SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1msk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AKD_A_CAMA420_0
(CYTOCHROME P450CAM)		 1msk COBALAMIN-DEPENDENT
METHIONINE SYNTHASE
(Escherichia
coli) 		5 / 11 TYR A1181
LEU A1103
VAL A1063
GLY A 997
THR A1161
 None
 1.29A 1akdA-1mskA:
undetectable		 1akdA-1mskA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_B_803B311_1
(ANTIGEN CD11A (P180))		 1msk COBALAMIN-DEPENDENT
METHIONINE SYNTHASE
(Escherichia
coli) 		4 / 7 VAL A 934
LEU A1155
VAL A1157
LEU A1103
 ACT  A1302 (-3.9A)
None
None
None
 0.87A 1cqpA-1mskA:
undetectable
1cqpB-1mskA:
undetectable		 1cqpA-1mskA:
17.91
1cqpB-1mskA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_A_CAMA503_0
(CYTOCHROME P450-CAM)		 1msk COBALAMIN-DEPENDENT
METHIONINE SYNTHASE
(Escherichia
coli) 		5 / 9 TYR A1181
LEU A1103
VAL A1063
GLY A 997
THR A1161
 None
 1.28A 1dz8A-1mskA:
0.0		 1dz8A-1mskA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_B_CAMB502_0
(CYTOCHROME P450-CAM)		 1msk COBALAMIN-DEPENDENT
METHIONINE SYNTHASE
(Escherichia
coli) 		5 / 9 TYR A1181
LEU A1103
VAL A1063
GLY A 997
THR A1161
 None
 1.31A 1dz8B-1mskA:
0.0		 1dz8B-1mskA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_B_CAMB502_0
(CYTOCHROME P450-CAM)		 1msk COBALAMIN-DEPENDENT
METHIONINE SYNTHASE
(Escherichia
coli) 		5 / 9 TYR A1181
LEU A1103
VAL A1063
GLY A 997
THR A1161
 None
 1.29A 1dz9B-1mskA:
0.0		 1dz9B-1mskA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E6W_C_ESTC302_1
(SHORT CHAIN
3-HYDROXYACYL-COA
DEHYDROGENASE)		 1msk COBALAMIN-DEPENDENT
METHIONINE SYNTHASE
(Escherichia
coli) 		4 / 4 ALA A1115
GLN A1131
TYR A1114
LEU A1120
 None
 1.49A 1e6wC-1mskA:
undetectable		 1e6wC-1mskA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHO_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1msk COBALAMIN-DEPENDENT
METHIONINE SYNTHASE
(Escherichia
coli) 		5 / 9 THR A1161
GLY A 997
LEU A1067
SER A1176
GLY A1066
 None
 1.27A 1jhoA-1mskA:
undetectable		 1jhoA-1mskA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1msk COBALAMIN-DEPENDENT
METHIONINE SYNTHASE
(Escherichia
coli) 		5 / 8 THR A1161
GLY A 997
LEU A1067
SER A1176
GLY A1066
 None
 1.29A 1jhqA-1mskA:
undetectable		 1jhqA-1mskA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHR_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1msk COBALAMIN-DEPENDENT
METHIONINE SYNTHASE
(Escherichia
coli) 		5 / 9 THR A1161
GLY A 997
LEU A1067
SER A1176
GLY A1066
 None
 1.32A 1jhrA-1mskA:
undetectable		 1jhrA-1mskA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1msk COBALAMIN-DEPENDENT
METHIONINE SYNTHASE
(Escherichia
coli) 		5 / 9 THR A1161
GLY A 997
LEU A1067
SER A1176
GLY A1066
 None
 1.31A 1l4nA-1mskA:
undetectable		 1l4nA-1mskA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5K_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1msk COBALAMIN-DEPENDENT
METHIONINE SYNTHASE
(Escherichia
coli) 		5 / 9 THR A1161
GLY A 997
LEU A1067
SER A1176
GLY A1066
 None
 1.29A 1l5kA-1mskA:
undetectable		 1l5kA-1mskA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5L_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1msk COBALAMIN-DEPENDENT
METHIONINE SYNTHASE
(Escherichia
coli) 		5 / 9 THR A1161
GLY A 997
LEU A1067
SER A1176
GLY A1066
 None
 1.29A 1l5lA-1mskA:
undetectable		 1l5lA-1mskA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1msk COBALAMIN-DEPENDENT
METHIONINE SYNTHASE
(Escherichia
coli) 		5 / 9 THR A1161
GLY A 997
LEU A1067
SER A1176
GLY A1066
 None
 1.29A 1l5mA-1mskA:
1.3		 1l5mA-1mskA:
22.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MSK_A_ACTA1302_0
(COBALAMIN-DEPENDENT
METHIONINE SYNTHASE)		 1msk COBALAMIN-DEPENDENT
METHIONINE SYNTHASE
(Escherichia
coli) 		4 / 4 GLN A 932
VAL A 934
ARG A1106
TYR A1111
 ACT  A1302 ( 4.3A)
ACT  A1302 (-3.9A)
ACT  A1302 (-4.0A)
ACT  A1302 (-4.7A)
 0.02A 1mskA-1mskA:
53.9		 1mskA-1mskA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MSK_A_SAMA1301_0
(COBALAMIN-DEPENDENT
METHIONINE SYNTHASE)		 1msk COBALAMIN-DEPENDENT
METHIONINE SYNTHASE
(Escherichia
coli) 		10 / 10 ASP A 946
ARG A1094
GLU A1097
ARG A1134
PRO A1135
ALA A1136
TYR A1139
PRO A1140
ALA A1141
TYR A1189
 SAM  A1301 (-3.5A)
SAM  A1301 (-3.4A)
SAM  A1301 (-4.0A)
SAM  A1301 (-3.7A)
SAM  A1301 (-4.5A)
SAM  A1301 (-3.8A)
SAM  A1301 (-3.8A)
SAM  A1301 ( 4.1A)
SAM  A1301 (-3.1A)
SAM  A1301 (-4.1A)
 0.01A 1mskA-1mskA:
53.9		 1mskA-1mskA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_A_CAMA1420_0
(CYTOCHROME P450-CAM)		 1msk COBALAMIN-DEPENDENT
METHIONINE SYNTHASE
(Escherichia
coli) 		5 / 10 TYR A1181
LEU A1103
VAL A1063
THR A1161
VAL A1157
 None
 1.28A 1o76A-1mskA:
0.0		 1o76A-1mskA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 1msk COBALAMIN-DEPENDENT
METHIONINE SYNTHASE
(Escherichia
coli) 		5 / 11 TYR A1181
LEU A1103
VAL A1063
GLY A 997
ILE A1151
 None
 1.21A 1phgA-1mskA:
undetectable		 1phgA-1mskA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG1_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 1msk COBALAMIN-DEPENDENT
METHIONINE SYNTHASE
(Escherichia
coli) 		3 / 3 TRP A1112
VAL A 925
PRO A 924
 None
 0.86A 1rg1A-1mskA:
undetectable		 1rg1A-1mskA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH0_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 1msk COBALAMIN-DEPENDENT
METHIONINE SYNTHASE
(Escherichia
coli) 		3 / 3 TRP A1112
VAL A 925
PRO A 924
 None
 0.86A 1rh0A-1mskA:
undetectable		 1rh0A-1mskA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 1msk COBALAMIN-DEPENDENT
METHIONINE SYNTHASE
(Escherichia
coli) 		6 / 11 TYR A1181
LEU A1103
VAL A1063
GLY A 997
THR A1161
VAL A1157
 None
 1.37A 2a1nA-1mskA:
undetectable		 2a1nA-1mskA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 1msk COBALAMIN-DEPENDENT
METHIONINE SYNTHASE
(Escherichia
coli) 		5 / 9 TYR A1181
LEU A1103
VAL A1063
GLY A 997
ILE A1151
 None
 1.12A 2a1oB-1mskA:
0.0		 2a1oB-1mskA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 1msk COBALAMIN-DEPENDENT
METHIONINE SYNTHASE
(Escherichia
coli) 		3 / 3 TYR A1102
GLU A1105
ASN A1119
 None
 1.00A 2y7hC-1mskA:
0.0		 2y7hC-1mskA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUN_A_CCSA165_0
(LYSOZYME)		 1msk COBALAMIN-DEPENDENT
METHIONINE SYNTHASE
(Escherichia
coli) 		3 / 3 ASN A 912
ALA A1039
LYS A1035
 None
 0.86A 3runA-1mskA:
undetectable		 3runA-1mskA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 1msk COBALAMIN-DEPENDENT
METHIONINE SYNTHASE
(Escherichia
coli) 		4 / 5 ALA A1090
MET A 983
PHE A 950
ASN A1084
 None
 1.43A 3uq6A-1mskA:
undetectable		 3uq6A-1mskA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 1msk COBALAMIN-DEPENDENT
METHIONINE SYNTHASE
(Escherichia
coli) 		3 / 4 ARG A 996
GLY A 997
GLU A 935
 None
 0.66A 4z2dB-1mskA:
0.0
4z2dC-1mskA:
undetectable		 4z2dB-1mskA:
22.38
4z2dC-1mskA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		 1msk COBALAMIN-DEPENDENT
METHIONINE SYNTHASE
(Escherichia
coli) 		4 / 8 PRO A1135
PHE A1182
SER A1183
TYR A1114
 SAM  A1301 (-4.5A)
None
None
None
 1.11A 5amiB-1mskA:
0.0		 5amiB-1mskA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1msk COBALAMIN-DEPENDENT
METHIONINE SYNTHASE
(Escherichia
coli) 		4 / 7 ALA A 909
ASP A1010
THR A1146
GLU A1147
 None
 0.91A 5bs8A-1mskA:
0.0
5bs8C-1mskA:
undetectable
5bs8D-1mskA:
undetectable		 5bs8A-1mskA:
21.10
5bs8C-1mskA:
21.10
5bs8D-1mskA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1msk COBALAMIN-DEPENDENT
METHIONINE SYNTHASE
(Escherichia
coli) 		4 / 7 ALA A 909
ASP A1010
THR A1146
GLU A1147
 None
 0.86A 5btgA-1mskA:
undetectable
5btgC-1mskA:
undetectable
5btgD-1mskA:
undetectable		 5btgA-1mskA:
21.10
5btgC-1mskA:
21.10
5btgD-1mskA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 1msk COBALAMIN-DEPENDENT
METHIONINE SYNTHASE
(Escherichia
coli) 		6 / 9 TYR A1181
LEU A1103
VAL A1063
GLY A 997
THR A1161
VAL A1157
 None
 1.45A 5cp4A-1mskA:
0.0		 5cp4A-1mskA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1msk COBALAMIN-DEPENDENT
METHIONINE SYNTHASE
(Escherichia
coli) 		3 / 3 ASP A1081
ASN A1084
ASP A 979
 None
 0.72A 5vopA-1mskA:
undetectable		 5vopA-1mskA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1msk COBALAMIN-DEPENDENT
METHIONINE SYNTHASE
(Escherichia
coli) 		3 / 3 ASP A1081
ASN A1084
ASP A 979
 None
 0.76A 5vopB-1mskA:
undetectable		 5vopB-1mskA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1msk COBALAMIN-DEPENDENT
METHIONINE SYNTHASE
(Escherichia
coli) 		3 / 3 THR A1146
GLU A1144
HIS A1027
 None
 0.80A 5xiqB-1mskA:
undetectable		 5xiqB-1mskA:
22.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 1msk COBALAMIN-DEPENDENT
METHIONINE SYNTHASE
(Escherichia
coli) 		11 / 11 ASP A 946
PRO A 949
ARG A1094
GLU A1097
ARG A1134
PRO A1135
ALA A1136
TYR A1139
PRO A1140
ALA A1141
TYR A1189
 SAM  A1301 (-3.5A)
None
SAM  A1301 (-3.4A)
SAM  A1301 (-4.0A)
SAM  A1301 (-3.7A)
SAM  A1301 (-4.5A)
SAM  A1301 (-3.8A)
SAM  A1301 (-3.8A)
SAM  A1301 ( 4.1A)
SAM  A1301 (-3.1A)
SAM  A1301 (-4.1A)
 0.16A 6bm5A-1mskA:
50.7		 6bm5A-1mskA:
100.00