SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1mw9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA999_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 1mw9 DNA TOPOISOMERASE I
(Escherichia
coli) 		6 / 12 VAL X   8
ILE X 142
ILE X 147
PHE X 139
VAL X  27
LEU X  21
 None
 1.22A 1qhsA-1mw9X:
undetectable		 1qhsA-1mw9X:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC439_0
(ADP-RIBOSYL CYCLASE)		 1mw9 DNA TOPOISOMERASE I
(Escherichia
coli) 		3 / 3 TRP X  79
PHE X 568
TRP X  76
 None
 1.41A 1r15C-1mw9X:
undetectable		 1r15C-1mw9X:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF469_0
(ADP-RIBOSYL CYCLASE)		 1mw9 DNA TOPOISOMERASE I
(Escherichia
coli) 		3 / 3 TRP X  79
PHE X 568
TRP X  76
 None
 1.40A 1r15F-1mw9X:
undetectable		 1r15F-1mw9X:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_G_NCAG479_0
(ADP-RIBOSYL CYCLASE)		 1mw9 DNA TOPOISOMERASE I
(Escherichia
coli) 		3 / 3 TRP X  79
PHE X 568
TRP X  76
 None
 1.41A 1r15G-1mw9X:
undetectable		 1r15G-1mw9X:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_H_NCAH489_0
(ADP-RIBOSYL CYCLASE)		 1mw9 DNA TOPOISOMERASE I
(Escherichia
coli) 		3 / 3 TRP X  79
PHE X 568
TRP X  76
 None
 1.39A 1r15H-1mw9X:
undetectable		 1r15H-1mw9X:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AW1_A_COXA264_1
(CARBONIC ANHYDRASE
II)		 1mw9 DNA TOPOISOMERASE I
(Escherichia
coli) 		5 / 12 VAL X 268
LEU X 413
VAL X 415
LEU X 234
THR X 226
 None
 0.83A 2aw1A-1mw9X:
0.0		 2aw1A-1mw9X:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2003_1
(SERUM ALBUMIN)		 1mw9 DNA TOPOISOMERASE I
(Escherichia
coli) 		5 / 9 LEU X 537
PHE X 571
LEU X 530
LEU X 183
ALA X 578
 None
 1.40A 2bxeA-1mw9X:
2.4		 2bxeA-1mw9X:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2002_1
(SERUM ALBUMIN)		 1mw9 DNA TOPOISOMERASE I
(Escherichia
coli) 		4 / 8 ARG X 168
ALA X 164
GLU X 547
VAL X 563
 None
 0.82A 2bxgA-1mw9X:
undetectable		 2bxgA-1mw9X:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GEH_A_NHYA300_1
(CARBONIC ANHYDRASE 2)		 1mw9 DNA TOPOISOMERASE I
(Escherichia
coli) 		4 / 8 VAL X 268
VAL X 415
LEU X 234
THR X 226
 None
 0.84A 2gehA-1mw9X:
undetectable		 2gehA-1mw9X:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1mw9 DNA TOPOISOMERASE I
(Escherichia
coli) 		5 / 12 LEU X 486
ALA X 200
ILE X 504
THR X 503
LEU X 537
 None
 1.10A 2jn3A-1mw9X:
undetectable		 2jn3A-1mw9X:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 1mw9 DNA TOPOISOMERASE I
(Escherichia
coli) 		3 / 3 LEU X  37
LEU X  67
PHE X 170
 None
 0.67A 2pgrA-1mw9X:
undetectable		 2pgrA-1mw9X:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 1mw9 DNA TOPOISOMERASE I
(Escherichia
coli) 		4 / 6 LEU X 234
THR X 226
ARG X 271
LEU X 422
 None
 0.89A 2wm3A-1mw9X:
3.3		 2wm3A-1mw9X:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1mw9 DNA TOPOISOMERASE I
(Escherichia
coli) 		4 / 8 GLY X 128
GLU X 125
ILE X 106
ALA X 100
 None
 0.83A 3aodA-1mw9X:
undetectable		 3aodA-1mw9X:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_3
(PHOSPHOLIPASE A2)		 1mw9 DNA TOPOISOMERASE I
(Escherichia
coli) 		3 / 3 PRO X 349
PHE X 343
LYS X 346
 None
 1.27A 3bjwG-1mw9X:
undetectable		 3bjwG-1mw9X:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1mw9 DNA TOPOISOMERASE I
(Escherichia
coli) 		4 / 8 LEU X 564
ARG X 169
GLY X 176
MET X 178
 None
 1.12A 3hcrA-1mw9X:
3.4		 3hcrA-1mw9X:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1mw9 DNA TOPOISOMERASE I
(Escherichia
coli) 		4 / 7 LEU X 564
ARG X 169
GLY X 176
MET X 178
 None
 1.01A 3hcrB-1mw9X:
5.5		 3hcrB-1mw9X:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		 1mw9 DNA TOPOISOMERASE I
(Escherichia
coli) 		5 / 12 MET X 538
GLU X 547
LEU X 486
ARG X 168
LEU X 203
 None
 1.14A 3hm1A-1mw9X:
undetectable		 3hm1A-1mw9X:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O01_B_DXCB1_0
(CELL INVASION
PROTEIN SIPD)		 1mw9 DNA TOPOISOMERASE I
(Escherichia
coli) 		5 / 9 ARG X 369
ILE X 394
ASN X 326
ALA X 367
LEU X 289
 None
 1.46A 3o01A-1mw9X:
1.3
3o01B-1mw9X:
0.0		 3o01A-1mw9X:
18.80
3o01B-1mw9X:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_A_478A200_1
(HIV-1 PROTEASE)		 1mw9 DNA TOPOISOMERASE I
(Escherichia
coli) 		4 / 6 GLU X  63
PRO X  75
ARG X  64
GLY X  65
 None
 1.45A 3oxvA-1mw9X:
undetectable		 3oxvA-1mw9X:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG306_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1mw9 DNA TOPOISOMERASE I
(Escherichia
coli) 		3 / 3 ARG X 136
ARG X 365
ASP X 113
 None
None
SO4  X2009 (-4.5A)
 1.01A 3wipG-1mw9X:
undetectable
3wipH-1mw9X:
undetectable		 3wipG-1mw9X:
18.58
3wipH-1mw9X:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 1mw9 DNA TOPOISOMERASE I
(Escherichia
coli) 		4 / 8 LEU X  86
TYR X  83
GLU X  84
HIS X 122
 None
 1.37A 3zmdA-1mw9X:
6.0
3zmdB-1mw9X:
6.3		 3zmdA-1mw9X:
16.02
3zmdB-1mw9X:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_C_ESTC600_1
(ESTROGEN RECEPTOR
BETA)		 1mw9 DNA TOPOISOMERASE I
(Escherichia
coli) 		5 / 12 GLU X 547
ARG X 168
ILE X 504
ILE X 501
LEU X 203
 None
 1.31A 4j24C-1mw9X:
0.9		 4j24C-1mw9X:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 1mw9 DNA TOPOISOMERASE I
(Escherichia
coli) 		5 / 12 GLU X 547
ARG X 168
ILE X 504
ILE X 501
LEU X 203
 None
 1.26A 4j26B-1mw9X:
1.3		 4j26B-1mw9X:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 1mw9 DNA TOPOISOMERASE I
(Escherichia
coli) 		5 / 8 LYS X 423
ALA X 424
GLY X 426
LEU X 450
LEU X 234
 None
 1.41A 4po0A-1mw9X:
undetectable		 4po0A-1mw9X:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_B_ACTB403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1mw9 DNA TOPOISOMERASE I
(Escherichia
coli) 		3 / 3 ARG X 448
ASP X 447
ARG X 427
 None
 0.69A 4wq4B-1mw9X:
undetectable		 4wq4B-1mw9X:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1mw9 DNA TOPOISOMERASE I
(Escherichia
coli) 		4 / 4 GLY X 315
LEU X 289
PHE X 284
ILE X 394
 None
 0.95A 4xv2A-1mw9X:
undetectable		 4xv2A-1mw9X:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 1mw9 DNA TOPOISOMERASE I
(Escherichia
coli) 		3 / 3 ARG X 493
ASN X 548
ASP X 541
 None
 0.78A 5gwxA-1mw9X:
undetectable		 5gwxA-1mw9X:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1mw9 DNA TOPOISOMERASE I
(Escherichia
coli) 		5 / 12 VAL X 510
ALA X 200
VAL X 204
GLY X 492
THR X 496
 None
 1.25A 5igiA-1mw9X:
undetectable		 5igiA-1mw9X:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_D_CCSD14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 1mw9 DNA TOPOISOMERASE I
(Escherichia
coli) 		5 / 12 GLY X 298
GLU X 479
GLY X 300
VAL X 301
THR X 304
 None
 1.22A 5o4yD-1mw9X:
undetectable
5o4yE-1mw9X:
undetectable		 5o4yD-1mw9X:
3.39
5o4yE-1mw9X:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1mw9 DNA TOPOISOMERASE I
(Escherichia
coli) 		4 / 8 ALA X  12
GLU X 313
ILE X 142
ILE X 147
 None
 0.95A 5t8sA-1mw9X:
undetectable		 5t8sA-1mw9X:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_F_EZLF302_1
(ALPHA-CARBONIC
ANHYDRASE)		 1mw9 DNA TOPOISOMERASE I
(Escherichia
coli) 		4 / 8 VAL X 268
VAL X 415
LEU X 234
THR X 226
 None
 0.74A 5tt3F-1mw9X:
undetectable		 5tt3F-1mw9X:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECF_I_DVAI3010_0
(VLM2
DODECADEPSIPEPTIDE)		 1mw9 DNA TOPOISOMERASE I
(Escherichia
coli) 		3 / 3 PHE X 284
ARG X 296
ALA X 400
 None
 0.96A 6ecfB-1mw9X:
3.8		 6ecfB-1mw9X:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_ACTA405_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 1mw9 DNA TOPOISOMERASE I
(Escherichia
coli) 		4 / 6 THR X 543
ARG X 195
GLN X 197
ILE X 491
 None
 1.41A 6ef6A-1mw9X:
undetectable		 6ef6A-1mw9X:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 1mw9 DNA TOPOISOMERASE I
(Escherichia
coli) 		5 / 11 ILE X 394
ALA X 400
GLY X 281
PHE X 284
ALA X 292
 None
 1.13A 6ieyA-1mw9X:
2.9
6ieyB-1mw9X:
3.0		 6ieyA-1mw9X:
19.77
6ieyB-1mw9X:
19.77