SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1mty'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
4 / 7 GLY B 131
ARG D  18
ILE B 203
GLY B 126
None
0.85A 11gsB-1mtyB:
undetectable
11gsB-1mtyB:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K2T_A_H4BA1760_1
(NITRIC-OXIDE
SYNTHASE)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
4 / 7 VAL D  28
TRP D  31
PHE D  35
GLU D 132
None
1.50A 1k2tA-1mtyD:
undetectable
1k2tB-1mtyD:
undetectable
1k2tA-1mtyD:
21.72
1k2tB-1mtyD:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LZZ_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
4 / 7 VAL D  28
TRP D  31
PHE D  35
GLU D 132
None
1.48A 1lzzA-1mtyD:
undetectable
1lzzB-1mtyD:
undetectable
1lzzA-1mtyD:
21.72
1lzzB-1mtyD:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M00_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
4 / 7 VAL D  28
TRP D  31
PHE D  35
GLU D 132
None
1.50A 1m00A-1mtyD:
undetectable
1m00B-1mtyD:
undetectable
1m00A-1mtyD:
21.72
1m00B-1mtyD:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMW_A_H4BA1760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
4 / 7 VAL D  28
TRP D  31
PHE D  35
GLU D 132
None
1.48A 1mmwA-1mtyD:
undetectable
1mmwB-1mtyD:
undetectable
1mmwA-1mtyD:
21.72
1mmwB-1mtyD:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA734_1
(ALPHA AMYLASE)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
4 / 6 TRP D 371
HIS D 344
TYR D 376
GLY D 378
None
1.35A 1mxdA-1mtyD:
undetectable
1mxdA-1mtyD:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OM4_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
4 / 7 PHE D  35
GLU D 132
VAL D  28
TRP D  31
None
1.50A 1om4A-1mtyD:
undetectable
1om4B-1mtyD:
undetectable
1om4A-1mtyD:
21.44
1om4B-1mtyD:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_1
(ESTROGEN RECEPTOR
BETA)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
5 / 12 LEU D 349
LEU D 405
ILE D 469
GLY D 178
LEU D 180
None
0.92A 1qknA-1mtyD:
2.3
1qknA-1mtyD:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_B_DAHB208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
6 / 12 GLU D 144
HIS D 147
LEU D 204
GLU D 209
ILE D 239
GLU D 243
FE  D   4 (-2.4A)
FE  D   4 ( 3.2A)
None
FE  D   3 ( 2.8A)
None
FE  D   3 ( 2.5A)
1.49A 1rnrB-1mtyD:
18.2
1rnrB-1mtyD:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB6_0
(GRAMICIDIN A)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE
METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus;
Methylococcus
capsulatus)
3 / 3 ALA B  17
VAL D  95
TRP D  99
None
0.88A 1tkqB-1mtyB:
undetectable
1tkqB-1mtyB:
3.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
3 / 3 ARG B 168
VAL D 112
GLY D 183
None
0.48A 2avvE-1mtyB:
undetectable
2avvE-1mtyB:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G6H_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
4 / 8 VAL D  28
TRP D  31
PHE D  35
GLU D 132
None
1.49A 2g6hA-1mtyD:
undetectable
2g6hB-1mtyD:
undetectable
2g6hA-1mtyD:
21.88
2g6hB-1mtyD:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACHA546_0
(ACETYLCHOLINESTERASE)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
4 / 8 TYR D 387
GLU D 291
HIS D 343
GLY D 287
None
1.07A 2ha4A-1mtyD:
undetectable
2ha4A-1mtyD:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
4 / 7 TYR D 387
GLU D 291
HIS D 343
GLY D 287
None
1.09A 2ha4B-1mtyD:
undetectable
2ha4B-1mtyD:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_B_ECNB1406_1
(CYTOCHROME P450 130)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
5 / 11 PRO B 327
GLY B 322
LEU B 234
TYR B 252
VAL B 251
None
0.81A 2uvnB-1mtyB:
0.1
2uvnB-1mtyB:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_G_RBFG200_1
(DODECIN)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
4 / 8 GLN D 140
TYR D  46
ARG B 168
THR D  44
FE  D   3 (-4.5A)
None
None
None
1.24A 2vxaF-1mtyD:
0.0
2vxaG-1mtyD:
0.0
2vxaI-1mtyD:
0.0
2vxaF-1mtyD:
10.11
2vxaG-1mtyD:
10.11
2vxaI-1mtyD:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_G_RBFG200_1
(DODECIN)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
4 / 8 GLN D 205
TYR D  46
ARG B 168
THR D  44
None
1.21A 2vxaF-1mtyD:
0.0
2vxaG-1mtyD:
0.0
2vxaI-1mtyD:
0.0
2vxaF-1mtyD:
10.11
2vxaG-1mtyD:
10.11
2vxaI-1mtyD:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
3 / 3 ARG B  42
ARG B 103
PRO B 101
None
0.88A 2wljA-1mtyB:
2.1
2wljA-1mtyB:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
4 / 6 TYR D 351
TRP D 390
TYR D 347
ILE D 386
None
1.44A 2xz5A-1mtyD:
undetectable
2xz5B-1mtyD:
0.0
2xz5A-1mtyD:
16.63
2xz5B-1mtyD:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
4 / 7 ILE D 386
TYR D 351
TRP D 390
TYR D 347
None
1.42A 2xz5D-1mtyD:
0.0
2xz5E-1mtyD:
0.0
2xz5D-1mtyD:
16.63
2xz5E-1mtyD:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLO_A_TESA1920_1
(ANDROGEN RECEPTOR)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
5 / 12 GLN B 258
VAL B 360
ARG B 262
THR B 321
PHE B 246
None
1.49A 2yloA-1mtyB:
undetectable
2yloA-1mtyB:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBV_A_ADNA501_1
(UNCHARACTERIZED
CONSERVED PROTEIN)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
5 / 10 TYR D 156
VAL D 154
ASN D 100
PHE D 158
ASN D 161
None
1.26A 2zbvA-1mtyD:
0.0
2zbvB-1mtyD:
0.0
2zbvA-1mtyD:
19.00
2zbvB-1mtyD:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
3 / 3 PRO D 300
GLU D 373
TYR D 376
None
0.66A 2zmbA-1mtyD:
undetectable
2zmbA-1mtyD:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
5 / 9 THR G  41
LEU G  32
ILE G 122
ILE G 112
GLY B  79
None
1.04A 3cv9A-1mtyG:
undetectable
3cv9A-1mtyG:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HSN_B_H4BB1760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
4 / 7 PHE D  35
GLU D 132
VAL D  28
TRP D  31
None
1.48A 3hsnA-1mtyD:
undetectable
3hsnB-1mtyD:
undetectable
3hsnA-1mtyD:
21.44
3hsnB-1mtyD:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
4 / 8 THR D 213
GLY D 113
ALA D 117
THR D 121
None
0.76A 3jusB-1mtyD:
undetectable
3jusB-1mtyD:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_D_ACTD601_0
(CHOLINE OXIDASE)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE
METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus;
Methylococcus
capsulatus)
4 / 5 ILE D 145
TRP B 105
HIS B 106
VAL B 110
None
1.33A 3nneD-1mtyD:
0.0
3nneD-1mtyD:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_A_ESLA700_1
(ESTROGEN RECEPTOR)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
5 / 12 LEU D 349
LEU D 405
ILE D 469
GLY D 178
LEU D 180
None
0.98A 3q95A-1mtyD:
undetectable
3q95A-1mtyD:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
5 / 8 PHE B 335
ALA B 227
PHE B 256
ASN B 155
ALA B 151
None
1.38A 3t3sD-1mtyB:
undetectable
3t3sD-1mtyB:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
3 / 3 ARG D 463
MET G 140
ARG G 143
None
0.79A 3uvvA-1mtyD:
0.0
3uvvA-1mtyD:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE
METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus;
Methylococcus
capsulatus)
3 / 3 LYS B  75
ARG G  44
LEU G  54
None
1.36A 3v4tE-1mtyB:
0.0
3v4tE-1mtyB:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_B_ACTB1114_0
(BLR5658 PROTEIN)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
3 / 3 TRP D 308
TRP D 301
THR D 283
None
1.39A 4bboB-1mtyD:
undetectable
4bboB-1mtyD:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
5 / 12 ASP B 240
ASN B 242
LEU B 171
GLY B 166
SER B 164
None
1.33A 4djfB-1mtyB:
undetectable
4djfB-1mtyB:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRI_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5
SERINE/THREONINE-PRO
TEIN KINASE MTOR)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
5 / 10 LEU G  60
THR G  11
TRP G  15
ASP G  52
TYR G  53
None
1.49A 4driB-1mtyG:
1.5
4driB-1mtyG:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
4 / 7 LEU B 332
ALA B 227
VAL B 223
ILE B 193
None
0.97A 4eyrA-1mtyB:
undetectable
4eyrA-1mtyB:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE
METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus;
Methylococcus
capsulatus)
3 / 3 TYR B  37
HIS D 486
ARG D 173
None
0.85A 4htfA-1mtyB:
undetectable
4htfA-1mtyB:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
4 / 7 HIS D 147
ASP D 143
VAL B 110
GLU D  71
FE  D   4 ( 3.2A)
None
None
None
1.05A 4hvrA-1mtyD:
undetectable
4hvrA-1mtyD:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
4 / 8 SER D 428
LEU D 429
CYH D 426
PHE D 408
None
1.20A 4j7uD-1mtyD:
undetectable
4j7uD-1mtyD:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
3 / 3 GLU G 132
ARG G 115
HIS G 111
None
0.58A 4kf9A-1mtyG:
0.0
4kf9A-1mtyG:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_2
(PROTEASE)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
5 / 10 LEU D  86
VAL D 154
PRO D 233
THR D 234
ILE D 231
None
1.07A 4njuB-1mtyD:
undetectable
4njuB-1mtyD:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_2
(PROTEASE)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
5 / 10 LEU D  86
VAL D 154
PRO D 233
THR D 234
ILE D 231
None
1.07A 4njuD-1mtyD:
undetectable
4njuD-1mtyD:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
4 / 4 THR B  53
ARG B  99
GLU B  50
VAL B 174
None
1.47A 4odoC-1mtyB:
undetectable
4odoC-1mtyB:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
4 / 7 PRO G 124
GLU B  89
GLU G  61
ASP G  38
None
1.21A 4uacA-1mtyG:
undetectable
4uacA-1mtyG:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH5_A_H4BA760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
4 / 7 VAL D  28
TRP D  31
PHE D  35
GLU D 132
None
1.49A 4uh5A-1mtyD:
0.0
4uh5B-1mtyD:
0.0
4uh5A-1mtyD:
20.83
4uh5B-1mtyD:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3U_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
4 / 7 VAL D  28
TRP D  31
PHE D  35
GLU D 132
None
1.50A 4v3uA-1mtyD:
0.0
4v3uB-1mtyD:
0.1
4v3uA-1mtyD:
21.03
4v3uB-1mtyD:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE
METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus;
Methylococcus
capsulatus)
3 / 3 ASP B  71
ARG G 115
PRO B  81
None
1.02A 4wanC-1mtyB:
undetectable
4wanC-1mtyB:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_B_ACTB403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
3 / 3 ARG B   9
ASP B  13
ARG B   8
None
0.56A 4wq4B-1mtyB:
0.7
4wq4B-1mtyB:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
3 / 3 LEU D 485
ASP D 170
ILE D 469
None
0.62A 4xi3D-1mtyD:
undetectable
4xi3D-1mtyD:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP9_C_1WEC706_1
(TRANSPORTER)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
4 / 4 PHE B  76
ASP D 190
GLY D 195
SER B  82
None
1.44A 4xp9C-1mtyB:
0.0
4xp9C-1mtyB:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
3 / 3 VAL D 154
PHE D  79
ARG D 146
None
0.99A 4xr4B-1mtyD:
undetectable
4xr4B-1mtyD:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y28_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
5 / 9 ARG G 138
ALA G 107
LEU G 139
GLY G 136
PHE D 448
None
1.33A 4y28A-1mtyG:
undetectable
4y28J-1mtyG:
0.0
4y28A-1mtyG:
11.74
4y28J-1mtyG:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_ACTA608_0
(SERUM ALBUMIN)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE
METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus;
Methylococcus
capsulatus)
3 / 3 LYS G 157
ARG G 156
HIS D 439
None
1.14A 4zbrA-1mtyG:
0.3
4zbrA-1mtyG:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGM_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
4 / 7 PHE D  35
GLU D 132
VAL D  28
TRP D  31
None
1.48A 5agmA-1mtyD:
0.0
5agmB-1mtyD:
0.0
5agmA-1mtyD:
21.44
5agmB-1mtyD:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_B_ACTB404_0
(D-ALANINE--D-ALANINE
LIGASE)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
4 / 7 TYR D 137
GLY D 250
SER D 201
LEU D 204
None
1.05A 5bphB-1mtyD:
undetectable
5bphB-1mtyD:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVU_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
4 / 6 VAL D  28
TRP D  31
PHE D  35
GLU D 132
None
1.47A 5fvuA-1mtyD:
0.0
5fvuB-1mtyD:
0.0
5fvuA-1mtyD:
20.83
5fvuB-1mtyD:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVV_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
4 / 7 VAL D  28
TRP D  31
PHE D  35
GLU D 132
None
1.49A 5fvvA-1mtyD:
0.0
5fvvB-1mtyD:
0.0
5fvvA-1mtyD:
20.83
5fvvB-1mtyD:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVW_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
4 / 7 VAL D  28
TRP D  31
PHE D  35
GLU D 132
None
1.46A 5fvwA-1mtyD:
undetectable
5fvwB-1mtyD:
undetectable
5fvwA-1mtyD:
20.83
5fvwB-1mtyD:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVX_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
4 / 7 VAL D  28
TRP D  31
PHE D  35
GLU D 132
None
1.48A 5fvxA-1mtyD:
0.0
5fvxB-1mtyD:
0.0
5fvxA-1mtyD:
20.83
5fvxB-1mtyD:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE
METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus;
Methylococcus
capsulatus)
4 / 4 VAL D  23
GLU D  27
GLY B 198
LEU B 195
None
1.39A 5g5gC-1mtyD:
0.0
5g5gC-1mtyD:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE
METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus;
Methylococcus
capsulatus)
5 / 12 ALA D  47
GLY D 195
SER D 194
GLY G 131
HIS G 111
None
1.10A 5gwxA-1mtyD:
undetectable
5gwxA-1mtyD:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE
METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus;
Methylococcus
capsulatus)
3 / 3 ARG D 175
PRO B  58
ASN D 116
None
0.88A 5jwaA-1mtyD:
undetectable
5jwaH-1mtyD:
undetectable
5jwaA-1mtyD:
20.58
5jwaH-1mtyD:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
3 / 3 HIS D  96
SER D 294
LYS D 297
None
1.46A 5os7A-1mtyD:
0.0
5os7A-1mtyD:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_H_EZLH303_1
(ALPHA-CARBONIC
ANHYDRASE)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
4 / 8 HIS D 246
LEU D 124
THR D 121
ALA D 120
FE  D   3 ( 3.3A)
None
None
None
0.92A 5tt3H-1mtyD:
undetectable
5tt3H-1mtyD:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO5_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
4 / 7 VAL D  28
TRP D  31
PHE D  35
GLU D 132
None
1.50A 5uo5A-1mtyD:
undetectable
5uo5B-1mtyD:
undetectable
5uo5A-1mtyD:
20.83
5uo5B-1mtyD:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUX_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
4 / 7 VAL D  28
TRP D  31
PHE D  35
GLU D 132
None
1.49A 5vuxA-1mtyD:
undetectable
5vuxB-1mtyD:
undetectable
5vuxA-1mtyD:
20.83
5vuxB-1mtyD:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
5 / 12 LEU B 332
VAL B 359
GLU B 156
PHE B 265
THR B 277
None
1.48A 5xiqB-1mtyB:
undetectable
5xiqB-1mtyB:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
4 / 6 ILE D 403
ARG D 514
THR D 508
LEU D 495
None
1.02A 5z86N-1mtyD:
1.0
5z86W-1mtyD:
0.0
5z86N-1mtyD:
21.34
5z86W-1mtyD:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
4 / 6 ILE D 403
ARG D 514
THR D 508
LEU D 495
None
1.03A 5zcoN-1mtyD:
2.8
5zcoW-1mtyD:
0.0
5zcoN-1mtyD:
21.34
5zcoW-1mtyD:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV1_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
4 / 7 VAL D  28
TRP D  31
PHE D  35
GLU D 132
None
1.48A 6av1A-1mtyD:
undetectable
6av1B-1mtyD:
undetectable
6av1A-1mtyD:
10.37
6av1B-1mtyD:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV3_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
4 / 7 VAL D  28
TRP D  31
PHE D  35
GLU D 132
None
1.49A 6av3A-1mtyD:
undetectable
6av3B-1mtyD:
undetectable
6av3A-1mtyD:
10.37
6av3B-1mtyD:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV4_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
4 / 7 VAL D  28
TRP D  31
PHE D  35
GLU D 132
None
1.49A 6av4A-1mtyD:
undetectable
6av4B-1mtyD:
undetectable
6av4A-1mtyD:
10.37
6av4B-1mtyD:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV5_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
4 / 7 VAL D  28
TRP D  31
PHE D  35
GLU D 132
None
1.50A 6av5A-1mtyD:
undetectable
6av5B-1mtyD:
undetectable
6av5A-1mtyD:
10.37
6av5B-1mtyD:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
5 / 9 ALA D 119
ILE D 118
PHE B 181
GLY B 183
GLY D 122
None
1.29A 6awoA-1mtyD:
undetectable
6awoA-1mtyD:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
5 / 9 ALA D 119
ILE D 118
PHE B 181
GLY B 183
GLY D 122
None
1.30A 6awqA-1mtyD:
undetectable
6awqA-1mtyD:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
5 / 12 TYR D 137
PHE D  60
ALA B 167
ALA D 119
LEU D 204
None
1.04A 6aybA-1mtyD:
undetectable
6aybA-1mtyD:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
5 / 12 VAL B 177
MET B  35
VAL D 154
PHE D 236
GLY D 113
None
1.22A 6brdA-1mtyB:
undetectable
6brdA-1mtyB:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
5 / 12 VAL B 177
MET B  35
VAL D 154
PHE D 236
GLY D 113
None
1.04A 6brdC-1mtyB:
undetectable
6brdC-1mtyB:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CID_A_H4BA802_0
(NITRIC OXIDE
SYNTHASE, BRAIN)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
4 / 7 VAL D  28
TRP D  31
PHE D  35
GLU D 132
None
1.50A 6cidA-1mtyD:
undetectable
6cidB-1mtyD:
undetectable
6cidA-1mtyD:
10.37
6cidB-1mtyD:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
4 / 8 ILE G 122
THR G  94
VAL G  95
SER G  89
None
1.06A 6fbvC-1mtyG:
undetectable
6fbvC-1mtyG:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
4 / 7 ASP D 365
ARG D 391
LYS D  98
TYR D 351
None
1.26A 6g31G-1mtyD:
undetectable
6g31G-1mtyD:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB402_0
(CASEIN KINASE II
SUBUNIT ALPHA)
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus)
3 / 3 HIS D  96
SER D 294
LYS D 297
None
1.46A 6gmdB-1mtyD:
0.0
6gmdB-1mtyD:
21.09