SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1mxs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))		 1mxs KDPG ALDOLASE
(Pseudomonas
putida) 		5 / 8 ARG A  76
LEU A  79
GLY A  65
ILE A  35
VAL A  81
 None
 1.30A 1d4sB-1mxsA:
undetectable		 1d4sB-1mxsA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)		 1mxs KDPG ALDOLASE
(Pseudomonas
putida) 		5 / 12 LEU A  42
VAL A  81
LEU A  56
ILE A  33
ILE A  35
 None
 1.19A 2gj5A-1mxsA:
undetectable		 2gj5A-1mxsA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 1mxs KDPG ALDOLASE
(Pseudomonas
putida) 		4 / 5 ILE A 112
PRO A 125
VAL A  71
PHE A 102
 None
 1.16A 2ygnA-1mxsA:
undetectable		 2ygnA-1mxsA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 1mxs KDPG ALDOLASE
(Pseudomonas
putida) 		4 / 5 ALA A 100
GLN A 101
ILE A 121
ARG A  19
 None
 1.44A 2z0aA-1mxsA:
undetectable		 2z0aA-1mxsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 1mxs KDPG ALDOLASE
(Pseudomonas
putida) 		4 / 5 LEU A  66
ALA A  97
VAL A 103
ILE A 121
 None
 0.99A 4xe3A-1mxsA:
undetectable		 4xe3A-1mxsA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)		 1mxs KDPG ALDOLASE
(Pseudomonas
putida) 		5 / 8 VAL A 117
GLY A 136
ALA A 138
GLY A 140
MET A  13
 None
 1.43A 4zjzB-1mxsA:
undetectable		 4zjzB-1mxsA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 1mxs KDPG ALDOLASE
(Pseudomonas
putida) 		4 / 5 ALA A 100
ALA A  83
ILE A  69
LEU A  66
 None
 0.53A 5jncD-1mxsA:
0.0		 5jncD-1mxsA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1mxs KDPG ALDOLASE
(Pseudomonas
putida) 		4 / 8 ARG A 143
ILE A 108
LEU A 123
GLY A 116
 None
 0.86A 5nooD-1mxsA:
undetectable		 5nooD-1mxsA:
20.50