SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1n3s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 1n3s GTP CYCLOHYDROLASE I
(Escherichia
coli) 		5 / 11 ALA A 121
VAL A 141
VAL A 171
LEU A  14
ALA A 161
 None
 1.24A 1n4hA-1n3sA:
0.0		 1n4hA-1n3sA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 1n3s GTP CYCLOHYDROLASE I
(Escherichia
coli) 		5 / 12 PHE A 144
ILE A 158
VAL A 141
ILE A 137
ALA A 161
 None
 0.94A 3fpjA-1n3sA:
undetectable		 3fpjA-1n3sA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 1n3s GTP CYCLOHYDROLASE I
(Escherichia
coli) 		5 / 10 GLU A  20
LEU A  14
ILE A 140
LEU A 165
PHE A  83
 None
 1.15A 3jw5B-1n3sA:
undetectable		 3jw5B-1n3sA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1n3s GTP CYCLOHYDROLASE I
(Escherichia
coli) 		5 / 11 LEU A 162
VAL A 141
ALA A 121
ALA A 124
THR A 100
 None
 1.13A 3mdtB-1n3sA:
undetectable		 3mdtB-1n3sA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 1n3s GTP CYCLOHYDROLASE I
(Escherichia
coli) 		5 / 9 VAL A 217
LEU A 106
ARG A 218
ALA A 177
VAL A 178
 None
 1.17A 6c2mB-1n3sA:
undetectable		 6c2mB-1n3sA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_1
(STIE PROTEIN)		 1n3s GTP CYCLOHYDROLASE I
(Escherichia
coli) 		4 / 5 THR A 109
THR A 105
GLN A 142
ASP A 103
 None
 1.42A 6ectA-1n3sA:
undetectable		 6ectA-1n3sA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_1
(STIE PROTEIN)		 1n3s GTP CYCLOHYDROLASE I
(Escherichia
coli) 		4 / 5 THR A 116
THR A 105
GLN A 142
ASP A 103
 None
 1.35A 6ectA-1n3sA:
undetectable		 6ectA-1n3sA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_1
(STIE PROTEIN)		 1n3s GTP CYCLOHYDROLASE I
(Escherichia
coli) 		4 / 5 THR A 109
THR A 105
GLN A 142
ASP A 103
 None
 1.46A 6ecxA-1n3sA:
undetectable		 6ecxA-1n3sA:
19.94