SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1n26'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)		 1n26 IL-6 RECEPTOR ALPHA
CHAIN
(Homo
sapiens) 		4 / 8 PRO A  98
SER A 184
GLY A 116
TRP A 115
 None
 1.00A 2qd3A-1n26A:
undetectable		 2qd3A-1n26A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		 1n26 IL-6 RECEPTOR ALPHA
CHAIN
(Homo
sapiens) 		4 / 7 VAL A 179
SER A 177
THR A  17
LEU A  90
 None
 1.19A 3arrA-1n26A:
6.8		 3arrA-1n26A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)		 1n26 IL-6 RECEPTOR ALPHA
CHAIN
(Homo
sapiens) 		4 / 6 VAL A 171
VAL A 131
PHE A 168
ARG A   4
 None
 1.25A 3bjwF-1n26A:
0.0		 3bjwF-1n26A:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1n26 IL-6 RECEPTOR ALPHA
CHAIN
(Homo
sapiens) 		4 / 6 GLN A 153
TYR A 148
GLN A 147
SER A 152
 None
None
NDG  A 636 (-3.9A)
None
 1.04A 3peoG-1n26A:
undetectable		 3peoG-1n26A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJQ_A_27RA401_1
(DNA POLYMERASE III
SUBUNIT BETA)		 1n26 IL-6 RECEPTOR ALPHA
CHAIN
(Homo
sapiens) 		4 / 5 TYR A 148
THR A 125
PRO A 121
VAL A  93
 None
 1.48A 4mjqA-1n26A:
undetectable		 4mjqA-1n26A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		 1n26 IL-6 RECEPTOR ALPHA
CHAIN
(Homo
sapiens) 		4 / 7 VAL A 217
ILE A 260
VAL A 271
ILE A 203
 None
 0.80A 5bmvC-1n26A:
undetectable		 5bmvC-1n26A:
19.20