SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1mwo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_B_QPSB1501_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		6 / 12 TYR A  62
ARG A 196
ASP A 198
GLU A 222
HIS A 288
ASP A 289
 None
ZN  A 441 ( 4.8A)
ZN  A 441 ( 4.2A)
ZN  A 441 (-2.0A)
None
ZN  A 441 (-4.0A)
 0.64A 1dedB-1mwoA:
28.9		 1dedB-1mwoA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		5 / 10 LEU A  70
SER A  51
LEU A  47
ALA A 105
ILE A  93
 None
 1.24A 1g5yC-1mwoA:
undetectable		 1g5yC-1mwoA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		5 / 12 TRP A  18
HIS A 111
GLY A 161
GLU A 222
ASP A 289
 None
None
None
ZN  A 441 (-2.0A)
ZN  A 441 (-4.0A)
 0.74A 1kxhA-1mwoA:
30.4		 1kxhA-1mwoA:
22.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		9 / 9 GLY A   9
LYS A 241
PRO A 278
GLU A 307
GLY A 308
GLY A 338
GLY A 339
ASP A 358
ARG A 361
 None
 0.20A 1mxdA-1mwoA:
67.0		 1mxdA-1mwoA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		6 / 9 GLY A   9
LYS A 241
PRO A 278
GLY A 308
GLY A 339
ASP A 358
 None
 1.12A 1mxdA-1mwoA:
67.0		 1mxdA-1mwoA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		5 / 9 GLY A  10
GLY A 338
GLY A 339
ASP A 358
ARG A 361
 None
 0.74A 1mxdA-1mwoA:
67.0		 1mxdA-1mwoA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		6 / 9 LYS A 241
PRO A 278
GLU A 307
GLY A 308
GLY A 338
ASP A 358
 None
 1.22A 1mxdA-1mwoA:
67.0		 1mxdA-1mwoA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		6 / 6 SER A 132
THR A 140
ASN A 142
LEU A 144
ASP A 145
TRP A 171
 None
 0.21A 1mxdA-1mwoA:
67.0		 1mxdA-1mwoA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MXD_A_ACRA734_1
(ALPHA AMYLASE)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		6 / 6 ASN A 328
TRP A 331
HIS A 390
TYR A 392
GLY A 394
TRP A 399
 None
 0.27A 1mxdA-1mwoA:
67.0		 1mxdA-1mwoA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MXD_A_ACRA735_1
(ALPHA AMYLASE)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		12 / 12 TRP A  18
TYR A  62
HIS A 111
PHE A 159
ARG A 196
ASP A 198
TYR A 199
LYS A 201
GLU A 222
TRP A 224
HIS A 288
ASP A 289
 None
None
None
None
ZN  A 441 ( 4.8A)
ZN  A 441 ( 4.2A)
None
None
ZN  A 441 (-2.0A)
None
None
ZN  A 441 (-4.0A)
 0.17A 1mxdA-1mwoA:
67.0		 1mxdA-1mwoA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		11 / 11 GLY A   9
LYS A 241
PRO A 278
PHE A 279
GLU A 307
GLY A 308
GLN A 309
GLY A 338
GLY A 339
ASP A 358
ARG A 361
 None
 0.27A 1mxgA-1mwoA:
66.0		 1mxgA-1mwoA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		8 / 11 GLY A   9
LYS A 241
PRO A 278
PHE A 279
GLY A 308
GLN A 309
GLY A 339
ASP A 358
 None
 1.00A 1mxgA-1mwoA:
66.0		 1mxgA-1mwoA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		6 / 11 GLY A  10
GLN A 309
GLY A 338
GLY A 339
ASP A 358
ARG A 361
 None
 1.08A 1mxgA-1mwoA:
66.0		 1mxgA-1mwoA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		6 / 11 LYS A 241
PRO A 278
GLU A 307
GLY A 308
GLY A 338
ASP A 358
 None
 1.21A 1mxgA-1mwoA:
66.0		 1mxgA-1mwoA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		8 / 8 SER A 132
THR A 140
ASN A 142
LEU A 144
ASP A 145
GLU A 150
LYS A 169
TRP A 171
 None
 0.52A 1mxgA-1mwoA:
66.0		 1mxgA-1mwoA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		7 / 7 TYR A   3
ASN A 328
TRP A 331
HIS A 390
TYR A 392
GLY A 394
TRP A 399
 None
 0.30A 1mxgA-1mwoA:
66.0		 1mxgA-1mwoA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		3 / 3 SER A 136
GLY A 137
ARG A 112
 None
 0.45A 1t9wA-1mwoA:
0.0		 1t9wA-1mwoA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1435_1
(CHITINASE)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		3 / 3 TRP A  37
GLU A 318
TYR A 314
 None
ZN  A 438 (-2.0A)
None
 0.88A 2a3aA-1mwoA:
5.6		 2a3aA-1mwoA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		4 / 8 ILE A 303
LEU A 329
ILE A 330
HIS A 333
 None
 0.87A 2azxA-1mwoA:
undetectable		 2azxA-1mwoA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OWC_A_ACRA600_1
(4-ALPHA-GLUCANOTRANS
FERASE)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		5 / 11 TYR A  62
ASP A 198
HIS A 288
ASP A 289
TRP A  18
 None
ZN  A 441 ( 4.2A)
None
ZN  A 441 (-4.0A)
None
 0.94A 2owcA-1mwoA:
17.6		 2owcA-1mwoA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OWW_A_ACRA600_1
(4-ALPHA-GLUCANOTRANS
FERASE)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		5 / 11 TYR A  62
ASP A 198
HIS A 288
ASP A 289
TRP A  18
 None
ZN  A 441 ( 4.2A)
None
ZN  A 441 (-4.0A)
None
 0.96A 2owwA-1mwoA:
17.5		 2owwA-1mwoA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		4 / 8 SER A 430
PHE A 384
VAL A 404
TYR A 392
 None
 1.25A 2wekA-1mwoA:
undetectable		 2wekA-1mwoA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		4 / 8 SER A 430
PHE A 384
VAL A 404
TYR A 392
 None
 1.26A 2wekB-1mwoA:
undetectable		 2wekB-1mwoA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		4 / 5 SER A 430
PHE A 384
VAL A 404
TYR A 392
 None
 1.13A 2x7hA-1mwoA:
undetectable		 2x7hA-1mwoA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		4 / 5 SER A 430
PHE A 384
VAL A 404
TYR A 392
 None
 1.09A 2x7hB-1mwoA:
undetectable		 2x7hB-1mwoA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		4 / 6 ILE A  30
ILE A 327
LEU A  47
MET A  13
 None
 0.99A 3adsA-1mwoA:
0.0		 3adsA-1mwoA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		4 / 7 ILE A  30
ILE A 327
LEU A  47
MET A  13
 None
 0.98A 3adxA-1mwoA:
undetectable		 3adxA-1mwoA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		4 / 7 GLY A 157
HIS A 167
HIS A 168
HIS A 147
 CA  A 442 (-4.3A)
None
ZN  A 436 ( 4.9A)
ZN  A 436 (-3.2A)
 1.12A 3ai8A-1mwoA:
undetectable		 3ai8A-1mwoA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_1
(GLUCOSYLTRANSFERASE-
SI)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		5 / 12 ARG A 196
ASP A 198
GLU A 222
HIS A 288
ASP A 289
 ZN  A 441 ( 4.8A)
ZN  A 441 ( 4.2A)
ZN  A 441 (-2.0A)
None
ZN  A 441 (-4.0A)
 0.67A 3aicA-1mwoA:
10.8		 3aicA-1mwoA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_1
(GLUCOSYLTRANSFERASE-
SI)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		5 / 12 ARG A 196
ASP A 198
GLU A 222
HIS A 288
ASP A 289
 ZN  A 441 ( 4.8A)
ZN  A 441 ( 4.2A)
ZN  A 441 (-2.0A)
None
ZN  A 441 (-4.0A)
 0.62A 3aicB-1mwoA:
9.4		 3aicB-1mwoA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_C_ACRC5044_1
(GLUCOSYLTRANSFERASE-
SI)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		6 / 12 ARG A 196
ASP A 198
GLU A 222
HIS A 288
ASP A 289
TYR A  62
 ZN  A 441 ( 4.8A)
ZN  A 441 ( 4.2A)
ZN  A 441 (-2.0A)
None
ZN  A 441 (-4.0A)
None
 0.63A 3aicC-1mwoA:
10.9		 3aicC-1mwoA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_D_ACRD5044_1
(GLUCOSYLTRANSFERASE-
SI)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		5 / 12 ARG A 196
ASP A 198
GLU A 222
HIS A 288
ASP A 289
 ZN  A 441 ( 4.8A)
ZN  A 441 ( 4.2A)
ZN  A 441 (-2.0A)
None
ZN  A 441 (-4.0A)
 0.73A 3aicD-1mwoA:
10.9		 3aicD-1mwoA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_1
(GLUCOSYLTRANSFERASE-
SI)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		5 / 12 ARG A 196
ASP A 198
GLU A 222
HIS A 288
ASP A 289
 ZN  A 441 ( 4.8A)
ZN  A 441 ( 4.2A)
ZN  A 441 (-2.0A)
None
ZN  A 441 (-4.0A)
 0.68A 3aicE-1mwoA:
10.9		 3aicE-1mwoA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_1
(GLUCOSYLTRANSFERASE-
SI)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		5 / 12 ARG A 196
ASP A 198
GLU A 222
HIS A 288
ASP A 289
 ZN  A 441 ( 4.8A)
ZN  A 441 ( 4.2A)
ZN  A 441 (-2.0A)
None
ZN  A 441 (-4.0A)
 0.64A 3aicF-1mwoA:
10.8		 3aicF-1mwoA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_1
(GLUCOSYLTRANSFERASE-
SI)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		5 / 12 ARG A 196
ASP A 198
GLU A 222
HIS A 288
ASP A 289
 ZN  A 441 ( 4.8A)
ZN  A 441 ( 4.2A)
ZN  A 441 (-2.0A)
None
ZN  A 441 (-4.0A)
 0.64A 3aicG-1mwoA:
10.9		 3aicG-1mwoA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_1
(GLUCOSYLTRANSFERASE-
SI)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		5 / 12 ARG A 196
ASP A 198
GLU A 222
HIS A 288
ASP A 289
 ZN  A 441 ( 4.8A)
ZN  A 441 ( 4.2A)
ZN  A 441 (-2.0A)
None
ZN  A 441 (-4.0A)
 0.72A 3aicH-1mwoA:
10.9		 3aicH-1mwoA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		3 / 3 GLY A 363
GLY A 339
GLY A 357
 None
 0.41A 3bogC-1mwoA:
undetectable		 3bogC-1mwoA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		3 / 3 GLY A 363
GLY A 339
GLY A 357
 None
 0.40A 3bogD-1mwoA:
undetectable		 3bogD-1mwoA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		4 / 8 GLY A  23
GLY A  24
GLY A  84
THR A  78
 None
 0.70A 3d41A-1mwoA:
undetectable		 3d41A-1mwoA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		3 / 3 GLU A 181
SER A 136
VAL A 134
 None
 0.83A 3eeoA-1mwoA:
undetectable		 3eeoA-1mwoA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		5 / 10 VAL A 200
VAL A 208
LEU A 212
TRP A 211
GLY A 221
 None
 1.29A 3ls4H-1mwoA:
undetectable		 3ls4H-1mwoA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		4 / 6 PHE A 353
VAL A 274
THR A 283
PHE A 302
 None
 1.34A 3ltwA-1mwoA:
undetectable		 3ltwA-1mwoA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_B_SAMB6735_0
(N-LYSINE
METHYLTRANSFERASE
SETD6
TRANSCRIPTION FACTOR
P65)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		5 / 11 VAL A 375
ALA A 414
TYR A 423
ALA A 301
ASN A 369
 None
 1.34A 3qxyB-1mwoA:
undetectable
3qxyQ-1mwoA:
undetectable		 3qxyB-1mwoA:
20.32
3qxyQ-1mwoA:
6.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_1
(HIV-1 PROTEASE)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		5 / 11 GLY A 338
VAL A  11
GLY A  10
GLY A   9
THR A 283
 None
 0.70A 3ufnA-1mwoA:
undetectable		 3ufnA-1mwoA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_B_DVAB8_0
(VAL-GRAMICIDIN A)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		3 / 3 TRP A 195
VAL A 220
TRP A 211
 None
 1.27A 3zq8A-1mwoA:
undetectable
3zq8B-1mwoA:
undetectable		 3zq8A-1mwoA:
5.71
3zq8B-1mwoA:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_B_DVAB8_0
(VAL-GRAMICIDIN A)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		3 / 3 TRP A 214
VAL A 208
TRP A 215
 None
 1.42A 3zq8A-1mwoA:
undetectable
3zq8B-1mwoA:
undetectable		 3zq8A-1mwoA:
5.71
3zq8B-1mwoA:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_B_DVAB8_0
(VAL-GRAMICIDIN A)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		3 / 3 TRP A 215
VAL A 207
TRP A 214
 None
 1.26A 3zq8A-1mwoA:
undetectable
3zq8B-1mwoA:
undetectable		 3zq8A-1mwoA:
5.71
3zq8B-1mwoA:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_B_DVAB8_0
(VAL-GRAMICIDIN A)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		3 / 3 TRP A 215
VAL A 208
TRP A 214
 None
 1.43A 3zq8A-1mwoA:
undetectable
3zq8B-1mwoA:
undetectable		 3zq8A-1mwoA:
5.71
3zq8B-1mwoA:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_D_DVAD8_0
(VAL-GRAMICIDIN A)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		3 / 3 TRP A 214
VAL A 208
TRP A 177
 None
 1.06A 3zq8C-1mwoA:
undetectable
3zq8D-1mwoA:
undetectable		 3zq8C-1mwoA:
5.71
3zq8D-1mwoA:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		5 / 8 ILE A 165
ASP A 145
PHE A 131
SER A  55
GLY A 114
 None
 1.13A 4ac9C-1mwoA:
2.6		 4ac9C-1mwoA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		5 / 8 ILE A 165
ASP A 145
PHE A 131
SER A  55
GLY A 114
 None
 1.12A 4acbC-1mwoA:
2.3		 4acbC-1mwoA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1490_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		3 / 3 GLU A  72
TYR A  73
SER A 136
 None
 0.73A 4at0A-1mwoA:
undetectable		 4at0A-1mwoA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD302_0
(GLUTATHIONE
TRANSFERASE GTE1)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		3 / 3 TYR A  67
PHE A 146
ARG A 112
 None
 1.14A 4g19D-1mwoA:
0.0		 4g19D-1mwoA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		5 / 10 ALA A   1
ILE A 101
GLY A   9
LEU A   6
ASP A 193
 None
 1.45A 5ajqB-1mwoA:
undetectable		 5ajqB-1mwoA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_1
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		5 / 12 ARG A 196
ASP A 198
GLU A 222
HIS A 288
ASP A 289
 ZN  A 441 ( 4.8A)
ZN  A 441 ( 4.2A)
ZN  A 441 (-2.0A)
None
ZN  A 441 (-4.0A)
 0.51A 5csyB-1mwoA:
5.4		 5csyB-1mwoA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_2
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		4 / 5 TYR A 306
PHE A 279
HIS A 333
PRO A 278
 None
 1.14A 5csyB-1mwoA:
5.4		 5csyB-1mwoA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		5 / 12 LEU A   6
LEU A  89
PHE A 192
ILE A  93
HIS A  97
 None
 1.36A 5dv4A-1mwoA:
undetectable		 5dv4A-1mwoA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		4 / 5 ILE A  30
ILE A 101
HIS A  97
VAL A 103
 None
 0.84A 5jmnA-1mwoA:
0.0		 5jmnA-1mwoA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA610_0
(ALPHA-AMYLASE)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		7 / 12 TRP A  18
TYR A  62
HIS A 111
ASP A 198
LYS A 201
HIS A 288
ASP A 289
 None
None
None
ZN  A 441 ( 4.2A)
None
None
ZN  A 441 (-4.0A)
 0.61A 6ag0A-1mwoA:
39.6		 6ag0A-1mwoA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_0
(ALPHA-AMYLASE)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		5 / 12 TRP A  18
ASP A 198
LYS A 201
HIS A 288
ASP A 289
 None
ZN  A 441 ( 4.2A)
None
None
ZN  A 441 (-4.0A)
 0.59A 6ag0C-1mwoA:
39.6		 6ag0C-1mwoA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_0
(ALPHA-AMYLASE)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		5 / 12 TRP A  18
ASP A 198
TYR A 249
HIS A 288
ASP A 289
 None
ZN  A 441 ( 4.2A)
None
None
ZN  A 441 (-4.0A)
 0.77A 6ag0C-1mwoA:
39.6		 6ag0C-1mwoA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		5 / 9 SER A 189
GLY A 191
ILE A 190
PHE A 192
PHE A  68
 None
 1.34A 6ebpA-1mwoA:
0.0		 6ebpA-1mwoA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_2
(-)		 1mwo ALPHA AMYLASE
(Pyrococcus
woesei) 		5 / 9 THR A 158
GLY A 157
GLY A 202
HIS A 167
VAL A 207
 None
CA  A 442 (-4.3A)
CA  A 442 (-4.0A)
None
None
 1.14A 6gnfA-1mwoA:
undetectable		 6gnfA-1mwoA:
19.54