SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1mum'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 1mum 2-METHYLISOCITRATE
LYASE
(Escherichia
coli) 		5 / 12 GLY A  46
VAL A  49
LEU A 237
PHE A 186
HIS A 113
 None
 1.14A 1mx1E-1mumA:
undetectable		 1mx1E-1mumA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2002_1
(SERUM ALBUMIN)		 1mum 2-METHYLISOCITRATE
LYASE
(Escherichia
coli) 		4 / 9 ILE A 114
ALA A  94
VAL A  97
LYS A 102
 None
 0.68A 2vufB-1mumA:
undetectable		 2vufB-1mumA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 1mum 2-METHYLISOCITRATE
LYASE
(Escherichia
coli) 		5 / 10 GLY A  24
ALA A  41
PHE A 186
LEU A 208
ARG A 158
 None
None
None
None
MG  A1001 ( 4.8A)
 1.20A 3a3yA-1mumA:
1.2		 3a3yA-1mumA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)		 1mum 2-METHYLISOCITRATE
LYASE
(Escherichia
coli) 		5 / 12 LEU A  83
ALA A  41
LEU A  14
LEU A  20
MET A 156
 None
 1.11A 3erdA-1mumA:
undetectable		 3erdA-1mumA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		 1mum 2-METHYLISOCITRATE
LYASE
(Escherichia
coli) 		5 / 12 LEU A  83
ALA A  41
LEU A  14
LEU A  20
MET A 156
 None
 1.15A 3hm1A-1mumA:
undetectable		 3hm1A-1mumA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 1mum 2-METHYLISOCITRATE
LYASE
(Escherichia
coli) 		4 / 7 LEU A 208
ARG A 158
GLY A  24
TYR A  43
 None
MG  A1001 ( 4.8A)
None
None
 0.92A 4cp3A-1mumA:
undetectable
4cp3B-1mumA:
0.0		 4cp3A-1mumA:
20.74
4cp3B-1mumA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 1mum 2-METHYLISOCITRATE
LYASE
(Escherichia
coli) 		3 / 3 LEU A 112
MET A 104
ASP A 139
 None
 0.80A 4j7xB-1mumA:
2.7		 4j7xB-1mumA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1mum 2-METHYLISOCITRATE
LYASE
(Escherichia
coli) 		4 / 8 VAL A 250
TYR A 251
VAL A 263
ILE A 264
 None
 0.77A 4jq1B-1mumA:
4.1		 4jq1B-1mumA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 1mum 2-METHYLISOCITRATE
LYASE
(Escherichia
coli) 		5 / 12 LEU A  83
ALA A  41
LEU A  14
LEU A  20
MET A 156
 None
 1.11A 4zn7A-1mumA:
undetectable		 4zn7A-1mumA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 1mum 2-METHYLISOCITRATE
LYASE
(Escherichia
coli) 		5 / 11 LEU A  83
ALA A  41
LEU A  14
LEU A  20
MET A 156
 None
 1.08A 4zn7B-1mumA:
undetectable		 4zn7B-1mumA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1mum 2-METHYLISOCITRATE
LYASE
(Escherichia
coli) 		5 / 9 ALA A 239
GLY A  52
PHE A 240
SER A  45
GLY A  24
 None
 1.36A 6awoA-1mumA:
undetectable		 6awoA-1mumA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1mum 2-METHYLISOCITRATE
LYASE
(Escherichia
coli) 		5 / 9 ALA A 239
GLY A  52
PHE A 240
SER A  45
GLY A  24
 None
 1.37A 6awqA-1mumA:
undetectable		 6awqA-1mumA:
19.67