SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1n4d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1n4d VITAMIN B12
TRANSPORT PROTEIN
BTUF
(Escherichia
coli) 		5 / 12 ILE A  90
ALA A  94
LEU A 117
ALA A 114
VAL A 160
 None
 1.10A 1xdkA-1n4dA:
undetectable		 1xdkA-1n4dA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1n4d VITAMIN B12
TRANSPORT PROTEIN
BTUF
(Escherichia
coli) 		5 / 12 ILE A  90
ALA A  94
LEU A 117
ALA A 114
VAL A 160
 None
 1.04A 3dzyA-1n4dA:
undetectable		 3dzyA-1n4dA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2W_A_ELVA397_1
(INTEGRASE)		 1n4d VITAMIN B12
TRANSPORT PROTEIN
BTUF
(Escherichia
coli) 		4 / 5 ASP A  30
TYR A  28
PRO A   9
GLU A  13
 None
 1.23A 3l2wA-1n4dA:
1.2		 3l2wA-1n4dA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)		 1n4d VITAMIN B12
TRANSPORT PROTEIN
BTUF
(Escherichia
coli) 		4 / 7 ASP A  30
TYR A  28
PRO A   9
GLU A  13
 None
 1.17A 3s3oA-1n4dA:
2.0		 3s3oA-1n4dA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 1n4d VITAMIN B12
TRANSPORT PROTEIN
BTUF
(Escherichia
coli) 		4 / 8 VAL A 160
LYS A 125
ILE A 230
ALA A 232
 None
 0.77A 4qrcA-1n4dA:
undetectable		 4qrcA-1n4dA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1n4d VITAMIN B12
TRANSPORT PROTEIN
BTUF
(Escherichia
coli) 		4 / 7 LEU A 138
ARG A 224
THR A 218
LEU A 217
 None
 0.98A 5b1bA-1n4dA:
0.3
5b1bJ-1n4dA:
0.0		 5b1bA-1n4dA:
18.31
5b1bJ-1n4dA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 1n4d VITAMIN B12
TRANSPORT PROTEIN
BTUF
(Escherichia
coli) 		4 / 5 ASP A  86
VAL A  72
GLY A  66
ALA A  68
 None
 0.87A 5hwaA-1n4dA:
0.0		 5hwaA-1n4dA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_2_PQN2843_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 1n4d VITAMIN B12
TRANSPORT PROTEIN
BTUF
(Escherichia
coli) 		5 / 12 ILE A 229
ILE A  20
ALA A  18
LEU A  97
ALA A 114
 None
 1.30A 5oy02-1n4dA:
undetectable		 5oy02-1n4dA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_C_9CRC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1n4d VITAMIN B12
TRANSPORT PROTEIN
BTUF
(Escherichia
coli) 		5 / 12 ILE A  90
ALA A  94
LEU A 117
ALA A 114
VAL A 160
 None
 1.02A 5z12C-1n4dA:
undetectable		 5z12C-1n4dA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZGB_B_PQNB844_1
(PSAB)		 1n4d VITAMIN B12
TRANSPORT PROTEIN
BTUF
(Escherichia
coli) 		5 / 9 ILE A 230
ARG A  98
ALA A 114
LEU A  97
ALA A  96
 None
 1.47A 5zgbB-1n4dA:
undetectable		 5zgbB-1n4dA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 1n4d VITAMIN B12
TRANSPORT PROTEIN
BTUF
(Escherichia
coli) 		5 / 10 ILE A 229
ILE A  20
ALA A  18
LEU A  97
ALA A 114
 None
 1.30A 5zjiB-1n4dA:
2.8		 5zjiB-1n4dA:
15.92