SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1n31'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB6_0
(GRAMICIDIN A)		 1n31 L-CYSTEINE/CYSTINE
LYASE C-DES
(Synechocystis
sp.
PCC
6714) 		3 / 3 TRP A 313
ALA A 332
VAL A 335
 None
 0.88A 1c4dA-1n31A:
undetectable
1c4dB-1n31A:
undetectable		 1c4dA-1n31A:
4.98
1c4dB-1n31A:
4.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_C_DVAC6_0
(GRAMICIDIN A)		 1n31 L-CYSTEINE/CYSTINE
LYASE C-DES
(Synechocystis
sp.
PCC
6714) 		3 / 3 ALA A 332
VAL A 335
TRP A 313
 None
 0.75A 1c4dC-1n31A:
undetectable
1c4dD-1n31A:
undetectable		 1c4dC-1n31A:
4.98
1c4dD-1n31A:
4.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD6_0
(GRAMICIDIN A)		 1n31 L-CYSTEINE/CYSTINE
LYASE C-DES
(Synechocystis
sp.
PCC
6714) 		3 / 3 TRP A 313
ALA A 332
VAL A 335
 None
 0.81A 1c4dC-1n31A:
undetectable
1c4dD-1n31A:
undetectable		 1c4dC-1n31A:
4.98
1c4dD-1n31A:
4.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1n31 L-CYSTEINE/CYSTINE
LYASE C-DES
(Synechocystis
sp.
PCC
6714) 		5 / 10 THR A 140
ALA A 146
LEU A 163
VAL A 196
ILE A 179
 None
 1.27A 1claA-1n31A:
0.0		 1claA-1n31A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 1n31 L-CYSTEINE/CYSTINE
LYASE C-DES
(Synechocystis
sp.
PCC
6714) 		5 / 8 GLY A  26
ALA A 223
LEU A 334
ILE A 305
HIS A 373
 CYS  A2002 (-4.8A)
None
None
None
None
 1.06A 1yajC-1n31A:
undetectable		 1yajC-1n31A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 1n31 L-CYSTEINE/CYSTINE
LYASE C-DES
(Synechocystis
sp.
PCC
6714) 		5 / 8 GLY A  29
GLY A  26
ALA A 223
ILE A 305
HIS A 373
 None
CYS  A2002 (-4.8A)
None
None
None
 1.09A 1yajC-1n31A:
undetectable		 1yajC-1n31A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 1n31 L-CYSTEINE/CYSTINE
LYASE C-DES
(Synechocystis
sp.
PCC
6714) 		5 / 12 GLY A  26
PHE A  25
TYR A 358
ALA A 199
ALA A 223
 CYS  A2002 (-4.8A)
None
None
PLP  A2001 (-3.4A)
None
 1.06A 2avdB-1n31A:
3.8		 2avdB-1n31A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 1n31 L-CYSTEINE/CYSTINE
LYASE C-DES
(Synechocystis
sp.
PCC
6714) 		5 / 12 GLY A  27
PHE A  25
TYR A 358
ALA A 199
ALA A 223
 CYS  A2002 (-3.3A)
None
None
PLP  A2001 (-3.4A)
None
 1.40A 2avdB-1n31A:
3.8		 2avdB-1n31A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1n31 L-CYSTEINE/CYSTINE
LYASE C-DES
(Synechocystis
sp.
PCC
6714) 		5 / 12 THR A 170
GLY A 171
GLY A 333
GLN A 200
ILE A 362
 None
None
None
CYS  A2002 ( 4.2A)
None
 1.33A 2azxA-1n31A:
2.4		 2azxA-1n31A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1n31 L-CYSTEINE/CYSTINE
LYASE C-DES
(Synechocystis
sp.
PCC
6714) 		5 / 12 THR A 170
GLY A 171
GLY A 333
GLN A 200
ILE A 362
 None
None
None
CYS  A2002 ( 4.2A)
None
 1.35A 2azxB-1n31A:
2.2		 2azxB-1n31A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_A_X2NA1480_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1n31 L-CYSTEINE/CYSTINE
LYASE C-DES
(Synechocystis
sp.
PCC
6714) 		5 / 12 TYR A  43
MET A  42
ALA A  35
ALA A  56
THR A 276
 None
 1.23A 2x2nA-1n31A:
undetectable		 2x2nA-1n31A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_1
(PROTEASE)		 1n31 L-CYSTEINE/CYSTINE
LYASE C-DES
(Synechocystis
sp.
PCC
6714) 		5 / 8 ASP A 197
GLY A 198
ALA A 199
GLY A 233
LEU A 234
 PLP  A2001 (-2.6A)
None
PLP  A2001 (-3.4A)
None
None
 1.27A 3em6A-1n31A:
undetectable		 3em6A-1n31A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_0
(UNCHARACTERIZED
PROTEIN)		 1n31 L-CYSTEINE/CYSTINE
LYASE C-DES
(Synechocystis
sp.
PCC
6714) 		5 / 12 LEU A 286
VAL A 231
GLY A 232
LEU A  63
ILE A  60
 None
 1.05A 3ijdB-1n31A:
0.1		 3ijdB-1n31A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 1n31 L-CYSTEINE/CYSTINE
LYASE C-DES
(Synechocystis
sp.
PCC
6714) 		5 / 12 PHE A  75
LEU A 285
ILE A  82
PHE A 219
GLY A 221
 None
 0.97A 3lbdA-1n31A:
0.0		 3lbdA-1n31A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 1n31 L-CYSTEINE/CYSTINE
LYASE C-DES
(Synechocystis
sp.
PCC
6714) 		4 / 7 ILE A 179
LEU A 174
SER A 201
VAL A  88
 None
None
None
PLP  A2001 (-4.1A)
 0.96A 3r9vA-1n31A:
undetectable
3r9vB-1n31A:
undetectable		 3r9vA-1n31A:
18.09
3r9vB-1n31A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		 1n31 L-CYSTEINE/CYSTINE
LYASE C-DES
(Synechocystis
sp.
PCC
6714) 		4 / 6 GLY A 315
LEU A 385
ASN A 382
GLU A 378
 None
 0.98A 3zqtA-1n31A:
undetectable		 3zqtA-1n31A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD393_1
(TETX2 PROTEIN)		 1n31 L-CYSTEINE/CYSTINE
LYASE C-DES
(Synechocystis
sp.
PCC
6714) 		4 / 5 ILE A 118
ILE A 107
TYR A 132
GLU A 106
 None
 1.19A 4a99D-1n31A:
undetectable		 4a99D-1n31A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 1n31 L-CYSTEINE/CYSTINE
LYASE C-DES
(Synechocystis
sp.
PCC
6714) 		4 / 6 LEU A 167
LEU A 174
ILE A 179
THR A 140
 None
 0.97A 4do3B-1n31A:
0.0		 4do3B-1n31A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 1n31 L-CYSTEINE/CYSTINE
LYASE C-DES
(Synechocystis
sp.
PCC
6714) 		5 / 12 LEU A  67
LEU A  71
ILE A  84
PHE A 219
GLY A 221
 None
 1.01A 4lmnA-1n31A:
undetectable		 4lmnA-1n31A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 1n31 L-CYSTEINE/CYSTINE
LYASE C-DES
(Synechocystis
sp.
PCC
6714) 		5 / 11 LEU A 174
VAL A 194
CYH A 183
LEU A 150
ALA A 146
 None
 1.12A 4p65B-1n31A:
undetectable
4p65D-1n31A:
undetectable
4p65G-1n31A:
undetectable
4p65H-1n31A:
undetectable		 4p65B-1n31A:
9.13
4p65D-1n31A:
9.13
4p65G-1n31A:
3.95
4p65H-1n31A:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 1n31 L-CYSTEINE/CYSTINE
LYASE C-DES
(Synechocystis
sp.
PCC
6714) 		4 / 5 GLY A 284
ALA A  35
GLY A 227
PRO A 228
 None
 0.94A 4u9uA-1n31A:
2.4		 4u9uA-1n31A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 1n31 L-CYSTEINE/CYSTINE
LYASE C-DES
(Synechocystis
sp.
PCC
6714) 		4 / 5 GLY A 284
ALA A  35
GLY A 227
PRO A 228
 None
 0.93A 4u9uB-1n31A:
2.4		 4u9uB-1n31A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1n31 L-CYSTEINE/CYSTINE
LYASE C-DES
(Synechocystis
sp.
PCC
6714) 		4 / 7 LEU A  67
ARG A  68
LEU A  71
LEU A 285
 None
 0.81A 4wg0L-1n31A:
undetectable
4wg0M-1n31A:
undetectable		 4wg0L-1n31A:
1.55
4wg0M-1n31A:
1.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 1n31 L-CYSTEINE/CYSTINE
LYASE C-DES
(Synechocystis
sp.
PCC
6714) 		5 / 12 ALA A  70
ALA A  65
ILE A  64
LEU A  63
ALA A  35
 None
 1.00A 5bw4B-1n31A:
undetectable		 5bw4B-1n31A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUK_A_SNPA1236_1
(MROUPO)		 1n31 L-CYSTEINE/CYSTINE
LYASE C-DES
(Synechocystis
sp.
PCC
6714) 		4 / 7 ILE A 130
ILE A 162
ILE A 120
LEU A 195
 None
 0.82A 5fukA-1n31A:
0.0
5fukB-1n31A:
0.0		 5fukA-1n31A:
20.81
5fukB-1n31A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_K_IPHK101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 1n31 L-CYSTEINE/CYSTINE
LYASE C-DES
(Synechocystis
sp.
PCC
6714) 		4 / 6 VAL A 339
HIS A 323
HIS A 321
LEU A 319
 None
 1.42A 5hrqH-1n31A:
undetectable
5hrqK-1n31A:
undetectable
5hrqL-1n31A:
undetectable		 5hrqH-1n31A:
6.61
5hrqK-1n31A:
3.95
5hrqL-1n31A:
6.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 1n31 L-CYSTEINE/CYSTINE
LYASE C-DES
(Synechocystis
sp.
PCC
6714) 		4 / 5 ASP A 366
VAL A 349
GLY A 344
ALA A 347
 None
 1.03A 5hwaA-1n31A:
0.0		 5hwaA-1n31A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 1n31 L-CYSTEINE/CYSTINE
LYASE C-DES
(Synechocystis
sp.
PCC
6714) 		3 / 3 VAL A 335
SER A 309
TRP A 313
 None
 0.89A 5jwaA-1n31A:
undetectable		 5jwaA-1n31A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W3J_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1n31 L-CYSTEINE/CYSTINE
LYASE C-DES
(Synechocystis
sp.
PCC
6714) 		4 / 8 VAL A  77
ASP A  78
HIS A 237
GLY A 268
 None
 0.86A 5w3jB-1n31A:
undetectable		 5w3jB-1n31A:
21.74