SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1mus'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))		 1mus TN5 TRANSPOSASE
(Escherichia
coli) 		5 / 8 ARG A 210
LEU A 300
ALA A 312
GLY A 236
VAL A 282
 None
 1.03A 1d4sB-1musA:
undetectable		 1d4sB-1musA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA8_0
(GRAMICIDIN A)		 1mus TN5 TRANSPOSASE
(Escherichia
coli) 		3 / 4 VAL A 361
TRP A 450
TRP A  12
 None
EDO  A 483 (-4.5A)
None
 1.09A 1gmkA-1musA:
undetectable
1gmkB-1musA:
undetectable		 1gmkA-1musA:
4.17
1gmkB-1musA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_D_FUAD705_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1mus TN5 TRANSPOSASE
(Escherichia
coli) 		5 / 12 PHE A  17
SER A  19
LEU A  22
VAL A  69
ALA A  71
 None
 1.28A 1q23D-1musA:
0.8
1q23E-1musA:
0.0		 1q23D-1musA:
16.87
1q23E-1musA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_D_FUAD705_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1mus TN5 TRANSPOSASE
(Escherichia
coli) 		5 / 12 SER A  19
LEU A  22
VAL A  69
PHE A  63
ALA A  71
 None
 1.23A 1q23D-1musA:
0.8
1q23E-1musA:
0.0		 1q23D-1musA:
16.87
1q23E-1musA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1mus TN5 TRANSPOSASE
(Escherichia
coli) 		5 / 12 SER A  19
LEU A  22
VAL A  69
PHE A  63
ALA A  71
 None
 1.21A 1q23H-1musA:
0.0
1q23I-1musA:
0.9		 1q23H-1musA:
16.87
1q23I-1musA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 1mus TN5 TRANSPOSASE
(Escherichia
coli) 		5 / 10 VAL A  34
ILE A 355
PHE A  17
ALA A  77
VAL A  69
 None
 1.10A 3me6A-1musA:
0.0		 3me6A-1musA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		 1mus TN5 TRANSPOSASE
(Escherichia
coli) 		5 / 9 VAL A  34
ILE A 355
PHE A  17
ALA A  20
VAL A  69
 None
 1.24A 3me6C-1musA:
undetectable		 3me6C-1musA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		 1mus TN5 TRANSPOSASE
(Escherichia
coli) 		5 / 9 VAL A  34
ILE A 355
PHE A  17
ALA A  77
VAL A  69
 None
 1.12A 3me6C-1musA:
undetectable		 3me6C-1musA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		 1mus TN5 TRANSPOSASE
(Escherichia
coli) 		5 / 9 VAL A  34
ILE A 355
PHE A  17
ALA A  20
VAL A  69
 None
 1.15A 3me6D-1musA:
undetectable		 3me6D-1musA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		 1mus TN5 TRANSPOSASE
(Escherichia
coli) 		5 / 9 VAL A  34
ILE A 355
PHE A  17
ALA A  77
VAL A  69
 None
 1.26A 3me6D-1musA:
undetectable		 3me6D-1musA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 1mus TN5 TRANSPOSASE
(Escherichia
coli) 		5 / 12 HIS A   7
LEU A 366
LEU A 422
ALA A 430
ALA A 428
 None
 1.16A 3vw7A-1musA:
0.0		 3vw7A-1musA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1mus TN5 TRANSPOSASE
(Escherichia
coli) 		4 / 8 ILE A 429
GLY A 452
VAL A 396
SER A   4
 None
 0.79A 4acbB-1musA:
undetectable
4acbC-1musA:
undetectable		 4acbB-1musA:
21.76
4acbC-1musA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 1mus TN5 TRANSPOSASE
(Escherichia
coli) 		5 / 10 ARG A 431
ALA A 428
LEU A 432
GLY A 433
ALA A 465
 None
 1.20A 4fe1A-1musA:
0.0
4fe1J-1musA:
0.0		 4fe1A-1musA:
20.86
4fe1J-1musA:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 1mus TN5 TRANSPOSASE
(Escherichia
coli) 		5 / 10 ARG A 431
ALA A 428
LEU A 432
GLY A 433
ALA A 466
 None
 1.11A 4fe1A-1musA:
0.0
4fe1J-1musA:
0.0		 4fe1A-1musA:
20.86
4fe1J-1musA:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG1_A_ACTA504_0
(FAD:PROTEIN FMN
TRANSFERASE)		 1mus TN5 TRANSPOSASE
(Escherichia
coli) 		4 / 5 SER A 211
LYS A 212
ARG A 215
LEU A 301
 None
 1.13A 4ig1A-1musA:
0.5		 4ig1A-1musA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_1_PQN12001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 1mus TN5 TRANSPOSASE
(Escherichia
coli) 		5 / 11 ARG A 431
ALA A 428
LEU A 432
GLY A 433
ALA A 465
 None
 1.04A 4l6v1-1musA:
undetectable
4l6v6-1musA:
1.2		 4l6v1-1musA:
19.42
4l6v6-1musA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_1_PQN12001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 1mus TN5 TRANSPOSASE
(Escherichia
coli) 		5 / 11 ARG A 431
ALA A 428
LEU A 432
GLY A 433
ALA A 466
 None
 1.21A 4l6v1-1musA:
undetectable
4l6v6-1musA:
1.2		 4l6v1-1musA:
19.42
4l6v6-1musA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)		 1mus TN5 TRANSPOSASE
(Escherichia
coli) 		5 / 12 LEU A 356
LEU A  38
ALA A  60
ILE A  64
ILE A  46
 None
 1.12A 4o2bB-1musA:
undetectable		 4o2bB-1musA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 1mus TN5 TRANSPOSASE
(Escherichia
coli) 		3 / 3 ALA A 169
GLN A 198
GLY A 275
 None
 0.63A 4odoC-1musA:
0.3		 4odoC-1musA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P68_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1mus TN5 TRANSPOSASE
(Escherichia
coli) 		5 / 11 ILE A  74
SER A  49
ILE A  46
ILE A 355
THR A  28
 None
 1.48A 4p68A-1musA:
undetectable		 4p68A-1musA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		 1mus TN5 TRANSPOSASE
(Escherichia
coli) 		5 / 9 LEU A 309
LEU A 263
GLY A 236
LEU A 265
ALA A 284
 None
 0.92A 5dqfA-1musA:
undetectable		 5dqfA-1musA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1mus TN5 TRANSPOSASE
(Escherichia
coli) 		3 / 3 LYS A 273
LEU A 197
ILE A 270
 None
 0.82A 5kc4A-1musA:
1.0		 5kc4A-1musA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)		 1mus TN5 TRANSPOSASE
(Escherichia
coli) 		5 / 12 LEU A 356
LEU A  38
ALA A  60
ILE A  64
ILE A  46
 None
 1.06A 5mioB-1musA:
undetectable		 5mioB-1musA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_C_08JC602_1
(CYTOCHROME P450 3A4)		 1mus TN5 TRANSPOSASE
(Escherichia
coli) 		4 / 7 SER A 172
LEU A 143
ALA A  94
ILE A 325
 None
 0.89A 5te8C-1musA:
undetectable		 5te8C-1musA:
22.12