SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1n7f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 1n7f AMPA RECEPTOR
INTERACTING PROTEIN
GRIP
(Rattus
norvegicus) 		5 / 12 ALA A 707
GLY A 705
GLY A 704
LYS A 703
GLY A 716
 None
 0.97A 1sqfA-1n7fA:
undetectable		 1sqfA-1n7fA:
13.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 1n7f AMPA RECEPTOR
INTERACTING PROTEIN
GRIP
(Rattus
norvegicus) 		5 / 11 LEU A 682
GLY A 683
ILE A 684
ILE A 686
LEU A 739
 None
 0.98A 2kawA-1n7fA:
12.5		 2kawA-1n7fA:
31.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1n7f AMPA RECEPTOR
INTERACTING PROTEIN
GRIP
(Rattus
norvegicus) 		5 / 11 ALA A 712
LEU A 682
ILE A 684
ILE A 719
THR A 710
 None
 1.06A 2w9sA-1n7fA:
undetectable		 2w9sA-1n7fA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 1n7f AMPA RECEPTOR
INTERACTING PROTEIN
GRIP
(Rattus
norvegicus) 		5 / 12 ILE A 684
LEU A 701
ILE A 750
VAL A 746
LEU A 675
 None
 1.00A 3a51C-1n7fA:
undetectable		 3a51C-1n7fA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1n7f AMPA RECEPTOR
INTERACTING PROTEIN
GRIP
(Rattus
norvegicus) 		5 / 12 LEU A 748
LEU A 739
GLN A 740
ILE A 696
LEU A 732
 None
 1.08A 3datA-1n7fA:
undetectable		 3datA-1n7fA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1n7f AMPA RECEPTOR
INTERACTING PROTEIN
GRIP
(Rattus
norvegicus) 		5 / 11 ALA A 707
LEU A 748
ILE A 686
LEU A 739
THR A 710
 None
 1.28A 3fl9C-1n7fA:
undetectable		 3fl9C-1n7fA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1n7f AMPA RECEPTOR
INTERACTING PROTEIN
GRIP
(Rattus
norvegicus) 		5 / 9 ALA A 707
LEU A 748
ILE A 686
LEU A 739
THR A 710
 None
 1.31A 3fl9H-1n7fA:
undetectable		 3fl9H-1n7fA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 1n7f AMPA RECEPTOR
INTERACTING PROTEIN
GRIP
(Rattus
norvegicus) 		5 / 11 ALA A 712
LEU A 748
LEU A 682
ILE A 686
THR A 710
 None
 1.12A 3jw5A-1n7fA:
undetectable		 3jw5A-1n7fA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 1n7f AMPA RECEPTOR
INTERACTING PROTEIN
GRIP
(Rattus
norvegicus) 		5 / 10 ALA A 712
LEU A 748
LEU A 682
ILE A 686
THR A 710
 None
 1.12A 3jw5B-1n7fA:
undetectable		 3jw5B-1n7fA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 1n7f AMPA RECEPTOR
INTERACTING PROTEIN
GRIP
(Rattus
norvegicus) 		5 / 10 GLY A 743
LEU A 748
LEU A 739
ASN A 723
ILE A 722
 None
 1.14A 3wdmD-1n7fA:
undetectable		 3wdmD-1n7fA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1n7f AMPA RECEPTOR
INTERACTING PROTEIN
GRIP
(Rattus
norvegicus) 		5 / 9 VAL A 673
LEU A 748
GLY A 683
LEU A 682
THR A 710
 None
 1.13A 6czmA-1n7fA:
undetectable
6czmB-1n7fA:
undetectable		 6czmA-1n7fA:
14.33
6czmB-1n7fA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1n7f AMPA RECEPTOR
INTERACTING PROTEIN
GRIP
(Rattus
norvegicus) 		5 / 8 GLY A 683
LEU A 682
THR A 710
VAL A 673
LEU A 748
 None
 1.11A 6czmD-1n7fA:
undetectable
6czmF-1n7fA:
undetectable		 6czmD-1n7fA:
14.33
6czmF-1n7fA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1n7f AMPA RECEPTOR
INTERACTING PROTEIN
GRIP
(Rattus
norvegicus) 		5 / 10 VAL A 673
LEU A 748
GLY A 683
LEU A 682
THR A 710
 None
 1.12A 6czmE-1n7fA:
0.0
6czmF-1n7fA:
undetectable		 6czmE-1n7fA:
14.33
6czmF-1n7fA:
14.33