SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1mzh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1mzh DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Aquifex
aeolicus) 		4 / 8 GLY A 306
ALA A 290
THR A 303
ILE A 108
 None
 0.82A 1gtnP-1mzhA:
undetectable
1gtnQ-1mzhA:
undetectable		 1gtnP-1mzhA:
19.53
1gtnQ-1mzhA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ILQ_C_ACAC7_1
(INTERLEUKIN-8
PRECURSOR
INTERLEUKIN-8
RECEPTOR A)		 1mzh DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Aquifex
aeolicus) 		4 / 6 HIS A 317
PHE A 313
ASP A 103
MET A 101
 None
 0.92A 1ilqA-1mzhA:
0.1
1ilqC-1mzhA:
undetectable		 1ilqA-1mzhA:
17.22
1ilqC-1mzhA:
4.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_3
(POL POLYPROTEIN)		 1mzh DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Aquifex
aeolicus) 		5 / 12 GLY A 297
ASP A 299
ILE A 276
GLY A 274
ILE A 268
 None
 1.15A 2avsB-1mzhA:
undetectable		 2avsB-1mzhA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 1mzh DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Aquifex
aeolicus) 		4 / 7 ILE A 108
ARG A 300
ASP A 188
GLU A 186
 None
 0.97A 2qebA-1mzhA:
undetectable		 2qebA-1mzhA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 1mzh DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Aquifex
aeolicus) 		4 / 7 ILE A 108
ARG A 300
ASP A 188
GLU A 186
 None
 0.92A 2qebB-1mzhA:
undetectable		 2qebB-1mzhA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 1mzh DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Aquifex
aeolicus) 		4 / 8 SER A 129
ILE A 122
ASN A 110
VAL A 137
 None
 0.70A 3dcjB-1mzhA:
undetectable		 3dcjB-1mzhA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_1
(PROTEASE)		 1mzh DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Aquifex
aeolicus) 		5 / 8 LEU A 267
ALA A 272
VAL A 278
ILE A 240
ILE A 268
 None
 1.23A 3ekpA-1mzhA:
undetectable		 3ekpA-1mzhA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1mzh DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Aquifex
aeolicus) 		6 / 12 GLY A 133
ASP A 103
ILE A 284
GLY A 306
ALA A 310
ALA A 290
 None
 1.26A 3sudC-1mzhA:
undetectable		 3sudC-1mzhA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V7P_A_BEZA430_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 1mzh DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Aquifex
aeolicus) 		4 / 7 GLY A 282
SER A 281
SER A 252
PHE A 162
 None
 0.77A 3v7pA-1mzhA:
6.1		 3v7pA-1mzhA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1mzh DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Aquifex
aeolicus) 		5 / 9 ALA A 184
ALA A 179
ALA A 176
ALA A 218
SER A 217
 None
 1.10A 4twdA-1mzhA:
0.0
4twdB-1mzhA:
0.0
4twdC-1mzhA:
0.0
4twdD-1mzhA:
0.0
4twdE-1mzhA:
0.0		 4twdA-1mzhA:
20.57
4twdB-1mzhA:
20.57
4twdC-1mzhA:
20.57
4twdD-1mzhA:
20.57
4twdE-1mzhA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1mzh DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Aquifex
aeolicus) 		5 / 8 ILE A 276
VAL A 104
ILE A 284
ILE A 309
ASP A 109
 None
 1.34A 5hi2A-1mzhA:
undetectable		 5hi2A-1mzhA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_A_IPHA101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 1mzh DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Aquifex
aeolicus) 		4 / 5 CYH A 138
CYH A 157
HIS A 143
LEU A 113
 None
 1.40A 5hrqA-1mzhA:
undetectable
5hrqB-1mzhA:
undetectable
5hrqF-1mzhA:
undetectable		 5hrqA-1mzhA:
6.74
5hrqB-1mzhA:
13.94
5hrqF-1mzhA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 1mzh DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Aquifex
aeolicus) 		4 / 6 CYH A 138
CYH A 157
HIS A 143
LEU A 113
 None
 1.40A 5hrqD-1mzhA:
undetectable
5hrqG-1mzhA:
undetectable
5hrqH-1mzhA:
undetectable		 5hrqD-1mzhA:
13.94
5hrqG-1mzhA:
6.74
5hrqH-1mzhA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_K_IPHK101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 1mzh DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Aquifex
aeolicus) 		4 / 6 CYH A 138
CYH A 157
HIS A 143
LEU A 113
 None
 1.42A 5hrqH-1mzhA:
undetectable
5hrqK-1mzhA:
undetectable
5hrqL-1mzhA:
undetectable		 5hrqH-1mzhA:
13.94
5hrqK-1mzhA:
6.74
5hrqL-1mzhA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_2
(-)		 1mzh DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Aquifex
aeolicus) 		4 / 5 THR A 169
THR A 215
HIS A 220
GLY A 161
 None
 1.17A 6gbnC-1mzhA:
2.8		 6gbnC-1mzhA:
21.38