SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1mzr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 1mzr 2,5-DIKETO-D-GLUCONA
TE REDUCTASE A
(Escherichia
coli) 		4 / 8 HIS A 222
LEU A 227
SER A 186
GLU A 163
 None
 1.11A 1i7zA-1mzrA:
undetectable		 1i7zA-1mzrA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA156_1
(CALMODULIN)		 1mzr 2,5-DIKETO-D-GLUCONA
TE REDUCTASE A
(Escherichia
coli) 		5 / 8 ILE A 217
ILE A 258
GLU A 257
VAL A 202
ILE A 203
 None
 1.45A 1linA-1mzrA:
undetectable		 1linA-1mzrA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1mzr 2,5-DIKETO-D-GLUCONA
TE REDUCTASE A
(Escherichia
coli) 		4 / 7 GLY A  20
PRO A   5
PHE A 243
ASN A 242
 None
 0.87A 1oniG-1mzrA:
undetectable
1oniI-1mzrA:
undetectable		 1oniG-1mzrA:
17.28
1oniI-1mzrA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 1mzr 2,5-DIKETO-D-GLUCONA
TE REDUCTASE A
(Escherichia
coli) 		5 / 12 PHE A  73
GLY A  20
SER A  45
ILE A 219
ASP A  47
 None
 1.17A 3iv6B-1mzrA:
undetectable		 3iv6B-1mzrA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUV_A_ASDA126_1
(STEROID
DELTA-ISOMERASE)		 1mzr 2,5-DIKETO-D-GLUCONA
TE REDUCTASE A
(Escherichia
coli) 		5 / 12 PHE A 141
PHE A 274
VAL A 111
MET A 124
ALA A 120
 None
GOL  A 910 ( 4.6A)
None
None
None
 1.29A 3nuvA-1mzrA:
0.0		 3nuvA-1mzrA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 1mzr 2,5-DIKETO-D-GLUCONA
TE REDUCTASE A
(Escherichia
coli) 		4 / 5 ILE A 230
SER A 233
LYS A 232
GLY A  22
 None
PO4  A 901 (-2.6A)
None
None
 0.97A 3tkdB-1mzrA:
undetectable		 3tkdB-1mzrA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 1mzr 2,5-DIKETO-D-GLUCONA
TE REDUCTASE A
(Escherichia
coli) 		4 / 5 ILE A 230
SER A 233
LYS A 232
GLY A  22
 None
PO4  A 901 (-2.6A)
None
None
 0.95A 3tkdA-1mzrA:
undetectable		 3tkdA-1mzrA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 1mzr 2,5-DIKETO-D-GLUCONA
TE REDUCTASE A
(Escherichia
coli) 		4 / 8 THR A  48
LEU A  99
LEU A  97
GLY A  59
 None
 0.81A 4c9nA-1mzrA:
undetectable		 4c9nA-1mzrA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 1mzr 2,5-DIKETO-D-GLUCONA
TE REDUCTASE A
(Escherichia
coli) 		3 / 3 LEU A  90
ASP A  82
ILE A  74
 None
 0.66A 4xi3D-1mzrA:
undetectable		 4xi3D-1mzrA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 1mzr 2,5-DIKETO-D-GLUCONA
TE REDUCTASE A
(Escherichia
coli) 		5 / 10 GLY A  59
ASN A  28
ILE A  74
LEU A  62
LEU A  97
 None
 1.12A 4xj7A-1mzrA:
undetectable
4xj7B-1mzrA:
undetectable		 4xj7A-1mzrA:
22.94
4xj7B-1mzrA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1mzr 2,5-DIKETO-D-GLUCONA
TE REDUCTASE A
(Escherichia
coli) 		4 / 5 THR A  48
ALA A  49
THR A  76
TYR A 105
 None
 1.06A 5ecmA-1mzrA:
undetectable		 5ecmA-1mzrA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1mzr 2,5-DIKETO-D-GLUCONA
TE REDUCTASE A
(Escherichia
coli) 		4 / 6 THR A  48
ALA A  49
THR A  76
TYR A 105
 None
 0.97A 5ecoA-1mzrA:
0.6		 5ecoA-1mzrA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1mzr 2,5-DIKETO-D-GLUCONA
TE REDUCTASE A
(Escherichia
coli) 		5 / 7 LEU A  10
ILE A 159
GLY A 137
LEU A 106
ILE A  46
 None
 1.16A 5vkqA-1mzrA:
undetectable
5vkqB-1mzrA:
undetectable		 5vkqA-1mzrA:
10.27
5vkqB-1mzrA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1mzr 2,5-DIKETO-D-GLUCONA
TE REDUCTASE A
(Escherichia
coli) 		5 / 7 LEU A  10
LEU A  19
ILE A 159
GLY A 137
LEU A 106
 None
 1.12A 5vkqA-1mzrA:
undetectable
5vkqB-1mzrA:
undetectable		 5vkqA-1mzrA:
10.27
5vkqB-1mzrA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1mzr 2,5-DIKETO-D-GLUCONA
TE REDUCTASE A
(Escherichia
coli) 		5 / 8 LEU A  10
ILE A 159
GLY A 137
LEU A 106
ILE A  46
 None
 1.17A 5vkqB-1mzrA:
undetectable
5vkqC-1mzrA:
undetectable		 5vkqB-1mzrA:
10.27
5vkqC-1mzrA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1mzr 2,5-DIKETO-D-GLUCONA
TE REDUCTASE A
(Escherichia
coli) 		5 / 8 LEU A  10
LEU A  19
ILE A 159
GLY A 137
LEU A 106
 None
 1.13A 5vkqB-1mzrA:
undetectable
5vkqC-1mzrA:
undetectable		 5vkqB-1mzrA:
10.27
5vkqC-1mzrA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1mzr 2,5-DIKETO-D-GLUCONA
TE REDUCTASE A
(Escherichia
coli) 		6 / 12 LEU A  39
ARG A  44
ILE A  46
GLY A  20
ILE A 239
LEU A 106
 None
 1.20A 5ycnA-1mzrA:
0.0		 5ycnA-1mzrA:
24.39