SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1n4k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_A_DVAA6_0
(GRAMICIDIN A)		 1n4k INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Mus
musculus) 		3 / 3 ALA A 429
VAL A 399
TRP A 398
 None
 0.96A 1grmA-1n4kA:
undetectable		 1grmA-1n4kA:
3.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_B_DVAB6_0
(GRAMICIDIN A)		 1n4k INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Mus
musculus) 		3 / 3 ALA A 429
VAL A 399
TRP A 398
 None
 0.96A 1grmB-1n4kA:
undetectable		 1grmB-1n4kA:
3.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 1n4k INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Mus
musculus) 		6 / 12 ALA A 449
ASP A 448
ASN A 447
GLY A 454
ILE A 456
ILE A 515
 None
 1.38A 2qakA-1n4kA:
undetectable		 2qakA-1n4kA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1n4k INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Mus
musculus) 		3 / 3 THR A 397
SER A 354
LYS A 417
 None
 0.97A 3aocC-1n4kA:
undetectable		 3aocC-1n4kA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA3_0
(FERROCHELATASE)		 1n4k INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Mus
musculus) 		3 / 3 PRO A 405
LEU A 416
ARG A 265
 None
None
I3P  A1000 (-3.0A)
 0.89A 3aqiA-1n4kA:
undetectable		 3aqiA-1n4kA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 1n4k INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Mus
musculus) 		4 / 5 TYR A 313
SER A 366
GLU A 317
ASP A 363
 None
 1.21A 4xueA-1n4kA:
undetectable		 4xueA-1n4kA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSA_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 1n4k INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Mus
musculus) 		4 / 4 TYR A 313
SER A 366
GLU A 317
ASP A 363
 None
 1.19A 5lsaA-1n4kA:
undetectable		 5lsaA-1n4kA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_A_BEZA507_0
(BETA-LACTAMASE VIM-2)		 1n4k INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Mus
musculus) 		3 / 3 THR A 596
HIS A 600
ASN A 602
 None
 0.95A 5n4tA-1n4kA:
0.0		 5n4tA-1n4kA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YVN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 1n4k INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Mus
musculus) 		4 / 6 LEU A 509
GLN A 513
LEU A 308
LEU A 281
 None
 1.19A 5yvnA-1n4kA:
5.8		 5yvnA-1n4kA:
19.95