SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1n8y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1n8y PROTOONCOPROTEIN
(Rattus
norvegicus) 		4 / 7 ILE C 409
GLU C 300
LEU C 283
GLY C 441
 None
 0.77A 1mt1H-1n8yC:
undetectable
1mt1K-1n8yC:
undetectable		 1mt1H-1n8yC:
11.95
1mt1K-1n8yC:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1n8y PROTOONCOPROTEIN
(Rattus
norvegicus) 		4 / 8 LEU C 283
GLY C 441
ILE C 409
GLU C 300
 None
 0.71A 1n13A-1n8yC:
undetectable
1n13F-1n8yC:
undetectable		 1n13A-1n8yC:
7.00
1n13F-1n8yC:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 1n8y PROTOONCOPROTEIN
(Rattus
norvegicus) 		5 / 9 GLY C 443
SER C 421
LEU C 444
PHE C 465
LEU C 473
 None
 1.44A 1y7iA-1n8yC:
undetectable		 1y7iA-1n8yC:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_B_ACTB2002_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 1n8y PROTOONCOPROTEIN
(Rattus
norvegicus) 		4 / 6 TYR C 420
SER C  16
ALA C  15
THR C  19
 None
 1.13A 1yvpB-1n8yC:
undetectable		 1yvpB-1n8yC:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_B_ADNB1502_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1n8y PROTOONCOPROTEIN
(Rattus
norvegicus) 		4 / 7 ARG C 117
GLU C 186
PRO C 172
ALA C 170
 None
 1.42A 2ejgB-1n8yC:
undetectable		 2ejgB-1n8yC:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA6_A_SCKA902_1
(ACETYLCHOLINESTERASE)		 1n8y PROTOONCOPROTEIN
(Rattus
norvegicus) 		5 / 10 GLU C  39
MET C  62
ASN C  37
LEU C 119
LEU C 116
 None
 1.49A 2ha6A-1n8yC:
undetectable		 2ha6A-1n8yC:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		 1n8y PROTOONCOPROTEIN
(Rattus
norvegicus) 		5 / 12 ALA C 221
LEU C 232
ALA C 233
GLN C  53
GLN C  75
 None
 1.27A 2jjpA-1n8yC:
undetectable		 2jjpA-1n8yC:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1n8y PROTOONCOPROTEIN
(Rattus
norvegicus) 		5 / 12 GLY C 503
LEU C 434
GLY C 433
GLY C 501
ILE C 429
 None
 1.05A 2nxeB-1n8yC:
undetectable		 2nxeB-1n8yC:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1n8y PROTOONCOPROTEIN
(Rattus
norvegicus) 		4 / 8 ILE C 409
GLU C 300
LEU C 283
GLY C 441
 None
 0.71A 2qqdB-1n8yC:
undetectable
2qqdC-1n8yC:
undetectable		 2qqdB-1n8yC:
11.95
2qqdC-1n8yC:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 1n8y PROTOONCOPROTEIN
(Rattus
norvegicus) 		5 / 10 LEU C 424
ALA C 445
LEU C 440
LEU C 437
ILE C 385
 None
 1.08A 2w9gA-1n8yC:
undetectable		 2w9gA-1n8yC:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 1n8y PROTOONCOPROTEIN
(Rattus
norvegicus) 		5 / 10 LEU C 424
ALA C 445
LEU C 440
LEU C 437
ILE C 385
 None
 1.11A 2w9hA-1n8yC:
undetectable		 2w9hA-1n8yC:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1n8y PROTOONCOPROTEIN
(Rattus
norvegicus) 		5 / 12 GLY C 503
LEU C 434
GLY C 433
GLY C 501
ILE C 429
 None
 1.08A 2zbpA-1n8yC:
undetectable		 2zbpA-1n8yC:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 1n8y PROTOONCOPROTEIN
(Rattus
norvegicus) 		4 / 8 GLY C 323
GLY C 351
GLY C 387
ILE C 410
 None
 0.62A 3d41A-1n8yC:
undetectable		 3d41A-1n8yC:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_0
(PUTATIVE RRNA
METHYLASE)		 1n8y PROTOONCOPROTEIN
(Rattus
norvegicus) 		5 / 12 ASP C 396
GLY C 433
GLN C 506
LEU C 376
PRO C 373
 None
 1.01A 3eeyD-1n8yC:
undetectable		 3eeyD-1n8yC:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1n8y PROTOONCOPROTEIN
(Rattus
norvegicus) 		5 / 10 TYR C  28
ILE C  64
GLY C   6
VAL C  80
LEU C  52
 None
 1.22A 3elzB-1n8yC:
undetectable		 3elzB-1n8yC:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1n8y PROTOONCOPROTEIN
(Rattus
norvegicus) 		5 / 10 TYR C  28
ILE C  64
GLY C   6
VAL C  80
LEU C  52
 None
 1.20A 3elzC-1n8yC:
0.0		 3elzC-1n8yC:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1n8y PROTOONCOPROTEIN
(Rattus
norvegicus) 		5 / 10 TYR C  28
ILE C  64
GLY C   6
VAL C  80
LEU C  52
 None
 1.28A 3em0A-1n8yC:
undetectable		 3em0A-1n8yC:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 1n8y PROTOONCOPROTEIN
(Rattus
norvegicus) 		5 / 11 LEU C 424
ALA C 445
LEU C 440
LEU C 437
ILE C 385
 None
 1.06A 3frbX-1n8yC:
undetectable		 3frbX-1n8yC:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 1n8y PROTOONCOPROTEIN
(Rattus
norvegicus) 		4 / 7 LEU C 424
LEU C 432
ASN C 477
THR C 458
 None
 1.05A 3lm8A-1n8yC:
undetectable
3lm8C-1n8yC:
undetectable		 3lm8A-1n8yC:
15.84
3lm8C-1n8yC:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1n8y PROTOONCOPROTEIN
(Rattus
norvegicus) 		5 / 8 LEU C 353
SER C 352
LEU C 401
ILE C 335
PHE C 355
 None
 1.31A 3ln1A-1n8yC:
undetectable		 3ln1A-1n8yC:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1n8y PROTOONCOPROTEIN
(Rattus
norvegicus) 		5 / 7 LEU C 353
SER C 352
LEU C 401
ILE C 335
PHE C 355
 None
 1.30A 3ln1B-1n8yC:
undetectable		 3ln1B-1n8yC:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 1n8y PROTOONCOPROTEIN
(Rattus
norvegicus) 		3 / 3 SER C 366
ASP C 338
ASN C 339
 None
 1.00A 3lslA-1n8yC:
undetectable
3lslD-1n8yC:
undetectable		 3lslA-1n8yC:
17.88
3lslD-1n8yC:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 1n8y PROTOONCOPROTEIN
(Rattus
norvegicus) 		4 / 5 TYR C 268
THR C 269
PHE C 270
LEU C 283
 None
 1.19A 3qelC-1n8yC:
undetectable		 3qelC-1n8yC:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_0
(MNMC2)		 1n8y PROTOONCOPROTEIN
(Rattus
norvegicus) 		5 / 12 GLY C 412
GLY C 443
LEU C 444
TYR C 420
LEU C 292
 None
 1.18A 3vywA-1n8yC:
undetectable		 3vywA-1n8yC:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_0
(MNMC2)		 1n8y PROTOONCOPROTEIN
(Rattus
norvegicus) 		5 / 12 GLY C 412
GLY C 443
LEU C 444
TYR C 420
LEU C 292
 None
 1.22A 3vywB-1n8yC:
undetectable		 3vywB-1n8yC:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_0
(MNMC2)		 1n8y PROTOONCOPROTEIN
(Rattus
norvegicus) 		5 / 12 GLY C 412
GLY C 443
LEU C 444
TYR C 420
LEU C 292
 None
 1.16A 3vywD-1n8yC:
undetectable		 3vywD-1n8yC:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1n8y PROTOONCOPROTEIN
(Rattus
norvegicus) 		4 / 6 THR C 386
GLY C 412
ARG C 408
LEU C 292
 None
 1.18A 4acaC-1n8yC:
undetectable		 4acaC-1n8yC:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1n8y PROTOONCOPROTEIN
(Rattus
norvegicus) 		5 / 12 ALA C 393
SER C 392
GLN C 375
ILE C 335
SER C 337
 None
 1.22A 4c49A-1n8yC:
0.0		 4c49A-1n8yC:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1n8y PROTOONCOPROTEIN
(Rattus
norvegicus) 		5 / 10 LEU C 353
ILE C 385
GLY C 387
PHE C 355
THR C 423
 None
 1.07A 4fakA-1n8yC:
undetectable		 4fakA-1n8yC:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1n8y PROTOONCOPROTEIN
(Rattus
norvegicus) 		4 / 8 LEU C 382
LEU C 407
LEU C 434
ILE C 349
 None
 0.84A 4klaA-1n8yC:
undetectable		 4klaA-1n8yC:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)		 1n8y PROTOONCOPROTEIN
(Rattus
norvegicus) 		5 / 12 LEU C 422
LEU C 389
LEU C 353
ALA C 354
LEU C 427
 None
 1.10A 4ltwA-1n8yC:
undetectable		 4ltwA-1n8yC:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1n8y PROTOONCOPROTEIN
(Rattus
norvegicus) 		4 / 8 LEU C  92
VAL C  58
TRP C 184
LEU C 119
 None
 1.01A 4pwdC-1n8yC:
0.0		 4pwdC-1n8yC:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB307_1
(CHITOSANASE)		 1n8y PROTOONCOPROTEIN
(Rattus
norvegicus) 		4 / 7 ARG C  81
GLY C  60
THR C  83
VAL C  34
 None
 0.99A 4qwpB-1n8yC:
undetectable		 4qwpB-1n8yC:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1n8y PROTOONCOPROTEIN
(Rattus
norvegicus) 		3 / 3 VAL C  72
LEU C  49
VAL C  69
 None
 0.58A 4wq4A-1n8yC:
undetectable		 4wq4A-1n8yC:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 1n8y PROTOONCOPROTEIN
(Rattus
norvegicus) 		4 / 5 LEU C 453
GLU C 480
LEU C 472
HIS C 448
 None
 1.29A 4xi3B-1n8yC:
undetectable		 4xi3B-1n8yC:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1n8y PROTOONCOPROTEIN
(Rattus
norvegicus) 		5 / 12 ILE C 414
GLY C 412
TYR C 388
GLU C 327
ALA C 354
 None
 1.19A 5igvA-1n8yC:
undetectable		 5igvA-1n8yC:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 1n8y PROTOONCOPROTEIN
(Rattus
norvegicus) 		5 / 12 VAL C 132
TRP C 148
LEU C 119
LEU C 116
VAL C  94
 None
 1.23A 5im2A-1n8yC:
undetectable		 5im2A-1n8yC:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1n8y PROTOONCOPROTEIN
(Rattus
norvegicus) 		4 / 6 VAL C 293
LEU C 324
SER C 352
ILE C 335
 None
 1.01A 5jw1A-1n8yC:
undetectable		 5jw1A-1n8yC:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1n8y PROTOONCOPROTEIN
(Rattus
norvegicus) 		3 / 3 THR C  83
THR C   5
LEU C 292
 None
 0.57A 5m66D-1n8yC:
undetectable		 5m66D-1n8yC:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1n8y PROTOONCOPROTEIN
(Rattus
norvegicus) 		4 / 8 GLY C 433
LEU C 434
VAL C 459
LEU C 424
 None
 0.85A 6czmD-1n8yC:
undetectable
6czmF-1n8yC:
undetectable		 6czmD-1n8yC:
21.22
6czmF-1n8yC:
21.22