SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ms8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_A_ZMRA466_1
(NEURAMINIDASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		6 / 12 ARG A  35
ASP A  59
GLU A 230
ARG A 245
ARG A 314
TYR A 342
 DAN  A 700 (-3.0A)
DAN  A 700 (-2.7A)
DAN  A 700 (-3.3A)
DAN  A 700 (-2.8A)
DAN  A 700 (-3.0A)
DAN  A 700 (-3.5A)
 0.87A 1a4gA-1ms8A:
23.8		 1a4gA-1ms8A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_1
(NEURAMINIDASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		5 / 12 ARG A  35
GLU A 230
ARG A 245
ARG A 314
TYR A 342
 DAN  A 700 (-3.0A)
DAN  A 700 (-3.3A)
DAN  A 700 (-2.8A)
DAN  A 700 (-3.0A)
DAN  A 700 (-3.5A)
 0.98A 1a4gB-1ms8A:
23.5		 1a4gB-1ms8A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		5 / 11 ILE A 131
ASP A  96
LEU A 176
GLY A 177
PHE A 175
 None
DAN  A 700 (-3.3A)
None
None
None
 1.29A 1ju6A-1ms8A:
0.0		 1ju6A-1ms8A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		5 / 10 ILE A 131
ASP A  96
LEU A 176
GLY A 177
PHE A 175
 None
DAN  A 700 (-3.3A)
None
None
None
 1.29A 1ju6C-1ms8A:
0.0		 1ju6C-1ms8A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		5 / 10 VAL A  99
GLY A 180
ALA A  38
SER A 344
LEU A 355
 None
 1.09A 1pxxA-1ms8A:
undetectable		 1pxxA-1ms8A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		5 / 12 VAL A  99
GLY A 180
ALA A  38
SER A 344
LEU A 355
 None
 1.10A 1pxxC-1ms8A:
undetectable		 1pxxC-1ms8A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1477_1
(NEURAMINIDASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		6 / 12 ARG A  35
ASP A  59
GLU A 230
ARG A 245
ARG A 314
TYR A 342
 DAN  A 700 (-3.0A)
DAN  A 700 (-2.7A)
DAN  A 700 (-3.3A)
DAN  A 700 (-2.8A)
DAN  A 700 (-3.0A)
DAN  A 700 (-3.5A)
 0.94A 2cmlA-1ms8A:
3.7		 2cmlA-1ms8A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2477_1
(NEURAMINIDASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		6 / 12 ARG A  35
ASP A  59
GLU A 230
ARG A 245
ARG A 314
TYR A 342
 DAN  A 700 (-3.0A)
DAN  A 700 (-2.7A)
DAN  A 700 (-3.3A)
DAN  A 700 (-2.8A)
DAN  A 700 (-3.0A)
DAN  A 700 (-3.5A)
 0.95A 2cmlB-1ms8A:
20.2		 2cmlB-1ms8A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3477_1
(NEURAMINIDASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		5 / 12 ARG A  35
ASP A  59
GLU A 230
ARG A 245
TYR A 342
 DAN  A 700 (-3.0A)
DAN  A 700 (-2.7A)
DAN  A 700 (-3.3A)
DAN  A 700 (-2.8A)
DAN  A 700 (-3.5A)
 0.71A 2cmlC-1ms8A:
4.7		 2cmlC-1ms8A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4477_1
(NEURAMINIDASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		5 / 12 ARG A  35
ASP A  59
GLU A 230
ARG A 245
TYR A 342
 DAN  A 700 (-3.0A)
DAN  A 700 (-2.7A)
DAN  A 700 (-3.3A)
DAN  A 700 (-2.8A)
DAN  A 700 (-3.5A)
 0.67A 2cmlD-1ms8A:
20.5		 2cmlD-1ms8A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4477_1
(NEURAMINIDASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		5 / 12 ARG A  35
ASP A  59
GLU A 230
ARG A 314
TYR A 342
 DAN  A 700 (-3.0A)
DAN  A 700 (-2.7A)
DAN  A 700 (-3.3A)
DAN  A 700 (-3.0A)
DAN  A 700 (-3.5A)
 1.03A 2cmlD-1ms8A:
20.5		 2cmlD-1ms8A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F0Z_A_ZMRA381_1
(SIALIDASE 2)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		5 / 12 ARG A  35
GLU A 230
ARG A 245
ARG A 314
TYR A 342
 DAN  A 700 (-3.0A)
DAN  A 700 (-3.3A)
DAN  A 700 (-2.8A)
DAN  A 700 (-3.0A)
DAN  A 700 (-3.5A)
 0.77A 2f0zA-1ms8A:
37.2		 2f0zA-1ms8A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F10_A_BCZA382_0
(SIALIDASE 2)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		6 / 12 ARG A  35
ARG A  53
GLU A 230
ARG A 245
ARG A 314
TYR A 342
 DAN  A 700 (-3.0A)
DAN  A 700 (-3.0A)
DAN  A 700 (-3.3A)
DAN  A 700 (-2.8A)
DAN  A 700 (-3.0A)
DAN  A 700 (-3.5A)
 0.85A 2f10A-1ms8A:
36.6		 2f10A-1ms8A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		5 / 12 THR A  65
VAL A  42
ALA A  38
VAL A 101
TYR A 192
 None
 1.32A 2g72B-1ms8A:
undetectable		 2g72B-1ms8A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		3 / 3 LEU A 392
LEU A 612
PHE A 422
 None
 0.72A 2pgrA-1ms8A:
undetectable		 2pgrA-1ms8A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_B_SALB1305_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		4 / 5 SER A 229
ARG A 245
PRO A 283
GLY A 284
 DAN  A 700 ( 4.3A)
DAN  A 700 (-2.8A)
None
None
 1.33A 2y7kB-1ms8A:
undetectable		 2y7kB-1ms8A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1001_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		4 / 6 SER A 229
ARG A 245
PRO A 283
GLY A 284
 DAN  A 700 ( 4.3A)
DAN  A 700 (-2.8A)
None
None
 1.49A 2y7pA-1ms8A:
0.0		 2y7pA-1ms8A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_1
(NEURAMINIDASE A)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		6 / 12 ARG A  35
ASP A  51
ASP A  96
ARG A 245
ARG A 314
TYR A 342
 DAN  A 700 (-3.0A)
None
DAN  A 700 (-3.3A)
DAN  A 700 (-2.8A)
DAN  A 700 (-3.0A)
DAN  A 700 (-3.5A)
 0.97A 2ya7A-1ms8A:
40.0		 2ya7A-1ms8A:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_1
(NEURAMINIDASE A)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		6 / 12 ARG A  35
ASP A  51
ASP A  96
ARG A 245
ARG A 314
TYR A 342
 DAN  A 700 (-3.0A)
None
DAN  A 700 (-3.3A)
DAN  A 700 (-2.8A)
DAN  A 700 (-3.0A)
DAN  A 700 (-3.5A)
 0.97A 2ya7B-1ms8A:
39.9		 2ya7B-1ms8A:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_1
(NEURAMINIDASE A)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		5 / 12 ARG A  35
ASP A  51
ARG A 245
ARG A 314
TYR A 342
 DAN  A 700 (-3.0A)
None
DAN  A 700 (-2.8A)
DAN  A 700 (-3.0A)
DAN  A 700 (-3.5A)
 0.81A 2ya7C-1ms8A:
36.1		 2ya7C-1ms8A:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_1
(NEURAMINIDASE A)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		5 / 12 ARG A  35
ASP A  51
ASP A  96
ARG A 245
ARG A 314
 DAN  A 700 (-3.0A)
None
DAN  A 700 (-3.3A)
DAN  A 700 (-2.8A)
DAN  A 700 (-3.0A)
 0.86A 2ya7C-1ms8A:
36.1		 2ya7C-1ms8A:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_1
(NEURAMINIDASE A)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		6 / 12 ARG A  35
ASP A  51
ASP A  96
ARG A 245
ARG A 314
TYR A 342
 DAN  A 700 (-3.0A)
None
DAN  A 700 (-3.3A)
DAN  A 700 (-2.8A)
DAN  A 700 (-3.0A)
DAN  A 700 (-3.5A)
 0.98A 2ya7D-1ms8A:
39.5		 2ya7D-1ms8A:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		4 / 6 THR A 415
VAL A 414
LEU A 419
SER A 393
 None
 1.03A 3b6rB-1ms8A:
0.0		 3b6rB-1ms8A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7E_A_ZMRA1001_1
(NEURAMINIDASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		6 / 12 ARG A  35
ASP A  59
GLU A 230
ARG A 245
ARG A 314
TYR A 342
 DAN  A 700 (-3.0A)
DAN  A 700 (-2.7A)
DAN  A 700 (-3.3A)
DAN  A 700 (-2.8A)
DAN  A 700 (-3.0A)
DAN  A 700 (-3.5A)
 0.97A 3b7eA-1ms8A:
20.2		 3b7eA-1ms8A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7E_B_ZMRB1002_1
(NEURAMINIDASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		6 / 12 ARG A  35
ASP A  59
GLU A 230
ARG A 245
ARG A 314
TYR A 342
 DAN  A 700 (-3.0A)
DAN  A 700 (-2.7A)
DAN  A 700 (-3.3A)
DAN  A 700 (-2.8A)
DAN  A 700 (-3.0A)
DAN  A 700 (-3.5A)
 0.96A 3b7eB-1ms8A:
20.4		 3b7eB-1ms8A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		4 / 5 ASP A  96
ARG A  35
ILE A  63
VAL A  66
 DAN  A 700 (-3.3A)
DAN  A 700 (-3.0A)
None
None
 1.17A 3eigA-1ms8A:
undetectable		 3eigA-1ms8A:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAN_A_SVRA158_1
(UNCHARACTERIZED
PROTEIN AT3G22680)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		5 / 11 GLN A 286
PRO A  97
TRP A 263
ILE A 207
ILE A 183
 None
 1.26A 3ganA-1ms8A:
undetectable		 3ganA-1ms8A:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_2
(ADENOSYLHOMOCYSTEINA
SE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		4 / 5 GLN A  80
THR A  79
GLU A  28
THR A  27
 None
 1.23A 3glqA-1ms8A:
undetectable		 3glqA-1ms8A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_2
(ADENOSYLHOMOCYSTEINA
SE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		4 / 5 GLN A  80
THR A  79
GLU A  28
THR A  27
 None
 1.39A 3glqB-1ms8A:
undetectable		 3glqB-1ms8A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		4 / 7 VAL A 547
VAL A 558
LEU A 565
SER A 568
 None
 0.87A 3hs6B-1ms8A:
undetectable		 3hs6B-1ms8A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IXL_A_PACA5000_0
(ARYLMALONATE
DECARBOXYLASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		5 / 10 THR A 550
TYR A 559
SER A 557
GLY A 556
GLY A 569
 None
 1.46A 3ixlA-1ms8A:
undetectable		 3ixlA-1ms8A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_0
(NEURAMINIDASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		5 / 12 ARG A  35
ASP A  59
GLU A 230
ARG A 245
ARG A 314
 DAN  A 700 (-3.0A)
DAN  A 700 (-2.7A)
DAN  A 700 (-3.3A)
DAN  A 700 (-2.8A)
DAN  A 700 (-3.0A)
 0.82A 3k37B-1ms8A:
23.3		 3k37B-1ms8A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_B_BCZB1001_0
(NEURAMINIDASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		5 / 12 ARG A  35
ASP A  59
GLU A 230
ARG A 245
TYR A 342
 DAN  A 700 (-3.0A)
DAN  A 700 (-2.7A)
DAN  A 700 (-3.3A)
DAN  A 700 (-2.8A)
DAN  A 700 (-3.5A)
 0.64A 3k39B-1ms8A:
23.4		 3k39B-1ms8A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		3 / 3 SER A 598
GLY A 588
SER A 517
 None
 0.62A 3loqA-1ms8A:
undetectable		 3loqA-1ms8A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		3 / 3 SER A   6
SER A   5
HIS A 356
 None
 0.70A 3mzeA-1ms8A:
2.2		 3mzeA-1ms8A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		4 / 5 GLN A  80
THR A  79
GLU A  28
THR A  27
 None
 1.49A 3n58A-1ms8A:
undetectable		 3n58A-1ms8A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_A_ZMRA901_1
(NEURAMINIDASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		5 / 12 ARG A  35
GLU A 230
ARG A 245
ARG A 314
TYR A 342
 DAN  A 700 (-3.0A)
DAN  A 700 (-3.3A)
DAN  A 700 (-2.8A)
DAN  A 700 (-3.0A)
DAN  A 700 (-3.5A)
 1.01A 3sanA-1ms8A:
20.6		 3sanA-1ms8A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_B_ZMRB901_1
(NEURAMINIDASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		5 / 12 ARG A  35
GLU A 230
ARG A 245
ARG A 314
TYR A 342
 DAN  A 700 (-3.0A)
DAN  A 700 (-3.3A)
DAN  A 700 (-2.8A)
DAN  A 700 (-3.0A)
DAN  A 700 (-3.5A)
 1.01A 3sanB-1ms8A:
12.0		 3sanB-1ms8A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI5_A_ZMRA1002_1
(NEURAMINIDASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		6 / 12 ARG A  35
ASP A  59
GLU A 230
ARG A 245
ARG A 314
TYR A 342
 DAN  A 700 (-3.0A)
DAN  A 700 (-2.7A)
DAN  A 700 (-3.3A)
DAN  A 700 (-2.8A)
DAN  A 700 (-3.0A)
DAN  A 700 (-3.5A)
 0.93A 3ti5A-1ms8A:
11.1		 3ti5A-1ms8A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI5_B_ZMRB1002_1
(NEURAMINIDASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		6 / 12 ARG A  35
ASP A  59
GLU A 230
ARG A 245
ARG A 314
TYR A 342
 DAN  A 700 (-3.0A)
DAN  A 700 (-2.7A)
DAN  A 700 (-3.3A)
DAN  A 700 (-2.8A)
DAN  A 700 (-3.0A)
DAN  A 700 (-3.5A)
 0.93A 3ti5B-1ms8A:
7.2		 3ti5B-1ms8A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_1
(NEURAMINIDASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		6 / 12 ARG A  35
ASP A  59
GLU A 230
ARG A 245
ARG A 314
TYR A 342
 DAN  A 700 (-3.0A)
DAN  A 700 (-2.7A)
DAN  A 700 (-3.3A)
DAN  A 700 (-2.8A)
DAN  A 700 (-3.0A)
DAN  A 700 (-3.5A)
 0.92A 3ticA-1ms8A:
20.2		 3ticA-1ms8A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_B_ZMRB1002_1
(NEURAMINIDASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		5 / 12 ARG A  35
ASP A  59
GLU A 230
ARG A 245
TYR A 342
 DAN  A 700 (-3.0A)
DAN  A 700 (-2.7A)
DAN  A 700 (-3.3A)
DAN  A 700 (-2.8A)
DAN  A 700 (-3.5A)
 0.68A 3ticB-1ms8A:
20.0		 3ticB-1ms8A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_B_ZMRB1002_1
(NEURAMINIDASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		5 / 12 ASP A  59
GLU A 230
ARG A 245
ARG A 314
TYR A 342
 DAN  A 700 (-2.7A)
DAN  A 700 (-3.3A)
DAN  A 700 (-2.8A)
DAN  A 700 (-3.0A)
DAN  A 700 (-3.5A)
 0.94A 3ticB-1ms8A:
20.0		 3ticB-1ms8A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_C_ZMRC1002_1
(NEURAMINIDASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		6 / 12 ARG A  35
ASP A  59
GLU A 230
ARG A 245
ARG A 314
TYR A 342
 DAN  A 700 (-3.0A)
DAN  A 700 (-2.7A)
DAN  A 700 (-3.3A)
DAN  A 700 (-2.8A)
DAN  A 700 (-3.0A)
DAN  A 700 (-3.5A)
 0.93A 3ticC-1ms8A:
20.1		 3ticC-1ms8A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_D_ZMRD1002_1
(NEURAMINIDASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		6 / 12 ARG A  35
ASP A  59
GLU A 230
ARG A 245
ARG A 314
TYR A 342
 DAN  A 700 (-3.0A)
DAN  A 700 (-2.7A)
DAN  A 700 (-3.3A)
DAN  A 700 (-2.8A)
DAN  A 700 (-3.0A)
DAN  A 700 (-3.5A)
 0.92A 3ticD-1ms8A:
20.2		 3ticD-1ms8A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		5 / 10 THR A  65
PHE A  11
LEU A 106
VAL A  42
VAL A  99
 None
 1.21A 3u9fE-1ms8A:
undetectable		 3u9fE-1ms8A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1490_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		3 / 3 GLU A  78
TYR A  69
SER A 150
 None
 0.68A 4at0A-1ms8A:
0.0		 4at0A-1ms8A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_1
(NEURAMINIDASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		6 / 12 ARG A  35
ASP A  59
GLU A 230
ARG A 245
ARG A 314
TYR A 342
 DAN  A 700 (-3.0A)
DAN  A 700 (-2.7A)
DAN  A 700 (-3.3A)
DAN  A 700 (-2.8A)
DAN  A 700 (-3.0A)
DAN  A 700 (-3.5A)
 0.95A 4b7nA-1ms8A:
11.2		 4b7nA-1ms8A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_1
(NEURAMINIDASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		6 / 12 ARG A  35
ASP A  59
GLU A 230
ARG A 245
ARG A 314
TYR A 342
 DAN  A 700 (-3.0A)
DAN  A 700 (-2.7A)
DAN  A 700 (-3.3A)
DAN  A 700 (-2.8A)
DAN  A 700 (-3.0A)
DAN  A 700 (-3.5A)
 0.99A 4b7qA-1ms8A:
10.7		 4b7qA-1ms8A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_B_ZMRB601_1
(NEURAMINIDASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		5 / 12 ARG A  35
ASP A  59
GLU A 230
ARG A 245
TYR A 342
 DAN  A 700 (-3.0A)
DAN  A 700 (-2.7A)
DAN  A 700 (-3.3A)
DAN  A 700 (-2.8A)
DAN  A 700 (-3.5A)
 0.74A 4b7qB-1ms8A:
20.3		 4b7qB-1ms8A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_1
(NEURAMINIDASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		6 / 12 ARG A  35
ASP A  59
GLU A 230
ARG A 245
ARG A 314
TYR A 342
 DAN  A 700 (-3.0A)
DAN  A 700 (-2.7A)
DAN  A 700 (-3.3A)
DAN  A 700 (-2.8A)
DAN  A 700 (-3.0A)
DAN  A 700 (-3.5A)
 0.97A 4b7qC-1ms8A:
10.7		 4b7qC-1ms8A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_D_ZMRD601_1
(NEURAMINIDASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		5 / 12 ARG A  35
ASP A  59
GLU A 230
ARG A 245
TYR A 342
 DAN  A 700 (-3.0A)
DAN  A 700 (-2.7A)
DAN  A 700 (-3.3A)
DAN  A 700 (-2.8A)
DAN  A 700 (-3.5A)
 0.74A 4b7qD-1ms8A:
10.6		 4b7qD-1ms8A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_D_ZMRD601_1
(NEURAMINIDASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		5 / 12 ASP A  59
GLU A 230
ARG A 245
ARG A 314
TYR A 342
 DAN  A 700 (-2.7A)
DAN  A 700 (-3.3A)
DAN  A 700 (-2.8A)
DAN  A 700 (-3.0A)
DAN  A 700 (-3.5A)
 1.00A 4b7qD-1ms8A:
10.6		 4b7qD-1ms8A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_A_ZMRA700_1
(NEURAMINIDASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		5 / 12 ARG A  35
ASP A  59
GLU A 230
ARG A 245
ARG A 314
 DAN  A 700 (-3.0A)
DAN  A 700 (-2.7A)
DAN  A 700 (-3.3A)
DAN  A 700 (-2.8A)
DAN  A 700 (-3.0A)
 0.85A 4cpnA-1ms8A:
23.4		 4cpnA-1ms8A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_A_ZMRA700_1
(NEURAMINIDASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		5 / 12 ARG A  35
ASP A  59
GLU A 230
ARG A 245
TYR A 342
 DAN  A 700 (-3.0A)
DAN  A 700 (-2.7A)
DAN  A 700 (-3.3A)
DAN  A 700 (-2.8A)
DAN  A 700 (-3.5A)
 0.73A 4cpnA-1ms8A:
23.4		 4cpnA-1ms8A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_B_ZMRB700_1
(NEURAMINIDASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		5 / 12 ARG A  35
ASP A  59
GLU A 230
ARG A 245
ARG A 314
 DAN  A 700 (-3.0A)
DAN  A 700 (-2.7A)
DAN  A 700 (-3.3A)
DAN  A 700 (-2.8A)
DAN  A 700 (-3.0A)
 0.84A 4cpnB-1ms8A:
24.2		 4cpnB-1ms8A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_B_ZMRB700_1
(NEURAMINIDASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		5 / 12 ARG A  35
ASP A  59
GLU A 230
ARG A 245
TYR A 342
 DAN  A 700 (-3.0A)
DAN  A 700 (-2.7A)
DAN  A 700 (-3.3A)
DAN  A 700 (-2.8A)
DAN  A 700 (-3.5A)
 0.69A 4cpnB-1ms8A:
24.2		 4cpnB-1ms8A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_A_ZMRA1471_1
(NEURAMINIDASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		5 / 12 ARG A  35
GLU A 230
ARG A 245
ARG A 314
TYR A 342
 DAN  A 700 (-3.0A)
DAN  A 700 (-3.3A)
DAN  A 700 (-2.8A)
DAN  A 700 (-3.0A)
DAN  A 700 (-3.5A)
 1.01A 4cpzA-1ms8A:
6.6		 4cpzA-1ms8A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_A_ZMRA1471_1
(NEURAMINIDASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		5 / 12 ARG A  35
LEU A 176
ARG A 245
ARG A 314
TYR A 342
 DAN  A 700 (-3.0A)
None
DAN  A 700 (-2.8A)
DAN  A 700 (-3.0A)
DAN  A 700 (-3.5A)
 1.41A 4cpzA-1ms8A:
6.6		 4cpzA-1ms8A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_B_ZMRB1471_1
(NEURAMINIDASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		5 / 12 ARG A  35
GLU A 230
ARG A 245
ARG A 314
TYR A 342
 DAN  A 700 (-3.0A)
DAN  A 700 (-3.3A)
DAN  A 700 (-2.8A)
DAN  A 700 (-3.0A)
DAN  A 700 (-3.5A)
 0.97A 4cpzB-1ms8A:
23.7		 4cpzB-1ms8A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_B_ZMRB1471_1
(NEURAMINIDASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		5 / 12 ARG A  35
LEU A 176
ARG A 245
ARG A 314
TYR A 342
 DAN  A 700 (-3.0A)
None
DAN  A 700 (-2.8A)
DAN  A 700 (-3.0A)
DAN  A 700 (-3.5A)
 1.40A 4cpzB-1ms8A:
23.7		 4cpzB-1ms8A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_1
(NEURAMINIDASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		6 / 12 ARG A  35
ASP A  59
GLU A 230
ARG A 245
ARG A 314
TYR A 342
 DAN  A 700 (-3.0A)
DAN  A 700 (-2.7A)
DAN  A 700 (-3.3A)
DAN  A 700 (-2.8A)
DAN  A 700 (-3.0A)
DAN  A 700 (-3.5A)
 0.96A 4cpzC-1ms8A:
23.4		 4cpzC-1ms8A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_D_ZMRD1471_1
(NEURAMINIDASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		5 / 12 ARG A  35
GLU A 230
ARG A 245
ARG A 314
TYR A 342
 DAN  A 700 (-3.0A)
DAN  A 700 (-3.3A)
DAN  A 700 (-2.8A)
DAN  A 700 (-3.0A)
DAN  A 700 (-3.5A)
 0.96A 4cpzD-1ms8A:
23.5		 4cpzD-1ms8A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_1
(NEURAMINIDASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		6 / 12 ARG A  35
ASP A  59
GLU A 230
ARG A 245
ARG A 314
TYR A 342
 DAN  A 700 (-3.0A)
DAN  A 700 (-2.7A)
DAN  A 700 (-3.3A)
DAN  A 700 (-2.8A)
DAN  A 700 (-3.0A)
DAN  A 700 (-3.5A)
 0.97A 4cpzE-1ms8A:
24.0		 4cpzE-1ms8A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_1
(NEURAMINIDASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		5 / 12 ARG A  35
ASP A  59
GLU A 230
ARG A 245
TYR A 342
 DAN  A 700 (-3.0A)
DAN  A 700 (-2.7A)
DAN  A 700 (-3.3A)
DAN  A 700 (-2.8A)
DAN  A 700 (-3.5A)
 0.69A 4cpzF-1ms8A:
23.8		 4cpzF-1ms8A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_1
(NEURAMINIDASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		5 / 12 ARG A  35
ASP A  59
GLU A 230
ARG A 314
TYR A 342
 DAN  A 700 (-3.0A)
DAN  A 700 (-2.7A)
DAN  A 700 (-3.3A)
DAN  A 700 (-3.0A)
DAN  A 700 (-3.5A)
 1.06A 4cpzF-1ms8A:
23.8		 4cpzF-1ms8A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_1
(NEURAMINIDASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		6 / 12 ARG A  35
ASP A  59
GLU A 230
ARG A 245
ARG A 314
TYR A 342
 DAN  A 700 (-3.0A)
DAN  A 700 (-2.7A)
DAN  A 700 (-3.3A)
DAN  A 700 (-2.8A)
DAN  A 700 (-3.0A)
DAN  A 700 (-3.5A)
 0.93A 4cpzG-1ms8A:
23.6		 4cpzG-1ms8A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_1
(NEURAMINIDASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		5 / 12 ARG A  35
ASP A  59
GLU A 230
ARG A 245
TYR A 342
 DAN  A 700 (-3.0A)
DAN  A 700 (-2.7A)
DAN  A 700 (-3.3A)
DAN  A 700 (-2.8A)
DAN  A 700 (-3.5A)
 0.65A 4cpzH-1ms8A:
23.4		 4cpzH-1ms8A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		4 / 7 ASP A  59
ASP A  51
GLU A 357
ASP A  96
 DAN  A 700 (-2.7A)
None
None
DAN  A 700 (-3.3A)
 0.91A 4feuB-1ms8A:
0.5		 4feuB-1ms8A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		4 / 8 ASP A  59
ASP A  51
GLU A 357
ASP A  96
 DAN  A 700 (-2.7A)
None
None
DAN  A 700 (-3.3A)
 0.96A 4feuF-1ms8A:
0.4		 4feuF-1ms8A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		4 / 7 ASP A  59
ASP A  51
GLU A 357
ASP A  96
 DAN  A 700 (-2.7A)
None
None
DAN  A 700 (-3.3A)
 0.96A 4fevD-1ms8A:
0.5		 4fevD-1ms8A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		4 / 7 ASP A  59
ASP A  51
GLU A 357
ASP A  96
 DAN  A 700 (-2.7A)
None
None
DAN  A 700 (-3.3A)
 0.97A 4fevF-1ms8A:
0.0		 4fevF-1ms8A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		4 / 8 ASP A  59
ASP A  51
GLU A 357
ASP A  96
 DAN  A 700 (-2.7A)
None
None
DAN  A 700 (-3.3A)
 0.95A 4fewD-1ms8A:
1.4		 4fewD-1ms8A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		4 / 8 ASP A  59
ASP A  51
GLU A 357
ASP A  96
 DAN  A 700 (-2.7A)
None
None
DAN  A 700 (-3.3A)
 0.95A 4fewF-1ms8A:
undetectable		 4fewF-1ms8A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		4 / 7 ASP A  59
ASP A  51
GLU A 357
ASP A  96
 DAN  A 700 (-2.7A)
None
None
DAN  A 700 (-3.3A)
 0.95A 4fexB-1ms8A:
0.7		 4fexB-1ms8A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		4 / 8 ASP A  59
ASP A  51
GLU A 357
ASP A  96
 DAN  A 700 (-2.7A)
None
None
DAN  A 700 (-3.3A)
 1.03A 4gkhB-1ms8A:
0.0		 4gkhB-1ms8A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		4 / 8 ASP A  59
ASP A  51
GLU A 357
ASP A  96
 DAN  A 700 (-2.7A)
None
None
DAN  A 700 (-3.3A)
 0.98A 4gkhF-1ms8A:
0.0		 4gkhF-1ms8A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		4 / 7 ASP A  59
ASP A  51
GLU A 357
ASP A  96
 DAN  A 700 (-2.7A)
None
None
DAN  A 700 (-3.3A)
 0.97A 4gkhG-1ms8A:
undetectable		 4gkhG-1ms8A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		4 / 8 ASP A  59
ASP A  51
GLU A 357
ASP A  96
 DAN  A 700 (-2.7A)
None
None
DAN  A 700 (-3.3A)
 0.99A 4gkhC-1ms8A:
0.4
4gkhK-1ms8A:
0.0		 4gkhC-1ms8A:
18.18
4gkhK-1ms8A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		4 / 8 ASP A  59
ASP A  51
GLU A 357
ASP A  96
 DAN  A 700 (-2.7A)
None
None
DAN  A 700 (-3.3A)
 0.96A 4gkiA-1ms8A:
undetectable		 4gkiA-1ms8A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		4 / 8 ASP A  59
ASP A  51
GLU A 357
ASP A  96
 DAN  A 700 (-2.7A)
None
None
DAN  A 700 (-3.3A)
 0.96A 4gkiE-1ms8A:
0.8
4gkiG-1ms8A:
undetectable		 4gkiE-1ms8A:
18.18
4gkiG-1ms8A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HAJ_A_DXCA75_0
(PPCA)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		4 / 7 ILE A 131
LEU A 109
LYS A 218
GLY A 214
 None
 0.96A 4hajA-1ms8A:
undetectable		 4hajA-1ms8A:
7.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_1
(NEURAMINIDASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		6 / 12 ARG A  35
ASP A  59
GLU A 230
ARG A 245
ARG A 314
TYR A 342
 DAN  A 700 (-3.0A)
DAN  A 700 (-2.7A)
DAN  A 700 (-3.3A)
DAN  A 700 (-2.8A)
DAN  A 700 (-3.0A)
DAN  A 700 (-3.5A)
 0.92A 4i00A-1ms8A:
2.3		 4i00A-1ms8A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_1
(MEMBRANE LIPOPROTEIN
TPN38(B))		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		5 / 12 SER A 285
TYR A 342
ASP A  96
TYR A 119
GLY A 284
 None
DAN  A 700 (-3.5A)
DAN  A 700 (-3.3A)
DAN  A 700 (-4.2A)
None
 1.11A 4iilA-1ms8A:
undetectable		 4iilA-1ms8A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		3 / 3 ASP A  51
LEU A 366
VAL A  47
 None
 0.70A 4jecB-1ms8A:
undetectable		 4jecB-1ms8A:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		4 / 7 GLN A 325
THR A 269
LEU A 270
THR A 303
 None
 1.07A 4mbsA-1ms8A:
0.0		 4mbsA-1ms8A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_1
(NEURAMINIDASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		5 / 12 ARG A  35
ASP A  59
GLU A 230
ARG A 314
TYR A 342
 DAN  A 700 (-3.0A)
DAN  A 700 (-2.7A)
DAN  A 700 (-3.3A)
DAN  A 700 (-3.0A)
DAN  A 700 (-3.5A)
 1.01A 4mwxA-1ms8A:
19.9		 4mwxA-1ms8A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		3 / 3 ARG A  35
ASP A  59
ARG A 314
 DAN  A 700 (-3.0A)
DAN  A 700 (-2.7A)
DAN  A 700 (-3.0A)
 0.78A 4mx0A-1ms8A:
19.9		 4mx0A-1ms8A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_1
(PROTEASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		5 / 12 GLY A  44
ASP A  73
ASP A  72
THR A 142
ILE A 147
 None
 1.12A 4njvA-1ms8A:
undetectable		 4njvA-1ms8A:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		3 / 3 SER A 393
ASP A 389
GLN A 325
 None
 0.94A 4oltA-1ms8A:
0.0
4oltB-1ms8A:
0.0		 4oltA-1ms8A:
18.31
4oltB-1ms8A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		3 / 3 GLN A 325
SER A 393
ASP A 389
 None
 0.95A 4qwpA-1ms8A:
0.0
4qwpB-1ms8A:
0.0		 4qwpA-1ms8A:
18.31
4qwpB-1ms8A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA5_A_ZMRA501_1
(NEURAMINIDASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		6 / 12 ARG A  35
ASP A  59
GLU A 230
ARG A 245
ARG A 314
TYR A 342
 DAN  A 700 (-3.0A)
DAN  A 700 (-2.7A)
DAN  A 700 (-3.3A)
DAN  A 700 (-2.8A)
DAN  A 700 (-3.0A)
DAN  A 700 (-3.5A)
 0.99A 4wa5A-1ms8A:
8.1		 4wa5A-1ms8A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		4 / 7 PHE A  34
THR A  79
VAL A  31
PHE A  20
 None
 0.91A 4wnvD-1ms8A:
undetectable		 4wnvD-1ms8A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		4 / 8 GLY A 587
SER A 592
GLY A 460
PHE A 455
 None
 0.74A 5alcL-1ms8A:
undetectable		 5alcL-1ms8A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		5 / 12 HIS A 546
ILE A 627
LEU A 622
THR A 397
LEU A 419
 None
 0.99A 5byjA-1ms8A:
undetectable		 5byjA-1ms8A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		5 / 12 ALA A 341
ASP A  96
THR A  98
THR A  65
SER A 343
 None
DAN  A 700 (-3.3A)
None
None
None
 1.20A 5hfjG-1ms8A:
undetectable		 5hfjG-1ms8A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		5 / 12 ILE A 627
GLY A 628
THR A 629
LEU A 620
VAL A 485
 None
 1.24A 5hw4A-1ms8A:
undetectable		 5hw4A-1ms8A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		5 / 12 ILE A 627
GLY A 628
THR A 629
LEU A 620
VAL A 485
 None
 1.23A 5hw4C-1ms8A:
0.3		 5hw4C-1ms8A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L17_A_ZMRA512_1
(NEURAMINIDASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		6 / 12 ARG A  35
ASP A  59
GLU A 230
ARG A 245
ARG A 314
TYR A 342
 DAN  A 700 (-3.0A)
DAN  A 700 (-2.7A)
DAN  A 700 (-3.3A)
DAN  A 700 (-2.8A)
DAN  A 700 (-3.0A)
DAN  A 700 (-3.5A)
 0.91A 5l17A-1ms8A:
20.2		 5l17A-1ms8A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		4 / 7 GLN A 332
GLY A 331
GLN A 469
TRP A 320
 None
 1.14A 5vlmE-1ms8A:
undetectable		 5vlmE-1ms8A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		4 / 6 SER A 343
ARG A  35
GLU A 357
TYR A 342
 None
DAN  A 700 (-3.0A)
None
DAN  A 700 (-3.5A)
 1.23A 5x7pA-1ms8A:
7.0		 5x7pA-1ms8A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		4 / 6 SER A 343
ARG A  35
GLU A 357
TYR A 342
 None
DAN  A 700 (-3.0A)
None
DAN  A 700 (-3.5A)
 1.29A 5x7pB-1ms8A:
5.6		 5x7pB-1ms8A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Q_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		4 / 6 SER A 343
ARG A  35
GLU A 357
TYR A 342
 None
DAN  A 700 (-3.0A)
None
DAN  A 700 (-3.5A)
 1.27A 5x7qB-1ms8A:
6.9		 5x7qB-1ms8A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7R_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		4 / 6 SER A 343
ARG A  35
GLU A 357
TYR A 342
 None
DAN  A 700 (-3.0A)
None
DAN  A 700 (-3.5A)
 1.29A 5x7rB-1ms8A:
5.6		 5x7rB-1ms8A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		4 / 5 VAL A 181
PRO A 193
GLY A 178
TYR A 192
 None
 1.34A 5x80A-1ms8A:
undetectable
5x80B-1ms8A:
undetectable		 5x80A-1ms8A:
14.04
5x80B-1ms8A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		4 / 5 PRO A 193
GLY A 178
TYR A 192
VAL A 181
 None
 1.29A 5x80C-1ms8A:
undetectable
5x80D-1ms8A:
undetectable		 5x80C-1ms8A:
14.04
5x80D-1ms8A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		4 / 7 SER A 598
SER A 498
GLY A 496
LEU A 500
 None
 1.10A 6btxA-1ms8A:
undetectable		 6btxA-1ms8A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_1
(SIALIDASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		6 / 12 ARG A  35
ARG A  53
ASP A  96
ARG A 245
ASP A 247
TYR A 342
 DAN  A 700 (-3.0A)
DAN  A 700 (-3.0A)
DAN  A 700 (-3.3A)
DAN  A 700 (-2.8A)
None
DAN  A 700 (-3.5A)
 0.91A 6ekuA-1ms8A:
38.0		 6ekuA-1ms8A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_1
(SIALIDASE)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		7 / 12 ARG A  35
ARG A  53
ASP A  96
GLU A 230
ARG A 245
ARG A 314
TYR A 342
 DAN  A 700 (-3.0A)
DAN  A 700 (-3.0A)
DAN  A 700 (-3.3A)
DAN  A 700 (-3.3A)
DAN  A 700 (-2.8A)
DAN  A 700 (-3.0A)
DAN  A 700 (-3.5A)
 0.85A 6ekuA-1ms8A:
38.0		 6ekuA-1ms8A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_A_H98A501_1
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		4 / 4 ASP A 125
SER A 116
SER A 118
ASN A 173
 None
 1.48A 6iblA-1ms8A:
0.0		 6iblA-1ms8A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_B_H98B501_1
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 1ms8 TRANS-SIALIDASE
(Trypanosoma
cruzi) 		4 / 4 ASP A 125
SER A 116
SER A 118
ASN A 173
 None
 1.48A 6iblB-1ms8A:
0.6		 6iblB-1ms8A:
21.61