j6cB-1mroA:0.0","4j6cB-1mroA:20.54"],["4J6D_A_TESA503_1","CYTOCHROME P450 MONOOXYGENASE","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",5,"ALA A 252;ALA A 254;ALA A 255;VAL A 208;GLN A 206","None","1.11A","4j6dA-1mroA:undetectable","4j6dA-1mroA:20.54"],["4J6D_B_TESB502_1","CYTOCHROME P450 MONOOXYGENASE","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",5,"ALA A 252;ALA A 254;ALA A 255;VAL A 208;GLN A 206","None","1.10A","4j6dB-1mroA:undetectable","4j6dB-1mroA:20.54"],["4J6D_B_TESB502_1","CYTOCHROME P450 MONOOXYGENASE","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",5,"MET A 235;ALA A 252;ALA A 254;ALA A 255;GLN A 206","None","1.12A","4j6dB-1mroA:undetectable","4j6dB-1mroA:20.54"],["4JBT_A_ASDA501_1","CYTOCHROME P450 MONOOXYGENASE","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",5,"ALA A 252;ALA A 254;ALA A 255;VAL A 208;GLN A 206","None","1.11A","4jbtA-1mroA:undetectable","4jbtA-1mroA:20.54"],["4JBT_A_ASDA501_1","CYTOCHROME P450 MONOOXYGENASE","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",5,"MET A 235;ALA A 252;ALA A 254;ALA A 255;GLN A 206","None","1.11A","4jbtA-1mroA:undetectable","4jbtA-1mroA:20.54"],["4JBT_B_ASDB502_1","CYTOCHROME P450 MONOOXYGENASE","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",5,"ALA A 252;ALA A 254;ALA A 255;VAL A 208;GLN A 206","None","1.12A","4jbtB-1mroA:0.0","4jbtB-1mroA:20.54"],["4JBT_B_ASDB502_1","CYTOCHROME P450 MONOOXYGENASE","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",5,"MET A 235;ALA A 252;ALA A 254;ALA A 255;GLN A 206","None","1.11A","4jbtB-1mroA:0.0","4jbtB-1mroA:20.54"],["4JEC_B_478B401_1","HIV-1 PROTEASE;HIV-1 PROTEASE","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",6,"LEU A 120;VAL A 124;ILE A 129;ILE A 231;VAL A 115;ILE A 116","None","1.19A","4jecA-1mroA:undetectable","4jecA-1mroA:11.19"],["4ODO_B_FK5B203_2","PEPTIDYL-PROLYL CIS-TRANS ISOMERASE SLYD;PEPTIDYL-PROLYL CIS-TRANS ISOMERASE SLYD","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",3,"ALA C  44;GLN C 190;GLY C 152","None","0.64A","4odoC-1mroC:undetectable","4odoC-1mroC:22.08"],["4QGI_A_ROCA101_2","PROTEASE;PROTEASE","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",6,"LEU A 120;VAL A 124;ILE A 129;ILE A 231;VAL A 115;ILE A 116","None","1.44A","4qgiB-1mroA:undetectable","4qgiB-1mroA:10.74"],["4R20_A_AERA602_1","CYTOCHROME P450 FAMILY 17 POLYPEPTIDE 2","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",4,"ALA A 420;GLU A 469;GLY A 284;VAL A 303","None","0.86A","4r20A-1mroA:undetectable","4r20A-1mroA:20.40"],["5A1R_A_STRA600_1","CYTOCHROME P450 3A4","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",4,"PHE A 529;ASP A 521;PHE A 522;PHE A 520","None","1.08A","5a1rA-1mroA:0.0","5a1rA-1mroA:20.38"],["5D0Y_A_FOLA201_0","CONSERVED HYPOTHETICAL MEMBRANE PROTEIN","1mro","METHYL-COENZYME M REDUCTASE;METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis;Methanothermobacter marburgensis",5,"GLN A 395;GLY A 397;PHE A 346;THR A 378;HIS C 158","MGN A 400 ( 4.8A);MGN A 400 (-3.6A);None;None;None","1.46A","5d0yA-1mroA:1.4","5d0yA-1mroA:15.11"],["5GWZ_D_010D6_0","N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE;PEDV MAIN PROTEASE","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",3,"MET A 431;HIS A 484;GLY A 442","None","0.81A","5gwzB-1mroA:0.0","5gwzB-1mroA:20.47"],["5GWZ_D_010D6_0","N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE;PEDV MAIN PROTEASE","1mro","METHYL-COENZYME M REDUCTASE;METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis;Methanothermobacter marburgensis",3,"MET A 367;HIS C 238;GLY A 423","None","0.78A","5gwzB-1mroA:0.0","5gwzB-1mroA:20.47"],["5KQX_A_ROCA101_2","PROTEASE E35D-SQV;PROTEASE E35D-SQV","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",5,"LEU A 120;VAL A 124;ILE A 129;ILE A 231;ILE A 116","None","1.13A","5kqxB-1mroA:undetectable","5kqxB-1mroA:11.01"],["5KSN_A_NIZA809_1","CATALASE-PEROXIDASE","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",5,"ARG A 471;GLU A 469;GLN A 421;LEU A 424;THR A 422","None","1.49A","5ksnA-1mroA:1.2","5ksnA-1mroA:21.66"],["5LF7_V_6V8V303_0","PROTEASOME SUBUNIT BETA TYPE-3;PROTEASOME SUBUNIT BETA TYPE-7","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",5,"ALA A 309;THR A 310;GLY A 490;ASP A 316;LEU A 320","None;None;None;None;TP7 A9000 (-4.2A)","1.03A","5lf7V-1mroA:2.1;5lf7W-1mroA:undetectable","5lf7V-1mroA:18.23;5lf7W-1mroA:16.24"],["5MQT_C_STIC302_1","DEOXYCYTIDINE KINASE","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",5,"ILE C 123;PRO C  21;GLU C  22;LEU C  25;TYR C 109","None","1.44A","5mqtC-1mroC:undetectable","5mqtC-1mroC:24.26"],["5NU7_A_RTLA201_0","RETINOL-BINDING PROTEIN 4","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",4,"ALA A 374;MET A 431;TYR A 428;GLN A 449","None","0.98A","5nu7A-1mroA:undetectable","5nu7A-1mroA:14.44"],["5SXT_A_NIZA807_1","CATALASE-PEROXIDASE","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",5,"ARG A 471;GLU A 469;GLN A 421;LEU A 424;THR A 422","None","1.46A","5sxtA-1mroA:0.9","5sxtA-1mroA:21.80"],["5VOO_E_C2FE3001_0","5-METHYLTETRAHYDROFOLATE HOMOCYSTEINE S-METHYLTRANSFERASE","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",5,"GLY A 418;VAL A 308;LEU A 305;GLY A 410;ILE A 491","None","1.19A","5vooE-1mroA:undetectable","5vooE-1mroA:20.66"],["5VOO_F_C2FF3001_0","5-METHYLTETRAHYDROFOLATE HOMOCYSTEINE S-METHYLTRANSFERASE","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",5,"GLY A 418;VAL A 308;LEU A 305;GLY A 410;ILE A 491","None","1.18A","5vooF-1mroA:undetectable","5vooF-1mroA:20.66"],["5W97_J_CHDJ101_1","CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",4,"TYR A 338;ARG A 526;MET A 313;THR A 310","None","1.36A","5w97J-1mroA:0.0","5w97J-1mroA:8.11"],["5WAU_J_CHDJ101_1","CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",4,"TYR A 338;ARG A 526;MET A 313;THR A 310","None","1.34A","5wauJ-1mroA:0.0","5wauJ-1mroA:8.11"],["5Z86_J_CHDJ101_0","CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",4,"TYR A 338;ARG A 526;MET A 313;THR A 310","None","1.32A","5z86J-1mroA:0.0","5z86J-1mroA:8.11"],["6A4I_A_TRPA403_0","TRYPTOPHAN 2,3-DIOXYGENASE","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",4,"ARG A 471;GLU A 469;THR A 422;PRO A 495","None","1.04A","6a4iA-1mroA:0.0","6a4iA-1mroA:20.04"],["6A4I_B_TRPB403_0","TRYPTOPHAN 2,3-DIOXYGENASE","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",4,"ARG A 471;GLU A 469;THR A 422;PRO A 495","None","1.04A","6a4iB-1mroA:0.0","6a4iB-1mroA:20.04"],["6CDQ_A_NIZA809_1","CATALASE-PEROXIDASE","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",5,"ARG A 471;GLU A 469;GLN A 421;LEU A 424;THR A 422","None","1.42A","6cdqA-1mroA:0.9","6cdqA-1mroA:8.94"],["6DEB_B_MTXB303_1","BIFUNCTIONAL PROTEIN FOLD","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",4,"TYR A 315;GLN A 485;GLY A 220;ILE A 101","None","1.48A","6debB-1mroA:undetectable","6debB-1mroA:9.86"],["6MN5_D_LLLD301_0","AMINOGLYCOSIDE N(3)-ACETYLTRANSFERASE, AAC(3)-IVA","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",4,"ASP A 344;ARG A 302;ASP A 306;CYH A 290","None","1.48A","6mn5D-1mroA:0.0","6mn5D-1mroA:10.00"]]