SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1mtp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		 1mtp SERINE PROTEINASE
INHIBITOR (SERPIN),
CHAIN A
(Thermobifida
fusca) 		5 / 12 LEU A 286
ALA A  50
LEU A 279
PRO A  66
LEU A  70
 None
 1.23A 1og5A-1mtpA:
undetectable		 1og5A-1mtpA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKT_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 1mtp SERINE PROTEINASE
INHIBITOR (SERPIN),
CHAIN A
(Thermobifida
fusca) 		5 / 10 LEU A 158
ALA A 156
LEU A 294
LEU A 286
MET A 105
 None
 1.37A 1qktA-1mtpA:
undetectable		 1qktA-1mtpA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_B_IBPB2002_1
(SERUM ALBUMIN)		 1mtp SERINE PROTEINASE
INHIBITOR (SERPIN),
CHAIN A
(Thermobifida
fusca) 		5 / 10 LEU A 286
LEU A 279
ALA A 284
LEU A 271
VAL A 276
 None
 1.05A 2bxgB-1mtpA:
undetectable		 2bxgB-1mtpA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)		 1mtp SERINE PROTEINASE
INHIBITOR (SERPIN),
CHAIN A
(Thermobifida
fusca) 		4 / 4 LEU A 240
PRO A 235
LEU A 239
ARG A 246
 None
 1.41A 2hrcA-1mtpA:
undetectable		 2hrcA-1mtpA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		 1mtp SERINE PROTEINASE
INHIBITOR (SERPIN),
CHAIN A
(Thermobifida
fusca) 		5 / 12 HIS A 301
LEU A 162
ALA A 161
THR A 137
GLN A 263
 None
 1.20A 2jjpA-1mtpA:
undetectable		 2jjpA-1mtpA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1mtp SERINE PROTEINASE
INHIBITOR (SERPIN),
CHAIN A
SERINE PROTEINASE
INHIBITOR (SERPIN),
CHAIN B
(Thermobifida
fusca) 		5 / 8 LEU A 219
ALA A  84
LEU A 162
ALA A 315
PHE B 354
 None
 1.28A 2vcvF-1mtpA:
undetectable		 2vcvF-1mtpA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)		 1mtp SERINE PROTEINASE
INHIBITOR (SERPIN),
CHAIN A
SERINE PROTEINASE
INHIBITOR (SERPIN),
CHAIN B
(Thermobifida
fusca) 		5 / 10 ILE B 344
LEU A 162
LEU A 305
GLY A 314
ALA A 164
 None
 1.22A 2xf3A-1mtpB:
undetectable		 2xf3A-1mtpB:
7.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 1mtp SERINE PROTEINASE
INHIBITOR (SERPIN),
CHAIN A
(Thermobifida
fusca) 		5 / 11 THR A 212
MET A 210
LEU A 243
PRO A 235
LEU A  17
 None
 1.21A 3a51A-1mtpA:
undetectable		 3a51A-1mtpA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 1mtp SERINE PROTEINASE
INHIBITOR (SERPIN),
CHAIN A
SERINE PROTEINASE
INHIBITOR (SERPIN),
CHAIN B
(Thermobifida
fusca;
Thermobifida
fusca) 		3 / 3 ARG A 306
ASP B 363
ASP A 308
 None
 0.86A 3jayA-1mtpA:
0.0		 3jayA-1mtpA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 1mtp SERINE PROTEINASE
INHIBITOR (SERPIN),
CHAIN A
SERINE PROTEINASE
INHIBITOR (SERPIN),
CHAIN B
(Thermobifida
fusca;
Thermobifida
fusca) 		3 / 3 ARG A 306
ASP B 363
ASP A 308
 None
 0.90A 3jb2A-1mtpA:
0.0		 3jb2A-1mtpA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_1
(PROTEASE)		 1mtp SERINE PROTEINASE
INHIBITOR (SERPIN),
CHAIN A
SERINE PROTEINASE
INHIBITOR (SERPIN),
CHAIN B
(Thermobifida
fusca) 		5 / 9 LEU A 213
ALA A 166
ASP A  82
VAL B 346
LEU B 353
 None
 1.42A 3wsjA-1mtpA:
0.0		 3wsjA-1mtpA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_2
(ADENOSINE KINASE)		 1mtp SERINE PROTEINASE
INHIBITOR (SERPIN),
CHAIN A
(Thermobifida
fusca) 		4 / 4 LEU A  43
SER A  38
LEU A 267
LEU A  46
 None
 1.05A 4n09A-1mtpA:
undetectable		 4n09A-1mtpA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 1mtp SERINE PROTEINASE
INHIBITOR (SERPIN),
CHAIN A
(Thermobifida
fusca) 		5 / 12 LEU A 145
THR A 298
ALA A 319
ALA A 317
ILE A 157
 None
 0.85A 4o2bD-1mtpA:
undetectable		 4o2bD-1mtpA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1mtp SERINE PROTEINASE
INHIBITOR (SERPIN),
CHAIN A
(Thermobifida
fusca) 		4 / 7 THR A 318
HIS A  12
LEU A  69
SER A  85
 None
 0.99A 4pfjA-1mtpA:
undetectable		 4pfjA-1mtpA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_D_LOCD502_1
(TUBULIN BETA CHAIN)		 1mtp SERINE PROTEINASE
INHIBITOR (SERPIN),
CHAIN A
(Thermobifida
fusca) 		5 / 12 LEU A 145
THR A 298
ALA A 319
ALA A 317
ILE A 157
 None
 0.78A 4x1iD-1mtpA:
undetectable		 4x1iD-1mtpA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_D_LOCD502_2
(TUBULIN BETA CHAIN)		 1mtp SERINE PROTEINASE
INHIBITOR (SERPIN),
CHAIN A
(Thermobifida
fusca) 		5 / 12 LEU A 145
THR A 298
ALA A 319
ALA A 317
ILE A 157
 None
 0.77A 4x1yD-1mtpA:
undetectable		 4x1yD-1mtpA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 1mtp SERINE PROTEINASE
INHIBITOR (SERPIN),
CHAIN A
(Thermobifida
fusca) 		5 / 12 LEU A 145
THR A 298
ALA A 319
ALA A 317
ILE A 157
 None
 0.87A 4x20B-1mtpA:
undetectable		 4x20B-1mtpA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWC_A_FK5A201_1
(FK506-BINDING
PROTEIN 1A)		 1mtp SERINE PROTEINASE
INHIBITOR (SERPIN),
CHAIN A
SERINE PROTEINASE
INHIBITOR (SERPIN),
CHAIN B
(Thermobifida
fusca) 		5 / 11 VAL A 221
ILE B 344
PHE B 354
ILE A  33
PHE A 259
 None
 1.31A 5hwcA-1mtpA:
undetectable		 5hwcA-1mtpA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KLA_A_ACTA1505_0
(MATERNAL PROTEIN
PUMILIO)		 1mtp SERINE PROTEINASE
INHIBITOR (SERPIN),
CHAIN A
(Thermobifida
fusca) 		3 / 3 HIS A 244
LYS A   5
PHE A   7
 None
 1.20A 5klaA-1mtpA:
undetectable		 5klaA-1mtpA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDM_A_ADNA904_1
(ATP-CITRATE SYNTHASE)		 1mtp SERINE PROTEINASE
INHIBITOR (SERPIN),
CHAIN A
(Thermobifida
fusca) 		4 / 4 THR A  54
ASP A 285
ARG A  51
LEU A 286
 None
 1.28A 5tdmA-1mtpA:
0.0		 5tdmA-1mtpA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_0
(REGULATORY PROTEIN
TETR)		 1mtp SERINE PROTEINASE
INHIBITOR (SERPIN),
CHAIN A
(Thermobifida
fusca) 		5 / 12 ALA A  47
LEU A 158
VAL A 276
ASP A 297
PHE A 280
 None
 1.29A 5vlmC-1mtpA:
0.9		 5vlmC-1mtpA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_0
(REGULATORY PROTEIN
TETR)		 1mtp SERINE PROTEINASE
INHIBITOR (SERPIN),
CHAIN A
(Thermobifida
fusca) 		5 / 12 ALA A  50
LEU A 158
VAL A 276
ASP A 297
PHE A 280
 None
 1.46A 5vlmC-1mtpA:
0.9		 5vlmC-1mtpA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1mtp SERINE PROTEINASE
INHIBITOR (SERPIN),
CHAIN A
(Thermobifida
fusca) 		4 / 6 LEU A  70
ARG A  86
THR A 159
LEU A 158
 None
 1.02A 5x1fA-1mtpA:
0.0
5x1fJ-1mtpA:
0.0		 5x1fA-1mtpA:
20.79
5x1fJ-1mtpA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 1mtp SERINE PROTEINASE
INHIBITOR (SERPIN),
CHAIN A
(Thermobifida
fusca) 		5 / 12 LEU A 145
THR A 298
ALA A 319
ALA A 317
ILE A 157
 None
 0.83A 5xiwB-1mtpA:
undetectable		 5xiwB-1mtpA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 1mtp SERINE PROTEINASE
INHIBITOR (SERPIN),
CHAIN A
SERINE PROTEINASE
INHIBITOR (SERPIN),
CHAIN B
(Thermobifida
fusca;
Thermobifida
fusca) 		4 / 6 VAL B 345
LEU A  17
LEU A  13
HIS A  12
 None
 0.96A 6e43B-1mtpB:
undetectable		 6e43B-1mtpB:
8.03