SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1n8p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		 1n8p CYSTATHIONINE
GAMMA-LYASE
(Saccharomyces
cerevisiae) 		5 / 9 PHE A 181
PRO A 147
ILE A 370
PRO A 284
GLY A 305
 PLP  A 400 (-4.3A)
None
None
None
None
 1.50A 13gsB-1n8pA:
0.0		 13gsB-1n8pA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 1n8p CYSTATHIONINE
GAMMA-LYASE
(Saccharomyces
cerevisiae) 		4 / 5 THR A 106
GLU A 145
THR A 148
HIS A 350
 None
PLP  A 400 ( 4.7A)
None
None
 1.03A 1d4fA-1n8pA:
undetectable		 1d4fA-1n8pA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 1n8p CYSTATHIONINE
GAMMA-LYASE
(Saccharomyces
cerevisiae) 		4 / 5 THR A 106
GLU A 145
THR A 148
HIS A 350
 None
PLP  A 400 ( 4.7A)
None
None
 1.02A 1d4fD-1n8pA:
undetectable		 1d4fD-1n8pA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)		 1n8p CYSTATHIONINE
GAMMA-LYASE
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 204
VAL A 257
GLY A 306
GLY A 305
 None
 0.88A 1ekjE-1n8pA:
undetectable
1ekjF-1n8pA:
undetectable		 1ekjE-1n8pA:
22.96
1ekjF-1n8pA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1n8p CYSTATHIONINE
GAMMA-LYASE
(Saccharomyces
cerevisiae) 		3 / 3 THR A 377
LEU A 381
LEU A 388
 None
 0.54A 1mz9C-1n8pA:
undetectable		 1mz9C-1n8pA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 1n8p CYSTATHIONINE
GAMMA-LYASE
(Saccharomyces
cerevisiae) 		3 / 3 THR A  10
GLU A  17
ASP A  20
 None
 0.85A 1nt2A-1n8pA:
0.5		 1nt2A-1n8pA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1n8p CYSTATHIONINE
GAMMA-LYASE
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 113
ALA A 114
HIS A 117
 None
 0.74A 1q23C-1n8pA:
0.7		 1q23C-1n8pA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1n8p CYSTATHIONINE
GAMMA-LYASE
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 113
ALA A 114
HIS A 117
 None
 0.72A 1q23G-1n8pA:
0.9		 1q23G-1n8pA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1n8p CYSTATHIONINE
GAMMA-LYASE
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 113
ALA A 114
HIS A 117
 None
 0.75A 1q23L-1n8pA:
0.9		 1q23L-1n8pA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 1n8p CYSTATHIONINE
GAMMA-LYASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 306
GLY A 305
GLY A 304
LEU A 152
PRO A 284
 None
 1.17A 1qzzA-1n8pA:
2.9		 1qzzA-1n8pA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 1n8p CYSTATHIONINE
GAMMA-LYASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 306
GLY A 305
GLY A 304
LEU A 152
PRO A 284
 None
 1.15A 1xdsA-1n8pA:
undetectable		 1xdsA-1n8pA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1n8p CYSTATHIONINE
GAMMA-LYASE
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 230
ILE A 234
PHE A  76
ILE A  86
 None
 0.76A 2azxA-1n8pA:
2.4		 2azxA-1n8pA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1n8p CYSTATHIONINE
GAMMA-LYASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  15
ALA A  70
PRO A 184
GLY A  73
TYR A 185
 None
 0.96A 2igtA-1n8pA:
3.5		 2igtA-1n8pA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1n8p CYSTATHIONINE
GAMMA-LYASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  15
ALA A  70
PRO A 184
GLY A  73
TYR A 185
 None
 0.98A 2igtB-1n8pA:
3.5		 2igtB-1n8pA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1n8p CYSTATHIONINE
GAMMA-LYASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  15
ALA A  70
PRO A 184
GLY A  73
TYR A 185
 None
 0.94A 2igtC-1n8pA:
3.7		 2igtC-1n8pA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 1n8p CYSTATHIONINE
GAMMA-LYASE
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 152
THR A 148
ILE A 186
HIS A 299
 None
 1.40A 2jfaB-1n8pA:
undetectable		 2jfaB-1n8pA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_1
(PHOSPHOLIPASE A2)		 1n8p CYSTATHIONINE
GAMMA-LYASE
(Saccharomyces
cerevisiae) 		4 / 5 VAL A 198
VAL A 197
THR A  85
THR A 180
 None
None
None
PLP  A 400 ( 4.1A)
 1.05A 3bjwA-1n8pA:
0.0		 3bjwA-1n8pA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_3
(PHOSPHOLIPASE A2)		 1n8p CYSTATHIONINE
GAMMA-LYASE
(Saccharomyces
cerevisiae) 		4 / 5 VAL A 198
VAL A 197
THR A  85
THR A 180
 None
None
None
PLP  A 400 ( 4.1A)
 1.10A 3bjwG-1n8pA:
0.0		 3bjwG-1n8pA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_1
(PHOSPHOLIPASE A2)		 1n8p CYSTATHIONINE
GAMMA-LYASE
(Saccharomyces
cerevisiae) 		4 / 5 VAL A 198
VAL A 197
THR A  85
THR A 180
 None
None
None
PLP  A 400 ( 4.1A)
 1.06A 3bjwC-1n8pA:
0.0		 3bjwC-1n8pA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_2
(PHOSPHOLIPASE A2)		 1n8p CYSTATHIONINE
GAMMA-LYASE
(Saccharomyces
cerevisiae) 		4 / 5 VAL A 198
VAL A 197
THR A  85
THR A 180
 None
None
None
PLP  A 400 ( 4.1A)
 1.04A 3bjwD-1n8pA:
0.0		 3bjwD-1n8pA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		 1n8p CYSTATHIONINE
GAMMA-LYASE
(Saccharomyces
cerevisiae) 		3 / 3 PRO A  28
SER A  30
ASN A  59
 None
 0.80A 3lslG-1n8pA:
0.9		 3lslG-1n8pA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 1n8p CYSTATHIONINE
GAMMA-LYASE
(Saccharomyces
cerevisiae) 		4 / 8 SER A 309
ASP A 101
GLU A 343
GLU A 333
 None
 1.00A 3sg9B-1n8pA:
0.2		 3sg9B-1n8pA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_1
(HIV-1 PROTEASE)		 1n8p CYSTATHIONINE
GAMMA-LYASE
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 193
ALA A 194
ASP A 195
THR A 146
 None
 0.54A 3so9A-1n8pA:
undetectable		 3so9A-1n8pA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_A_NCAA1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 1n8p CYSTATHIONINE
GAMMA-LYASE
(Saccharomyces
cerevisiae) 		4 / 7 THR A 180
ASN A 149
TYR A 103
TYR A 204
 PLP  A 400 ( 4.1A)
None
PLP  A 400 (-3.6A)
None
 1.42A 4a3uA-1n8pA:
undetectable		 4a3uA-1n8pA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_NCAB1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 1n8p CYSTATHIONINE
GAMMA-LYASE
(Saccharomyces
cerevisiae) 		4 / 7 THR A 180
ASN A 149
TYR A 103
TYR A 204
 PLP  A 400 ( 4.1A)
None
PLP  A 400 (-3.6A)
None
 1.43A 4a3uB-1n8pA:
undetectable		 4a3uB-1n8pA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 1n8p CYSTATHIONINE
GAMMA-LYASE
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 193
ALA A 194
ASP A 195
THR A 146
 None
 0.74A 4eyrB-1n8pA:
undetectable		 4eyrB-1n8pA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 1n8p CYSTATHIONINE
GAMMA-LYASE
(Saccharomyces
cerevisiae) 		3 / 3 SER A 340
ASP A 274
ASP A 383
 None
 0.51A 4uckA-1n8pA:
undetectable		 4uckA-1n8pA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_C_Y70C151_1
(CEREBLON ISOFORM 4)		 1n8p CYSTATHIONINE
GAMMA-LYASE
(Saccharomyces
cerevisiae) 		4 / 8 ASN A 149
PRO A 150
PHE A 181
TYR A 283
 None
None
PLP  A 400 (-4.3A)
None
 1.42A 4v2zC-1n8pA:
undetectable		 4v2zC-1n8pA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1n8p CYSTATHIONINE
GAMMA-LYASE
(Saccharomyces
cerevisiae) 		3 / 3 SER A  94
ALA A  96
VAL A  97
 None
 0.63A 4x20C-1n8pA:
undetectable		 4x20C-1n8pA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1n8p CYSTATHIONINE
GAMMA-LYASE
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 335
TYR A 103
SER A 200
 None
PLP  A 400 (-3.6A)
PLP  A 400 (-2.7A)
 0.71A 5iktA-1n8pA:
undetectable		 5iktA-1n8pA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1n8p CYSTATHIONINE
GAMMA-LYASE
(Saccharomyces
cerevisiae) 		3 / 3 SER A 200
ALA A 201
THR A 246
 PLP  A 400 (-2.7A)
None
None
 0.63A 5n0xB-1n8pA:
1.8		 5n0xB-1n8pA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1n8p CYSTATHIONINE
GAMMA-LYASE
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 250
GLY A 249
GLY A 207
LEU A  67
THR A 252
 None
 0.99A 5o96G-1n8pA:
undetectable		 5o96G-1n8pA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1n8p CYSTATHIONINE
GAMMA-LYASE
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 364
ASP A 365
LEU A 342
 None
 0.81A 5uhbC-1n8pA:
undetectable		 5uhbC-1n8pA:
16.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_H_ADNH503_2
(ADENOSYLHOMOCYSTEINA
SE)		 1n8p CYSTATHIONINE
GAMMA-LYASE
(Saccharomyces
cerevisiae) 		4 / 5 THR A 106
GLU A 145
THR A 146
LEU A 175
 None
PLP  A 400 ( 4.7A)
None
None
 1.31A 5utuH-1n8pA:
undetectable		 5utuH-1n8pA:
21.50