SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1mzj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 1mzj BETA-KETOACYLSYNTHAS
E III
(Streptomyces
sp.
R1128) 		6 / 12 ALA A 313
GLY A 182
GLY A 310
GLY A 311
LEU A  15
PHE A  11
 None
 1.23A 1eizA-1mzjA:
undetectable		 1eizA-1mzjA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)		 1mzj BETA-KETOACYLSYNTHAS
E III
(Streptomyces
sp.
R1128) 		5 / 12 ALA A 313
GLY A 182
GLY A 310
GLY A 311
PHE A  11
 None
 0.88A 1ej0A-1mzjA:
undetectable		 1ej0A-1mzjA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 1mzj BETA-KETOACYLSYNTHAS
E III
(Streptomyces
sp.
R1128) 		5 / 11 ALA A  75
HIS A 142
ARG A  70
ARG A  69
LEU A 107
 None
 1.06A 1mjlA-1mzjA:
undetectable
1mjlB-1mzjA:
undetectable		 1mjlA-1mzjA:
14.16
1mjlB-1mzjA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1mzj BETA-KETOACYLSYNTHAS
E III
(Streptomyces
sp.
R1128) 		5 / 10 LEU A 128
LEU A  15
VAL A 143
GLY A 176
SER A  12
 None
 1.14A 1pxxA-1mzjA:
undetectable		 1pxxA-1mzjA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1mzj BETA-KETOACYLSYNTHAS
E III
(Streptomyces
sp.
R1128) 		5 / 9 LEU A 128
LEU A  15
VAL A 143
GLY A 176
SER A  12
 None
 1.12A 1pxxB-1mzjA:
undetectable		 1pxxB-1mzjA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1mzj BETA-KETOACYLSYNTHAS
E III
(Streptomyces
sp.
R1128) 		5 / 10 LEU A 128
LEU A  15
VAL A 143
GLY A 176
SER A  12
 None
 1.13A 1pxxD-1mzjA:
undetectable		 1pxxD-1mzjA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 1mzj BETA-KETOACYLSYNTHAS
E III
(Streptomyces
sp.
R1128) 		5 / 12 ALA A  67
ALA A 170
ALA A 172
VAL A  14
LEU A 128
 None
 1.29A 1rbpA-1mzjA:
undetectable		 1rbpA-1mzjA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 1mzj BETA-KETOACYLSYNTHAS
E III
(Streptomyces
sp.
R1128) 		4 / 8 LEU A 331
VAL A  17
GLY A  16
LEU A 301
 None
 0.97A 1s1xA-1mzjA:
0.0		 1s1xA-1mzjA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)		 1mzj BETA-KETOACYLSYNTHAS
E III
(Streptomyces
sp.
R1128) 		5 / 12 ILE A 316
GLY A 326
PRO A 185
GLY A 184
VAL A 233
 None
 1.05A 1vptA-1mzjA:
undetectable		 1vptA-1mzjA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_2
(POL POLYPROTEIN)		 1mzj BETA-KETOACYLSYNTHAS
E III
(Streptomyces
sp.
R1128) 		5 / 12 LEU A 144
GLY A 108
ALA A 109
ASN A 111
ILE A  82
 None
 0.92A 2f80B-1mzjA:
undetectable		 2f80B-1mzjA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 1mzj BETA-KETOACYLSYNTHAS
E III
(Streptomyces
sp.
R1128) 		6 / 12 GLY A 184
ALA A 240
ALA A 325
LEU A 246
LEU A 241
LEU A 330
 None
 1.31A 2nyuA-1mzjA:
undetectable		 2nyuA-1mzjA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 1mzj BETA-KETOACYLSYNTHAS
E III
(Streptomyces
sp.
R1128) 		5 / 12 LEU A 144
GLY A 108
ALA A 109
ASN A 111
ILE A  82
 None
 0.91A 2qakB-1mzjA:
undetectable		 2qakB-1mzjA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1mzj BETA-KETOACYLSYNTHAS
E III
(Streptomyces
sp.
R1128) 		5 / 12 VAL A  14
LEU A 314
LEU A 298
GLY A 184
LEU A 128
 None
 1.03A 3n8wA-1mzjA:
undetectable		 3n8wA-1mzjA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1mzj BETA-KETOACYLSYNTHAS
E III
(Streptomyces
sp.
R1128) 		5 / 12 VAL A  14
LEU A 314
LEU A 298
GLY A 184
LEU A 128
 None
 1.07A 3n8zA-1mzjA:
undetectable		 3n8zA-1mzjA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1mzj BETA-KETOACYLSYNTHAS
E III
(Streptomyces
sp.
R1128) 		5 / 12 LEU A 322
TYR A 324
ALA A 122
GLY A 317
GLY A 319
 None
None
None
None
ACE  A 502 ( 3.9A)
 1.18A 3ou7A-1mzjA:
undetectable		 3ou7A-1mzjA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1mzj BETA-KETOACYLSYNTHAS
E III
(Streptomyces
sp.
R1128) 		5 / 12 LEU A 322
TYR A 324
ALA A 122
GLY A 317
GLY A 319
 None
None
None
None
ACE  A 502 ( 3.9A)
 1.17A 3ou7D-1mzjA:
undetectable		 3ou7D-1mzjA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_1
(ADENOSINE KINASE,
PUTATIVE)		 1mzj BETA-KETOACYLSYNTHAS
E III
(Streptomyces
sp.
R1128) 		5 / 12 ILE A  82
LEU A 107
GLY A  16
ALA A  75
GLY A 176
 None
 1.03A 3uq6B-1mzjA:
undetectable		 3uq6B-1mzjA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 1mzj BETA-KETOACYLSYNTHAS
E III
(Streptomyces
sp.
R1128) 		5 / 8 GLY A 169
MET A  63
GLY A  64
LEU A  99
VAL A 146
 None
 1.30A 3v1nA-1mzjA:
undetectable		 3v1nA-1mzjA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1mzj BETA-KETOACYLSYNTHAS
E III
(Streptomyces
sp.
R1128) 		6 / 12 VAL A 143
LEU A  15
VAL A 302
PHE A 124
ILE A 183
LEU A 329
 None
 1.42A 3w68B-1mzjA:
undetectable		 3w68B-1mzjA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1mzj BETA-KETOACYLSYNTHAS
E III
(Streptomyces
sp.
R1128) 		5 / 9 ASP A 153
VAL A  87
THR A 148
GLN A  61
GLY A  64
 None
 1.26A 4acaB-1mzjA:
undetectable
4acaC-1mzjA:
undetectable		 4acaB-1mzjA:
21.86
4acaC-1mzjA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1mzj BETA-KETOACYLSYNTHAS
E III
(Streptomyces
sp.
R1128) 		5 / 11 ALA A 325
GLY A 326
VAL A 233
VAL A 294
CYH A 125
 None
 0.97A 4c5lA-1mzjA:
undetectable		 4c5lA-1mzjA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1mzj BETA-KETOACYLSYNTHAS
E III
(Streptomyces
sp.
R1128) 		5 / 9 ALA A 325
GLY A 326
VAL A 233
VAL A 294
CYH A 125
 None
 0.97A 4c5lB-1mzjA:
undetectable		 4c5lB-1mzjA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1mzj BETA-KETOACYLSYNTHAS
E III
(Streptomyces
sp.
R1128) 		5 / 10 ALA A 325
GLY A 326
VAL A 233
VAL A 294
CYH A 125
 None
 0.91A 4c5lC-1mzjA:
undetectable		 4c5lC-1mzjA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1mzj BETA-KETOACYLSYNTHAS
E III
(Streptomyces
sp.
R1128) 		5 / 10 ALA A 325
GLY A 326
VAL A 233
VAL A 294
CYH A 125
 None
 0.98A 4c5lD-1mzjA:
undetectable		 4c5lD-1mzjA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1mzj BETA-KETOACYLSYNTHAS
E III
(Streptomyces
sp.
R1128) 		5 / 10 ALA A 325
GLY A 326
VAL A 233
VAL A 294
CYH A 125
 None
 0.90A 4c5nB-1mzjA:
undetectable		 4c5nB-1mzjA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1mzj BETA-KETOACYLSYNTHAS
E III
(Streptomyces
sp.
R1128) 		5 / 10 ALA A 325
GLY A 326
VAL A 233
VAL A 294
CYH A 125
 None
 0.90A 4c5nD-1mzjA:
undetectable		 4c5nD-1mzjA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 1mzj BETA-KETOACYLSYNTHAS
E III
(Streptomyces
sp.
R1128) 		4 / 6 PHE A 318
ALA A 229
LEU A 267
VAL A 266
 None
 0.88A 4dubA-1mzjA:
0.0		 4dubA-1mzjA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 1mzj BETA-KETOACYLSYNTHAS
E III
(Streptomyces
sp.
R1128) 		4 / 6 PHE A 318
ALA A 229
LEU A 267
VAL A 266
 None
 0.91A 4dubB-1mzjA:
undetectable		 4dubB-1mzjA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_1_PQN12001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 1mzj BETA-KETOACYLSYNTHAS
E III
(Streptomyces
sp.
R1128) 		5 / 11 GLY A 310
ALA A 313
LEU A 329
GLY A 182
ALA A 119
 None
 1.19A 4l6v1-1mzjA:
undetectable
4l6v6-1mzjA:
undetectable		 4l6v1-1mzjA:
18.83
4l6v6-1mzjA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1mzj BETA-KETOACYLSYNTHAS
E III
(Streptomyces
sp.
R1128) 		5 / 8 LEU A 144
VAL A  85
ALA A 104
LEU A 107
GLY A  64
 None
 1.26A 4zauA-1mzjA:
undetectable		 4zauA-1mzjA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)		 1mzj BETA-KETOACYLSYNTHAS
E III
(Streptomyces
sp.
R1128) 		5 / 8 PRO A 335
VAL A 302
GLY A  18
ALA A  71
GLY A  16
 None
 1.04A 4zjzA-1mzjA:
undetectable		 4zjzA-1mzjA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)		 1mzj BETA-KETOACYLSYNTHAS
E III
(Streptomyces
sp.
R1128) 		5 / 8 PRO A 335
VAL A 302
GLY A  18
ALA A  71
GLY A  16
 None
 1.04A 4zjzB-1mzjA:
undetectable		 4zjzB-1mzjA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 1mzj BETA-KETOACYLSYNTHAS
E III
(Streptomyces
sp.
R1128) 		4 / 7 GLY A 321
SER A 197
ARG A 224
GLY A 196
 None
 0.88A 5e26A-1mzjA:
0.0
5e26B-1mzjA:
0.0		 5e26A-1mzjA:
22.56
5e26B-1mzjA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1mzj BETA-KETOACYLSYNTHAS
E III
(Streptomyces
sp.
R1128) 		5 / 12 LEU A 128
LEU A 117
VAL A 186
GLY A 326
ALA A 325
 None
 0.98A 5jw1B-1mzjA:
0.0		 5jw1B-1mzjA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 1mzj BETA-KETOACYLSYNTHAS
E III
(Streptomyces
sp.
R1128) 		5 / 12 VAL A 302
GLY A  18
ALA A  67
LEU A 107
LEU A 144
 None
 1.08A 5xxiA-1mzjA:
undetectable		 5xxiA-1mzjA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_B_P2EB1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 1mzj BETA-KETOACYLSYNTHAS
E III
(Streptomyces
sp.
R1128) 		4 / 5 PRO A 332
VAL A  17
GLY A 317
VAL A 255
 None
 1.11A 6ak3B-1mzjA:
undetectable		 6ak3B-1mzjA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_B_P2EB1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 1mzj BETA-KETOACYLSYNTHAS
E III
(Streptomyces
sp.
R1128) 		4 / 5 PRO A 332
VAL A  17
GLY A 326
VAL A 255
 None
 1.00A 6ak3B-1mzjA:
undetectable		 6ak3B-1mzjA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 1mzj BETA-KETOACYLSYNTHAS
E III
(Streptomyces
sp.
R1128) 		5 / 11 ALA A 313
LEU A 251
VAL A 273
ILE A 264
ALA A 237
 None
 1.28A 6h1lB-1mzjA:
undetectable		 6h1lB-1mzjA:
21.44