SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1mx3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A28_B_STRB2_1
(PROGESTERONE
RECEPTOR)		 1mx3 C-TERMINAL BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 223
LEU A 226
LEU A 201
LEU A 235
THR A 251
 None
 1.24A 1a28B-1mx3A:
undetectable		 1a28B-1mx3A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 1mx3 C-TERMINAL BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 9 ILE A 339
VAL A  30
GLY A  72
ALA A  49
LEU A  45
 None
 1.11A 1e7bA-1mx3A:
undetectable		 1e7bA-1mx3A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZUC_B_T98B202_1
(PROGESTERONE
RECEPTOR)		 1mx3 C-TERMINAL BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 223
LEU A 226
LEU A 177
LEU A 235
THR A 251
 None
 1.01A 1zucB-1mx3A:
undetectable		 1zucB-1mx3A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZUC_B_T98B202_1
(PROGESTERONE
RECEPTOR)		 1mx3 C-TERMINAL BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 223
LEU A 226
LEU A 201
LEU A 235
THR A 251
 None
 1.14A 1zucB-1mx3A:
undetectable		 1zucB-1mx3A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		 1mx3 C-TERMINAL BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 8 ARG A 192
LEU A 139
VAL A 262
VAL A 189
 None
 0.99A 2bdmA-1mx3A:
undetectable		 2bdmA-1mx3A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 1mx3 C-TERMINAL BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 11 THR A 132
ILE A 136
ILE A 179
ALA A 190
ALA A 193
 None
 1.20A 2qhfA-1mx3A:
undetectable		 2qhfA-1mx3A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1mx3 C-TERMINAL BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 11 ALA A 123
SER A 124
GLY A  99
ILE A  98
VAL A  40
 None
None
ACY  A4000 ( 3.8A)
None
None
 1.31A 2uxpB-1mx3A:
0.0		 2uxpB-1mx3A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1mx3 C-TERMINAL BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 310
GLU A 272
VAL A 270
ILE A 284
ARG A 283
 None
 1.18A 3datA-1mx3A:
undetectable		 3datA-1mx3A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 1mx3 C-TERMINAL BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 9 ILE A  95
ILE A 115
ALA A  91
LEU A  92
LEU A  81
 None
 1.10A 3ozvB-1mx3A:
2.9		 3ozvB-1mx3A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 1mx3 C-TERMINAL BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 6 ARG A 337
ILE A 339
VAL A  48
LEU A  45
 None
 0.92A 4em2A-1mx3A:
0.2		 4em2A-1mx3A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1mx3 C-TERMINAL BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 7 GLY A 267
GLY A 268
ASN A 243
GLU A 295
 None
None
NAD  A1000 (-4.2A)
None
 0.81A 4fgkB-1mx3A:
4.9		 4fgkB-1mx3A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 1mx3 C-TERMINAL BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ALA A 265
LEU A 223
LEU A 227
ILE A 247
THR A 264
 NAD  A1000 (-3.9A)
None
None
None
None
 0.83A 4m2xC-1mx3A:
4.4		 4m2xC-1mx3A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 1mx3 C-TERMINAL BINDING
PROTEIN 1
(Homo
sapiens) 		3 / 3 SER A 324
MET A 327
ASP A 130
 None
 0.91A 4mm4B-1mx3A:
0.0		 4mm4B-1mx3A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 1mx3 C-TERMINAL BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 CYH A 232
LEU A 217
LEU A 226
LEU A 227
ALA A 259
 None
 1.35A 4rtbA-1mx3A:
undetectable		 4rtbA-1mx3A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)		 1mx3 C-TERMINAL BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 6 LEU A  32
ILE A  62
HIS A  63
PRO A  28
 None
 0.99A 4xi3C-1mx3A:
undetectable		 4xi3C-1mx3A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1mx3 C-TERMINAL BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 6 THR A 132
ALA A 129
THR A 128
HIS A 236
 None
None
NAD  A1000 (-3.4A)
None
 1.00A 5ecoA-1mx3A:
2.5		 5ecoA-1mx3A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 1mx3 C-TERMINAL BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 8 ILE A 115
LEU A  92
ILE A  95
ILE A 105
 None
 0.68A 5numA-1mx3A:
undetectable		 5numA-1mx3A:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 1mx3 C-TERMINAL BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A 284
ASP A 271
LEU A 139
PHE A 299
GLY A 302
 None
 1.06A 5uxdB-1mx3A:
0.0		 5uxdB-1mx3A:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W3J_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1mx3 C-TERMINAL BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 8 VAL A 270
ASP A 271
GLU A 272
LEU A 279
 None
 0.85A 5w3jB-1mx3A:
undetectable		 5w3jB-1mx3A:
22.65