SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1n2m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1n2m PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		4 / 6 LEU A  31
ASP A  35
LEU A  38
GLY A  44
 MRD  A7006 ( 4.2A)
None
None
None
 0.15A 1mt1G-1n2mA:
3.4
1mt1J-1n2mA:
18.3		 1mt1G-1n2mA:
100.00
1mt1J-1n2mA:
67.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1n2m PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		4 / 7 LEU A  31
ASP A  35
LEU A  38
GLY A  44
 MRD  A7006 ( 4.2A)
None
None
None
 0.19A 1mt1H-1n2mA:
18.1
1mt1K-1n2mA:
3.2		 1mt1H-1n2mA:
67.88
1mt1K-1n2mA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1N13_D_AG2D7015_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1n2m PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		4 / 7 LEU A  31
ASP A  35
LEU A  38
GLY A  44
 MRD  A7006 ( 4.2A)
None
None
None
 0.19A 1n13D-1n2mA:
18.2
1n13E-1n2mA:
3.0		 1n13D-1n2mA:
67.88
1n13E-1n2mA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1n2m PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		4 / 8 LEU A  31
ASP A  35
LEU A  38
GLY A  44
 MRD  A7006 ( 4.2A)
None
None
None
 0.20A 1n13A-1n2mA:
3.7
1n13F-1n2mA:
18.4		 1n13A-1n2mA:
100.00
1n13F-1n2mA:
67.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1n2m PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		4 / 6 LEU A  31
ASP A  35
LEU A  38
GLY A  44
 MRD  A7006 ( 4.2A)
None
None
None
 0.24A 1n13H-1n2mA:
18.3
1n13K-1n2mA:
3.3		 1n13H-1n2mA:
67.88
1n13K-1n2mA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1n2m PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		4 / 7 LEU A  31
ASP A  35
LEU A  38
GLY A  44
 MRD  A7006 ( 4.2A)
None
None
None
 0.20A 1n13G-1n2mA:
3.4
1n13J-1n2mA:
18.5		 1n13G-1n2mA:
100.00
1n13J-1n2mA:
67.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1n2m PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		4 / 7 LEU A  31
ASP A  35
LEU A  38
GLY A  44
 MRD  A7006 ( 4.2A)
None
None
None
 0.23A 2qqcD-1n2mA:
18.4
2qqcE-1n2mA:
3.0		 2qqcD-1n2mA:
99.11
2qqcE-1n2mA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1n2m PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		4 / 8 LEU A  31
ASP A  35
LEU A  38
GLY A  44
 MRD  A7006 ( 4.2A)
None
None
None
 0.21A 2qqcH-1n2mA:
18.4
2qqcK-1n2mA:
3.3		 2qqcH-1n2mA:
99.11
2qqcK-1n2mA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1n2m PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		4 / 8 LEU A  31
ASP A  35
LEU A  38
GLY A  44
 MRD  A7006 ( 4.2A)
None
None
None
 0.22A 2qqdB-1n2mA:
18.5
2qqdC-1n2mA:
29.7		 2qqdB-1n2mA:
100.00
2qqdC-1n2mA:
98.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)		 1n2m PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		4 / 8 PHE A  34
ALA A  41
ALA A 159
THR A  75
 MRD  A7006 ( 3.9A)
None
None
None
 0.94A 3t3sD-1n2mA:
undetectable		 3t3sD-1n2mA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		 1n2m PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		5 / 9 ILE A  93
ALA A 161
LEU A  64
ILE A 144
THR A  75
 None
 1.21A 3tq8A-1n2mA:
undetectable		 3tq8A-1n2mA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 1n2m PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		5 / 10 ILE A  93
ALA A 161
LEU A  64
ILE A 144
THR A  75
 None
 1.17A 4g8zX-1n2mA:
undetectable		 4g8zX-1n2mA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_2
(ANDROGEN RECEPTOR)		 1n2m PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		4 / 7 LEU A  39
ASN A  40
LEU A  64
MET A  69
 None
 1.00A 4okwA-1n2mA:
undetectable		 4okwA-1n2mA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 1n2m PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A  44
GLY A  42
LEU A  67
ASN A  40
LEU A  48
 None
 1.19A 4x61A-1n2mA:
undetectable		 4x61A-1n2mA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1n2m PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A  23
VAL A  21
ALA A 161
LEU A  48
THR A  75
 None
 0.81A 5hieA-1n2mA:
undetectable		 5hieA-1n2mA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1n2m PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A  23
VAL A  21
ALA A 161
LEU A  48
THR A  75
 None
 0.82A 5hieB-1n2mA:
undetectable		 5hieB-1n2mA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1n2m PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A  23
VAL A  21
ALA A 161
LEU A  48
THR A  75
 None
 0.81A 5hieD-1n2mA:
undetectable		 5hieD-1n2mA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1n2m PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLU A 111
VAL A 150
LEU A 153
ARG A  50
ILE A  80
 None
 1.20A 5vooE-1n2mA:
undetectable		 5vooE-1n2mA:
19.11