SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1n11'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 1n11 ANKYRIN
(Homo
sapiens) 		5 / 12 ALA A 544
HIS A 561
LEU A 556
LEU A 523
ALA A 511
 None
 1.08A 1bzfA-1n11A:
undetectable		 1bzfA-1n11A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1n11 ANKYRIN
(Homo
sapiens) 		4 / 4 THR A 783
LEU A 786
VAL A 750
LEU A 753
 None
 0.85A 1fbmD-1n11A:
undetectable		 1fbmD-1n11A:
6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 1n11 ANKYRIN
(Homo
sapiens) 		3 / 3 ARG A 512
TYR A 546
LYS A 545
 None
 0.84A 1uujB-1n11A:
undetectable		 1uujB-1n11A:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 1n11 ANKYRIN
(Homo
sapiens) 		4 / 4 GLY A 767
SER A 764
ILE A 773
HIS A 739
 None
 1.10A 1yajJ-1n11A:
undetectable		 1yajJ-1n11A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1n11 ANKYRIN
(Homo
sapiens) 		4 / 5 LEU A 474
GLN A 471
THR A 472
THR A 518
 None
 1.29A 2zj0B-1n11A:
undetectable		 2zj0B-1n11A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1n11 ANKYRIN
(Homo
sapiens) 		4 / 4 LEU A 474
GLN A 471
THR A 472
THR A 518
 None
 1.37A 2zj0D-1n11A:
undetectable		 2zj0D-1n11A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA3_0
(FERROCHELATASE)		 1n11 ANKYRIN
(Homo
sapiens) 		3 / 3 PRO A 539
LEU A 555
ARG A 558
 None
 0.77A 3aqiA-1n11A:
undetectable		 3aqiA-1n11A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA3_0
(FERROCHELATASE)		 1n11 ANKYRIN
(Homo
sapiens) 		3 / 3 PRO A 572
LEU A 588
ARG A 591
 None
 0.89A 3aqiA-1n11A:
undetectable		 3aqiA-1n11A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB5_0
(FERROCHELATASE)		 1n11 ANKYRIN
(Homo
sapiens) 		3 / 3 PRO A 572
LEU A 588
ARG A 591
 None
 0.86A 3aqiB-1n11A:
undetectable		 3aqiB-1n11A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1100_1
(SERUM ALBUMIN)		 1n11 ANKYRIN
(Homo
sapiens) 		4 / 4 LEU A 507
ARG A 550
LEU A 554
ALA A 543
 None
 1.09A 3b9mA-1n11A:
undetectable		 3b9mA-1n11A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_2
(PHOSPHOLIPASE A2)		 1n11 ANKYRIN
(Homo
sapiens) 		5 / 11 LEU A 622
GLY A 625
SER A 594
PRO A 595
THR A 604
 None
 1.20A 3bjwB-1n11A:
undetectable		 3bjwB-1n11A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 1n11 ANKYRIN
(Homo
sapiens) 		5 / 11 LEU A 622
GLY A 625
SER A 594
PRO A 595
THR A 604
 None
 1.20A 3bjwE-1n11A:
undetectable		 3bjwE-1n11A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_3
(PHOSPHOLIPASE A2)		 1n11 ANKYRIN
(Homo
sapiens) 		5 / 11 LEU A 622
GLY A 625
SER A 594
PRO A 595
THR A 604
 None
 1.20A 3bjwH-1n11A:
undetectable		 3bjwH-1n11A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A81_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 1n11 ANKYRIN
(Homo
sapiens) 		5 / 12 ILE A 749
GLY A 745
ILE A 773
ASN A 728
LEU A 786
 None
 1.24A 4a81A-1n11A:
undetectable		 4a81A-1n11A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 1n11 ANKYRIN
(Homo
sapiens) 		4 / 7 ALA A 610
ALA A 628
LEU A 606
THR A 604
 None
 0.85A 4du2A-1n11A:
0.0		 4du2A-1n11A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 1n11 ANKYRIN
(Homo
sapiens) 		4 / 7 ALA A 610
ALA A 628
LEU A 606
THR A 604
 None
 0.89A 4du2B-1n11A:
0.0		 4du2B-1n11A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 1n11 ANKYRIN
(Homo
sapiens) 		4 / 8 ALA A 618
GLY A 626
LEU A 622
LEU A 653
 None
 0.88A 4po0A-1n11A:
undetectable		 4po0A-1n11A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_A_4LEA401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1n11 ANKYRIN
(Homo
sapiens) 		5 / 8 ALA A 510
ALA A 521
LEU A 490
LEU A 474
ALA A 478
 None
 0.98A 4z90A-1n11A:
0.0
4z90B-1n11A:
0.0
4z90C-1n11A:
0.0
4z90D-1n11A:
0.0
4z90E-1n11A:
0.0		 4z90A-1n11A:
18.64
4z90B-1n11A:
18.64
4z90C-1n11A:
18.64
4z90D-1n11A:
18.64
4z90E-1n11A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1n11 ANKYRIN
(Homo
sapiens) 		5 / 7 LEU A 490
LEU A 474
ALA A 478
ALA A 510
ALA A 521
 None
 1.01A 4z90F-1n11A:
undetectable
4z90G-1n11A:
undetectable
4z90H-1n11A:
undetectable
4z90J-1n11A:
undetectable		 4z90F-1n11A:
18.64
4z90G-1n11A:
18.64
4z90H-1n11A:
18.64
4z90J-1n11A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1n11 ANKYRIN
(Homo
sapiens) 		5 / 12 VAL A 683
LEU A 622
ALA A 642
PRO A 671
GLY A 661
 None
 0.83A 5syeB-1n11A:
undetectable		 5syeB-1n11A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1n11 ANKYRIN
(Homo
sapiens) 		5 / 12 VAL A 683
LEU A 622
ALA A 642
PRO A 671
GLY A 661
 None
 0.93A 6b0iB-1n11A:
undetectable		 6b0iB-1n11A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB502_0
(ADENOSYLHOMOCYSTEINA
SE)		 1n11 ANKYRIN
(Homo
sapiens) 		5 / 12 HIS A 673
GLN A 644
ASN A 665
LEU A 669
HIS A 640
 None
 1.40A 6exiB-1n11A:
undetectable		 6exiB-1n11A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_0
(ADENOSYLHOMOCYSTEINA
SE)		 1n11 ANKYRIN
(Homo
sapiens) 		5 / 12 HIS A 673
GLN A 644
ASN A 665
LEU A 669
HIS A 640
 None
 1.39A 6exiD-1n11A:
undetectable		 6exiD-1n11A:
11.81