SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1n5x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 9 ASP A 429
ALA A 338
VAL A 342
GLY A  47
GLY A 145
 FAD  A3005 (-4.1A)
FAD  A3005 (-3.5A)
None
FAD  A3005 (-4.0A)
None
 1.04A 1bcuH-1n5xA:
undetectable		 1bcuH-1n5xA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 10 GLY A 915
GLY A1006
HIS A 884
ALA A1079
ILE A1007
 None
None
None
TEI  A3006 ( 3.8A)
None
 0.97A 1c9sL-1n5xA:
0.0
1c9sV-1n5xA:
0.0		 1c9sL-1n5xA:
4.96
1c9sV-1n5xA:
4.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		4 / 6 ILE A1097
ARG A1100
TYR A1024
VAL A1090
 None
 0.87A 1db1A-1n5xA:
0.0		 1db1A-1n5xA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		4 / 8 CYH A 150
GLY A 795
GLY A 796
GLN A 585
 FES  A3001 ( 2.3A)
None
MTE  A3003 (-3.8A)
None
 0.74A 1ekjA-1n5xA:
undetectable
1ekjB-1n5xA:
undetectable		 1ekjA-1n5xA:
10.37
1ekjB-1n5xA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		4 / 7 CYH A 150
GLY A 795
GLY A 796
GLN A 585
 FES  A3001 ( 2.3A)
None
MTE  A3003 (-3.8A)
None
 0.80A 1ekjE-1n5xA:
undetectable
1ekjF-1n5xA:
undetectable		 1ekjE-1n5xA:
10.37
1ekjF-1n5xA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		4 / 8 GLN A 585
CYH A 150
GLY A 795
GLY A 796
 None
FES  A3001 ( 2.3A)
None
MTE  A3003 (-3.8A)
 0.77A 1ekjE-1n5xA:
undetectable
1ekjF-1n5xA:
undetectable		 1ekjE-1n5xA:
10.37
1ekjF-1n5xA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		4 / 8 CYH A 150
GLY A 795
GLY A 796
GLN A 585
 FES  A3001 ( 2.3A)
None
MTE  A3003 (-3.8A)
None
 0.78A 1ekjG-1n5xA:
undetectable
1ekjH-1n5xA:
undetectable		 1ekjG-1n5xA:
10.37
1ekjH-1n5xA:
10.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		8 / 8 GLU A 802
LEU A 873
ARG A 880
PHE A 914
THR A1010
VAL A1011
LEU A1014
ALA A1079
 TEI  A3006 ( 3.2A)
TEI  A3006 (-4.8A)
TEI  A3006 (-3.5A)
TEI  A3006 (-3.6A)
TEI  A3006 (-2.8A)
TEI  A3006 (-4.8A)
None
TEI  A3006 ( 3.8A)
 0.30A 1fiqC-1n5xA:
64.9		 1fiqC-1n5xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FO4_A_SALA3005_1
(XANTHINE
DEHYDROGENASE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		9 / 9 GLU A 802
LEU A 873
SER A 876
ARG A 880
PHE A 914
THR A1010
VAL A1011
LEU A1014
ALA A1079
 TEI  A3006 ( 3.2A)
TEI  A3006 (-4.8A)
TEI  A3006 (-3.5A)
TEI  A3006 (-3.5A)
TEI  A3006 (-3.6A)
TEI  A3006 (-2.8A)
TEI  A3006 (-4.8A)
None
TEI  A3006 ( 3.8A)
 0.34A 1fo4A-1n5xA:
46.6		 1fo4A-1n5xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FO4_A_SALA3005_1
(XANTHINE
DEHYDROGENASE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 9 SER A 876
PHE A 914
VAL A1011
LEU A1014
ALA A1078
 TEI  A3006 (-3.5A)
TEI  A3006 (-3.6A)
TEI  A3006 (-4.8A)
None
MOS  A3004 (-3.0A)
 1.20A 1fo4A-1n5xA:
46.6		 1fo4A-1n5xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		7 / 7 GLU A 802
SER A 876
ARG A 880
PHE A 914
THR A1010
VAL A1011
ALA A1078
 TEI  A3006 ( 3.2A)
TEI  A3006 (-3.5A)
TEI  A3006 (-3.5A)
TEI  A3006 (-3.6A)
TEI  A3006 (-2.8A)
TEI  A3006 (-4.8A)
MOS  A3004 (-3.0A)
 0.27A 1fo4B-1n5xA:
46.5		 1fo4B-1n5xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		4 / 7 SER A 876
PHE A 914
VAL A1011
ALA A1079
 TEI  A3006 (-3.5A)
TEI  A3006 (-3.6A)
TEI  A3006 (-4.8A)
TEI  A3006 ( 3.8A)
 1.02A 1fo4B-1n5xA:
46.5		 1fo4B-1n5xA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 12 GLY A 915
GLY A1006
HIS A 884
ALA A1079
ILE A1007
 None
None
None
TEI  A3006 ( 3.8A)
None
 0.98A 1gtnL-1n5xA:
0.0
1gtnV-1n5xA:
0.0		 1gtnL-1n5xA:
4.96
1gtnV-1n5xA:
4.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JFF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		6 / 12 VAL A 330
LEU A 404
LEU A 372
THR A 373
PRO A 410
GLY A 296
 None
FAD  A3005 (-4.6A)
None
None
None
None
 1.23A 1jffB-1n5xA:
undetectable		 1jffB-1n5xA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 11 GLY A1039
GLY A1041
GLU A1037
ARG A 793
GLY A 795
 MTE  A3003 (-3.7A)
None
None
None
None
 0.96A 1jg3A-1n5xA:
undetectable		 1jg3A-1n5xA:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 11 GLY A1039
GLY A1041
GLU A1037
ARG A 793
GLY A 796
 MTE  A3003 (-3.7A)
None
None
None
MTE  A3003 (-3.8A)
 1.10A 1jg3A-1n5xA:
undetectable		 1jg3A-1n5xA:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_B_ADNB550_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 11 GLY A1039
GLY A1041
GLU A1037
ARG A 793
GLY A 795
 MTE  A3003 (-3.7A)
None
None
None
None
 0.93A 1jg3B-1n5xA:
undetectable		 1jg3B-1n5xA:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_B_ADNB550_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 11 GLY A1039
GLY A1041
GLU A1037
ARG A 793
GLY A 796
 MTE  A3003 (-3.7A)
None
None
None
MTE  A3003 (-3.8A)
 1.12A 1jg3B-1n5xA:
undetectable		 1jg3B-1n5xA:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 12 ASP A1026
GLU A1114
ILE A1056
PRO A1057
ILE A1061
 None
 1.19A 1kijA-1n5xA:
undetectable		 1kijA-1n5xA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		4 / 7 ASP A 638
GLY A 668
ILE A 666
ALA A 813
 None
 0.55A 1n49A-1n5xA:
undetectable		 1n49A-1n5xA:
6.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_2
(PROTEASE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 11 ASN A 644
ASP A 638
GLY A 668
ILE A 666
ILE A 640
 None
 0.86A 1n49B-1n5xA:
undetectable		 1n49B-1n5xA:
6.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_1
(PROTEASE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 11 ASN A 644
ASP A 638
GLY A 668
ILE A 666
ILE A 640
 None
 0.86A 1n49C-1n5xA:
undetectable		 1n49C-1n5xA:
6.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 12 LEU A  30
LEU A  36
GLY A  35
THR A  24
ILE A  77
 None
 1.43A 1p93A-1n5xA:
undetectable		 1p93A-1n5xA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 12 SER A 368
LEU A 312
VAL A 308
PHE A 299
THR A 324
 None
 1.31A 1q23B-1n5xA:
0.1		 1q23B-1n5xA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		4 / 6 LEU A 521
TRP A 993
LEU A1167
PHE A1313
 None
 0.79A 1ru9H-1n5xA:
undetectable
1ru9L-1n5xA:
0.0		 1ru9H-1n5xA:
10.71
1ru9L-1n5xA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		4 / 6 LEU A 521
TRP A 993
LEU A1167
PHE A1313
 None
 0.77A 1rukH-1n5xA:
undetectable
1rukL-1n5xA:
0.0		 1rukH-1n5xA:
10.71
1rukL-1n5xA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TD7_A_NFLA2001_1
(PHOSPHOLIPASE A2
ISOFORM 3)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 9 LEU A1243
ILE A1178
PHE A1199
GLY A1193
PHE A1239
 None
 1.35A 1td7A-1n5xA:
undetectable		 1td7A-1n5xA:
6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_S_TRPS81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 11 GLY A1006
HIS A 884
ALA A1079
ILE A1007
GLY A 915
 None
None
TEI  A3006 ( 3.8A)
None
None
 0.96A 1utdS-1n5xA:
undetectable
1utdT-1n5xA:
undetectable		 1utdS-1n5xA:
4.96
1utdT-1n5xA:
4.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WYG_A_SALA4005_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		10 / 10 GLU A 802
LEU A 873
SER A 876
ARG A 880
PHE A 914
PHE A1009
THR A1010
ALA A1078
ALA A1079
GLU A1261
 TEI  A3006 ( 3.2A)
TEI  A3006 (-4.8A)
TEI  A3006 (-3.5A)
TEI  A3006 (-3.5A)
TEI  A3006 (-3.6A)
TEI  A3006 (-4.8A)
TEI  A3006 (-2.8A)
MOS  A3004 (-3.0A)
TEI  A3006 ( 3.8A)
MOS  A3004 ( 3.7A)
 0.45A 1wygA-1n5xA:
44.6		 1wygA-1n5xA:
86.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_A_RBFA300_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 11 GLY A 732
SER A 731
TRP A 926
ILE A 922
ALA A 844
 None
 1.37A 2a58A-1n5xA:
undetectable
2a58E-1n5xA:
undetectable		 2a58A-1n5xA:
9.24
2a58E-1n5xA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_D_RBFD303_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 11 ILE A 922
ALA A 844
GLY A 732
SER A 731
TRP A 926
 None
 1.38A 2a58C-1n5xA:
undetectable
2a58D-1n5xA:
undetectable		 2a58C-1n5xA:
9.24
2a58D-1n5xA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_O_CHDO229_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 11 ARG A 912
PHE A 798
GLY A 800
GLN A1040
THR A1036
 MTE  A3003 ( 3.4A)
MTE  A3003 (-3.6A)
None
MTE  A3003 (-3.6A)
None
 1.44A 2dyrG-1n5xA:
0.0
2dyrN-1n5xA:
0.0
2dyrO-1n5xA:
0.0		 2dyrG-1n5xA:
5.06
2dyrN-1n5xA:
17.39
2dyrO-1n5xA:
10.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2E1Q_A_SALA2006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		6 / 6 ARG A 880
PHE A 914
THR A1010
VAL A1011
LEU A1014
ALA A1079
 TEI  A3006 (-3.5A)
TEI  A3006 (-3.6A)
TEI  A3006 (-2.8A)
TEI  A3006 (-4.8A)
None
TEI  A3006 ( 3.8A)
 0.30A 2e1qA-1n5xA:
45.7		 2e1qA-1n5xA:
89.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2E1Q_B_SALB3006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		4 / 4 ARG A 880
PHE A 914
THR A1010
ALA A1079
 TEI  A3006 (-3.5A)
TEI  A3006 (-3.6A)
TEI  A3006 (-2.8A)
TEI  A3006 ( 3.8A)
 0.26A 2e1qB-1n5xA:
45.7		 2e1qB-1n5xA:
89.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2E1Q_C_SALC4006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		6 / 6 ARG A 880
PHE A 914
THR A1010
VAL A1011
LEU A1014
ALA A1079
 TEI  A3006 (-3.5A)
TEI  A3006 (-3.6A)
TEI  A3006 (-2.8A)
TEI  A3006 (-4.8A)
None
TEI  A3006 ( 3.8A)
 0.26A 2e1qC-1n5xA:
45.7		 2e1qC-1n5xA:
89.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2E1Q_D_SALD5006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 5 ARG A 880
PHE A 914
THR A1010
LEU A1014
ALA A1079
 TEI  A3006 (-3.5A)
TEI  A3006 (-3.6A)
TEI  A3006 (-2.8A)
None
TEI  A3006 ( 3.8A)
 0.21A 2e1qD-1n5xA:
45.7		 2e1qD-1n5xA:
89.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_N_CHDN1604_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 11 ARG A 912
PHE A 798
GLY A 800
GLN A1040
THR A1036
 MTE  A3003 ( 3.4A)
MTE  A3003 (-3.6A)
None
MTE  A3003 (-3.6A)
None
 1.45A 2eimG-1n5xA:
0.0
2eimN-1n5xA:
0.3
2eimO-1n5xA:
0.0		 2eimG-1n5xA:
5.06
2eimN-1n5xA:
17.39
2eimO-1n5xA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_D_CHDD702_0
(FERROCHELATASE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		3 / 3 ARG A 381
GLY A 399
PRO A 400
 None
 0.69A 2hreD-1n5xA:
0.0		 2hreD-1n5xA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		6 / 12 VAL A 330
LEU A 404
LEU A 372
THR A 373
PRO A 410
GLY A 296
 None
FAD  A3005 (-4.6A)
None
None
None
None
 1.23A 2hxfB-1n5xA:
undetectable		 2hxfB-1n5xA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXH_B_TA1B601_1
(TUBULIN BETA CHAIN)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		6 / 12 VAL A 330
LEU A 404
LEU A 372
THR A 373
PRO A 410
GLY A 296
 None
FAD  A3005 (-4.6A)
None
None
None
None
 1.23A 2hxhB-1n5xA:
undetectable		 2hxhB-1n5xA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		3 / 3 ALA A 590
GLY A 795
SER A 111
 None
None
FES  A3001 ( 4.9A)
 0.59A 2ivuA-1n5xA:
undetectable		 2ivuA-1n5xA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 12 ALA A 811
LEU A 814
ALA A 815
THR A 819
GLN A 626
 None
 0.98A 2jjpA-1n5xA:
undetectable		 2jjpA-1n5xA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_1
(PROTEASE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 12 LEU A  80
ASP A  59
ILE A  65
VAL A  85
VAL A  83
 None
 0.94A 2nnkA-1n5xA:
undetectable		 2nnkA-1n5xA:
5.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_3
(PROTEASE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 12 LEU A  80
ASP A  59
ILE A  65
VAL A  85
VAL A  83
 None
 0.97A 2nnkB-1n5xA:
undetectable		 2nnkB-1n5xA:
5.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		4 / 5 LEU A 494
ALA A 491
LEU A 513
MET A 438
 None
 1.24A 2oaxA-1n5xA:
undetectable		 2oaxA-1n5xA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 12 ASP A 429
ALA A 338
VAL A 342
GLY A  47
GLY A 145
 FAD  A3005 (-4.1A)
FAD  A3005 (-3.5A)
None
FAD  A3005 (-4.0A)
None
 1.10A 2p16A-1n5xA:
undetectable		 2p16A-1n5xA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P4N_B_TA1B601_1
(TUBULIN BETA CHAIN)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		6 / 12 VAL A 330
LEU A 404
LEU A 372
THR A 373
PRO A 410
GLY A 296
 None
FAD  A3005 (-4.6A)
None
None
None
None
 1.22A 2p4nB-1n5xA:
undetectable		 2p4nB-1n5xA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		4 / 6 PHE A1009
ILE A1085
GLY A1035
GLY A1034
 TEI  A3006 (-4.8A)
None
None
None
 0.78A 2qx6A-1n5xA:
undetectable
2qx6B-1n5xA:
undetectable		 2qx6A-1n5xA:
10.51
2qx6B-1n5xA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WBE_B_TA1B1439_1
(TUBULIN BETA-2B
CHAIN)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		6 / 12 VAL A 330
LEU A 404
LEU A 372
THR A 373
PRO A 410
GLY A 296
 None
FAD  A3005 (-4.6A)
None
None
None
None
 1.23A 2wbeB-1n5xA:
undetectable		 2wbeB-1n5xA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 10 ALA A 811
ALA A 815
THR A 819
LEU A 603
VAL A 632
 None
 1.33A 2wuzA-1n5xA:
undetectable		 2wuzA-1n5xA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		4 / 7 PHE A 655
ALA A 811
ALA A 815
THR A 819
 None
 0.89A 2wx2A-1n5xA:
undetectable		 2wx2A-1n5xA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 12 THR A 262
VAL A 345
SER A  69
SER A 123
GLY A  46
 FAD  A3005 (-3.2A)
None
None
None
FES  A3002 ( 3.1A)
 1.11A 2x2iA-1n5xA:
undetectable		 2x2iA-1n5xA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		4 / 8 GLN A 918
PHE A 914
GLY A 915
GLY A 800
 None
TEI  A3006 (-3.6A)
None
None
 0.84A 2y6rB-1n5xA:
undetectable		 2y6rB-1n5xA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 12 LEU A 372
ILE A 409
ILE A 407
PHE A 365
PHE A 390
 None
 0.96A 2ygqA-1n5xA:
0.0		 2ygqA-1n5xA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 12 LEU A 372
ILE A 409
LEU A 312
ILE A 407
PHE A 365
 None
 1.00A 2ygqA-1n5xA:
0.0		 2ygqA-1n5xA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		4 / 5 LEU A 873
GLN A 767
THR A 803
THR A1010
 TEI  A3006 (-4.8A)
MOS  A3004 (-3.8A)
None
TEI  A3006 (-2.8A)
 1.07A 2zj0B-1n5xA:
undetectable		 2zj0B-1n5xA:
17.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		8 / 8 GLU A 802
SER A 876
ARG A 880
PHE A 914
THR A1010
VAL A1011
LEU A1014
ALA A1079
 TEI  A3006 ( 3.2A)
TEI  A3006 (-3.5A)
TEI  A3006 (-3.5A)
TEI  A3006 (-3.6A)
TEI  A3006 (-2.8A)
TEI  A3006 (-4.8A)
None
TEI  A3006 ( 3.8A)
 0.30A 3ax7A-1n5xA:
44.4		 3ax7A-1n5xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 8 SER A 876
PHE A 914
VAL A1011
LEU A1014
ALA A1078
 TEI  A3006 (-3.5A)
TEI  A3006 (-3.6A)
TEI  A3006 (-4.8A)
None
MOS  A3004 (-3.0A)
 1.12A 3ax7A-1n5xA:
44.4		 3ax7A-1n5xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AX7_B_SALB1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		9 / 9 GLU A 802
SER A 876
ARG A 880
PHE A 914
THR A1010
VAL A1011
LEU A1014
ALA A1078
ALA A1079
 TEI  A3006 ( 3.2A)
TEI  A3006 (-3.5A)
TEI  A3006 (-3.5A)
TEI  A3006 (-3.6A)
TEI  A3006 (-2.8A)
TEI  A3006 (-4.8A)
None
MOS  A3004 (-3.0A)
TEI  A3006 ( 3.8A)
 0.28A 3ax7B-1n5xA:
44.6		 3ax7B-1n5xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AX9_A_SALA1341_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		8 / 8 GLU A 802
LEU A 873
SER A 876
ARG A 880
PHE A 914
THR A1010
VAL A1011
ALA A1079
 TEI  A3006 ( 3.2A)
TEI  A3006 (-4.8A)
TEI  A3006 (-3.5A)
TEI  A3006 (-3.5A)
TEI  A3006 (-3.6A)
TEI  A3006 (-2.8A)
TEI  A3006 (-4.8A)
TEI  A3006 ( 3.8A)
 0.36A 3ax9A-1n5xA:
44.2		 3ax9A-1n5xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AX9_A_SALA1341_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		4 / 8 SER A 876
PHE A 914
VAL A1011
ALA A1078
 TEI  A3006 (-3.5A)
TEI  A3006 (-3.6A)
TEI  A3006 (-4.8A)
MOS  A3004 (-3.0A)
 0.99A 3ax9A-1n5xA:
44.2		 3ax9A-1n5xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		8 / 8 GLU A 802
LEU A 873
SER A 876
ARG A 880
PHE A 914
THR A1010
ALA A1078
ALA A1079
 TEI  A3006 ( 3.2A)
TEI  A3006 (-4.8A)
TEI  A3006 (-3.5A)
TEI  A3006 (-3.5A)
TEI  A3006 (-3.6A)
TEI  A3006 (-2.8A)
MOS  A3004 (-3.0A)
TEI  A3006 ( 3.8A)
 0.25A 3ax9B-1n5xA:
44.0		 3ax9B-1n5xA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		4 / 6 VAL A 440
GLN A 471
PHE A 477
ARG A 439
 None
 1.22A 3bjwF-1n5xA:
0.0		 3bjwF-1n5xA:
6.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		3 / 3 SER A 765
GLY A 795
GLY A 797
 None
None
MTE  A3003 (-3.3A)
 0.55A 3bogA-1n5xA:
undetectable
3bogC-1n5xA:
undetectable		 3bogA-1n5xA:
undetectable
3bogC-1n5xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_2
(PROTEASE
(RETROPEPSIN))		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 12 ASN A 644
ASP A 638
GLY A 668
ILE A 666
ILE A 640
 None
 0.88A 3bvbB-1n5xA:
undetectable		 3bvbB-1n5xA:
5.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		4 / 5 LEU A 454
GLN A 473
THR A 470
LEU A 513
 None
 1.19A 3ce6D-1n5xA:
undetectable		 3ce6D-1n5xA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 9 THR A 803
VAL A 810
LEU A 762
ILE A 787
GLY A 647
 None
 1.17A 3cv9A-1n5xA:
undetectable		 3cv9A-1n5xA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCO_B_TA1B601_1
(BOVINE BETA TUBULIN)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		6 / 12 VAL A 330
LEU A 404
LEU A 372
THR A 373
PRO A 410
GLY A 296
 None
FAD  A3005 (-4.6A)
None
None
None
None
 1.23A 3dcoB-1n5xA:
undetectable		 3dcoB-1n5xA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 12 LEU A  36
GLY A 588
GLY A  38
VAL A 121
LEU A  98
 None
 0.95A 3dh0B-1n5xA:
undetectable		 3dh0B-1n5xA:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		4 / 4 ILE A1253
GLN A1095
ILE A1085
LEU A1054
 None
 1.34A 3dzyD-1n5xA:
0.0		 3dzyD-1n5xA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EDL_B_TA1B601_1
(BETA TUBULIN)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		6 / 12 VAL A 330
LEU A 404
LEU A 372
THR A 373
PRO A 410
GLY A 296
 None
FAD  A3005 (-4.6A)
None
None
None
None
 1.24A 3edlB-1n5xA:
undetectable		 3edlB-1n5xA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 10 ILE A 407
ILE A 409
VAL A 326
GLY A 329
LEU A 305
 None
 1.32A 3em0A-1n5xA:
0.0		 3em0A-1n5xA:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_Q_TRPQ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		4 / 8 GLN A 333
VAL A 364
ILE A 407
VAL A 308
 None
 0.79A 3fi0Q-1n5xA:
undetectable		 3fi0Q-1n5xA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		3 / 3 MET A 927
CYH A 999
PRO A1002
 None
 0.76A 3h52C-1n5xA:
undetectable		 3h52C-1n5xA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IZ0_B_TA1B820_1
(BETA TUBULIN, CHAIN
B FROM PDB 1JFF)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		6 / 12 VAL A 330
LEU A 404
LEU A 372
THR A 373
PRO A 410
GLY A 296
 None
FAD  A3005 (-4.6A)
None
None
None
None
 1.22A 3iz0B-1n5xA:
undetectable		 3iz0B-1n5xA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 12 ILE A1253
GLY A1087
ALA A1019
ALA A1050
VAL A1049
 None
 0.83A 3jb2A-1n5xA:
0.0		 3jb2A-1n5xA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 12 ILE A1253
GLY A1087
ALA A1019
ALA A1050
VAL A1049
 None
 0.79A 3jb3A-1n5xA:
0.0		 3jb3A-1n5xA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 10 LEU A 312
VAL A 330
ILE A 407
LEU A 348
PHE A 365
 None
 1.10A 3jw5B-1n5xA:
undetectable		 3jw5B-1n5xA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 12 GLN A 767
GLY A 795
GLY A 797
LEU A 744
GLU A1037
 MOS  A3004 (-3.8A)
None
MTE  A3003 (-3.3A)
FES  A3001 (-4.0A)
None
 1.06A 3kkzA-1n5xA:
undetectable		 3kkzA-1n5xA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		4 / 8 GLY A 588
CYH A  48
CYH A 148
PHE A 798
 None
FES  A3002 (-2.3A)
FES  A3001 (-2.3A)
MTE  A3003 (-3.6A)
 1.08A 3ko0D-1n5xA:
undetectable
3ko0E-1n5xA:
0.2		 3ko0D-1n5xA:
5.64
3ko0E-1n5xA:
5.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		4 / 8 PHE A 655
ALA A 811
ALA A 815
THR A 819
 None
 0.83A 3l4dA-1n5xA:
undetectable		 3l4dA-1n5xA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		4 / 8 PHE A 655
ALA A 811
ALA A 815
THR A 819
 None
 0.90A 3l4dD-1n5xA:
undetectable		 3l4dD-1n5xA:
16.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		6 / 6 GLU A 802
ARG A 880
PHE A 914
THR A1010
ALA A1078
ALA A1079
 TEI  A3006 ( 3.2A)
TEI  A3006 (-3.5A)
TEI  A3006 (-3.6A)
TEI  A3006 (-2.8A)
MOS  A3004 (-3.0A)
TEI  A3006 ( 3.8A)
 0.35A 3ns1C-1n5xA:
60.7		 3ns1C-1n5xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		8 / 8 GLU A 802
SER A 876
ARG A 880
PHE A 914
THR A1010
LEU A1014
ALA A1078
ALA A1079
 TEI  A3006 ( 3.2A)
TEI  A3006 (-3.5A)
TEI  A3006 (-3.5A)
TEI  A3006 (-3.6A)
TEI  A3006 (-2.8A)
None
MOS  A3004 (-3.0A)
TEI  A3006 ( 3.8A)
 0.32A 3ns1L-1n5xA:
54.6		 3ns1L-1n5xA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		4 / 7 ALA A 669
VAL A 823
VAL A 671
LEU A 635
 None
 0.79A 3o14A-1n5xA:
undetectable		 3o14A-1n5xA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_B_NCAB192_0
(NICOTINAMIDASE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 11 PHE A1009
LEU A1014
TYR A1086
ILE A1085
SER A1082
 TEI  A3006 (-4.8A)
None
None
None
MTE  A3003 (-3.0A)
 1.50A 3o94B-1n5xA:
undetectable		 3o94B-1n5xA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 12 ILE A1056
VAL A1023
ILE A1021
CYH A1094
LEU A1098
 None
 0.56A 3oapA-1n5xA:
undetectable		 3oapA-1n5xA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		4 / 7 LEU A 607
VAL A 808
LEU A1219
ASP A 832
 None
 0.92A 3rgfA-1n5xA:
undetectable		 3rgfA-1n5xA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_1
(HIV-1 PROTEASE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 8 ASN A 644
ALA A 637
ASP A 638
ASP A 639
GLY A 668
 None
 1.26A 3so9A-1n5xA:
undetectable		 3so9A-1n5xA:
6.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_1
(HIV-1 PROTEASE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 8 ASN A 644
ALA A 637
ASP A 639
GLY A 668
ILE A 666
 None
 1.46A 3so9A-1n5xA:
undetectable		 3so9A-1n5xA:
6.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UNA_A_SALA1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		9 / 9 GLU A 802
LEU A 873
SER A 876
ARG A 880
PHE A 914
THR A1010
VAL A1011
LEU A1014
ALA A1079
 TEI  A3006 ( 3.2A)
TEI  A3006 (-4.8A)
TEI  A3006 (-3.5A)
TEI  A3006 (-3.5A)
TEI  A3006 (-3.6A)
TEI  A3006 (-2.8A)
TEI  A3006 (-4.8A)
None
TEI  A3006 ( 3.8A)
 0.28A 3unaA-1n5xA:
49.5		 3unaA-1n5xA:
99.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UNA_A_SALA1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 9 SER A 876
PHE A 914
VAL A1011
LEU A1014
ALA A1078
 TEI  A3006 (-3.5A)
TEI  A3006 (-3.6A)
TEI  A3006 (-4.8A)
None
MOS  A3004 (-3.0A)
 1.20A 3unaA-1n5xA:
49.5		 3unaA-1n5xA:
99.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UNA_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		9 / 9 GLU A 802
LEU A 873
SER A 876
ARG A 880
PHE A 914
THR A1010
VAL A1011
LEU A1014
ALA A1079
 TEI  A3006 ( 3.2A)
TEI  A3006 (-4.8A)
TEI  A3006 (-3.5A)
TEI  A3006 (-3.5A)
TEI  A3006 (-3.6A)
TEI  A3006 (-2.8A)
TEI  A3006 (-4.8A)
None
TEI  A3006 ( 3.8A)
 0.27A 3unaB-1n5xA:
46.7		 3unaB-1n5xA:
99.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UNA_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 9 SER A 876
PHE A 914
VAL A1011
LEU A1014
ALA A1078
 TEI  A3006 (-3.5A)
TEI  A3006 (-3.6A)
TEI  A3006 (-4.8A)
None
MOS  A3004 (-3.0A)
 1.18A 3unaB-1n5xA:
46.7		 3unaB-1n5xA:
99.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UNC_A_SALA1338_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		9 / 9 GLU A 802
LEU A 873
SER A 876
ARG A 880
PHE A 914
THR A1010
VAL A1011
LEU A1014
ALA A1079
 TEI  A3006 ( 3.2A)
TEI  A3006 (-4.8A)
TEI  A3006 (-3.5A)
TEI  A3006 (-3.5A)
TEI  A3006 (-3.6A)
TEI  A3006 (-2.8A)
TEI  A3006 (-4.8A)
None
TEI  A3006 ( 3.8A)
 0.29A 3uncA-1n5xA:
48.3		 3uncA-1n5xA:
99.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UNC_A_SALA1338_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 9 SER A 876
PHE A 914
VAL A1011
LEU A1014
ALA A1078
 TEI  A3006 (-3.5A)
TEI  A3006 (-3.6A)
TEI  A3006 (-4.8A)
None
MOS  A3004 (-3.0A)
 1.16A 3uncA-1n5xA:
48.3		 3uncA-1n5xA:
99.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UNC_B_SALB1338_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		9 / 9 GLU A 802
LEU A 873
SER A 876
ARG A 880
PHE A 914
THR A1010
VAL A1011
LEU A1014
ALA A1079
 TEI  A3006 ( 3.2A)
TEI  A3006 (-4.8A)
TEI  A3006 (-3.5A)
TEI  A3006 (-3.5A)
TEI  A3006 (-3.6A)
TEI  A3006 (-2.8A)
TEI  A3006 (-4.8A)
None
TEI  A3006 ( 3.8A)
 0.29A 3uncB-1n5xA:
46.8		 3uncB-1n5xA:
99.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UNC_B_SALB1338_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 9 SER A 876
PHE A 914
VAL A1011
LEU A1014
ALA A1078
 TEI  A3006 (-3.5A)
TEI  A3006 (-3.6A)
TEI  A3006 (-4.8A)
None
MOS  A3004 (-3.0A)
 1.15A 3uncB-1n5xA:
46.8		 3uncB-1n5xA:
99.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		7 / 7 GLU A 802
ARG A 880
PHE A 914
THR A1010
VAL A1011
LEU A1014
ALA A1079
 TEI  A3006 ( 3.2A)
TEI  A3006 (-3.5A)
TEI  A3006 (-3.6A)
TEI  A3006 (-2.8A)
TEI  A3006 (-4.8A)
None
TEI  A3006 ( 3.8A)
 0.29A 3uniA-1n5xA:
46.7		 3uniA-1n5xA:
99.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UNI_B_SALB1345_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		8 / 8 GLU A 802
LEU A 873
ARG A 880
PHE A 914
THR A1010
VAL A1011
LEU A1014
ALA A1079
 TEI  A3006 ( 3.2A)
TEI  A3006 (-4.8A)
TEI  A3006 (-3.5A)
TEI  A3006 (-3.6A)
TEI  A3006 (-2.8A)
TEI  A3006 (-4.8A)
None
TEI  A3006 ( 3.8A)
 0.28A 3uniB-1n5xA:
46.7		 3uniB-1n5xA:
99.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 12 ILE A1056
VAL A1023
ILE A1021
CYH A1094
LEU A1098
 None
 0.62A 3uvvB-1n5xA:
undetectable		 3uvvB-1n5xA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_B_MIYB2001_1
(TETX2 PROTEIN)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		4 / 8 GLN A 918
PHE A 914
GLY A 915
GLY A 800
 None
TEI  A3006 (-3.6A)
None
None
 0.83A 3v3nB-1n5xA:
undetectable		 3v3nB-1n5xA:
14.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_C_MIYC2001_1
(TETX2 PROTEIN)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		4 / 8 GLN A 918
PHE A 914
GLY A 915
GLY A 800
 None
TEI  A3006 (-3.6A)
None
None
 0.82A 3v3nC-1n5xA:
undetectable		 3v3nC-1n5xA:
14.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		3 / 3 THR A 321
VAL A 316
GLU A 325
 None
 0.74A 3v4tA-1n5xA:
0.0
3v4tD-1n5xA:
0.0		 3v4tA-1n5xA:
16.37
3v4tD-1n5xA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE506_1
(HEMOLYTIC LECTIN
CEL-III)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		4 / 6 ASN A1249
CYH A1247
GLY A1183
ASP A1181
 None
 1.30A 3w9tE-1n5xA:
undetectable		 3w9tE-1n5xA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 12 ALA A1089
LEU A1020
SER A1032
VAL A1031
ILE A1061
 None
 0.87A 4azvA-1n5xA:
undetectable		 4azvA-1n5xA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		3 / 3 LYS A1106
LYS A1105
PRO A1109
 None
 1.17A 4dv1L-1n5xA:
0.0		 4dv1L-1n5xA:
8.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 11 VAL A 789
THR A1070
ALA A 769
THR A 772
VAL A 764
 None
 1.18A 4e0fA-1n5xA:
0.0		 4e0fA-1n5xA:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 11 ALA A 613
GLY A1217
GLY A 868
ASN A 908
HIS A 665
 None
 1.20A 4e47C-1n5xA:
undetectable		 4e47C-1n5xA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		4 / 5 SER A1185
GLY A 574
THR A1083
VAL A1049
 None
None
MTE  A3003 (-4.5A)
None
 1.15A 4eohA-1n5xA:
2.5		 4eohA-1n5xA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_1_PQN12001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 11 SER A 111
GLY A 114
ARG A 793
GLY A1039
ALA A1053
 FES  A3001 ( 4.9A)
FES  A3001 (-4.0A)
None
MTE  A3003 (-3.7A)
None
 1.16A 4l6v1-1n5xA:
undetectable
4l6v6-1n5xA:
undetectable		 4l6v1-1n5xA:
19.91
4l6v6-1n5xA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_A_SAMA603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		4 / 7 PHE A1150
GLN A 957
THR A 953
ASP A 886
 None
 1.06A 4pcuA-1n5xA:
undetectable		 4pcuA-1n5xA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		4 / 7 GLU A1065
THR A1066
THR A1044
HIS A 579
 None
 1.07A 4pfjA-1n5xA:
undetectable		 4pfjA-1n5xA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		4 / 6 GLU A1065
THR A1066
THR A1044
HIS A 579
 None
 0.95A 4pfjB-1n5xA:
undetectable		 4pfjB-1n5xA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		4 / 6 GLU A1065
THR A1066
THR A1044
HIS A 579
 None
 1.06A 4pgfA-1n5xA:
undetectable		 4pgfA-1n5xA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 12 LEU A 348
ALA A 304
PHE A 299
LEU A 312
ILE A 297
 None
 0.96A 4pssA-1n5xA:
undetectable		 4pssA-1n5xA:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		4 / 8 ALA A1198
ASN A 887
THR A1154
SER A1080
 None
None
None
MTE  A3003 (-3.9A)
 0.76A 4r20A-1n5xA:
0.0		 4r20A-1n5xA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 12 ALA A1258
GLY A1006
GLU A 802
ALA A 910
GLY A 913
 None
None
TEI  A3006 ( 3.2A)
MOS  A3004 ( 4.7A)
None
 1.08A 4r29B-1n5xA:
0.0		 4r29B-1n5xA:
10.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		4 / 8 ASP A 571
SER A1051
PRO A1057
TRP A1113
 None
 1.01A 4uhxA-1n5xA:
41.7		 4uhxA-1n5xA:
50.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		4 / 8 ASP A 571
SER A1051
PRO A1057
TRP A1116
 None
 0.63A 4uhxA-1n5xA:
41.7		 4uhxA-1n5xA:
50.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UHX_A_RTZA3009_1
(ALDEHYDE OXIDASE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		4 / 8 ASP A 571
SER A1051
PRO A1057
TRP A1113
 None
 1.01A 4uhxA-1n5xA:
41.7		 4uhxA-1n5xA:
50.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		4 / 6 ILE A1063
VAL A1071
THR A1077
ARG A 793
 None
None
MTE  A3003 (-4.5A)
None
 0.96A 4xe5A-1n5xA:
0.0		 4xe5A-1n5xA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		3 / 3 LEU A  36
ASP A 595
ILE A  91
 None
 0.69A 4xi3D-1n5xA:
undetectable		 4xi3D-1n5xA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		3 / 3 LEU A 834
ASP A 740
ILE A 666
 None
 0.64A 4xi3D-1n5xA:
undetectable		 4xi3D-1n5xA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		4 / 8 PHE A 911
ALA A1198
LEU A1264
GLY A 913
 None
 0.89A 4xk8a-1n5xA:
undetectable		 4xk8a-1n5xA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 11 GLY A 296
VAL A 308
LEU A 313
LEU A 334
LEU A 331
 None
 1.13A 4zmeA-1n5xA:
undetectable		 4zmeA-1n5xA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 11 ALA A 613
GLY A1217
GLY A 868
ASN A 908
HIS A 665
 None
 1.19A 5ayfA-1n5xA:
undetectable		 5ayfA-1n5xA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		3 / 3 ASP A1297
GLU A 699
SER A 928
 None
 0.81A 5bw4B-1n5xA:
undetectable		 5bw4B-1n5xA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNW_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 12 VAL A 330
LEU A 404
LEU A 372
THR A 373
PRO A 410
 None
FAD  A3005 (-4.6A)
None
None
None
 0.98A 5hnwB-1n5xA:
undetectable		 5hnwB-1n5xA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNY_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 12 VAL A 330
LEU A 404
LEU A 372
THR A 373
PRO A 410
 None
FAD  A3005 (-4.6A)
None
None
None
 1.04A 5hnyB-1n5xA:
undetectable		 5hnyB-1n5xA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 12 GLU A 929
SER A 928
PHE A1271
THR A1301
ARG A1306
 None
 1.42A 5hnzB-1n5xA:
undetectable		 5hnzB-1n5xA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 12 LEU A 454
PHE A 519
LEU A 527
LEU A 524
PHE A 516
 None
 1.32A 5ieoA-1n5xA:
undetectable		 5ieoA-1n5xA:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		3 / 3 ASP A1311
ASN A1307
PHE A 516
 None
 0.92A 5jglB-1n5xA:
undetectable		 5jglB-1n5xA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JO9_A_SORA302_0
(RIBITOL
2-DEHYDROGENASE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 12 LEU A  34
THR A  87
GLU A  89
GLY A  35
LEU A  30
 None
 1.32A 5jo9A-1n5xA:
undetectable		 5jo9A-1n5xA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		4 / 8 ARG A 233
GLU A 232
GLY A 630
PRO A 629
 None
 0.97A 5kf8A-1n5xA:
undetectable		 5kf8A-1n5xA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		4 / 8 GLU A 232
GLY A 630
PRO A 629
ASP A 673
 None
 1.15A 5kf8A-1n5xA:
undetectable		 5kf8A-1n5xA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 12 VAL A 330
LEU A 404
THR A 373
PRO A 410
GLY A 296
 None
FAD  A3005 (-4.6A)
None
None
None
 1.27A 5ogcB-1n5xA:
undetectable		 5ogcB-1n5xA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_A_NIZA808_1
(CATALASE-PEROXIDASE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		4 / 8 GLU A  45
GLY A  42
LEU A 744
THR A 746
 None
FES  A3002 (-4.0A)
FES  A3001 (-4.0A)
None
 0.96A 5sxqA-1n5xA:
undetectable		 5sxqA-1n5xA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_A_NIZA807_1
(CATALASE-PEROXIDASE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		4 / 8 GLU A  45
GLY A  42
LEU A 744
THR A 746
 None
FES  A3002 (-4.0A)
FES  A3001 (-4.0A)
None
 0.96A 5sxtA-1n5xA:
1.2		 5sxtA-1n5xA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_B_NIZB808_1
(CATALASE-PEROXIDASE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		4 / 8 GLU A  45
GLY A  42
LEU A 744
THR A 746
 None
FES  A3002 (-4.0A)
FES  A3001 (-4.0A)
None
 0.97A 5sxtB-1n5xA:
undetectable		 5sxtB-1n5xA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		4 / 8 GLU A  45
GLY A  42
LEU A 744
THR A 746
 None
FES  A3002 (-4.0A)
FES  A3001 (-4.0A)
None
 0.96A 5syjB-1n5xA:
undetectable		 5syjB-1n5xA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		3 / 3 MET A 927
GLU A 939
ARG A 942
 None
 1.01A 5tjyA-1n5xA:
undetectable		 5tjyA-1n5xA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		3 / 3 MET A 927
GLU A 939
ARG A 942
 None
 0.92A 5tjzA-1n5xA:
2.3		 5tjzA-1n5xA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 12 ILE A 640
GLY A 642
GLY A 781
SER A 809
VAL A 654
 None
 0.84A 5twjA-1n5xA:
undetectable		 5twjA-1n5xA:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 10 ILE A 640
GLY A 642
GLY A 781
SER A 809
VAL A 654
 None
 0.81A 5twjB-1n5xA:
undetectable		 5twjB-1n5xA:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 11 ILE A 640
GLY A 642
GLY A 781
SER A 809
VAL A 654
 None
 0.84A 5twjD-1n5xA:
undetectable		 5twjD-1n5xA:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		3 / 3 THR A1314
THR A 510
ARG A1306
 None
 1.04A 5wm2A-1n5xA:
undetectable		 5wm2A-1n5xA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_A_ADNA506_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		4 / 6 TRP A 993
LEU A 521
GLU A 480
LEU A 483
 None
 1.23A 5xooA-1n5xA:
0.0		 5xooA-1n5xA:
5.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA411_0
(UNCHARACTERIZED
PROTEIN KDOO)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		3 / 3 LYS A1172
LEU A1174
ARG A 996
 None
 0.70A 5yw0A-1n5xA:
undetectable		 5yw0A-1n5xA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_B_9KLB402_0
(EST-Y29)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 12 SER A 123
PHE A1232
ILE A 156
LEU A 157
ALA A 142
 None
 1.12A 5zwrB-1n5xA:
0.0		 5zwrB-1n5xA:
15.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 12 LEU A  55
SER A 123
LEU A  26
THR A  25
GLY A  46
 None
None
None
None
FES  A3002 ( 3.1A)
 1.01A 6b0cD-1n5xA:
undetectable		 6b0cD-1n5xA:
4.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 12 VAL A 330
LEU A 404
LEU A 372
THR A 373
GLY A 296
 None
FAD  A3005 (-4.6A)
None
None
None
 0.90A 6b0cD-1n5xA:
undetectable		 6b0cD-1n5xA:
4.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		4 / 8 ILE A 120
THR A 117
THR A  39
GLU A  89
 None
 0.99A 6c06C-1n5xA:
undetectable		 6c06C-1n5xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_1
(CYTOCHROME P450 1A1)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		3 / 3 SER A 123
SER A  69
ALA A 338
 None
None
FAD  A3005 (-3.5A)
 0.73A 6dwnC-1n5xA:
undetectable		 6dwnC-1n5xA:
4.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA204_0
(N-ACETYLTRANSFERASE)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		4 / 5 LEU A 900
CYH A 901
THR A 903
GLY A 868
 None
 0.88A 6gtqA-1n5xA:
0.7		 6gtqA-1n5xA:
8.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUP_B_DZPB502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		 1n5x XANTHINE
DEHYDROGENASE
(Bos
taurus) 		5 / 11 ILE A 278
THR A 354
THR A 262
ASN A 261
MET A 268
 None
FAD  A3005 (-3.9A)
FAD  A3005 (-3.2A)
None
None
 1.41A 6hupA-1n5xA:
2.3
6hupB-1n5xA:
2.6		 6hupA-1n5xA:
6.69
6hupB-1n5xA:
5.24