SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1n61'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 1n61 CARBON MONOXIDE
DEHYDROGENASE MEDIUM
CHAIN
(Oligotropha
carboxidovorans) 		4 / 6 ASP C 124
GLY C 215
ILE C 214
ILE C  93
 FAD  C3932 (-3.8A)
None
None
None
 0.83A 1n49D-1n61C:
undetectable		 1n49D-1n61C:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_A_BEZA352_0
(D-AMINO-ACID OXIDASE)		 1n61 CARBON MONOXIDE
DEHYDROGENASE MEDIUM
CHAIN
(Oligotropha
carboxidovorans) 		4 / 6 LEU C 128
ILE C  94
ARG C 285
GLY C 180
 None
 0.94A 2du8A-1n61C:
undetectable		 2du8A-1n61C:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_B_BEZB1352_0
(D-AMINO-ACID OXIDASE)		 1n61 CARBON MONOXIDE
DEHYDROGENASE MEDIUM
CHAIN
(Oligotropha
carboxidovorans) 		4 / 6 LEU C 128
ILE C  94
ARG C 285
GLY C 180
 None
 0.92A 2du8B-1n61C:
undetectable		 2du8B-1n61C:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1n61 CARBON MONOXIDE
DEHYDROGENASE MEDIUM
CHAIN
(Oligotropha
carboxidovorans) 		4 / 7 LEU C 138
GLU C 165
ALA C  46
ILE C  40
 None
 0.74A 2xkwA-1n61C:
0.0		 2xkwA-1n61C:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 1n61 CARBON MONOXIDE
DEHYDROGENASE MEDIUM
CHAIN
(Oligotropha
carboxidovorans) 		4 / 6 LEU C  91
ALA C  89
LEU C  87
SER C  84
 None
 0.69A 3cfqA-1n61C:
undetectable		 3cfqA-1n61C:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 1n61 CARBON MONOXIDE
DEHYDROGENASE MEDIUM
CHAIN
(Oligotropha
carboxidovorans) 		5 / 12 LEU C 128
ALA C 278
ALA C 196
VAL C 219
ILE C  93
 None
 1.09A 3czhB-1n61C:
0.0		 3czhB-1n61C:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1n61 CARBON MONOXIDE
DEHYDROGENASE MEDIUM
CHAIN
(Oligotropha
carboxidovorans) 		5 / 12 GLY C 113
GLY C  33
GLY C  34
ILE C 170
ALA C 116
 FAD  C3932 ( 4.9A)
FAD  C3932 (-3.4A)
FAD  C3932 (-3.2A)
None
None
 0.97A 3douA-1n61C:
undetectable		 3douA-1n61C:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 1n61 CARBON MONOXIDE
DEHYDROGENASE MEDIUM
CHAIN
(Oligotropha
carboxidovorans) 		5 / 10 ILE C 253
LEU C 275
VAL C 200
VAL C 279
LEU C 243
 None
 0.99A 3gwxA-1n61C:
0.0		 3gwxA-1n61C:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1n61 CARBON MONOXIDE
DEHYDROGENASE MEDIUM
CHAIN
(Oligotropha
carboxidovorans) 		5 / 12 LEU C  21
ALA C  46
GLY C  33
ALA C  32
LEU C  54
 None
None
FAD  C3932 (-3.4A)
FAD  C3932 (-3.5A)
None
 1.01A 3ln1A-1n61C:
undetectable		 3ln1A-1n61C:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1n61 CARBON MONOXIDE
DEHYDROGENASE MEDIUM
CHAIN
(Oligotropha
carboxidovorans) 		5 / 12 LEU C  21
ALA C  46
GLY C  33
ALA C  32
LEU C  54
 None
None
FAD  C3932 (-3.4A)
FAD  C3932 (-3.5A)
None
 1.00A 3ln1B-1n61C:
undetectable		 3ln1B-1n61C:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1n61 CARBON MONOXIDE
DEHYDROGENASE MEDIUM
CHAIN
(Oligotropha
carboxidovorans) 		5 / 12 LEU C  21
ALA C  46
GLY C  33
ALA C  32
LEU C  54
 None
None
FAD  C3932 (-3.4A)
FAD  C3932 (-3.5A)
None
 1.01A 3ln1C-1n61C:
2.0		 3ln1C-1n61C:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1n61 CARBON MONOXIDE
DEHYDROGENASE MEDIUM
CHAIN
(Oligotropha
carboxidovorans) 		5 / 12 LEU C  21
ALA C  46
GLY C  33
ALA C  32
LEU C  54
 None
None
FAD  C3932 (-3.4A)
FAD  C3932 (-3.5A)
None
 1.01A 3ln1D-1n61C:
undetectable		 3ln1D-1n61C:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1n61 CARBON MONOXIDE
DEHYDROGENASE MEDIUM
CHAIN
(Oligotropha
carboxidovorans) 		5 / 12 LEU C  51
LEU C  21
GLY C  33
ALA C  32
LEU C  54
 None
None
FAD  C3932 (-3.4A)
FAD  C3932 (-3.5A)
None
 1.07A 3n8zA-1n61C:
3.0		 3n8zA-1n61C:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_1
(16S RRNA METHYLASE)		 1n61 CARBON MONOXIDE
DEHYDROGENASE MEDIUM
CHAIN
(Oligotropha
carboxidovorans) 		4 / 5 ASN C 118
ASP C 124
THR C 195
SER C  36
 FAD  C3932 (-4.1A)
FAD  C3932 (-3.8A)
None
FAD  C3932 (-2.6A)
 1.13A 3p2kC-1n61C:
undetectable		 3p2kC-1n61C:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)		 1n61 CARBON MONOXIDE
DEHYDROGENASE MEDIUM
CHAIN
(Oligotropha
carboxidovorans) 		5 / 12 LEU C  51
LEU C  21
GLY C  33
ALA C  32
LEU C  54
 None
None
FAD  C3932 (-3.4A)
FAD  C3932 (-3.5A)
None
 1.10A 3pghD-1n61C:
0.0		 3pghD-1n61C:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_2
(SECRETED ASPARTIC
PROTEASE)		 1n61 CARBON MONOXIDE
DEHYDROGENASE MEDIUM
CHAIN
(Oligotropha
carboxidovorans) 		4 / 7 SER C  84
ILE C  63
THR C  77
THR C 111
 None
None
None
FAD  C3932 (-2.9A)
 0.98A 3tneB-1n61C:
undetectable		 3tneB-1n61C:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 1n61 CARBON MONOXIDE
DEHYDROGENASE MEDIUM
CHAIN
(Oligotropha
carboxidovorans) 		5 / 8 MET C 274
GLY C 272
ILE C 214
LEU C 216
VAL C 247
 None
 1.19A 3v1nA-1n61C:
undetectable		 3v1nA-1n61C:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1n61 CARBON MONOXIDE
DEHYDROGENASE MEDIUM
CHAIN
(Oligotropha
carboxidovorans) 		4 / 4 ASP C 124
LEU C 100
ARG C 281
THR C 217
 FAD  C3932 (-3.8A)
None
None
None
 1.36A 4kjjA-1n61C:
undetectable		 4kjjA-1n61C:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1n61 CARBON MONOXIDE
DEHYDROGENASE MEDIUM
CHAIN
(Oligotropha
carboxidovorans) 		4 / 4 ASP C 124
LEU C 100
ARG C 281
THR C 217
 FAD  C3932 (-3.8A)
None
None
None
 1.38A 4kjkA-1n61C:
undetectable		 4kjkA-1n61C:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1n61 CARBON MONOXIDE
DEHYDROGENASE MEDIUM
CHAIN
(Oligotropha
carboxidovorans) 		4 / 5 ASP C 124
LEU C 100
ARG C 281
THR C 217
 FAD  C3932 (-3.8A)
None
None
None
 1.28A 4p3qA-1n61C:
undetectable		 4p3qA-1n61C:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1n61 CARBON MONOXIDE
DEHYDROGENASE MEDIUM
CHAIN
(Oligotropha
carboxidovorans) 		5 / 9 LEU C  51
LEU C  21
GLY C  33
ALA C  32
LEU C  54
 None
None
FAD  C3932 (-3.4A)
FAD  C3932 (-3.5A)
None
 1.06A 4rs0A-1n61C:
2.4		 4rs0A-1n61C:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 1n61 CARBON MONOXIDE
DEHYDROGENASE MEDIUM
CHAIN
(Oligotropha
carboxidovorans) 		5 / 8 ALA C 134
ALA C 135
ILE C 170
ALA C 160
LEU C 167
 None
None
None
None
FAD  C3932 (-4.3A)
 1.09A 4v1fA-1n61C:
undetectable
4v1fB-1n61C:
undetectable		 4v1fA-1n61C:
18.03
4v1fB-1n61C:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZ8_A_GCSA208_1
(GLUCANASE/CHITOSANAS
E)		 1n61 CARBON MONOXIDE
DEHYDROGENASE MEDIUM
CHAIN
(Oligotropha
carboxidovorans) 		4 / 7 GLU C  66
ARG C 171
GLU C 137
ALA C 169
 None
 1.19A 4zz8A-1n61C:
undetectable		 4zz8A-1n61C:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1n61 CARBON MONOXIDE
DEHYDROGENASE MEDIUM
CHAIN
(Oligotropha
carboxidovorans) 		4 / 5 TYR C 152
GLY C 114
TYR C 153
GLY C 122
 None
FAD  C3932 (-3.4A)
None
None
 1.02A 5ayfA-1n61C:
undetectable		 5ayfA-1n61C:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1n61 CARBON MONOXIDE
DEHYDROGENASE MEDIUM
CHAIN
(Oligotropha
carboxidovorans) 		5 / 12 GLY C 113
GLU C  66
ALA C  80
ILE C 172
MET C 129
 FAD  C3932 ( 4.9A)
None
None
None
None
 1.23A 5igvA-1n61C:
undetectable		 5igvA-1n61C:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1n61 CARBON MONOXIDE
DEHYDROGENASE MEDIUM
CHAIN
(Oligotropha
carboxidovorans) 		5 / 12 LEU C  21
ALA C  46
GLY C  33
ALA C  32
LEU C  54
 None
None
FAD  C3932 (-3.4A)
FAD  C3932 (-3.5A)
None
 1.03A 5jw1A-1n61C:
undetectable		 5jw1A-1n61C:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1n61 CARBON MONOXIDE
DEHYDROGENASE MEDIUM
CHAIN
(Oligotropha
carboxidovorans) 		5 / 12 LEU C  21
ALA C  46
GLY C  33
ALA C  32
LEU C  54
 None
None
FAD  C3932 (-3.4A)
FAD  C3932 (-3.5A)
None
 1.03A 5jw1B-1n61C:
0.0		 5jw1B-1n61C:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1n61 CARBON MONOXIDE
DEHYDROGENASE MEDIUM
CHAIN
(Oligotropha
carboxidovorans) 		5 / 12 LEU C  51
LEU C  21
ALA C  46
GLY C  33
ALA C  32
 None
None
None
FAD  C3932 (-3.4A)
FAD  C3932 (-3.5A)
 1.00A 5jw1B-1n61C:
0.0		 5jw1B-1n61C:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1n61 CARBON MONOXIDE
DEHYDROGENASE MEDIUM
CHAIN
(Oligotropha
carboxidovorans) 		5 / 12 LEU C  51
ALA C  46
GLY C  33
ALA C  32
LEU C  54
 None
None
FAD  C3932 (-3.4A)
FAD  C3932 (-3.5A)
None
 1.04A 5kirA-1n61C:
0.0		 5kirA-1n61C:
19.07