SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1mt5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
5 / 11 LEU A 496
ASN A 498
TYR A 493
GLY A 239
LEU A 372
None
None
None
MAY  A 600 (-3.6A)
MAY  A 600 (-4.6A)
1.40A 1fkpA-1mt5A:
undetectable
1fkpA-1mt5A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
4 / 8 SER A 457
SER A 376
ALA A 371
ILE A 368
None
1.05A 1gm7A-1mt5A:
0.0
1gm7B-1mt5A:
0.0
1gm7A-1mt5A:
17.05
1gm7B-1mt5A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA502_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
4 / 6 ASN A 498
ARG A 243
ILE A 491
GLY A 239
None
None
MAY  A 600 (-4.0A)
MAY  A 600 (-3.6A)
0.99A 1oniA-1mt5A:
0.0
1oniB-1mt5A:
0.0
1oniA-1mt5A:
13.04
1oniB-1mt5A:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD508_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
4 / 6 ASN A 498
ARG A 243
ILE A 491
GLY A 239
None
None
MAY  A 600 (-4.0A)
MAY  A 600 (-3.6A)
0.99A 1oniD-1mt5A:
0.0
1oniF-1mt5A:
0.0
1oniD-1mt5A:
13.04
1oniF-1mt5A:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
5 / 10 GLY A 136
VAL A 137
LEU A  79
LEU A 292
ALA A 179
None
1.43A 1pbcA-1mt5A:
undetectable
1pbcA-1mt5A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
5 / 12 PHE A 182
ALA A 223
LEU A 174
GLY A 220
LEU A 234
None
1.25A 1qabF-1mt5A:
0.0
1qabF-1mt5A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
4 / 5 LEU A 535
GLY A 402
ALA A 538
ILE A 534
None
0.73A 2aohB-1mt5A:
undetectable
2aohB-1mt5A:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
4 / 6 LEU A 234
LEU A 174
PRO A 231
VAL A 137
None
1.05A 2dqyC-1mt5A:
0.0
2dqyC-1mt5A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_A_SALA2006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
4 / 6 ARG A 344
THR A 513
VAL A 543
ALA A 341
None
1.08A 2e1qA-1mt5A:
undetectable
2e1qA-1mt5A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
4 / 5 ASP A 395
SER A 157
LEU A 154
GLY A 155
None
1.19A 2j2pA-1mt5A:
0.0
2j2pB-1mt5A:
0.0
2j2pA-1mt5A:
18.70
2j2pB-1mt5A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2MJI_A_KTRA201_1
(FATTY ACID-BINDING
PROTEIN, INTESTINAL)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
5 / 12 ILE A 533
THR A 483
LEU A 479
LEU A 475
ARG A 428
None
1.42A 2mjiA-1mt5A:
0.0
2mjiA-1mt5A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QM9_B_TDZB202_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
5 / 12 PHE A 363
TYR A 330
VAL A 552
SER A 457
ILE A 368
None
1.30A 2qm9B-1mt5A:
undetectable
2qm9B-1mt5A:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
5 / 12 LEU A  77
ASP A 286
GLY A 228
GLY A 229
LEU A  82
None
1.21A 2uvnA-1mt5A:
0.0
2uvnA-1mt5A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
4 / 8 SER A 193
GLN A 189
GLY A 402
GLY A 485
None
0.73A 2vinA-1mt5A:
undetectable
2vinA-1mt5A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_1
(NEURAMINIDASE A)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
5 / 12 ARG A 486
ILE A 534
ILE A 530
ASP A 529
LEU A 433
None
1.34A 2ya7C-1mt5A:
undetectable
2ya7C-1mt5A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
5 / 12 SER A 246
GLY A 281
GLY A 235
ASP A 237
LEU A 297
None
None
None
MAY  A 600 (-4.4A)
None
1.21A 2zw9A-1mt5A:
undetectable
2zw9A-1mt5A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
5 / 12 LEU A 234
GLY A 235
SER A 217
LEU A 280
LEU A 261
None
None
MAY  A 600 (-3.1A)
None
None
1.17A 3cjtG-1mt5A:
undetectable
3cjtG-1mt5A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_O_SAMO302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
6 / 12 LEU A 234
GLY A 235
SER A 217
VAL A 187
LEU A 280
LEU A 261
None
None
MAY  A 600 (-3.1A)
None
None
None
1.26A 3cjtO-1mt5A:
undetectable
3cjtO-1mt5A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_0
(PCZA361.24)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
5 / 12 GLY A 485
LEU A 481
LEU A 535
SER A 213
GLY A 215
None
1.04A 3g2oA-1mt5A:
undetectable
3g2oA-1mt5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_A_4CHA191_0
(DEHALOPEROXIDASE A)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
4 / 6 PHE A 182
HIS A 184
THR A 185
VAL A 114
None
1.08A 3lb3A-1mt5A:
0.0
3lb3A-1mt5A:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_B_4CHB192_0
(DEHALOPEROXIDASE A)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
4 / 6 PHE A 182
HIS A 184
THR A 185
VAL A 114
None
1.18A 3lb3B-1mt5A:
0.0
3lb3B-1mt5A:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
5 / 10 LEU A 496
ASN A 498
TYR A 493
GLY A 239
LEU A 372
None
None
None
MAY  A 600 (-3.6A)
MAY  A 600 (-4.6A)
1.22A 3lp1A-1mt5A:
0.0
3lp1A-1mt5A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MED_A_65BA561_0
(P51 REVERSE
TRANSCRIPTASE
P66 REVERSE
TRANSCRIPTASE)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
5 / 12 LEU A 496
ASN A 498
TYR A 493
GLY A 239
LEU A 372
None
None
None
MAY  A 600 (-3.6A)
MAY  A 600 (-4.6A)
1.36A 3medA-1mt5A:
0.0
3medB-1mt5A:
0.0
3medA-1mt5A:
21.78
3medB-1mt5A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
5 / 9 GLY A 379
GLN A 273
LEU A 375
LEU A 447
ILE A 451
None
1.45A 3nbqA-1mt5A:
undetectable
3nbqA-1mt5A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_D_URFD400_1
(URIDINE
PHOSPHORYLASE 1)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
5 / 9 GLY A 379
GLN A 273
LEU A 375
LEU A 447
ILE A 451
None
1.43A 3nbqD-1mt5A:
undetectable
3nbqD-1mt5A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
4 / 8 LEU A 364
TYR A 330
PHE A 363
TYR A 454
None
1.02A 3po7A-1mt5A:
undetectable
3po7A-1mt5A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
3 / 3 HIS A 184
SER A 218
GLU A 221
None
0.90A 3s8pA-1mt5A:
0.0
3s8pA-1mt5A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
3 / 3 THR A 115
ASN A 186
GLU A 143
None
0.68A 3v4tA-1mt5A:
0.0
3v4tC-1mt5A:
0.0
3v4tA-1mt5A:
23.20
3v4tC-1mt5A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
5 / 12 PRO A 338
LEU A 364
TYR A 330
PHE A 363
TYR A 454
None
1.04A 4a79A-1mt5A:
undetectable
4a79A-1mt5A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
5 / 12 PRO A 338
LEU A 364
TYR A 330
PHE A 363
TYR A 454
None
1.03A 4a79B-1mt5A:
0.0
4a79B-1mt5A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
5 / 12 PRO A 338
LEU A 364
TYR A 330
PHE A 363
TYR A 454
None
1.04A 4a7aB-1mt5A:
0.0
4a7aB-1mt5A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
5 / 12 VAL A 495
TYR A 335
LEU A 447
GLY A 378
ALA A 377
MAY  A 600 (-4.8A)
None
None
None
MAY  A 600 (-3.7A)
1.02A 4coxA-1mt5A:
undetectable
4coxA-1mt5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
5 / 12 VAL A 495
TYR A 335
LEU A 447
GLY A 378
ALA A 377
MAY  A 600 (-4.8A)
None
None
None
MAY  A 600 (-3.7A)
1.02A 4coxB-1mt5A:
0.0
4coxB-1mt5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
5 / 12 VAL A 495
TYR A 335
LEU A 447
GLY A 378
ALA A 377
MAY  A 600 (-4.8A)
None
None
None
MAY  A 600 (-3.7A)
1.02A 4coxD-1mt5A:
0.0
4coxD-1mt5A:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DO3_A_0LAA602_1
(FATTY-ACID AMIDE
HYDROLASE 1)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
5 / 5 LEU A 192
LEU A 404
MET A 436
THR A 488
TRP A 531
MAY  A 600 ( 4.2A)
None
None
MAY  A 600 ( 4.2A)
None
0.77A 4do3A-1mt5A:
68.6
4do3A-1mt5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
6 / 6 LEU A 192
LEU A 404
ILE A 407
MET A 436
THR A 488
TRP A 531
MAY  A 600 ( 4.2A)
None
None
None
MAY  A 600 ( 4.2A)
None
0.80A 4do3B-1mt5A:
68.3
4do3B-1mt5A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
4 / 5 ARG A 320
VAL A 287
LEU A 290
SER A 289
None
1.13A 4e1gA-1mt5A:
undetectable
4e1gA-1mt5A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_D_NCTD501_1
(CYTOCHROME P450 2A13)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
4 / 6 PHE A 194
PHE A 248
THR A 336
LEU A 535
None
0.97A 4ejgD-1mt5A:
undetectable
4ejgD-1mt5A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
5 / 10 TYR A 497
THR A 472
LEU A 470
ASP A 333
ILE A 368
None
1.16A 4jx1B-1mt5A:
undetectable
4jx1B-1mt5A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
3 / 3 LEU A 224
ILE A 225
ARG A 285
None
0.65A 4mk4B-1mt5A:
undetectable
4mk4B-1mt5A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
5 / 12 VAL A 495
TYR A 335
LEU A 447
GLY A 378
ALA A 377
MAY  A 600 (-4.8A)
None
None
None
MAY  A 600 (-3.7A)
1.07A 4otyB-1mt5A:
0.0
4otyB-1mt5A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
4 / 6 TYR A 100
ARG A 285
GLY A 226
SER A 227
None
1.25A 5bphA-1mt5A:
2.0
5bphA-1mt5A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
5 / 12 ILE A 407
GLY A 384
PHE A 432
THR A 488
LEU A 389
None
None
MAY  A 600 ( 4.9A)
MAY  A 600 ( 4.2A)
None
1.00A 5byjA-1mt5A:
undetectable
5byjA-1mt5A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_B_SALB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
4 / 7 VAL A 495
LEU A 447
GLY A 378
ALA A 377
MAY  A 600 (-4.8A)
None
None
MAY  A 600 (-3.7A)
0.69A 5f1aB-1mt5A:
undetectable
5f1aB-1mt5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
4 / 4 CYH A 293
LEU A 174
LEU A 134
ALA A 179
None
1.11A 5hpuA-1mt5A:
undetectable
5hpuB-1mt5A:
undetectable
5hpuA-1mt5A:
4.21
5hpuB-1mt5A:
4.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
4 / 4 LEU A 266
GLY A 265
SER A 264
SER A 262
None
1.22A 5uunA-1mt5A:
0.0
5uunA-1mt5A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB306_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
4 / 4 LEU A 266
GLY A 265
SER A 264
SER A 262
None
1.25A 5uunB-1mt5A:
0.0
5uunB-1mt5A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
5 / 7 GLY A 385
LEU A 389
LEU A 154
ILE A 405
LEU A 404
None
1.36A 5vkqA-1mt5A:
undetectable
5vkqB-1mt5A:
undetectable
5vkqA-1mt5A:
14.54
5vkqB-1mt5A:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
5 / 12 ALA A 179
PHE A 182
LEU A 134
VAL A  96
LEU A 224
None
1.11A 5x24A-1mt5A:
0.0
5x24A-1mt5A:
22.63