SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1n7g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 1n7g GDP-D-MANNOSE-4,6-DE
HYDRATASE
(Arabidopsis
thaliana) 		5 / 9 LEU A 300
VAL A 238
GLY A 239
ALA A 355
LEU A 352
 None
 1.15A 1e7bA-1n7gA:
undetectable		 1e7bA-1n7gA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 1n7g GDP-D-MANNOSE-4,6-DE
HYDRATASE
(Arabidopsis
thaliana) 		4 / 8 LEU A 212
SER A 163
PHE A 166
GLY A 167
 NDP  A 701 (-4.9A)
GDR  A 801 (-3.5A)
None
None
 0.72A 1fapB-1n7gA:
undetectable		 1fapB-1n7gA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 1n7g GDP-D-MANNOSE-4,6-DE
HYDRATASE
(Arabidopsis
thaliana) 		5 / 12 ILE A  30
LEU A  48
LEU A  49
TYR A 111
ILE A  33
 None
 0.92A 1fmlB-1n7gA:
undetectable		 1fmlB-1n7gA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 1n7g GDP-D-MANNOSE-4,6-DE
HYDRATASE
(Arabidopsis
thaliana) 		5 / 8 ALA A  90
GLY A  57
ILE A  33
PRO A 107
ILE A 102
 None
 1.28A 1hshD-1n7gA:
undetectable		 1hshD-1n7gA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 1n7g GDP-D-MANNOSE-4,6-DE
HYDRATASE
(Arabidopsis
thaliana) 		5 / 11 LEU A 321
GLU A 317
VAL A 318
GLU A 216
TRP A 255
 None
GDR  A 801 (-2.9A)
None
NDP  A 701 ( 4.8A)
None
 1.22A 1mrqA-1n7gA:
2.1		 1mrqA-1n7gA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUA_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1n7g GDP-D-MANNOSE-4,6-DE
HYDRATASE
(Arabidopsis
thaliana) 		5 / 10 ALA A  31
TYR A 111
LEU A  32
GLY A  57
GLY A  35
 None
None
None
None
NDP  A 701 (-3.2A)
 1.36A 1ruaH-1n7gA:
undetectable
1ruaL-1n7gA:
undetectable		 1ruaH-1n7gA:
20.47
1ruaL-1n7gA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUL_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1n7g GDP-D-MANNOSE-4,6-DE
HYDRATASE
(Arabidopsis
thaliana) 		5 / 9 ALA A  31
TYR A 111
LEU A  32
GLY A  57
GLY A  35
 None
None
None
None
NDP  A 701 (-3.2A)
 1.36A 1rulH-1n7gA:
undetectable
1rulL-1n7gA:
undetectable		 1rulH-1n7gA:
20.47
1rulL-1n7gA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1n7g GDP-D-MANNOSE-4,6-DE
HYDRATASE
(Arabidopsis
thaliana) 		4 / 6 ILE A 211
GLY A 161
ALA A 160
HIS A 193
 None
None
NDP  A 701 (-3.5A)
None
 0.85A 1wmqA-1n7gA:
0.0		 1wmqA-1n7gA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1n7g GDP-D-MANNOSE-4,6-DE
HYDRATASE
(Arabidopsis
thaliana) 		4 / 6 ILE A 211
GLY A 161
ALA A 160
HIS A 193
 None
None
NDP  A 701 (-3.5A)
None
 0.85A 1wmqB-1n7gA:
0.0		 1wmqB-1n7gA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1n7g GDP-D-MANNOSE-4,6-DE
HYDRATASE
(Arabidopsis
thaliana) 		4 / 6 ILE A 211
GLY A 161
ALA A 160
HIS A 193
 None
None
NDP  A 701 (-3.5A)
None
 0.87A 1wpuA-1n7gA:
0.0		 1wpuA-1n7gA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1n7g GDP-D-MANNOSE-4,6-DE
HYDRATASE
(Arabidopsis
thaliana) 		4 / 6 ILE A 211
GLY A 161
ALA A 160
HIS A 193
 None
None
NDP  A 701 (-3.5A)
None
 0.86A 1wpuB-1n7gA:
0.0		 1wpuB-1n7gA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1n7g GDP-D-MANNOSE-4,6-DE
HYDRATASE
(Arabidopsis
thaliana) 		4 / 6 ILE A 211
GLY A 161
ALA A 160
HIS A 193
 None
None
NDP  A 701 (-3.5A)
None
 0.87A 1wrqA-1n7gA:
0.0		 1wrqA-1n7gA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1n7g GDP-D-MANNOSE-4,6-DE
HYDRATASE
(Arabidopsis
thaliana) 		4 / 6 ILE A 211
GLY A 161
ALA A 160
HIS A 193
 None
None
NDP  A 701 (-3.5A)
None
 0.87A 1wrqB-1n7gA:
0.0		 1wrqB-1n7gA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		 1n7g GDP-D-MANNOSE-4,6-DE
HYDRATASE
(Arabidopsis
thaliana) 		5 / 12 ILE A  70
LEU A  84
VAL A  55
GLU A  46
LEU A  49
 None
 1.04A 2bxfA-1n7gA:
undetectable		 2bxfA-1n7gA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		 1n7g GDP-D-MANNOSE-4,6-DE
HYDRATASE
(Arabidopsis
thaliana) 		5 / 12 ILE A  70
LEU A  84
VAL A  55
GLU A  46
LEU A  49
 None
 1.03A 2bxfB-1n7gA:
undetectable		 2bxfB-1n7gA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 1n7g GDP-D-MANNOSE-4,6-DE
HYDRATASE
(Arabidopsis
thaliana) 		3 / 3 VAL A 119
ASN A 214
TRP A 255
 GDR  A 801 (-4.3A)
GDR  A 801 ( 3.1A)
None
 1.11A 2y00B-1n7gA:
undetectable		 2y00B-1n7gA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA802_1
(PROSTAGLANDIN
REDUCTASE 1)		 1n7g GDP-D-MANNOSE-4,6-DE
HYDRATASE
(Arabidopsis
thaliana) 		4 / 7 ASN A 248
GLY A 247
VAL A 225
ASP A 309
 None
GDR  A 801 (-3.6A)
GDR  A 801 (-3.6A)
None
 0.89A 2y05A-1n7gA:
5.0
2y05B-1n7gA:
5.5		 2y05A-1n7gA:
22.28
2y05B-1n7gA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_1
(REPRESSOR PROTEIN
MPHR(A))		 1n7g GDP-D-MANNOSE-4,6-DE
HYDRATASE
(Arabidopsis
thaliana) 		4 / 5 ASN A 198
ARG A 200
ASN A 209
ALA A 192
 None
 1.23A 3frqA-1n7gA:
undetectable		 3frqA-1n7gA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 1n7g GDP-D-MANNOSE-4,6-DE
HYDRATASE
(Arabidopsis
thaliana) 		4 / 7 ASN A 198
ARG A 200
ASN A 209
ALA A 192
 None
 1.21A 3frqB-1n7gA:
undetectable		 3frqB-1n7gA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 1n7g GDP-D-MANNOSE-4,6-DE
HYDRATASE
(Arabidopsis
thaliana) 		5 / 12 LEU A 354
ALA A 355
GLU A 358
ILE A 229
LEU A 298
 None
 1.02A 3q95B-1n7gA:
undetectable		 3q95B-1n7gA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		 1n7g GDP-D-MANNOSE-4,6-DE
HYDRATASE
(Arabidopsis
thaliana) 		4 / 7 GLN A 270
GLU A  54
GLU A 109
PRO A 107
 None
 1.41A 3ql6A-1n7gA:
0.0		 3ql6A-1n7gA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRI_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 1n7g GDP-D-MANNOSE-4,6-DE
HYDRATASE
(Arabidopsis
thaliana) 		5 / 10 LEU A 212
SER A 163
ARG A 253
PHE A 166
ASP A 276
 NDP  A 701 (-4.9A)
GDR  A 801 (-3.5A)
GDR  A 801 (-3.4A)
None
None
 1.46A 4driB-1n7gA:
0.0		 4driB-1n7gA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 1n7g GDP-D-MANNOSE-4,6-DE
HYDRATASE
(Arabidopsis
thaliana) 		4 / 8 LEU A 212
SER A 163
PHE A 166
THR A 176
 NDP  A 701 (-4.9A)
GDR  A 801 (-3.5A)
None
None
 0.95A 4drjB-1n7gA:
undetectable		 4drjB-1n7gA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 1n7g GDP-D-MANNOSE-4,6-DE
HYDRATASE
(Arabidopsis
thaliana) 		4 / 7 LEU A 138
ALA A 191
VAL A 133
ILE A 211
 None
 0.95A 4eyrA-1n7gA:
undetectable		 4eyrA-1n7gA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 1n7g GDP-D-MANNOSE-4,6-DE
HYDRATASE
(Arabidopsis
thaliana) 		5 / 11 LEU A 354
ALA A 355
GLU A 358
ILE A 229
LEU A 298
 None
 1.08A 4pxmB-1n7gA:
undetectable		 4pxmB-1n7gA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1n7g GDP-D-MANNOSE-4,6-DE
HYDRATASE
(Arabidopsis
thaliana) 		4 / 7 ILE A  33
LEU A 113
GLY A  38
GLY A  41
 None
NDP  A 701 (-4.3A)
NDP  A 701 (-3.3A)
None
 0.87A 5a06B-1n7gA:
6.1		 5a06B-1n7gA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 1n7g GDP-D-MANNOSE-4,6-DE
HYDRATASE
(Arabidopsis
thaliana) 		5 / 10 LEU A  44
GLU A 109
LEU A 269
MET A 268
GLY A 210
 None
 1.29A 5dxbA-1n7gA:
0.0		 5dxbA-1n7gA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 1n7g GDP-D-MANNOSE-4,6-DE
HYDRATASE
(Arabidopsis
thaliana) 		5 / 12 LEU A 354
ALA A 355
GLU A 358
ILE A 229
LEU A 298
 None
 1.09A 5gs4A-1n7gA:
undetectable		 5gs4A-1n7gA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		 1n7g GDP-D-MANNOSE-4,6-DE
HYDRATASE
(Arabidopsis
thaliana) 		3 / 3 PRO A 218
ARG A 227
GLU A 350
 None
 0.93A 5j6hA-1n7gA:
undetectable		 5j6hA-1n7gA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 1n7g GDP-D-MANNOSE-4,6-DE
HYDRATASE
(Arabidopsis
thaliana) 		5 / 10 LEU A  58
GLY A 136
ILE A 102
SER A  97
ALA A 143
 None
 0.84A 5l0zB-1n7gA:
2.6		 5l0zB-1n7gA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 1n7g GDP-D-MANNOSE-4,6-DE
HYDRATASE
(Arabidopsis
thaliana) 		3 / 3 ARG A 314
ARG A 220
ARG A 253
 GDR  A 801 (-3.3A)
GDR  A 801 ( 2.6A)
GDR  A 801 (-3.4A)
 1.04A 6bplA-1n7gA:
undetectable
6bplB-1n7gA:
undetectable		 6bplA-1n7gA:
12.00
6bplB-1n7gA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_B_ESTB602_1
(ESTROGEN RECEPTOR)		 1n7g GDP-D-MANNOSE-4,6-DE
HYDRATASE
(Arabidopsis
thaliana) 		5 / 10 LEU A  32
ALA A  31
MET A  85
ILE A  70
LEU A  44
 None
 1.38A 6cbzB-1n7gA:
undetectable		 6cbzB-1n7gA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_B_ESTB602_1
(ESTROGEN RECEPTOR)		 1n7g GDP-D-MANNOSE-4,6-DE
HYDRATASE
(Arabidopsis
thaliana) 		5 / 10 LEU A 354
ALA A 355
GLU A 358
ILE A 229
LEU A 298
 None
 1.11A 6cbzB-1n7gA:
undetectable		 6cbzB-1n7gA:
12.57