SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1n7d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXV_B_PNNB1001_0
(PENICILLIN ACYLASE)		 1n7d LOW-DENSITY
LIPOPROTEIN RECEPTOR
(Homo
sapiens) 		4 / 7 PHE A 634
SER A 376
ALA A 378
PHE A 593
 None
 1.16A 1fxvA-1n7dA:
undetectable
1fxvB-1n7dA:
undetectable		 1fxvA-1n7dA:
14.00
1fxvB-1n7dA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)		 1n7d LOW-DENSITY
LIPOPROTEIN RECEPTOR
(Homo
sapiens) 		5 / 11 HIS A 586
ILE A 602
HIS A 190
HIS A 562
ASP A 580
 None
 1.23A 2zweA-1n7dA:
undetectable
2zweB-1n7dA:
1.0		 2zweA-1n7dA:
16.08
2zweB-1n7dA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 1n7d LOW-DENSITY
LIPOPROTEIN RECEPTOR
(Homo
sapiens) 		5 / 11 HIS A 586
ILE A 602
HIS A 190
HIS A 562
ASP A 580
 None
 1.21A 2zwfA-1n7dA:
undetectable
2zwfB-1n7dA:
1.2		 2zwfA-1n7dA:
16.08
2zwfB-1n7dA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1n7d LOW-DENSITY
LIPOPROTEIN RECEPTOR
(Homo
sapiens) 		4 / 8 GLY A 642
GLU A 647
ASN A 644
ILE A 463
 None
 0.91A 3aodA-1n7dA:
undetectable		 3aodA-1n7dA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS8_A_BRLA503_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1n7d LOW-DENSITY
LIPOPROTEIN RECEPTOR
(Homo
sapiens) 		5 / 12 GLY A 552
SER A 566
ILE A 577
LEU A 613
LEU A 590
 None
 1.34A 3cs8A-1n7dA:
undetectable		 3cs8A-1n7dA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1n7d LOW-DENSITY
LIPOPROTEIN RECEPTOR
(Homo
sapiens) 		4 / 5 ILE A 607
PHE A 382
ASP A 630
GLU A 629
 None
 1.10A 3kp6A-1n7dA:
undetectable
3kp6B-1n7dA:
0.0		 3kp6A-1n7dA:
12.88
3kp6B-1n7dA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB501_1
(HEMOLYTIC LECTIN
CEL-III)		 1n7d LOW-DENSITY
LIPOPROTEIN RECEPTOR
(Homo
sapiens) 		4 / 5 ASP A 118
SER A 117
GLY A 116
ASP A 110
 CA  A1007 (-2.7A)
None
None
None
 1.46A 3w9tB-1n7dA:
0.0		 3w9tB-1n7dA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB501_1
(HEMOLYTIC LECTIN
CEL-III)		 1n7d LOW-DENSITY
LIPOPROTEIN RECEPTOR
(Homo
sapiens) 		4 / 5 ASP A 514
SER A 496
GLY A 495
TRP A 515
 None
 1.40A 3w9tB-1n7dA:
0.0		 3w9tB-1n7dA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1003_1
(HEMOLYTIC LECTIN
CEL-III)		 1n7d LOW-DENSITY
LIPOPROTEIN RECEPTOR
(Homo
sapiens) 		4 / 5 ASP A 118
SER A 117
GLY A 116
ASP A 110
 CA  A1007 (-2.7A)
None
None
None
 1.47A 3w9tC-1n7dA:
0.0		 3w9tC-1n7dA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1003_1
(HEMOLYTIC LECTIN
CEL-III)		 1n7d LOW-DENSITY
LIPOPROTEIN RECEPTOR
(Homo
sapiens) 		4 / 5 ASP A 514
SER A 496
GLY A 495
TRP A 515
 None
 1.39A 3w9tC-1n7dA:
0.0		 3w9tC-1n7dA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD501_1
(HEMOLYTIC LECTIN
CEL-III)		 1n7d LOW-DENSITY
LIPOPROTEIN RECEPTOR
(Homo
sapiens) 		4 / 5 ASP A 118
SER A 117
GLY A 116
ASP A 110
 CA  A1007 (-2.7A)
None
None
None
 1.47A 3w9tD-1n7dA:
0.0		 3w9tD-1n7dA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD501_1
(HEMOLYTIC LECTIN
CEL-III)		 1n7d LOW-DENSITY
LIPOPROTEIN RECEPTOR
(Homo
sapiens) 		4 / 5 ASP A 514
SER A 496
GLY A 495
TRP A 515
 None
 1.39A 3w9tD-1n7dA:
0.0		 3w9tD-1n7dA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF501_1
(HEMOLYTIC LECTIN
CEL-III)		 1n7d LOW-DENSITY
LIPOPROTEIN RECEPTOR
(Homo
sapiens) 		4 / 4 ASP A 514
SER A 496
GLY A 495
TRP A 515
 None
 1.38A 3w9tF-1n7dA:
0.0		 3w9tF-1n7dA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 1n7d LOW-DENSITY
LIPOPROTEIN RECEPTOR
(Homo
sapiens) 		3 / 3 TYR A 511
MET A 510
ILE A 467
 None
 0.91A 4c8bB-1n7dA:
undetectable		 4c8bB-1n7dA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 1n7d LOW-DENSITY
LIPOPROTEIN RECEPTOR
(Homo
sapiens) 		3 / 3 SER A 185
ASP A 601
ASP A 200
 None
None
CA  A1003 (-2.6A)
 0.66A 4uckA-1n7dA:
undetectable		 4uckA-1n7dA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1n7d LOW-DENSITY
LIPOPROTEIN RECEPTOR
(Homo
sapiens) 		4 / 5 GLY A 516
THR A 517
GLY A 552
LEU A 534
 None
 0.87A 5jlcA-1n7dA:
undetectable		 5jlcA-1n7dA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JM4_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1n7d LOW-DENSITY
LIPOPROTEIN RECEPTOR
(Homo
sapiens) 		4 / 5 PHE A 382
ILE A 607
MET A 391
ARG A 389
 None
 1.19A 5jm4A-1n7dA:
undetectable		 5jm4A-1n7dA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 1n7d LOW-DENSITY
LIPOPROTEIN RECEPTOR
(Homo
sapiens) 		5 / 11 HIS A 586
ILE A 602
HIS A 190
HIS A 562
ASP A 580
 None
 1.21A 5z0fA-1n7dA:
undetectable
5z0fB-1n7dA:
1.1		 5z0fA-1n7dA:
8.32
5z0fB-1n7dA:
6.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 1n7d LOW-DENSITY
LIPOPROTEIN RECEPTOR
(Homo
sapiens) 		5 / 11 HIS A 586
ILE A 602
HIS A 190
HIS A 562
ASP A 580
 None
 1.22A 5z0gA-1n7dA:
undetectable
5z0gB-1n7dA:
0.7		 5z0gA-1n7dA:
8.32
5z0gB-1n7dA:
6.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0H_B_DAHB98_0
(MELC
TYROSINASE)		 1n7d LOW-DENSITY
LIPOPROTEIN RECEPTOR
(Homo
sapiens) 		5 / 11 HIS A 586
ILE A 602
HIS A 190
HIS A 562
ASP A 580
 None
 1.20A 5z0hA-1n7dA:
undetectable
5z0hB-1n7dA:
0.7		 5z0hA-1n7dA:
8.32
5z0hB-1n7dA:
6.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 1n7d LOW-DENSITY
LIPOPROTEIN RECEPTOR
(Homo
sapiens) 		5 / 11 HIS A 586
ILE A 602
HIS A 190
HIS A 562
ASP A 580
 None
 1.22A 5z0iA-1n7dA:
undetectable
5z0iB-1n7dA:
1.1		 5z0iA-1n7dA:
8.32
5z0iB-1n7dA:
6.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0J_B_DAHB98_0
(MELC
TYROSINASE)		 1n7d LOW-DENSITY
LIPOPROTEIN RECEPTOR
(Homo
sapiens) 		5 / 11 HIS A 586
ILE A 602
HIS A 190
HIS A 562
ASP A 580
 None
 1.17A 5z0jA-1n7dA:
undetectable
5z0jB-1n7dA:
0.8		 5z0jA-1n7dA:
8.32
5z0jB-1n7dA:
6.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0L_B_DAHB98_0
(MELC
TYROSINASE)		 1n7d LOW-DENSITY
LIPOPROTEIN RECEPTOR
(Homo
sapiens) 		5 / 11 HIS A 586
ILE A 602
HIS A 190
HIS A 562
ASP A 580
 None
 1.22A 5z0lA-1n7dA:
undetectable
5z0lB-1n7dA:
1.0		 5z0lA-1n7dA:
8.32
5z0lB-1n7dA:
6.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0M_B_DAHB98_0
(MELC
TYROSINASE)		 1n7d LOW-DENSITY
LIPOPROTEIN RECEPTOR
(Homo
sapiens) 		5 / 11 HIS A 586
ILE A 602
HIS A 190
HIS A 562
ASP A 580
 None
 1.24A 5z0mA-1n7dA:
undetectable
5z0mB-1n7dA:
undetectable		 5z0mA-1n7dA:
8.32
5z0mB-1n7dA:
6.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DHB_A_BEZA202_0
(HEPATITIS A VIRUS
CELLULAR RECEPTOR 2)		 1n7d LOW-DENSITY
LIPOPROTEIN RECEPTOR
(Homo
sapiens) 		4 / 6 PHE A 588
ILE A 603
ASN A 604
ASP A 601
 None
 0.88A 6dhbA-1n7dA:
0.0		 6dhbA-1n7dA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 1n7d LOW-DENSITY
LIPOPROTEIN RECEPTOR
(Homo
sapiens) 		4 / 5 LEU A 661
THR A 489
PRO A 498
ARG A 499
 None
 0.93A 6ew0F-1n7dA:
undetectable		 6ew0F-1n7dA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 1n7d LOW-DENSITY
LIPOPROTEIN RECEPTOR
(Homo
sapiens) 		4 / 6 LEU A 661
THR A 489
PRO A 498
ARG A 499
 None
 0.93A 6ew0G-1n7dA:
undetectable		 6ew0G-1n7dA:
8.52