SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1muu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_A_FFOA1002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1muu GDP-MANNOSE
6-DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 342
GLY A 344
LEU A 338
VAL A 395
SER A 310
 None
 0.97A 1dfoA-1muuA:
2.7		 1dfoA-1muuA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_B_FFOB2002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1muu GDP-MANNOSE
6-DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 342
GLY A 344
LEU A 338
VAL A 395
SER A 310
 None
 0.97A 1dfoB-1muuA:
3.4		 1dfoB-1muuA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_C_FFOC3002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1muu GDP-MANNOSE
6-DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 342
GLY A 344
LEU A 338
VAL A 395
SER A 310
 None
 0.97A 1dfoC-1muuA:
2.8		 1dfoC-1muuA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1muu GDP-MANNOSE
6-DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 342
GLY A 344
LEU A 338
VAL A 395
SER A 310
 None
 0.98A 1dfoD-1muuA:
2.7		 1dfoD-1muuA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1muu GDP-MANNOSE
6-DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 342
GLY A 344
LEU A 338
VAL A 395
SER A 310
 None
 0.92A 1eqbA-1muuA:
2.7		 1eqbA-1muuA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1muu GDP-MANNOSE
6-DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 342
GLY A 344
LEU A 338
VAL A 395
SER A 310
 None
 0.92A 1eqbB-1muuA:
2.8		 1eqbB-1muuA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1muu GDP-MANNOSE
6-DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 342
GLY A 344
LEU A 338
VAL A 395
SER A 310
 None
 0.92A 1eqbC-1muuA:
2.8		 1eqbC-1muuA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1muu GDP-MANNOSE
6-DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 342
GLY A 344
LEU A 338
VAL A 395
SER A 310
 None
 0.93A 1eqbD-1muuA:
3.4		 1eqbD-1muuA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_2
(LIVER
CARBOXYLESTERASE I)		 1muu GDP-MANNOSE
6-DEHYDROGENASE
(Pseudomonas
aeruginosa) 		3 / 3 PHE A 223
LEU A 290
MET A 294
 None
 0.90A 1mx1D-1muuA:
undetectable		 1mx1D-1muuA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV5_A_65BA600_0
(REVERSE
TRANSCRIPTASE)		 1muu GDP-MANNOSE
6-DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 10 LEU A 276
VAL A 285
VAL A 234
PRO A 288
LEU A 290
 None
 1.35A 1sv5A-1muuA:
0.0		 1sv5A-1muuA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 1muu GDP-MANNOSE
6-DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 394
LEU A 330
SER A 333
VAL A 356
ILE A 373
 None
 1.04A 3frqB-1muuA:
undetectable		 3frqB-1muuA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 1muu GDP-MANNOSE
6-DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 9 TYR A 168
LEU A 187
MET A   1
PHE A  81
VAL A 120
 None
 1.48A 3jwqA-1muuA:
undetectable		 3jwqA-1muuA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 1muu GDP-MANNOSE
6-DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 8 GLY A 151
PHE A 150
ILE A  82
CYH A 103
 None
 0.88A 3ko0O-1muuA:
undetectable
3ko0Q-1muuA:
undetectable		 3ko0O-1muuA:
13.98
3ko0Q-1muuA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 1muu GDP-MANNOSE
6-DEHYDROGENASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 122
ASP A 169
GLN A  57
 None
 0.75A 3lcvB-1muuA:
3.0		 3lcvB-1muuA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_C_SAMC263_0
(NON-STRUCTURAL
PROTEIN 5)		 1muu GDP-MANNOSE
6-DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 147
GLY A 153
GLY A 151
GLU A 178
VAL A 125
 None
 0.86A 3p97C-1muuA:
3.1		 3p97C-1muuA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB323_0
(INVASIN IPAD)		 1muu GDP-MANNOSE
6-DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 7 ILE A   3
ILE A   5
LEU A  19
SER A  20
 None
 0.69A 3r9vA-1muuA:
undetectable
3r9vB-1muuA:
undetectable		 3r9vA-1muuA:
20.75
3r9vB-1muuA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1muu GDP-MANNOSE
6-DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 10 VAL A  11
PHE A  81
THR A 174
ILE A 176
TYR A 168
 NAD  A1001 (-3.8A)
None
None
None
None
 1.22A 3um5B-1muuA:
undetectable		 3um5B-1muuA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_D_QMRD301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1muu GDP-MANNOSE
6-DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 8 TYR A 168
CYH A  83
VAL A  79
ILE A   5
 None
 1.12A 4aftD-1muuA:
undetectable
4aftE-1muuA:
undetectable		 4aftD-1muuA:
21.00
4aftE-1muuA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_A_SAMA1263_0
(NON-STRUCTURAL
PROTEIN 5)		 1muu GDP-MANNOSE
6-DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 147
GLY A 153
GLY A 151
GLU A 178
VAL A 125
 None
 0.84A 4ctjA-1muuA:
2.9		 4ctjA-1muuA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_C_SAMC1263_0
(POLYPROTEIN)		 1muu GDP-MANNOSE
6-DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 147
GLY A 153
GLY A 151
GLU A 178
VAL A 125
 None
 0.87A 4ctkC-1muuA:
3.0		 4ctkC-1muuA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1muu GDP-MANNOSE
6-DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 8 LEU A 276
VAL A 285
VAL A 234
LEU A 290
 None
 1.02A 4q0bA-1muuA:
undetectable		 4q0bA-1muuA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_1
(PROTEASE)		 1muu GDP-MANNOSE
6-DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  12
ILE A  27
ILE A  82
VAL A  31
ILE A  99
 None
None
None
NAD  A1001 (-4.4A)
None
 1.01A 4q5mA-1muuA:
undetectable		 4q5mA-1muuA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_A_STRA604_1
(CYTOCHROME P450
21-HYDROXYLASE)		 1muu GDP-MANNOSE
6-DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A  29
SER A  77
VAL A 102
ILE A 106
LEU A  75
 None
None
NAD  A1001 (-4.4A)
None
None
 1.04A 4y8wA-1muuA:
undetectable		 4y8wA-1muuA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_A_GBMA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 1muu GDP-MANNOSE
6-DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 11 TYR A 191
LEU A  19
HIS A  24
ILE A   5
LEU A 186
 None
 1.33A 4yvpA-1muuA:
undetectable		 4yvpA-1muuA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 1muu GDP-MANNOSE
6-DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 TYR A 191
LEU A  19
HIS A  24
ILE A   5
LEU A 186
 None
 1.33A 4yvpB-1muuA:
undetectable		 4yvpB-1muuA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 1muu GDP-MANNOSE
6-DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 6 VAL A 241
LEU A 276
ILE A 230
ALA A 231
 None
 0.74A 4zf8A-1muuA:
0.0		 4zf8A-1muuA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)		 1muu GDP-MANNOSE
6-DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 6 TYR A 211
GLY A  92
SER A  88
LEU A  94
 None
 0.90A 5bphA-1muuA:
4.0		 5bphA-1muuA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_B_ACTB404_0
(D-ALANINE--D-ALANINE
LIGASE)		 1muu GDP-MANNOSE
6-DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 7 TYR A 211
GLY A  92
SER A  88
LEU A  94
 None
 0.92A 5bphB-1muuA:
4.3		 5bphB-1muuA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_C_ACTC403_0
(D-ALANINE--D-ALANINE
LIGASE)		 1muu GDP-MANNOSE
6-DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 4 TYR A 211
GLY A  92
SER A  88
LEU A  94
 None
 0.92A 5bphC-1muuA:
4.0		 5bphC-1muuA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_D_ACTD403_0
(D-ALANINE--D-ALANINE
LIGASE)		 1muu GDP-MANNOSE
6-DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 6 TYR A 211
GLY A  92
SER A  88
LEU A  94
 None
 0.93A 5bphD-1muuA:
4.0		 5bphD-1muuA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_O_BEZO801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1muu GDP-MANNOSE
6-DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 6 PHE A 305
SER A 310
HIS A 311
LEU A 307
 None
 0.98A 5dzka-1muuA:
2.9
5dzko-1muuA:
undetectable		 5dzka-1muuA:
18.88
5dzko-1muuA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1muu GDP-MANNOSE
6-DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 6 PHE A 305
SER A 310
HIS A 311
LEU A 307
 None
 0.90A 5dzkB-1muuA:
2.9
5dzkP-1muuA:
undetectable		 5dzkB-1muuA:
18.88
5dzkP-1muuA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1muu GDP-MANNOSE
6-DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 7 PHE A 305
SER A 310
HIS A 311
LEU A 307
 None
 1.06A 5dzkD-1muuA:
2.9
5dzkR-1muuA:
undetectable		 5dzkD-1muuA:
18.88
5dzkR-1muuA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1muu GDP-MANNOSE
6-DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 8 PHE A 305
SER A 310
HIS A 311
LEU A 307
 None
 1.10A 5dzkd-1muuA:
2.9
5dzkr-1muuA:
undetectable		 5dzkd-1muuA:
18.88
5dzkr-1muuA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1muu GDP-MANNOSE
6-DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 6 PHE A 305
SER A 310
HIS A 311
LEU A 307
 None
 0.93A 5dzke-1muuA:
2.9
5dzks-1muuA:
undetectable		 5dzke-1muuA:
18.88
5dzks-1muuA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1muu GDP-MANNOSE
6-DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 6 PHE A 305
SER A 310
HIS A 311
LEU A 307
 None
 0.94A 5dzkg-1muuA:
2.9
5dzku-1muuA:
undetectable		 5dzkg-1muuA:
18.88
5dzku-1muuA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 1muu GDP-MANNOSE
6-DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A  39
ARG A  59
LEU A  64
SER A  80
GLY A   7
 None
None
None
None
NAD  A1001 (-3.5A)
 1.13A 5l6eA-1muuA:
undetectable		 5l6eA-1muuA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)		 1muu GDP-MANNOSE
6-DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A  12
GLY A   9
ILE A   5
ALA A  13
GLY A  28
 None
NAD  A1001 (-3.1A)
None
None
None
 1.05A 6e5zA-1muuA:
5.4		 6e5zA-1muuA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 1muu GDP-MANNOSE
6-DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 7 ALA A  16
GLY A  17
LEU A  54
GLY A  62
 None
 0.72A 6nm4A-1muuA:
0.0		 6nm4A-1muuA:
19.25