SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1n94'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1n94 PROTEIN
FARNESYLTRANSFERASE
BETA SUBUNIT
(Rattus
norvegicus) 		5 / 11 HIS B  80
THR B 363
HIS B  78
ILE B 107
GLY B 348
 None
 1.13A 1c9sP-1n94B:
undetectable
1c9sQ-1n94B:
undetectable		 1c9sP-1n94B:
11.59
1c9sQ-1n94B:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 1n94 PROTEIN
FARNESYLTRANSFERASE
BETA SUBUNIT
(Rattus
norvegicus) 		5 / 11 HIS B  80
THR B 363
HIS B  78
ILE B 107
GLY B 348
 None
 1.11A 1gtfQ-1n94B:
undetectable
1gtfR-1n94B:
undetectable		 1gtfQ-1n94B:
11.59
1gtfR-1n94B:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_S_TRPS81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1n94 PROTEIN
FARNESYLTRANSFERASE
BETA SUBUNIT
(Rattus
norvegicus) 		5 / 11 HIS B  80
THR B 363
HIS B  78
ILE B 107
GLY B 348
 None
 1.14A 1utdS-1n94B:
undetectable
1utdT-1n94B:
undetectable		 1utdS-1n94B:
11.59
1utdT-1n94B:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_V_TRPV81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1n94 PROTEIN
FARNESYLTRANSFERASE
BETA SUBUNIT
(Rattus
norvegicus) 		5 / 11 GLY B 348
HIS B  80
THR B 363
HIS B  78
ILE B 107
 None
 1.14A 1utdL-1n94B:
undetectable
1utdV-1n94B:
undetectable		 1utdL-1n94B:
11.59
1utdV-1n94B:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1507_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 1n94 PROTEIN
FARNESYLTRANSFERASE
BETA SUBUNIT
(Rattus
norvegicus) 		3 / 3 GLN B 344
HIS B  78
ARG B  75
 None
 1.03A 1zlqA-1n94B:
undetectable		 1zlqA-1n94B:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)		 1n94 PROTEIN
FARNESYLTRANSFERASE
BETA SUBUNIT
(Rattus
norvegicus) 		4 / 6 LEU B 311
LEU B 256
PRO B 399
VAL B 400
 None
 1.07A 2dqyC-1n94B:
undetectable		 2dqyC-1n94B:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DXR_A_SORA1002_0
(LACTOTRANSFERRIN)		 1n94 PROTEIN
FARNESYLTRANSFERASE
BETA SUBUNIT
(Rattus
norvegicus) 		3 / 3 THR B 153
PRO B 148
TYR B 180
 None
 0.88A 2dxrA-1n94B:
undetectable		 2dxrA-1n94B:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDM_B_AGGB1462_1
(INTEGRIN ALPHA-IIB
INTEGRIN BETA-3)		 1n94 PROTEIN
FARNESYLTRANSFERASE
BETA SUBUNIT
(Rattus
norvegicus) 		5 / 12 TYR B 365
ASP B 297
TYR B 401
TYR B 154
GLU B 112
 None
ZN  B   2 (-2.3A)
None
None
None
 1.34A 2vdmA-1n94B:
undetectable
2vdmB-1n94B:
undetectable		 2vdmA-1n94B:
21.29
2vdmB-1n94B:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E00_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1n94 PROTEIN
FARNESYLTRANSFERASE
BETA SUBUNIT
(Rattus
norvegicus) 		5 / 12 ALA B 258
ALA B 257
ALA B 204
VAL B 408
ILE B 403
 None
 1.06A 3e00A-1n94B:
undetectable		 3e00A-1n94B:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 1n94 PROTEIN
FARNESYLTRANSFERASE
BETA SUBUNIT
(Rattus
norvegicus) 		5 / 9 ILE B 163
ILE B 162
LEU B 108
LEU B 130
ALA B 168
 None
 1.08A 3ozvB-1n94B:
undetectable		 3ozvB-1n94B:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U8Q_A_NPUA7231_1
(LACTOTRANSFERRIN)		 1n94 PROTEIN
FARNESYLTRANSFERASE
BETA SUBUNIT
(Rattus
norvegicus) 		4 / 5 THR B 153
GLY B 141
PRO B 148
TYR B 180
 None
 0.94A 3u8qA-1n94B:
undetectable		 3u8qA-1n94B:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EVR_A_BEZA401_0
(PUTATIVE ABC
TRANSPORTER SUBUNIT,
SUBSTRATE-BINDING
COMPONENT)		 1n94 PROTEIN
FARNESYLTRANSFERASE
BETA SUBUNIT
(Rattus
norvegicus) 		5 / 11 LEU B 150
PHE B 222
ALA B 258
SER B 203
PHE B 191
 None
 1.42A 4evrA-1n94B:
undetectable		 4evrA-1n94B:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FJP_A_NPSA711_1
(LACTOTRANSFERRIN)		 1n94 PROTEIN
FARNESYLTRANSFERASE
BETA SUBUNIT
(Rattus
norvegicus) 		4 / 6 THR B 153
GLY B 141
PRO B 148
TYR B 180
 None
 0.90A 4fjpA-1n94B:
undetectable		 4fjpA-1n94B:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRK_A_KTRA713_1
(LACTOTRANSFERRIN)		 1n94 PROTEIN
FARNESYLTRANSFERASE
BETA SUBUNIT
(Rattus
norvegicus) 		4 / 5 THR B 153
GLY B 141
PRO B 148
TYR B 180
 None
 0.86A 4grkA-1n94B:
undetectable		 4grkA-1n94B:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 1n94 PROTEIN
FARNESYLTRANSFERASE
BETA SUBUNIT
(Rattus
norvegicus) 		5 / 12 ILE B 372
TYR B 205
LEU B 262
TYR B 401
LEU B 310
 None
 1.32A 4j03A-1n94B:
undetectable		 4j03A-1n94B:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		 1n94 PROTEIN
FARNESYLTRANSFERASE
BETA SUBUNIT
(Rattus
norvegicus) 		3 / 3 ARG B 313
LEU B 310
GLU B 265
 None
 0.76A 4l3gF-1n94B:
undetectable		 4l3gF-1n94B:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 1n94 PROTEIN
FARNESYLTRANSFERASE
BETA SUBUNIT
(Rattus
norvegicus) 		5 / 12 ALA B 208
GLY B 255
LEU B 307
LEU B 310
ALA B 204
 None
 1.15A 4lg1C-1n94B:
undetectable		 4lg1C-1n94B:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1n94 PROTEIN
FARNESYLTRANSFERASE
BETA SUBUNIT
(Rattus
norvegicus) 		4 / 8 ILE B 261
LEU B 181
LEU B 178
ILE B 217
 None
 0.98A 4xtaB-1n94B:
undetectable		 4xtaB-1n94B:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1n94 PROTEIN
FARNESYLTRANSFERASE
BETA SUBUNIT
(Rattus
norvegicus) 		3 / 3 PHE B 284
ILE B  55
ASP B 297
 None
None
ZN  B   2 (-2.3A)
 0.64A 5cswA-1n94B:
undetectable		 5cswA-1n94B:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1n94 PROTEIN
FARNESYLTRANSFERASE
BETA SUBUNIT
(Rattus
norvegicus) 		3 / 3 PHE B 284
ILE B  55
ASP B 297
 None
None
ZN  B   2 (-2.3A)
 0.58A 5cswB-1n94B:
undetectable		 5cswB-1n94B:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 1n94 PROTEIN
FARNESYLTRANSFERASE
BETA SUBUNIT
(Rattus
norvegicus) 		4 / 8 LEU B 150
PHE B 191
ALA B 211
PHE B 222
 None
 0.91A 5m0oC-1n94B:
undetectable		 5m0oC-1n94B:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 1n94 PROTEIN
FARNESYLTRANSFERASE
BETA SUBUNIT
(Rattus
norvegicus) 		4 / 7 ALA B 226
GLY B 224
GLY B 189
GLU B 227
 None
 0.61A 5ybbB-1n94B:
undetectable		 5ybbB-1n94B:
22.42