SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1n7k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 1n7k DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Aeropyrum
pernix) 		4 / 8 CYH A  76
LEU A  99
ALA A 130
LEU A 129
 None
 1.01A 1hwiB-1n7kA:
undetectable		 1hwiB-1n7kA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 1n7k DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Aeropyrum
pernix) 		4 / 8 CYH A  76
LEU A  99
ALA A 130
LEU A 129
 None
 1.01A 1hwiC-1n7kA:
undetectable		 1hwiC-1n7kA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 1n7k DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Aeropyrum
pernix) 		5 / 9 ALA A 135
GLY A 102
ALA A 103
THR A  61
LEU A 106
 None
 0.88A 1nr6A-1n7kA:
undetectable		 1nr6A-1n7kA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 1n7k DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Aeropyrum
pernix) 		4 / 6 ILE A 219
ALA A 198
THR A 168
ALA A 186
 None
 0.86A 1w0gA-1n7kA:
undetectable		 1w0gA-1n7kA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_2
(HIV-1 PROTEASE)		 1n7k DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Aeropyrum
pernix) 		5 / 12 ARG A 184
GLY A 215
ALA A 216
ILE A 165
ALA A 143
 None
 1.08A 2b7zB-1n7kA:
undetectable		 2b7zB-1n7kA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		 1n7k DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Aeropyrum
pernix) 		5 / 12 LEU A  29
LEU A  67
VAL A  73
CYH A  53
GLU A  45
 None
 1.30A 2bxfB-1n7kA:
undetectable		 2bxfB-1n7kA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 1n7k DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Aeropyrum
pernix) 		4 / 8 LEU A 141
ILE A 140
PHE A  81
GLY A 171
 None
 0.88A 3b9lA-1n7kA:
undetectable		 3b9lA-1n7kA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_1
(PROTEASE)		 1n7k DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Aeropyrum
pernix) 		5 / 8 GLY A  50
ALA A  46
ASP A  48
GLY A  72
VAL A  55
 None
 1.50A 3em6A-1n7kA:
undetectable		 3em6A-1n7kA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_A_BEZA264_0
(ECHA1_1)		 1n7k DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Aeropyrum
pernix) 		4 / 8 ALA A  68
ILE A  64
LEU A  75
ALA A  46
 None
 0.68A 3r9tA-1n7kA:
undetectable		 3r9tA-1n7kA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_0
(MRNA CAPPING ENZYME
P5)		 1n7k DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Aeropyrum
pernix) 		5 / 12 GLY A 176
ALA A 211
LYS A 167
GLU A 142
VAL A 172
 None
 1.34A 5x6yA-1n7kA:
undetectable		 5x6yA-1n7kA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 1n7k DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Aeropyrum
pernix) 		5 / 11 ALA A 186
LEU A 185
VAL A 182
THR A 168
ILE A 219
 None
 0.91A 6h1lB-1n7kA:
undetectable		 6h1lB-1n7kA:
19.61