SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1n60'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_A_803A311_1
(ANTIGEN CD11A (P180))
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
5 / 10 VAL B 111
ILE B  64
TYR B 140
GLU B 137
VAL B  55
None
1.02A 1cqpA-1n60B:
undetectable
1cqpB-1n60B:
undetectable
1cqpA-1n60B:
14.33
1cqpB-1n60B:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_2
(DIHYDROFOLATE
REDUCTASE)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN
CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN

(Oligotropha
carboxidovorans)
3 / 3 TRP B 742
ARG A 112
THR A 140
None
None
FES  A4907 ( 4.8A)
0.94A 1df7A-1n60B:
undetectable
1df7A-1n60B:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
4 / 5 ARG B  14
LYS B  17
ALA B  15
ASP B 611
None
0.91A 1e7cA-1n60B:
undetectable
1e7cA-1n60B:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
1n60 CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN

(Oligotropha
carboxidovorans)
5 / 12 ILE A 149
ALA A 152
ALA A 153
LEU A  90
ALA A  89
None
0.95A 1fbyA-1n60A:
undetectable
1fbyA-1n60A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_B_9CRB1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
1n60 CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN

(Oligotropha
carboxidovorans)
5 / 12 ILE A 149
ALA A 152
ALA A 153
LEU A  90
ALA A  89
None
0.96A 1fbyB-1n60A:
undetectable
1fbyB-1n60A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
1n60 CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN

(Oligotropha
carboxidovorans)
5 / 12 ILE A 149
ALA A 152
ALA A 153
LEU A  90
ALA A  89
None
0.91A 1fm6A-1n60A:
undetectable
1fm6A-1n60A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
1n60 CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN

(Oligotropha
carboxidovorans)
5 / 12 ILE A 149
ALA A 152
ALA A 153
LEU A  90
ALA A  89
None
0.94A 1fm9A-1n60A:
undetectable
1fm9A-1n60A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
5 / 12 THR B 525
GLN B 528
GLU B 555
GLY B 531
TYR B 536
None
MCN  B4920 (-4.0A)
None
MCN  B4920 ( 4.2A)
None
1.31A 1httB-1n60B:
undetectable
1httB-1n60B:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)
1n60 CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN
CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans;
Oligotropha
carboxidovorans)
5 / 12 THR A 106
ARG B  27
TYR B  40
GLY B  38
GLY B  36
None
1.24A 1httD-1n60A:
undetectable
1httD-1n60A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JFF_B_TA1B601_1
(TUBULIN BETA CHAIN)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
5 / 12 VAL B 122
LEU B 235
LEU B 233
THR B 234
GLY B  48
None
1.06A 1jffB-1n60B:
undetectable
1jffB-1n60B:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN
CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN

(Oligotropha
carboxidovorans)
5 / 8 THR B 735
GLY A 133
LEU A 136
ARG A 112
GLY A  48
None
None
None
None
FES  A4908 (-3.9A)
1.23A 1jhqA-1n60B:
undetectable
1jhqA-1n60B:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHR_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN
CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN

(Oligotropha
carboxidovorans)
5 / 9 THR B 735
GLY A 133
LEU A 136
ARG A 112
GLY A  48
None
None
None
None
FES  A4908 (-3.9A)
1.20A 1jhrA-1n60B:
undetectable
1jhrA-1n60B:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
1n60 CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN

(Oligotropha
carboxidovorans)
5 / 12 ILE A 149
ALA A 152
ALA A 153
LEU A  90
ALA A  89
None
0.90A 1k74A-1n60A:
undetectable
1k74A-1n60A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
5 / 12 ILE B 489
GLY B 354
VAL B 392
ALA B  99
GLY B 569
None
None
None
None
OMO  B4921 ( 3.5A)
1.23A 1kiaB-1n60B:
undetectable
1kiaB-1n60B:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
5 / 12 ILE B 289
LEU B 233
GLY B 254
SER B 250
ILE B 260
None
1.22A 1kyvB-1n60B:
2.5
1kyvC-1n60B:
undetectable
1kyvB-1n60B:
12.33
1kyvC-1n60B:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
5 / 12 ILE B 289
LEU B 233
GLY B 254
SER B 250
ILE B 260
None
1.22A 1kyvC-1n60B:
undetectable
1kyvD-1n60B:
2.5
1kyvC-1n60B:
12.33
1kyvD-1n60B:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
5 / 12 ILE B 289
LEU B 233
GLY B 254
SER B 250
ILE B 260
None
1.22A 1kyvD-1n60B:
2.5
1kyvE-1n60B:
undetectable
1kyvD-1n60B:
12.33
1kyvE-1n60B:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5K_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN
CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN

(Oligotropha
carboxidovorans)
5 / 9 THR B 735
GLY A 133
LEU A 136
ARG A 112
GLY A  48
None
None
None
None
FES  A4908 (-3.9A)
1.21A 1l5kA-1n60B:
undetectable
1l5kA-1n60B:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5L_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN
CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN

(Oligotropha
carboxidovorans)
5 / 9 THR B 735
GLY A 133
LEU A 136
ARG A 112
GLY A  48
None
None
None
None
FES  A4908 (-3.9A)
1.23A 1l5lA-1n60B:
undetectable
1l5lA-1n60B:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN
CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN

(Oligotropha
carboxidovorans)
5 / 9 THR B 735
GLY A 133
LEU A 136
ARG A 112
GLY A  48
None
None
None
None
FES  A4908 (-3.9A)
1.21A 1l5mA-1n60B:
undetectable
1l5mA-1n60B:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA156_1
(CALMODULIN)
1n60 CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN

(Oligotropha
carboxidovorans)
5 / 8 ILE A  10
LEU A  35
ILE A  29
VAL A  52
ILE A  74
None
1.43A 1linA-1n60A:
undetectable
1linA-1n60A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
4 / 6 ASP B 685
GLY B 687
THR B 749
SER B 440
None
0.77A 1n4fA-1n60B:
undetectable
1n4fA-1n60B:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
4 / 6 ASP B 685
THR B 749
PRO B 750
SER B 440
None
0.87A 1n4fA-1n60B:
undetectable
1n4fA-1n60B:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
4 / 8 HIS B 213
PRO B 214
SER B 381
THR B  97
None
1.13A 1p7lC-1n60B:
undetectable
1p7lC-1n60B:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
4 / 8 HIS B 213
PRO B 214
SER B 381
THR B  97
None
1.12A 1p7lD-1n60B:
undetectable
1p7lD-1n60B:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFT_A_HSMA177_1
(PROTEIN
(FEMALE-SPECIFIC
HISTAMINE BINDING
PROTEIN 2))
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
5 / 10 TYR B  94
ASP B 163
TYR B 376
ASP B 101
VAL B 102
None
1.48A 1qftA-1n60B:
0.0
1qftA-1n60B:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFV_A_HSMA176_1
(PROTEIN
(FEMALE-SPECIFIC
HISTAMINE BINDING
PROTEIN 2))
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
5 / 10 TYR B  94
ASP B 163
TYR B 376
ASP B 101
VAL B 102
None
1.49A 1qfvA-1n60B:
0.0
1qfvA-1n60B:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
4 / 8 HIS B 213
PRO B 214
SER B 381
THR B  97
None
1.14A 1rg9A-1n60B:
undetectable
1rg9A-1n60B:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
4 / 8 HIS B 213
PRO B 214
SER B 381
THR B  97
None
1.14A 1rg9B-1n60B:
undetectable
1rg9B-1n60B:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
4 / 8 HIS B 213
PRO B 214
SER B 381
THR B  97
None
1.14A 1rg9C-1n60B:
undetectable
1rg9C-1n60B:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
4 / 8 HIS B 213
PRO B 214
SER B 381
THR B  97
None
1.13A 1rg9D-1n60B:
undetectable
1rg9D-1n60B:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_A_CAMA1422_0
(CYTOCHROME P450-CAM)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
4 / 7 PHE B 390
VAL B 275
GLY B 276
ASP B 347
None
0.96A 1t88A-1n60B:
0.0
1t88A-1n60B:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TH6_A_OINA401_1
(PHOSPHOLIPASE A2)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
4 / 7 GLY B 701
HIS B 766
TYR B 386
PRO B 214
None
1.17A 1th6A-1n60B:
undetectable
1th6A-1n60B:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_E_9CRE1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
1n60 CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN

(Oligotropha
carboxidovorans)
5 / 12 ILE A 149
ALA A 152
ALA A 153
LEU A  90
ALA A  89
None
0.92A 1xdkE-1n60A:
undetectable
1xdkE-1n60A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_A_9CRA201_1
(RXR-LIKE PROTEIN)
1n60 CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN

(Oligotropha
carboxidovorans)
5 / 12 ILE A 149
ALA A 152
ALA A 153
LEU A  90
ALA A  89
None
0.93A 1xiuA-1n60A:
undetectable
1xiuA-1n60A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_A_9CRA801_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
1n60 CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN

(Oligotropha
carboxidovorans)
5 / 12 ILE A 149
ALA A 152
ALA A 153
LEU A  90
ALA A  89
None
0.88A 1xlsA-1n60A:
undetectable
1xlsA-1n60A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_B_9CRB802_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
1n60 CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN

(Oligotropha
carboxidovorans)
5 / 12 ILE A 149
ALA A 152
ALA A 153
LEU A  90
ALA A  89
None
0.90A 1xlsB-1n60A:
undetectable
1xlsB-1n60A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_C_9CRC803_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
1n60 CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN

(Oligotropha
carboxidovorans)
5 / 12 ILE A 149
ALA A 152
ALA A 153
LEU A  90
ALA A  89
None
0.90A 1xlsC-1n60A:
undetectable
1xlsC-1n60A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_D_9CRD804_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
1n60 CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN

(Oligotropha
carboxidovorans)
5 / 12 ILE A 149
ALA A 152
ALA A 153
LEU A  90
ALA A  89
None
0.89A 1xlsD-1n60A:
undetectable
1xlsD-1n60A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_A_CAMA1422_0
(CYTOCHROME P450-CAM)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
4 / 7 PHE B 310
THR B 377
GLY B 374
ASP B 313
None
0.90A 2a1mA-1n60B:
undetectable
2a1mA-1n60B:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_A_CAMA1422_0
(CYTOCHROME P450-CAM)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
4 / 7 PHE B 390
VAL B 275
GLY B 276
ASP B 347
None
0.97A 2a1mA-1n60B:
undetectable
2a1mA-1n60B:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_G_REAG501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
1n60 CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN

(Oligotropha
carboxidovorans)
5 / 12 ILE A 149
ALA A 152
ALA A 153
LEU A  90
ALA A  89
None
0.94A 2aclG-1n60A:
undetectable
2aclG-1n60A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ARM_A_OINA401_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
4 / 7 GLY B 701
HIS B 766
TYR B 386
PRO B 214
None
1.18A 2armA-1n60B:
undetectable
2armA-1n60B:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
5 / 12 LEU B 459
GLU B 404
GLY B 482
SER B 414
ALA B 776
None
1.13A 2br4A-1n60B:
undetectable
2br4A-1n60B:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
5 / 12 LEU B 459
GLU B 404
GLY B 482
SER B 414
ALA B 776
None
1.03A 2br4D-1n60B:
undetectable
2br4D-1n60B:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
6 / 12 LEU B 459
GLU B 404
GLY B 482
SER B 414
ASP B 779
ALA B 776
None
1.17A 2br4F-1n60B:
undetectable
2br4F-1n60B:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXF_B_TA1B601_1
(TUBULIN BETA CHAIN)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
5 / 12 VAL B 122
LEU B 235
LEU B 233
THR B 234
GLY B  48
None
1.06A 2hxfB-1n60B:
undetectable
2hxfB-1n60B:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXH_B_TA1B601_1
(TUBULIN BETA CHAIN)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
5 / 12 VAL B 122
LEU B 235
LEU B 233
THR B 234
GLY B  48
None
1.06A 2hxhB-1n60B:
undetectable
2hxhB-1n60B:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_CCSB417_0
(ESTROGEN RECEPTOR)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
3 / 3 GLN B  19
LYS B  26
VAL B  28
None
0.71A 2jfaB-1n60B:
0.0
2jfaB-1n60B:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P4N_B_TA1B601_1
(TUBULIN BETA CHAIN)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
5 / 12 VAL B 122
LEU B 235
LEU B 233
THR B 234
GLY B  48
None
1.06A 2p4nB-1n60B:
undetectable
2p4nB-1n60B:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
4 / 5 LEU B 798
GLY B 802
ILE B 478
ILE B 668
None
0.81A 2q9rA-1n60B:
undetectable
2q9rA-1n60B:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
4 / 7 GLY B 237
THR B 238
CYH B 220
PHE B  54
None
1.14A 2qx4A-1n60B:
undetectable
2qx4B-1n60B:
undetectable
2qx4A-1n60B:
15.68
2qx4B-1n60B:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_L_ASDL1224_1
(GLUTATHIONE
S-TRANSFERASE A3)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
4 / 7 PHE B 342
LEU B 160
ALA B 341
PHE B 113
None
1.06A 2vcvL-1n60B:
0.0
2vcvL-1n60B:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WBE_B_TA1B1439_1
(TUBULIN BETA-2B
CHAIN)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
5 / 12 VAL B 122
LEU B 235
LEU B 233
THR B 234
GLY B  48
None
1.06A 2wbeB-1n60B:
undetectable
2wbeB-1n60B:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
4 / 5 PHE B 271
PRO B 734
VAL B 298
PHE B 728
MCN  B4920 ( 3.5A)
None
None
None
1.28A 2ygnA-1n60B:
undetectable
2ygnA-1n60B:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
6 / 12 ILE B 483
ILE B 481
MET B 479
ILE B 419
MET B 447
PHE B 663
None
1.33A 2ygoA-1n60B:
undetectable
2ygoA-1n60B:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS8_A_BRLA503_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
5 / 12 GLY B 280
ILE B 289
LEU B 233
LEU B  87
LEU B  82
None
1.26A 3cs8A-1n60B:
undetectable
3cs8A-1n60B:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCO_B_TA1B601_1
(BOVINE BETA TUBULIN)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
5 / 12 VAL B 122
LEU B 235
LEU B 233
THR B 234
GLY B  48
None
1.06A 3dcoB-1n60B:
undetectable
3dcoB-1n60B:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
3 / 3 ASP B 745
ASP B 452
ASP B 685
None
0.73A 3douA-1n60B:
undetectable
3douA-1n60B:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EDL_B_TA1B601_1
(BETA TUBULIN)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
5 / 12 VAL B 122
LEU B 235
LEU B 233
THR B 234
GLY B  48
None
1.04A 3edlB-1n60B:
undetectable
3edlB-1n60B:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_1
(PROTEASE)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
5 / 8 GLY B 276
ALA B 277
VAL B 249
GLY B 280
ILE B 245
None
1.20A 3ekpA-1n60B:
undetectable
3ekpA-1n60B:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
1n60 CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN

(Oligotropha
carboxidovorans)
5 / 10 ILE A 149
ALA A 152
ALA A 153
LEU A  90
ALA A  89
None
0.96A 3falC-1n60A:
undetectable
3falC-1n60A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
1n60 CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN

(Oligotropha
carboxidovorans)
5 / 11 ILE A 149
ALA A 152
ALA A 153
LEU A  90
ALA A  89
None
0.93A 3fc6A-1n60A:
undetectable
3fc6A-1n60A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
5 / 10 ALA B 322
LEU B 406
LEU B 417
ILE B 399
THR B 323
None
1.13A 3fl9E-1n60B:
undetectable
3fl9E-1n60B:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_A_T22A800_1
(DIPEPTIDYL PEPTIDASE
4)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
5 / 12 GLU B 437
SER B 751
TYR B 657
ASN B 654
HIS B 753
None
1.30A 3g0bA-1n60B:
undetectable
3g0bA-1n60B:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_A_T22A800_1
(DIPEPTIDYL PEPTIDASE
4)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN
CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN

(Oligotropha
carboxidovorans)
5 / 12 ARG B 126
GLU A  31
TYR A 104
TYR B  40
VAL B  44
None
1.45A 3g0bA-1n60B:
undetectable
3g0bA-1n60B:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_B_T22B800_1
(DIPEPTIDYL PEPTIDASE
4)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
5 / 12 GLU B 437
SER B 751
TYR B 657
ASN B 654
HIS B 753
None
1.31A 3g0bB-1n60B:
undetectable
3g0bB-1n60B:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_B_T22B800_1
(DIPEPTIDYL PEPTIDASE
4)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN
CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN

(Oligotropha
carboxidovorans)
5 / 12 ARG B 126
GLU A  31
TYR A 104
TYR B  40
VAL B  44
None
1.43A 3g0bB-1n60B:
undetectable
3g0bB-1n60B:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_C_T22C800_1
(DIPEPTIDYL PEPTIDASE
4)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
5 / 12 GLU B 437
SER B 751
TYR B 657
ASN B 654
HIS B 753
None
1.30A 3g0bC-1n60B:
undetectable
3g0bC-1n60B:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_C_T22C800_1
(DIPEPTIDYL PEPTIDASE
4)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN
CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN

(Oligotropha
carboxidovorans)
5 / 12 ARG B 126
GLU A  31
TYR A 104
TYR B  40
VAL B  44
None
1.45A 3g0bC-1n60B:
undetectable
3g0bC-1n60B:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_D_T22D800_1
(DIPEPTIDYL PEPTIDASE
4)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
5 / 12 GLU B 437
SER B 751
TYR B 657
ASN B 654
HIS B 753
None
1.31A 3g0bD-1n60B:
undetectable
3g0bD-1n60B:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G7X_A_HSMA174_1
(FEMALE-SPECIFIC
HISTAMINE-BINDING
PROTEIN 2)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
5 / 10 TYR B  94
ASP B 163
TYR B 376
ASP B 101
VAL B 102
None
1.49A 3g7xA-1n60B:
0.0
3g7xA-1n60B:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)
1n60 CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN
CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans;
Oligotropha
carboxidovorans)
3 / 3 ASP A  43
PHE B 728
SER B 306
None
1.02A 3i5uB-1n60A:
undetectable
3i5uB-1n60A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IZ0_B_TA1B820_1
(BETA TUBULIN, CHAIN
B FROM PDB 1JFF)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
5 / 12 VAL B 122
LEU B 235
LEU B 233
THR B 234
GLY B  48
None
1.02A 3iz0B-1n60B:
undetectable
3iz0B-1n60B:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN
CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN

(Oligotropha
carboxidovorans)
4 / 8 GLY B  36
CYH A  47
CYH A 137
PHE B 271
None
FES  A4908 (-2.2A)
FES  A4907 (-2.3A)
MCN  B4920 ( 3.5A)
0.98A 3ko0D-1n60B:
undetectable
3ko0E-1n60B:
0.0
3ko0D-1n60B:
8.91
3ko0E-1n60B:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN
CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN

(Oligotropha
carboxidovorans)
4 / 8 GLY B  36
CYH A  47
CYH A 137
PHE B 271
None
FES  A4908 (-2.2A)
FES  A4907 (-2.3A)
MCN  B4920 ( 3.5A)
0.99A 3ko0B-1n60B:
0.4
3ko0J-1n60B:
0.0
3ko0B-1n60B:
8.91
3ko0J-1n60B:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
1n60 CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN

(Oligotropha
carboxidovorans)
5 / 12 ILE A 149
ALA A 152
ALA A 153
LEU A  90
ALA A  89
None
0.95A 3oapA-1n60A:
undetectable
3oapA-1n60A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
3 / 3 TYR B 563
ASP B 507
ASP B 651
None
0.75A 3ou7B-1n60B:
undetectable
3ou7B-1n60B:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_A_BEZA264_0
(ECHA1_1)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
4 / 8 ALA B 521
ILE B 551
ALA B 584
ALA B 583
None
0.68A 3r9tA-1n60B:
undetectable
3r9tA-1n60B:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
5 / 11 ILE B 513
ILE B 551
ILE B 587
ALA B 537
GLU B 543
None
0.97A 3tmzA-1n60B:
0.0
3tmzA-1n60B:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1005_1
(HEMOLYTIC LECTIN
CEL-III)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN
CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN

(Oligotropha
carboxidovorans)
3 / 3 ASP B  43
GLY A  37
TYR B  40
None
0.76A 3w9tC-1n60B:
undetectable
3w9tC-1n60B:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG503_1
(HEMOLYTIC LECTIN
CEL-III)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN
CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN

(Oligotropha
carboxidovorans)
3 / 3 ASP B  43
GLY A  37
TYR B  40
None
0.75A 3w9tG-1n60B:
undetectable
3w9tG-1n60B:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_A_ADNA901_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
5 / 9 ALA B 537
ARG B  25
GLY B  20
ASN B 691
ILE B 756
None
1.32A 3wdmA-1n60B:
undetectable
3wdmA-1n60B:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)
1n60 CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN

(Oligotropha
carboxidovorans)
5 / 10 GLY A 134
ALA A  49
GLY A  48
CYH A  42
CYH A  50
None
None
FES  A4908 (-3.9A)
FES  A4908 (-2.3A)
FES  A4908 (-2.2A)
1.20A 4c5lC-1n60A:
undetectable
4c5lC-1n60A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)
1n60 CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN

(Oligotropha
carboxidovorans)
5 / 10 GLY A 134
ALA A  49
GLY A  48
CYH A  42
CYH A  50
None
None
FES  A4908 (-3.9A)
FES  A4908 (-2.3A)
FES  A4908 (-2.2A)
1.17A 4c5nD-1n60A:
undetectable
4c5nD-1n60A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN
CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN

(Oligotropha
carboxidovorans)
4 / 8 SER B 215
ASN B 273
GLY B 269
GLY A  41
None
None
MCN  B4920 ( 3.7A)
FES  A4908 (-4.3A)
0.74A 4fo4B-1n60B:
undetectable
4fo4B-1n60B:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
3 / 3 PRO B 755
TYR B 650
GLY B 577
None
0.70A 4g2zA-1n60B:
undetectable
4g2zA-1n60B:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
1n60 CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN

(Oligotropha
carboxidovorans)
5 / 12 ILE A 149
ALA A 152
ALA A 153
LEU A  90
ALA A  89
None
0.86A 4k6iA-1n60A:
undetectable
4k6iA-1n60A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOS_A_4KOA201_1
(UNCHARACTERIZED
PROTEIN)
1n60 CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN

(Oligotropha
carboxidovorans)
5 / 12 CYH A 105
PRO A 107
GLY A  48
ASN A 135
ILE A  40
FES  A4907 (-2.2A)
None
FES  A4908 (-3.9A)
None
FES  A4908 (-4.4A)
1.45A 4kosA-1n60A:
undetectable
4kosA-1n60A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
5 / 9 VAL B 582
ALA B 579
TYR B 650
GLY B 757
GLY B 577
None
1.35A 4mmbA-1n60B:
undetectable
4mmbA-1n60B:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
1n60 CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN

(Oligotropha
carboxidovorans)
5 / 12 ILE A 149
ALA A 152
ALA A 153
LEU A  90
ALA A  89
None
0.94A 4nqaH-1n60A:
undetectable
4nqaH-1n60A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_1
(ANDROGEN RECEPTOR)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
5 / 12 GLY B 802
GLN B 804
HIS B 793
ILE B 668
VAL B 777
None
1.18A 4okwA-1n60B:
0.0
4okwA-1n60B:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
3 / 3 VAL B 212
ALA B 708
PHE B 731
None
0.90A 4olbA-1n60B:
undetectable
4olbA-1n60B:
22.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
5 / 12 GLY B 354
ALA B 353
LEU B 370
GLU B 394
ILE B 358
None
1.31A 4pb1A-1n60B:
0.0
4pb1A-1n60B:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
5 / 12 ALA B 368
LEU B 320
GLY B 361
CYH B 359
TYR B 443
None
1.14A 4pclA-1n60B:
undetectable
4pclA-1n60B:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
4 / 5 THR B 525
THR B 567
THR B 656
HIS B 754
None
MCN  B4920 (-3.8A)
None
None
1.19A 4pgfB-1n60B:
undetectable
4pgfB-1n60B:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
3 / 3 GLN B 790
HIS B 788
ARG B 401
None
1.21A 4qyqA-1n60B:
undetectable
4qyqA-1n60B:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
3 / 3 GLN B 790
HIS B 788
ARG B 401
None
1.22A 4qyqB-1n60B:
0.0
4qyqB-1n60B:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_ADNA2414_1
(RNA-DIRECTED RNA
POLYMERASE L)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
4 / 6 GLU B 400
PHE B 486
PHE B 659
TYR B 443
None
1.14A 4uciA-1n60B:
0.3
4uciA-1n60B:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
4 / 7 GLU B 400
PHE B 486
PHE B 659
TYR B 443
None
1.15A 4uciB-1n60B:
0.3
4uciB-1n60B:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
4 / 5 GLY B 524
THR B 525
HIS B 243
GLY B 556
None
1.08A 4v20A-1n60B:
undetectable
4v20A-1n60B:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)
1n60 CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN
CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans;
Oligotropha
carboxidovorans)
4 / 5 GLY A 103
THR A 106
HIS A  39
GLY B  36
FES  A4907 (-4.1A)
None
None
None
1.13A 4v20A-1n60A:
undetectable
4v20A-1n60A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
3 / 3 VAL B 212
ALA B 708
PHE B 731
None
0.90A 4w5nA-1n60B:
undetectable
4w5nA-1n60B:
22.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
4 / 7 SER B 389
SER B 570
GLU B 488
GLU B 763
None
MCN  B4920 (-4.3A)
None
OMO  B4921 ( 3.3A)
1.18A 4xzkA-1n60B:
0.0
4xzkA-1n60B:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
5 / 12 LYS B 176
ASP B 373
HIS B 178
VAL B 375
ALA B 157
None
1.42A 4yhaA-1n60B:
undetectable
4yhaA-1n60B:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)
1n60 CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN

(Oligotropha
carboxidovorans)
3 / 3 THR A  23
HIS A  13
LEU A  35
None
0.88A 5axdC-1n60A:
undetectable
5axdC-1n60A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_A_ADNA302_1
(FLUORINASE)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
4 / 7 ASP B 439
THR B 656
PRO B 658
THR B 487
None
1.04A 5b6iA-1n60B:
undetectable
5b6iA-1n60B:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
5 / 12 THR B 525
GLN B 528
GLU B 555
GLY B 531
TYR B 536
None
MCN  B4920 (-4.0A)
None
MCN  B4920 ( 4.2A)
None
1.26A 5e3iA-1n60B:
undetectable
5e3iA-1n60B:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
5 / 11 THR B 525
GLN B 528
GLU B 555
GLY B 531
TYR B 536
None
MCN  B4920 (-4.0A)
None
MCN  B4920 ( 4.2A)
None
1.29A 5e3iB-1n60B:
undetectable
5e3iB-1n60B:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)
1n60 CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN
CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans;
Oligotropha
carboxidovorans)
5 / 11 THR A 106
ARG B  27
TYR B  40
GLY B  38
GLY B  36
None
1.29A 5e3iB-1n60A:
undetectable
5e3iB-1n60A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKL_B_SAMB8009_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN,HISTONE H3.1
PEPTIDE,ZINC FINGER
DOMAIN-CONTAINING
PROTEIN)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
5 / 12 LEU B 434
CYH B 359
GLY B 361
TYR B 363
HIS B 369
None
1.31A 5kklB-1n60B:
0.0
5kklB-1n60B:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
5 / 12 HIS B 532
ALA B 537
ILE B 546
ALA B 541
VAL B 519
MCN  B4920 (-3.7A)
None
None
None
None
1.04A 5n0tB-1n60B:
undetectable
5n0tB-1n60B:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
4 / 7 ASP B  30
PHE B  33
GLY B 529
GLY B 531
None
None
MCN  B4920 (-3.5A)
MCN  B4920 ( 4.2A)
0.99A 5n9xA-1n60B:
undetectable
5n9xA-1n60B:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)
1n60 CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN
CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans;
Oligotropha
carboxidovorans)
4 / 7 TYR A 104
THR B 219
THR B 238
VAL B  44
None
1.01A 5ov9A-1n60A:
undetectable
5ov9A-1n60A:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYF_B_TA1B502_1
(TUBULIN BETA CHAIN)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
5 / 12 VAL B 138
ASP B 139
ASP B 108
SER B  58
PRO B 142
None
1.34A 5syfB-1n60B:
undetectable
5syfB-1n60B:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_1
(S-ADENOSYLMETHIONINE
SYNTHASE)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
4 / 8 HIS B 213
PRO B 214
SER B 381
THR B  97
None
1.14A 5t8sB-1n60B:
undetectable
5t8sB-1n60B:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_A_9CRA503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
1n60 CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN

(Oligotropha
carboxidovorans)
5 / 12 ILE A 149
ALA A 152
ALA A 153
LEU A  90
ALA A  89
None
0.83A 5uanA-1n60A:
undetectable
5uanA-1n60A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
5 / 12 ILE B 540
ALA B 584
ALA B 591
ILE B 594
GLY B 643
None
0.86A 5veuB-1n60B:
0.5
5veuB-1n60B:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
1n60 CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN

(Oligotropha
carboxidovorans)
5 / 12 ILE A 149
ALA A 152
ALA A 153
LEU A  90
ALA A  89
None
0.92A 5z12B-1n60A:
undetectable
5z12B-1n60A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_C_9CRC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
1n60 CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN

(Oligotropha
carboxidovorans)
5 / 12 ILE A 149
ALA A 152
ALA A 153
LEU A  90
ALA A  89
None
0.97A 5z12C-1n60A:
undetectable
5z12C-1n60A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
4 / 5 GLY B 712
ASP B 794
ARG B 716
GLN B 790
None
1.32A 5zrfB-1n60B:
undetectable
5zrfB-1n60B:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
1n60 CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN

(Oligotropha
carboxidovorans)
5 / 12 ILE A 149
ALA A 152
ALA A 153
LEU A  90
ALA A  89
None
0.94A 6a5yD-1n60A:
undetectable
6a5yD-1n60A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
1n60 CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN

(Oligotropha
carboxidovorans)
5 / 12 ILE A 149
ALA A 152
ALA A 153
LEU A  90
ALA A  89
None
1.02A 6a5zD-1n60A:
undetectable
6a5zD-1n60A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN
CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN

(Oligotropha
carboxidovorans)
6 / 12 GLN B 221
GLY A  41
ASP B  42
VAL B 298
ALA A  49
LEU B 217
None
FES  A4908 (-4.3A)
None
None
None
FES  A4907 ( 4.1A)
1.36A 6bq4B-1n60B:
undetectable
6bq4B-1n60B:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
4 / 7 GLN B 528
GLY B 760
SER B 572
VAL B 490
MCN  B4920 (-4.0A)
MCN  B4920 (-3.6A)
MCN  B4920 (-2.6A)
None
0.72A 6ekzA-1n60B:
0.0
6ekzA-1n60B:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
4 / 6 ILE B 478
TYR B 781
LEU B 807
ARG B 476
None
1.23A 6f6jA-1n60B:
0.0
6f6jA-1n60B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_A_PQNA2001_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans)
5 / 10 SER B 381
GLY B 382
ALA B  99
LEU B  98
GLY B 276
None
1.39A 6hqbA-1n60B:
undetectable
6hqbJ-1n60B:
0.0
6hqbA-1n60B:
6.80
6hqbJ-1n60B:
3.96